KEGG   ENZYME: 2.3.3.8Help
Entry
EC 2.3.3.8                  Enzyme                                 

Name
ATP citrate synthase;
ATP-citric lyase;
ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-->acetyl-CoA] (ATP-dephosphorylating);
acetyl-CoA:oxaloacetate acetyltransferase (isomerizing;
ADP-phosphorylating);
adenosine triphosphate citrate lyase;
citrate cleavage enzyme;
citrate-ATP lyase;
citric cleavage enzyme;
ATP citrate (pro-S)-lyase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
Reaction(IUBMB)
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA [RN:R00352]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
phosphate [CPD:C00009];
acetyl-CoA [CPD:C00024];
oxaloacetate [CPD:C00036]
Product
ATP [CPD:C00002];
citrate [CPD:C00158];
CoA [CPD:C00010]
Comment
The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate---CoA ligase).
History
EC 2.3.3.8 created 1965 as EC 4.1.3.8, modified 1986, transferred 2002 to EC 2.3.3.8
Pathway
ec00020  Citrate cycle (TCA cycle)
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K01648  ATP citrate (pro-S)-lyase
K15230  ATP-citrate lyase alpha-subunit
K15231  ATP-citrate lyase beta-subunit
Genes
HSA: 47(ACLY)
PTR: 454672(ACLY)
PPS: 100981849(ACLY)
GGO: 101132535(ACLY)
PON: 100439535(ACLY)
NLE: 100601132(ACLY)
MCC: 708501(ACLY)
MCF: 102139439(ACLY)
CSAB: 103243859(ACLY)
RRO: 104680455(ACLY) 115894885 115894939 115894954
RBB: 108518356 108534726(ACLY)
CJC: 100405725(ACLY)
SBQ: 101051906(ACLY)
MMU: 104112(Acly)
MCAL: 110304306(Acly)
MPAH: 110332696(Acly)
RNO: 24159(Acly)
MUN: 110540730(Acly)
CGE: 100773325
NGI: 103735876(Acly)
HGL: 101700349(Acly)
CCAN: 109695762(Acly)
OCU: 100346747(ACLY)
TUP: 102487454(ACLY)
CFA: 607852(ACLY)
VVP: 112910827(ACLY)
AML: 100467494(ACLY)
UMR: 103672560(ACLY)
UAH: 113265439(ACLY)
ORO: 101368080(ACLY)
ELK: 111151216
FCA: 100422779(ACLY)
PTG: 102954566(ACLY)
PPAD: 109258552(ACLY)
AJU: 106972598(ACLY)
BTA: 511135(ACLY)
BOM: 102287054(ACLY)
BIU: 109573634(ACLY)
BBUB: 102393057(ACLY)
CHX: 102181894(ACLY)
OAS: 654404(ACLY)
SSC: 100125957(ACLY)
CFR: 102508520(ACLY)
CDK: 105090445(ACLY)
LVE: 103077497(ACLY)
OOR: 101277148(ACLY)
DLE: 111166237(ACLY)
ECB: 100053195(ACLY)
EPZ: 103550376(ACLY)
EAI: 106826361(ACLY)
MYB: 102246873(ACLY)
MYD: 102759921(ACLY)
MNA: 107538758(ACLY)
HAI: 109395729(ACLY)
DRO: 112298553(ACLY)
PALE: 102888049(ACLY)
RAY: 107513807(ACLY)
MJV: 108397138(ACLY)
LAV: 100667233(ACLY)
TMU: 101346806
MDO: 100011977(ACLY)
SHR: 100924578(ACLY)
PCW: 110198389(ACLY)
OAA: 100089333(ACLY)
GGA: 395373(ACLY)
MGP: 100544111(ACLY)
CJO: 107325118(ACLY)
NMEL: 110388478(ACLY)
APLA: 101793308(ACLY)
ACYG: 106048017(ACLY)
TGU: 100221719(ACLY)
LSR: 110471854(ACLY)
SCAN: 103821599(ACLY)
GFR: 102034815(ACLY)
FAB: 101805819(ACLY)
PHI: 102099293(ACLY)
PMAJ: 107215114(ACLY)
CCAE: 111939941(ACLY)
CCW: 104697755(ACLY)
ETL: 114063634(ACLY)
FPG: 101918381(ACLY)
FCH: 102047351(ACLY)
CLV: 102097494(ACLY)
EGZ: 104131387(ACLY)
NNI: 104009868(ACLY)
ACUN: 113489156(ACLY)
PADL: 103919491(ACLY)
AAM: 106487628(ACLY)
ASN: 102386616(ACLY)
AMJ: 102572777(ACLY)
PSS: 102444696(ACLY)
CMY: 102930695(ACLY)
CPIC: 101941763(ACLY)
ACS: 100557175(acly)
PVT: 110088988(ACLY)
PBI: 103067911(ACLY)
PMUR: 107303043(ACLY)
TSR: 106538254(ACLY)
PMUA: 114581513(ACLY)
GJA: 107116244(ACLY)
XLA: 495086(acly.S) 495316
XTR: 493390(acly)
NPR: 108788936(ACLY)
DRE: 436922(aclya)
IPU: 108258521(acly) 108273769
PHYP: 113528283(acly) 113535056
AMEX: 103023371 103042216(acly)
EEE: 113581553 113592331(acly)
TRU: 101069651 101072240(acly)
MZE: 101483257 101485070(acly)
ONL: 100690537(acly) 100706997
XMA: 102224554(acly) 102228484
XCO: 114152045 114159617(acly)
PRET: 103469414(acly) 103481260
CVG: 107099611(acly) 107099763
NFU: 107387857 107395298(acly)
KMR: 108243751(acly) 108249058
ALIM: 106516978 106527937(acly)
CSEM: 103381466 103393105(acly)
LCF: 108901343(acly) 108901721
SDU: 111217495(acly) 111220212
SLAL: 111652814(acly) 111657113
BPEC: 110154214 110161819(acly)
MALB: 109963029 109964230(acly)
ELS: 105013338(acly)
SFM: 108919709 108941823(acly)
PKI: 111842517 111855971(acly)
LCM: 102364563(ACLY)
CMK: 103185738(acly)
RTP: 109918067(acly)
CIN: 445783(acl)
SPU: 587157
SKO: 100377487
DME: Dmel_CG8322(ATPCL)
DER: 6548754
DSI: Dsimw501_GD25577(Dsim_GD25577)
DSR: 110178519
DPE: 6601350
DMN: 108159977
DWI: 6637856
DAZ: 108615968
DNV: 108654447
DHE: 111594006
MDE: 101891858
LCQ: 111680485
AAG: 5564509
AALB: 109425132
AME: 550686
BIM: 100745478
BTER: 100650219
CCAL: 108627768
OBB: 114876334
MPHA: 105839063
AEC: 105143187
ACEP: 105622935
PBAR: 105429784
VEM: 105560699
HST: 105188186
DQU: 106743343
CFO: 105250699
LHU: 105675266
PGC: 109855528
OBO: 105285413
PCF: 106788484
NVI: 100119651
CSOL: 105361316
MDL: 103568760
TCA: 656728
DPA: 109541269
NVL: 108569619
BMAN: 114247106
HAW: 110382034
TNL: 113505697
PXY: 105380677
API: 100165099(Atpcl)
DNX: 107173542
AGS: 114119839
RMD: 113557292
BTAB: 109033027
CLEC: 106665077
ZNE: 110839946
FCD: 110847723
PVM: 113820574
TUT: 107362563
DPTE: 113791137
CSCU: 111628825
PTEP: 107443062
CEL: CELE_B0365.1(acly-2) CELE_D1005.1(acly-1)
BMY: Bm1_26245
TSP: Tsp_01728
PCAN: 112564404
CRG: 105335901
MYI: 110465532
OBI: 106879485
SHX: MS3_06938
EPA: 110250736
AMIL: 114957318
PDAM: 113678655
SPIS: 111328982
DGT: 114530732
HMG: 100201862
AQU: 100640666
ATH: AT1G09430(ACLA-3) AT1G10670(ACLA-1) AT1G60810(ACLA-2) AT3G06650(ACLB-1) AT5G49460(ACLB-2)
LJA: Lj0g3v0068209.1(Lj0g3v0068209.1) Lj1g3v4804050.1(Lj1g3v4804050.1) Lj1g3v4804050.2(Lj1g3v4804050.2) Lj2g3v1415070.1(Lj2g3v1415070.1) Lj2g3v1415070.2(Lj2g3v1415070.2) Lj3g3v0937850.1(Lj3g3v0937850.1) Lj4g3v2265020.1(Lj4g3v2265020.1) Lj4g3v2266260.1(Lj4g3v2266260.1) Lj6g3v1915820.1(Lj6g3v1915820.1) Lj6g3v1915820.2(Lj6g3v1915820.2) Lj6g3v1915830.1(Lj6g3v1915830.1)
DOSA: Os01t0300200-01(Os01g0300200) Os11t0693800-01(Os11g0693800) Os11t0696200-01(Os11g0696200) Os12t0566300-01(Os12g0566300)
ATS: 109750159(LOC109750159) 109752526(LOC109752526) 109778001(LOC109778001) 109782165(LOC109782165)
ZMA: 100273868(cl718_1(752)) 100282948(pco080711) 100381760(pco065117) 103635086
NTE: NEUTE1DRAFT117451(NEUTE1DRAFT_117451) NEUTE1DRAFT123184(NEUTE1DRAFT_123184)
SMP: SMAC_06774(acl2) SMAC_06775(acl1)
BFU: BCIN_13g02430(CND16) BCIN_13g02440(CND6)
ANG: ANI_1_76094(An11g00510) ANI_1_78094(An11g00530)
CNE: CNJ00800
CNB: CNBJ2710
ABP: AGABI1DRAFT115583(AGABI1DRAFT_115583)
ABV: AGABI2DRAFT194501(AGABI2DRAFT_194501)
DFA: DFA_04229 DFA_09735(acly)
SMIN: v1.2.003200.t1(symbB.v1.2.003200.t1) v1.2.026551.t1(symbB.v1.2.026551.t1) v1.2.028198.t1(symbB.v1.2.028198.t1) v1.2.028199.t1(symbB.v1.2.028199.t1) v1.2.030373.t1(symbB.v1.2.030373.t1) v1.2.036589.t1(symbB.v1.2.036589.t1) v1.2.036589.t2(symbB.v1.2.036589.t2)
PTI: PHATRDRAFT_54477(ACL)
SPAR: SPRG_01813
SMUL: SMUL_0066(aclA) SMUL_0067(aclB)
PROC: Ptc2401_01122(sucC_1) Ptc2401_01123(sucD_2)
NDE: NIDE0834(aclB) NIDE0835(aclA)
NMV: NITMOv2_0690(aclB) NITMOv2_0691(aclA)
NIO: NITINOP_0227(aclA) NITINOP_0228(aclB)
NJA: NSJP_1799(aclB) NSJP_1800(aclA)
BANA: BARAN1_0735(aclB) BARAN1_0736(aclA)
LOKI: Lokiarch_34550(sucC_1)
 » show all
Taxonomy
Reference
1  [PMID:6749502]
  Authors
Lill U, Schreil A, Eggerer H.
  Title
Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase.
  Journal
Eur J Biochem 125:645-50 (1982)
DOI:10.1111/j.1432-1033.1982.tb06731.x
Reference
2
  Authors
Srere, P.A. and Lipmann, F.
  Title
An enzymatic reaction between citrate, adenosine triphosphate and coenzyme A.
  Journal
J Am Chem Soc 75:4874 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.8
IUBMB Enzyme Nomenclature: 2.3.3.8
ExPASy - ENZYME nomenclature database: 2.3.3.8
BRENDA, the Enzyme Database: 2.3.3.8
CAS: 9027-95-6

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