KEGG   ENZYME: 2.4.1.115Help
Entry
EC 2.4.1.115                Enzyme                                 

Name
anthocyanidin 3-O-glucosyltransferase;
uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase;
UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase;
UDP-glucose:cyanidin-3-O-glucosyltransferase;
UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase;
3-GT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase
Reaction(IUBMB)
UDP-D-glucose + an anthocyanidin = UDP + an anthocyanidin-3-O-beta-D-glucoside [RN:R03797]
Reaction(KEGG)
Substrate
UDP-D-glucose [CPD:C00029];
anthocyanidin [CPD:C02003]
Product
UDP [CPD:C00015];
anthocyanidin-3-O-beta-D-glucoside
Comment
The anthocyanidin compounds cyanidin, delphinidin, peonidin and to a lesser extent pelargonidin can act as substrates. The enzyme does not catalyse glucosylation of the 5-position of cyanidin and does not act on flavanols such as quercetin and kaempferol (cf. EC 2.4.1.91 flavonol 3-O-glucosyltransferase). In conjunction with EC 1.14.20.4, anthocyanidin oxygenase, it is involved in the conversion of leucoanthocyanidin into anthocyanidin 3-glucoside. It may act on the pseudobase precursor of the anthocyanidin rather than on the anthocyanidin itself [3].
History
EC 2.4.1.115 created 1984 (EC 2.4.1.233 created 2004, incorporated 2005), modified 2005
Pathway
ec00942  Anthocyanin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12930  anthocyanidin 3-O-glucosyltransferase
Genes
CIT: 102609299
CIC: CICLE_v10019770mg CICLE_v10030331mg
TCC: 18599492 18599494
GRA: 105787922
GHI: 107924731 107950567
GAB: 108466937
DZI: 111296738
EGR: 104450361 104450379
GMX: 100795736
GSJ: 114417828
VRA: 106766336
VAR: 108320291
CAM: 101489215(UGT78K4) 101501347(UGT78K5)
ADU: 107480473
AIP: 107631056
FVE: 101300000
RCN: 112185370
ZJU: 107414867
RCU: 8283075
JCU: 105649015
HBR: 110667678
MESC: 110621779
SLY: 101260093
SOT: 102577753
NSY: 104245263
NTO: 104111088
NAU: 109215787
INI: 109182028(UF3GT) 109191717
CCAV: 112507289
BVG: 104888025
SOE: 110803459
OSA: 4340373
DOSA: Os06t0192100-00(Os06g0192100) Os07t0148200-01(Os07g0148200)
OBR: 102711363
BDI: 100841090
ATS: 109740107(LOC109740107) 109747995(LOC109747995) 109747997(LOC109747997)
ZMA: 100217238 732800(BZ1)
DCT: 110095211
PEQ: 110031211
 » show all
Taxonomy
Reference
1  [PMID:751640]
  Authors
Kamsteeg J, van Brederode J, van Nigtevecht G.
  Title
Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica).
  Journal
Biochem Genet 16:1045-58 (1978)
Reference
2  [PMID:9535914]
  Authors
Ford CM, Boss PK, Hoj PB.
  Title
Cloning and characterization of Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, a homologue of the enzyme encoded by the maize Bronze-1 locus that may primarily serve to glucosylate anthocyanidins in vivo.
  Journal
J Biol Chem 273:9224-33 (1998)
DOI:10.1074/jbc.273.15.9224
  Sequence
[vvi:100233099]
Reference
3  [PMID:11316805]
  Authors
Nakajima  J, Tanaka Y, Yamazaki M, Saito K.
  Title
Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis.
  Journal
J Biol Chem 276:25797-803 (2001)
DOI:10.1074/jbc.M100744200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.115
IUBMB Enzyme Nomenclature: 2.4.1.115
ExPASy - ENZYME nomenclature database: 2.4.1.115
BRENDA, the Enzyme Database: 2.4.1.115
CAS: 65607-32-1

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