| Entry |
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| Name |
citrate (Re)-synthase;
(R)-citrate synthase;
Re-citrate-synthase;
citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA]
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| Class |
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
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| Sysname |
acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]
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| Reaction(IUBMB) |
acetyl-CoA + H2O + oxaloacetate = citrate + CoA [RN: R00351]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
This enzyme is inactivated by oxygen and is found in some anaerobes. Its stereospecificity is opposite to that of EC 2.3.3.1, citrate (Si)-synthase.
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| History |
EC 2.3.3.3 created 1972 as EC 4.1.3.28, transferred 2002 to EC 2.3.3.3
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
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| Genes |
| ALUS: | STSP2_00175(leuA_2) |
| PKP: | SK3146_05970(leuA_4) |
| CPAE: | CPAST_c14670(leuA2) |
| RPAY: | P0092_00635 P0092_14480 |
| BPRO: | PMF13cell1_03741(leuA_2) |
| CSC: | Csac_0724 Csac_0746 Csac_2456 |
| COB: | COB47_0468 COB47_2001 |
| CHD: | Calhy_0541 Calhy_2133 Calhy_2151 |
| COW: | Calow_0374 Calow_1908 |
| CKI: | Calkr_1788 Calkr_1803 Calkr_2241 |
| CLC: | Calla_0210 Calla_1186 Calla_1202 |
| CKN: | Calkro_0420 Calkro_2113 Calkro_2129 |
| CCHA: | ELD05_11145 ELD05_11265 ELD05_13070 |
| CDIA: | CaldiYA01_03730 CaldiYA01_19300 CaldiYA01_19440 |
| CNAG: | OTJ99_002069 OTJ99_002115 OTJ99_002304 |
| CMOR: | OTK00_000421 OTK00_000436 OTK00_000473 |
| CDAN: | SOJ16_000470 SOJ16_000485 SOJ16_002340 |
| LOKI: | Lokiarch_26360(leuA_2) Lokiarch_35110(leuA_4) |
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| Reference |
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| Authors |
Dittbrenner S, Chowdhury AA, Gottschalk G. |
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| Title |
The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate. |
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| Journal |
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| Reference |
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| Authors |
Gottschalk G. |
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| Title |
Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici. |
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| Journal |
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| Reference |
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| Authors |
Gottschalk G, Barker HA. |
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| Title |
Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.3.3.3 |
| ExPASy - ENZYME nomenclature database: | 2.3.3.3 |
| BRENDA, the Enzyme Database: | 2.3.3.3 |
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