KEGG   ENZYME: 2.3.3.8Help
Entry
EC 2.3.3.8                  Enzyme                                 

Name
ATP citrate synthase;
ATP-citric lyase;
ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-->acetyl-CoA] (ATP-dephosphorylating);
acetyl-CoA:oxaloacetate acetyltransferase (isomerizing;
ADP-phosphorylating);
adenosine triphosphate citrate lyase;
citrate cleavage enzyme;
citrate-ATP lyase;
citric cleavage enzyme;
ATP citrate (pro-S)-lyase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
Reaction(IUBMB)
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA [RN:R00352]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
phosphate [CPD:C00009];
acetyl-CoA [CPD:C00024];
oxaloacetate [CPD:C00036]
Product
ATP [CPD:C00002];
citrate [CPD:C00158];
CoA [CPD:C00010]
Comment
The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).
History
EC 2.3.3.8 created 1965 as EC 4.1.3.8, modified 1986, transferred 2002 to EC 2.3.3.8
Pathway
ec00020  Citrate cycle (TCA cycle)
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K01648  ATP citrate (pro-S)-lyase
K15230  ATP-citrate lyase alpha-subunit
K15231  ATP-citrate lyase beta-subunit
Genes
HSA: 47(ACLY)
PTR: 454672(ACLY)
PPS: 100981849(ACLY)
GGO: 101132535(ACLY)
PON: 100439535(ACLY)
NLE: 100601132(ACLY)
MCC: 708501(ACLY)
MCF: 102139439(ACLY)
CSAB: 103243859(ACLY)
RRO: 104680455(ACLY)
RBB: 108518356 108534726(ACLY)
CJC: 100405725(ACLY)
SBQ: 101051906(ACLY)
MMU: 104112(Acly)
RNO: 24159(Acly)
NGI: 103735876(Acly)
HGL: 101700349(Acly)
CCAN: 109695762(Acly)
OCU: 100346747(ACLY)
TUP: 102487454(ACLY)
CFA: 607852(ACLY)
AML: 100467494(ACLY)
UMR: 103672560(ACLY)
ORO: 101368080(ACLY)
FCA: 100422779(ACLY)
PTG: 102954566(ACLY)
AJU: 106972598(ACLY)
BTA: 511135(ACLY)
BOM: 102287054(ACLY)
BIU: 109573634(ACLY)
PHD: 102334260(ACLY)
CHX: 102181894(ACLY)
OAS: 654404(ACLY)
SSC: 100125957(ACLY)
CFR: 102508520(ACLY)
CDK: 105090445(ACLY)
LVE: 103077497(ACLY)
OOR: 101277148(ACLY)
ECB: 100053195(ACLY)
EPZ: 103550376(ACLY)
EAI: 106826361(ACLY)
MYB: 102246873(ACLY)
MYD: 102759921(ACLY)
HAI: 109395729(ACLY)
PALE: 102888049(ACLY)
LAV: 100667233(ACLY)
TMU: 101346806
MDO: 100011977(ACLY)
SHR: 100924578(ACLY)
OAA: 100089333
GGA: 395373(ACLY)
MGP: 100544111(ACLY)
CJO: 107325118(ACLY)
APLA: 101793308(ACLY)
ACYG: 106048017(ACLY)
TGU: 100221719(ACLY)
GFR: 102034815(ACLY)
FAB: 101805819(ACLY)
PHI: 102099293(ACLY)
PMAJ: 107215114(ACLY)
CCW: 104697755(ACLY)
FPG: 101918381(ACLY)
FCH: 102047351(ACLY)
CLV: 102097494(ACLY)
EGZ: 104131387(ACLY)
AAM: 106487628(ACLY)
ASN: 102386616(ACLY)
AMJ: 102572777(ACLY)
PSS: 102444696(ACLY)
CMY: 102930695(ACLY)
CPIC: 101941763(ACLY)
ACS: 100557175(acly)
PVT: 110088988(ACLY)
PBI: 103067911(ACLY)
GJA: 107116244(ACLY)
XLA: 495086(acly.S) 495316
XTR: 493390(acly)
NPR: 108788936(ACLY)
DRE: 436922(aclya)
IPU: 108258521(acly) 108273769
AMEX: 103023371 103042216(acly)
TRU: 101069651 101072240(acly)
LCO: 104926081(acly) 104930984
MZE: 101483257 101485070(acly)
XMA: 102224554(acly) 102228484
PRET: 103469414(acly) 103481260
NFU: 107387857 107395298(acly)
CSEM: 103381466 103393105(acly)
LCF: 108901343(acly) 108901721
BPEC: 110154214 110161819(acly)
ELS: 105013338(acly)
LCM: 102364563(ACLY)
CMK: 103185738(acly)
CIN: 445783(acl)
SPU: 587157(ACLY)
SKO: 100377487
DME: Dmel_CG8322(ATPCL)
DSI: Dsimw501_GD25577(Dsim_GD25577)
MDE: 101891858
AAG: 5564509
AME: 550686(ATPCL)
BIM: 100745478
BTER: 100650219
SOC: 105207846
AEC: 105143187
ACEP: 105622935
PBAR: 105429784
HST: 105188186
CFO: 105250699
LHU: 105675266
PGC: 109855528
NVI: 100119651
TCA: 656728
DPA: 109541269
NVL: 108569619
PXY: 105380677
API: 100165099(Atpcl)
DNX: 107173542
ZNE: 110839946
FCD: 110847723
TUT: 107362563
CEL: CELE_B0365.1(acly-2) CELE_D1005.1(acly-1)
BMY: Bm1_26245
TSP: Tsp_01728
CRG: 105335901
MYI: 110465532
OBI: 106879485
SHX: MS3_06938
EPA: 110250736
HMG: 100201862
AQU: 100640666
ATH: AT1G09430(ACLA-3) AT1G10670(ACLA-1) AT1G60810(ACLA-2) AT3G06650(ACLB-1) AT5G49460(ACLB-2)
LJA: Lj0g3v0068209.1(Lj0g3v0068209.1) Lj1g3v4804050.1(Lj1g3v4804050.1) Lj1g3v4804050.2(Lj1g3v4804050.2) Lj2g3v1415070.1(Lj2g3v1415070.1) Lj2g3v1415070.2(Lj2g3v1415070.2) Lj3g3v0937850.1(Lj3g3v0937850.1) Lj4g3v2265020.1(Lj4g3v2265020.1) Lj4g3v2266260.1(Lj4g3v2266260.1) Lj6g3v1915820.1(Lj6g3v1915820.1) Lj6g3v1915820.2(Lj6g3v1915820.2) Lj6g3v1915830.1(Lj6g3v1915830.1)
DOSA: Os01t0300200-01(Os01g0300200) Os11t0693800-01(Os11g0693800) Os11t0696200-01(Os11g0696200) Os12t0566300-01(Os12g0566300)
ATS: 109750159(LOC109750159) 109752526(LOC109752526) 109778001(LOC109778001) 109782165(LOC109782165)
ZMA: 100273868(cl718_1(752)) 100282948(pco080711) 100381760(pco065117) 103635086
NTE: NEUTE1DRAFT117451(NEUTE1DRAFT_117451) NEUTE1DRAFT123184(NEUTE1DRAFT_123184)
SMP: SMAC_06774(acl2) SMAC_06775(acl1)
BFU: BCIN_13g02440(CND6)
ANG: ANI_1_76094(An11g00510) ANI_1_78094(An11g00530)
CNE: CNJ00800
CNB: CNBJ2710
ABP: AGABI1DRAFT115583(AGABI1DRAFT_115583)
ABV: AGABI2DRAFT194501(AGABI2DRAFT_194501)
DFA: DFA_04229 DFA_09735(acly)
SMIN: v1.2.003200.t1(symbB.v1.2.003200.t1) v1.2.026551.t1(symbB.v1.2.026551.t1) v1.2.028198.t1(symbB.v1.2.028198.t1) v1.2.028199.t1(symbB.v1.2.028199.t1) v1.2.030373.t1(symbB.v1.2.030373.t1) v1.2.036589.t1(symbB.v1.2.036589.t1) v1.2.036589.t2(symbB.v1.2.036589.t2)
PTI: PHATRDRAFT_54477(ACL)
SPAR: SPRG_01813
SMUL: SMUL_0066(aclA) SMUL_0067(aclB)
PROC: Ptc2401_01122(sucC_1) Ptc2401_01123(sucD_2)
NDE: NIDE0834(aclB) NIDE0835(aclA)
NMV: NITMOv2_0690(aclB) NITMOv2_0691(aclA)
NIO: NITINOP_0227(aclA) NITINOP_0228(aclB)
NJA: NSJP_1799(aclB) NSJP_1800(aclA)
LOKI: Lokiarch_34550(sucC_1)
 » show all
Taxonomy
Reference
1  [PMID:6749502]
  Authors
Lill U, Schreil A, Eggerer H.
  Title
Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase.
  Journal
Eur J Biochem 125:645-50 (1982)
DOI:10.1111/j.1432-1033.1982.tb06731.x
Reference
2
  Authors
Srere, P.A. and Lipmann, F.
  Title
An enzymatic reaction between citrate, adenosine triphosphate and coenzyme A.
  Journal
J Am Chem Soc 75:4874 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.8
IUBMB Enzyme Nomenclature: 2.3.3.8
ExPASy - ENZYME nomenclature database: 2.3.3.8
BRENDA, the Enzyme Database: 2.3.3.8
CAS: 9027-95-6

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