KEGG   ENZYME: 2.4.1.102
Entry
EC 2.4.1.102                Enzyme                                 
Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I;
beta6-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase;
core 2 acetylglucosaminyltransferase;
core 6-beta-GlcNAc-transferase A;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase;
GCNT1;
GCNT3;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein] = UDP + O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] [RN:R04575 R05912]
Reaction(KEGG)
R04575 R05912(G);
(other) R05910(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein]
Product
UDP [CPD:C00015];
O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Comment
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2.
History
EC 2.4.1.102 created 1983, modified 2018
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00727  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Genes
HSA2650(GCNT1)
PTR472959(GCNT1)
PPS100990909(GCNT1)
GGO101144738(GCNT1)
PON100453351(GCNT1)
NLE100590764(GCNT1)
MCC704639(GCNT1)
MCF102121951(GCNT1)
MTHB126936832
CSAB103219612(GCNT1)
CATY105584201(GCNT1)
PANU101017569(GCNT1)
TGE112608675(GCNT1)
RRO104682177(GCNT1)
RBB108542654(GCNT1)
TFN117098448(GCNT1)
PTEH111543369(GCNT1)
CJC100397450(GCNT1)
SBQ101041046(GCNT1)
CSYR103262723(GCNT1)
MMUR105862366 105868687(GCNT1)
LCAT123646009(GCNT1)
OGA100944573(GCNT1)
MMU14537(Gcnt1)
MCAL110285874(Gcnt1)
MPAH110334399(Gcnt1)
RNO64043(Gcnt1)
MCOC116103632(Gcnt1)
MUN110557756(Gcnt1)
CGE100767124(Gcnt1)
MAUA106021036(Gcnt1)
PLEU114696918(Gcnt1)
MORG121454000(Gcnt1)
MFOT126512178
AAMP119820782(Gcnt1) 119826209
NGI103730640
HGL101713056(Gcnt1)
CPOC100730200(Gcnt1)
CCAN109693363(Gcnt1)
DORD105987179(Gcnt1)
DSP122095132(Gcnt1)
NCAR124964514
OCU100347030(GCNT1)
OPI101519978 101535946(GCNT1)
TUP102474618(GCNT1)
CFA484158(GCNT1)
CLUD125752083(GCNT1)
VVP112922094(GCNT1)
VLG121485845(GCNT1)
AML100481771(GCNT1)
UMR103663275(GCNT1)
UAH113269836(GCNT1)
UAR123781505(GCNT1)
ELK111153608
LLV125083876
MPUF101672304(GCNT1)
ORO101386761(GCNT1)
EJU114201578(GCNT1)
ZCA113935061(GCNT1)
MLX118026275(GCNT1)
NSU110579726(GCNT1)
FCA101093969(GCNT1)
PYU121013610(GCNT1)
PBG122475441(GCNT1)
LRUF124528625
PTG102952027(GCNT1)
PPAD109275372(GCNT1)
AJU106975313(GCNT1)
HHV120225185 120238445(GCNT1)
BTA281778(GCNT1)
BOM102285997(GCNT1)
BIU109562970(GCNT1)
BBUB102389154(GCNT1)
CHX102187590(GCNT1)
OAS101121316(GCNT1)
ODA120875090(GCNT1)
CCAD122420261 122452853(GCNT1)
SSC106508649(GCNT1)
CFR102509033(GCNT1)
CBAI105067290(GCNT1)
CDK105087407(GCNT1)
VPC102526638(GCNT1)
BACU103015488(GCNT1)
LVE103084201(GCNT1)
OOR101290151(GCNT1)
DLE111174579(GCNT1)
PCAD102994842(GCNT1)
PSIU116755224(GCNT1)
ECB100061416(GCNT1)
EPZ103548068(GCNT1)
EAI106825720(GCNT1)
MYB102248045(GCNT1)
MYD102759783(GCNT1)
MMYO118667441(GCNT1)
MLF102422957(GCNT1)
MNA107544975(GCNT1)
PKL118716468(GCNT1)
HAI109385744(GCNT1)
DRO112300312(GCNT1)
SHON118976054(GCNT1)
AJM119052108(GCNT1)
PDIC114509957(GCNT1)
PHAS123820191(GCNT1)
MMF118629590(GCNT1)
RFQ117032105(GCNT1)
PALE102898105(GCNT1)
PGIG120587436(GCNT1)
PVP105303996(GCNT1)
RAY107517197(GCNT1)
MJV108405009(GCNT1)
TOD119230799(GCNT1)
SARA101557267(GCNT1)
LAV100658096(GCNT1)
TMU101353425
DNM101424646(GCNT1)
MDO100011966(GCNT1)
GAS123231027(GCNT1)
SHR100921847(GCNT1)
PCW110214553(GCNT1)
OAA100075656(GCNT1)
GGA427260(GCNT1)
PCOC116234653(GCNT1)
MGP100544057(GCNT1)
CJO107306219(GCNT1)
NMEL110390082(GCNT1)
APLA101796875(GCNT1)
ACYG106044482(GCNT1)
AFUL116500908(GCNT1)
TGU100221628(GCNT1)
LSR110470687(GCNT1)
SCAN103819436(GCNT1)
PMOA120512071(GCNT1)
OTC121331666(GCNT1)
PRUF121363342(GCNT1)
GFR102041616(GCNT1)
FAB101808578(GCNT1)
PHI102103854(GCNT1)
PMAJ107198206(GCNT1)
CCAE111940833(GCNT1)
CCW104691986(GCNT1)
CBRC103616459(GCNT1)
ETL114072064(GCNT1)
ZAB102074966(GCNT1)
ACHL103798592(GCNT1)
FPG101912116(GCNT1)
FCH102047162(GCNT1)
CLV102085044(GCNT1)
EGZ104123222(GCNT1)
NNI104020877(GCNT1)
PLET104618040
PCRI104027187
PCAO104053129(GCNT1)
ACUN113490172(GCNT1)
TALA104359179(GCNT1)
PADL103920382(GCNT1)
AFOR103903950(GCNT1)
ACHC115337020(GCNT1)
HALD104314315
CCRI104163473(GCNT1)
CSTI104554032(GCNT1)
EHS104506716(GCNT1)
CMAC104481443
MUI104541776(GCNT1)
FGA104072782(GCNT1)
GSTE104264674
LDI104344038(GCNT1)
MNB103769372(GCNT1)
OHA104333382(GCNT1)
NNT104413060(GCNT1)
DPUB104298551(GCNT1)
PGUU104467207(GCNT1)
ACAR104530745
AVIT104273615(GCNT1)
CVF104284381(GCNT1)
CUCA104058399(GCNT1)
AAM106489914
AROW112965400(GCNT1)
NPD112958208(GCNT1)
TGT104579188(GCNT1)
DNE112983248(GCNT1)
SCAM104142803(GCNT1) 104152056
ASN102385228(GCNT1)
AMJ102563225(GCNT1)
CPOO109323663(GCNT1)
GGN109297578(GCNT1)
PSS102449351
CMY102941735(GCNT1)
CPIC101952241(GCNT1)
TST117879327(GCNT1)
CABI116821608(GCNT1)
MRV120407563(GCNT1)
ACS100565751(gcnt1)
PVT110076011(GCNT1)
SUND121924415(GCNT1)
PBI103048092(GCNT1)
PMUR107286167(GCNT1)
CTIG120316092(GCNT1)
TSR106544714(GCNT1)
PGUT117661427(GCNT1)
VKO123031433(GCNT1)
PMUA114606431(GCNT1)
ZVI118077026(GCNT1)
GJA107108744(GCNT1)
STOW125437302(GCNT1)
XLA380501(gcnt1.L) 495090(gcnt1.S)
XTR100490337(gcnt1)
NPR108788489(GCNT1)
RTEM120943002(GCNT1)
BBUF120989141(GCNT1)
BGAR122923147(GCNT1)
IPU108265617
PHYP113533424
SMEO124400333
TFD113645913 113656276 113657001
AMEX103024919(gcnt1) 111189883
EEE113567652(gcnt1)
TRU101066002
TNGGSTEN00029414G001
LCO104920349 104920350
ELY117252556
EFO125889659
PLEP121944981
SLUC116056910
PFLV114556226(gcnt1)
GAT120830993
PPUG119224778
MSAM119891357
CUD121509774
ALAT119019681 119020259 119020260
MZE101481222 101481511 101485293 112435648
ONL100695077 100695236 100695500 100711034 102079779 109194425 109201782 109204432
OAU116311867 116311880 116313061 116332432 116332433 116332434 120443083 120443084
OLA101157299(gcnt1)
OML112147969
XMA102217069
XHE116730048
PRET103470242(gcnt1)
PFOR103135354(gcnt1)
PLAI106951463(gcnt1)
PMEI106924505(gcnt1)
GAF122828439
CVG107087256
CTUL119781520 119797394
GMU124877841 124877902
NFU107394005 107394006 107394008
KMR108234497 108234507
ALIM106523800 106523801
NWH119413066 119413332
AOCE111575565 111576639
MCEP125011747 125012221
POV109638064(gcnt1)
SSEN122769726
HHIP117768421 117768422
HSP118114916 118114917 118114918 118114919
LCF108878093
SDU111230816 111230818
SLAL111652911(gcnt1)
XGL120805459
HCQ109520688(gcnt1)
BSPL114863217
SASA106585626(gcnt1)
OTW112249449
OGO124033034
ONE115110990
CCLU121584073
SFM108938500(gcnt1)
PKI111839312(gcnt1)
AANG118237394
LOC102691186(gcnt1)
PSPA121318921 121318929 121328228
ARUT117408409 117420839 117420920
LCM102357208(GCNT1)
CMK103186097 103188128
RTP109928202(gcnt1)
APLC110984114
SKO100372443 100372744 100373957 100375210 100379011
CELCELE_C54C8.11(gly-15) CELE_T15D6.2(gly-16)
CBRCBG_04363(Cbr-gly-15)
NAINECAME_01847 NECAME_01861 NECAME_07494
HROHELRODRAFT_106314 HELRODRAFT_141556 HELRODRAFT_72329
LGILOTGIDRAFT_104647 LOTGIDRAFT_108047 LOTGIDRAFT_163866 LOTGIDRAFT_54803 LOTGIDRAFT_73452
PCAN112553289 112553290 112554440 112561191 112562773 112562774 112562775 112568345 112568760 112568761 112568762 112568892 112570429 112571042 112574428 112575127
BGT106051358 106054203 106058043 106061498 106066663 106068870 106068871 106071886
GAE121366709 121375905 121376305 121378076 121378859 121378861 121378902 121379313 121384333 121385720 121385928 121386880 121389643 121391132
HRF124119522 124119523 124119524 124120096 124120233 124120235 124120248 124120253 124121794 124121808 124123113 124125089 124132696 124142190 124148336 124150987 124152028
HRJ124253757 124254618 124254619 124257643 124257644 124257647 124257669 124261325 124265796 124279184 124280091 124286439 124286440 124286577 124289654
CRG105320752 105334548 105335887 105336571 105336746 105336756 105343968 109619687 117685721 117685722 117685724 117685725 117685726 117691383 117691384 117691474
MYI110445188 110449075 110455573 110456784 110458069 110465295
PMAX117330518 117332605 117333071 117340932 117341076 117341501
MMER123524577 123527992 123532558 123532716 123535190 123539136 123541568 123549078 123551880 123557471 123558470 123561080 123561083 123561972 123562903 123562913 123563217 123563220 123563222 123563223 123564464 123564465 123566207
OBI106873990 106881820 106881829 106883007
OSN115212411 115216648 115216679 115216680 115220830 115220835 115222617 115223487
LAK106150782 106155088 106155707 106155709 106174181 106181126
SMMSmp_009810 Smp_154680
EGLEGR_09263
DGT114537562 114537592
XEN124435344 124435679
TADTRIADDRAFT_51949
 » show all
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr Res 120:3-16 (1983)
DOI:10.1016/0008-6215(83)88002-1
Reference
2  [PMID:6449508]
  Authors
Williams D, Longmore G, Matta KL, Schachter H.
  Title
Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase.
  Journal
J Biol Chem 255:11253-61 (1980)
Reference
3  [PMID:6449507]
  Authors
Williams D, Schachter H.
  Title
Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates.
  Journal
J Biol Chem 255:11247-52 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.102
IUBMB Enzyme Nomenclature: 2.4.1.102
ExPASy - ENZYME nomenclature database: 2.4.1.102
BRENDA, the Enzyme Database: 2.4.1.102
CAS: 95978-15-7

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