| Entry |
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| Name |
N-acetylgalactosaminide beta-1,3-galactosyltransferase;
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase;
uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase;
UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase;
UDP-Gal:alpha-D-GalNAc-1,3-alpha-D-GalNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase;
wbnJ (gene name);
wbiP (gene name);
C1GALT1 (gene name);
UDP-alpha-D-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
UDP-alpha-D-galactose:N-acetyl-alpha-D-galactosaminyl-R beta-1,3-galactosyltransferase (configuration-inverting)
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| Reaction(IUBMB) |
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [RN: R05908]
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| Reaction(KEGG) |
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| Substrate |
UDP-alpha-D-galactose [CPD: C00052];
N-acetyl-alpha-D-galactosaminyl-R [CPD: C04387]
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| Product |
UDP [CPD: C00015];
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [CPD: C04750]
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| Comment |
The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T-antigen. The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit.
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| History |
EC 2.4.1.122 created 1984 (EC 2.4.1.307 created 2013, incorporated 2016), modified 2016
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| Pathway |
| ec00512 | Mucin type O-glycan biosynthesis |
| ec00514 | Other types of O-glycan biosynthesis |
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| Orthology |
| K00731 | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase |
| K21366 | N-acetylgalactosaminide beta-1,3-galactosyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Hesford FJ, Berger EG, Van den Eijnden DH. |
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| Title |
Identification of the product formed by human erythrocyte galactosyltransferase. |
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| Journal |
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| Reference |
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| Authors |
Mendicino J, Sivakami S, Davila M, Chandrasekaran EV. |
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| Title |
Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa. |
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| Journal |
J Biol Chem 257:3987-94 (1982) |
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| Reference |
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| Authors |
Schachter H, Narasimhan S, Gleeson P, Vella G. |
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| Title |
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type. |
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| Journal |
Methods Enzymol 98:98-134 (1983) |
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| Reference |
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| Authors |
Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM |
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| Title |
Cloning and expression of human core 1 beta1,3-galactosyltransferase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Yi W, Perali RS, Eguchi H, Motari E, Woodward R, Wang PG |
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| Title |
Characterization of a bacterial beta-1,3-galactosyltransferase with application in the synthesis of tumor-associated T-antigen mimics. |
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| Journal |
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| Reference |
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| Authors |
Woodward R, Yi W, Li L, Zhao G, Eguchi H, Sridhar PR, Guo H, Song JK, Motari E, Cai L, Kelleher P, Liu X, Han W, Zhang W, Ding Y, Li M, Wang PG |
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| Title |
In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.122 |
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