| Entry |
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| Name |
glycogen(starch) synthase;
UDP-glucose---glycogen glucosyltransferase;
glycogen (starch) synthetase;
UDP-glucose-glycogen glucosyltransferase;
UDP-glycogen synthase;
UDPG-glycogen synthetase;
UDPG-glycogen transglucosylase;
uridine diphosphoglucose-glycogen glucosyltransferase;
UDP-glucose:glycogen 4-alpha-D-glucosyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
UDP-alpha-D-glucose:glycogen 4-alpha-D-glucosyltransferase (configuration-retaining)
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| Reaction(IUBMB) |
UDP-alpha-D-glucose + [(1->4)-alpha-D-glucosyl]n = UDP + [(1->4)-alpha-D-glucosyl]n+1 [RN: R00292 R06051]
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| Reaction(KEGG) |
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| Substrate |
UDP-alpha-D-glucose [CPD: C00029];
[(1->4)-alpha-D-glucosyl]n
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| Product |
UDP [CPD: C00015];
[(1->4)-alpha-D-glucosyl]n+1
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| Comment |
The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
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| History |
EC 2.4.1.11 created 1961
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| Pathway |
| ec00500 | Starch and sucrose metabolism |
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| Orthology |
| K16153 | glycogen phosphorylase/synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
ALGRANATI ID, CABIB E. |
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| Title |
The synthesis of glycogen in yeast. |
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| Journal |
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| Reference |
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| Authors |
BASU DK, BACHHAWAT BK. |
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| Title |
Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain. |
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| Journal |
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| Reference |
3 |
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| Authors |
Leloir, L.F. and Cardini, C.E. |
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| Title |
UDPG-glycogen transglucosylase. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 317-326. |
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| Reference |
|
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| Authors |
LELOIR LF, GOLDEMBERG SH. |
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| Title |
Synthesis of glycogen from uridine diphosphate glucose in liver. |
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| Journal |
J Biol Chem 235:919-23 (1960) |
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| Reference |
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| Authors |
Pitcher J, Smythe C, Cohen P. |
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| Title |
Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.4.1.11 |
| ExPASy - ENZYME nomenclature database: | 2.4.1.11 |
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