KEGG   ENZYME: 2.4.1.133
Entry
EC 2.4.1.133                Enzyme                                 
Name
xylosylprotein 4-beta-galactosyltransferase;
UDP-D-galactose:D-xylose galactosyltransferase;
UDP-D-galactose:xylose galactosyltransferase;
galactosyltransferase I;
uridine diphosphogalactose-xylose galactosyltransferase;
UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:O-beta-D-xylosyl-[protein] 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:[protein]-3-O-(beta-D-xylosyl)-L-serine 4-beta-D-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:R05926]
Reaction(KEGG)
R05926(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
[protein]-3-O-(beta-D-xylosyl)-L-serine
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.133 created 1984, modified 2002
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00733  xylosylprotein 4-beta-galactosyltransferase
Genes
HSA11285(B4GALT7)
PTR664711(B4GALT7)
PPS100969443(B4GALT7)
GGO109025277(B4GALT7)
PON100438606(B4GALT7)
NLE100593744(B4GALT7)
MCC701000(B4GALT7)
MCF102134376(B4GALT7)
CSAB103245067(B4GALT7)
CATY105581735(B4GALT7)
PANU101003386(B4GALT7)
TGE112625746(B4GALT7)
RRO104680468(B4GALT7)
RBB108544793(B4GALT7)
TFN117065314(B4GALT7)
PTEH111521589(B4GALT7) 111534967
CJC100397629(B4GALT7)
SBQ101049094(B4GALT7)
CSYR103249526(B4GALT7)
MMUR105883862(B4GALT7)
OGA100956774(B4GALT7)
MMU218271(B4galt7)
MCAL110308007(B4galt7)
MPAH110333877(B4galt7)
RNO364675(B4galt7)
MCOC116082210(B4galt7)
MUN110562812(B4galt7)
CGE100769652(B4galt7)
PLEU114689032(B4galt7)
NGI103732252(B4galt7)
HGL101713013(B4galt7)
CPOC100729826(B4galt7)
CCAN109685754(B4galt7)
DORD105985446(B4galt7)
DSP122096530(B4galt7)
NCAR124987572
OCU100358677(B4GALT7)
OPI101518876(B4GALT7)
TUP102469641(B4GALT7)
CFA481445(B4GALT7)
VVP112932460(B4GALT7)
VLG121495906(B4GALT7)
AML100466599(B4GALT7)
UMR103680002(B4GALT7)
UAH113261587(B4GALT7)
UAR123790464(B4GALT7)
ELK111158893
LLV125100636
MPUF101690863(B4GALT7)
ORO101362992(B4GALT7)
EJU114200733(B4GALT7)
ZCA113929186(B4GALT7) 118356697
MLX118016526(B4GALT7)
FCA101099172(B4GALT7)
PYU121010542(B4GALT7)
PBG122486414(B4GALT7)
PTG102949589(B4GALT7)
PPAD109278935(B4GALT7)
AJU106970084(B4GALT7)
HHV120246961(B4GALT7)
BTA507559(B4GALT7)
BOM102274604(B4GALT7)
BIU109561915(B4GALT7)
BBUB102408450(B4GALT7)
CHX102189205(B4GALT7)
OAS100316848(B4GALT7)
ODA120863841(B4GALT7)
CCAD122440023(B4GALT7)
SSC100316855(B4GALT7)
CFR102509297(B4GALT7)
CBAI105062027(B4GALT7)
CDK105099602(B4GALT7)
VPC102527005(B4GALT7) 102536649
BACU102998185(B4GALT7)
LVE103085357(B4GALT7)
OOR101274084(B4GALT7)
DLE111169845(B4GALT7)
PCAD102979710(B4GALT7)
PSIU116751432(B4GALT7)
ECB100058225(B4GALT7)
EPZ103541731(B4GALT7)
EAI106827174(B4GALT7)
MYB102252387(B4GALT7)
MYD102753871(B4GALT7)
MMYO118658036(B4GALT7)
MLF102426437(B4GALT7)
MNA107529783(B4GALT7)
PKL118710684(B4GALT7)
HAI109389791(B4GALT7)
DRO112320381(B4GALT7)
SHON118999761(B4GALT7)
AJM119035148(B4GALT7) 119046708
PDIC114510143(B4GALT7) 114510363
PHAS123812547(B4GALT7)
MMF118616332(B4GALT7)
RFQ117016721(B4GALT7)
PALE102884700(B4GALT7)
PGIG120616577(B4GALT7)
PVP105293497(B4GALT7)
RAY107517560(B4GALT7)
MJV108387396(B4GALT7)
TOD119236161(B4GALT7)
SARA101554415(B4GALT7)
LAV100674198(B4GALT7)
TMU101361238
DNM101439970(B4GALT7)
MDO100027902(B4GALT7)
GAS123235481(B4GALT7)
SHR100922950(B4GALT7)
PCW110216747(B4GALT7)
OAA100088745(B4GALT7)
GGA416359(B4GALT7)
PCOC116232056(B4GALT7)
MGP100549378(B4GALT7)
CJO107320474(B4GALT7)
NMEL110405386(B4GALT7)
APLA101799322(B4GALT7)
ACYG106042753(B4GALT7)
AFUL116494966(B4GALT7)
TGU100217536(B4GALT7)
LSR110470811(B4GALT7)
SCAN103817518(B4GALT7)
PMOA120498633(B4GALT7)
OTC121332411(B4GALT7)
PRUF121361478(B4GALT7)
GFR102032323(B4GALT7)
FAB101809350(B4GALT7)
PHI102110580(B4GALT7)
PMAJ107210581(B4GALT7)
CCAE111935384(B4GALT7) 111944046
CCW104689658(B4GALT7)
ETL114066303(B4GALT7)
ZAB102064765(B4GALT7)
FPG101912431(B4GALT7)
CLV102098527(B4GALT7)
EGZ104135892(B4GALT7)
NNI104019007(B4GALT7)
ACUN113485273(B4GALT7)
TALA104360238(B4GALT7)
PADL103912295(B4GALT7)
ACHC115334362(B4GALT7)
AAM106489923(B4GALT7)
AROW112964810(B4GALT7)
NPD112954334(B4GALT7)
DNE112996872(B4GALT7)
ASN112547986(B4GALT7)
AMJ102571339(B4GALT7)
CPOO109309887(B4GALT7)
GGN109289737(B4GALT7)
PSS102455627(B4GALT7)
CMY102946711(B4GALT7)
CPIC101942960(B4GALT7)
TST117881824(B4GALT7)
CABI116833302(B4GALT7)
MRV120370135(B4GALT7)
ACS100556890(b4galt7)
PVT110077329(B4GALT7)
SUND121923695(B4GALT7)
PBI103051226(B4GALT7)
PMUR107294701(B4GALT7) 107295191
PGUT117679685(B4GALT7)
VKO123034011(B4GALT7)
PMUA114591462(B4GALT7)
ZVI118080521(B4GALT7)
GJA107111554(B4GALT7) 107125262
XLA108710989(b4galt7.L) 495369(b4galt7.S)
XTR100144979(b4galt7)
NPR108798025(B4GALT7)
RTEM120932174(B4GALT7)
BBUF120978603(B4GALT7)
BGAR122925967(B4GALT7)
DRE445022(b4galt7)
SRX107717396 107741053
SANH107662034 107664790
SGH107563605 107598313
CCAR109095982 109095987
CAUA113057813 113089580 113114258
IPU100528903(b4galt7)
PHYP113529402(b4galt7)
SMEO124385562(b4galt7)
TFD113635812(b4galt7)
AMEX103030020(b4galt7)
EEE113573384(b4galt7)
TRU778009(b4galt7)
TNGGSTEN00024284G001
LCO104934784(b4galt7)
NCC104941972(b4galt7)
ELY117256826(b4galt7)
PLEP121947794(b4galt7)
SLUC116062527(b4galt7)
PFLV114563028(b4galt7)
GAT120818035(b4galt7)
PPUG119211488(b4galt7)
MSAM119888784(b4galt7)
CUD121516760(b4galt7)
MZE101464985(b4galt7)
ONL100693702(b4galt7)
OAU116329684(b4galt7)
OLA100049391(b4galt7)
OML112137839(b4galt7)
XMA102234949(b4galt7)
XCO114138996(b4galt7)
XHE116714757(b4galt7)
PRET103471472
PFOR103136846(b4galt7)
PLAI106935904(b4galt7)
PMEI106923357(b4galt7)
GAF122837413(b4galt7)
CVG107087474(b4galt7)
CTUL119777310(b4galt7)
GMU124860959(b4galt7)
NFU107380813(b4galt7)
KMR108249984(b4galt7)
ALIM106530302(b4galt7)
NWH119408831(b4galt7)
AOCE111585391(b4galt7)
CSEM103391078(b4galt7)
POV109641676(b4galt7)
SSEN122763021(b4galt7)
HHIP117769158(b4galt7)
LCF108889683(b4galt7)
SDU111235918(b4galt7)
SLAL111672926(b4galt7)
XGL120785489(b4galt7)
HCQ109516649(b4galt7)
BPEC110166076(b4galt7)
MALB109956763(b4galt7)
SASA106604202(b4galt7) 106612238
OTW112221272(b4galt7) 112255876
OMY110489184 110504523
OGO123993713 124010494
ONE115119021 115129185
SALP112069378 112080056
SNH120047856 120062522
ELS105026158(b4galt7)
SFM108923004(b4galt7)
PKI111834270(b4galt7)
AANG118222563(b4galt7)
LOC102684648(b4galt7)
PSPA121297175 121323785
ARUT117412848 117431368
LCM102365042(B4GALT7)
RTP109929884(b4galt7)
BFO118412888
BBEL109482916
CIN100175307 779002
SCLV120336078 120338772
SPU105443131
APLC110982496
SKO100370356
DMEDmel_CG11780(beta4GalT7)
DER6554264
DSE6619628
DSIDsimw501_GD21157(Dsim_beta4GalT7)
DYADyak_GE23542(Dyak_beta4GalT7)
DAN6507960
DSR110190568
DPODpse_GA11195
DPE6588650
DMN108155954
DWI6651162
DGR6570736
DMODmoj_GI22222(Dmoj_beta4GalT7)
DAZ108619392
DNV108658888
DHE111598813
DVI6631144
CCAT101450437
BOD106618947
MDE101901029
SCAC106089207
LCQ111680960
ACOZ120956816
AARA120904094
AAG5569772
AALB109411740
CQUCpipJ_CPIJ015322
CPII120429069
CNS116336709
AME551662
ACER107998423
ALAB122716037
BIM100740220
BBIF117216377
BVK117235307
BVAN117161300
BTER100644684
BPYO122570179
CCAL108632308
OBB114875322
MGEN117222099
NMEA116432664
CGIG122396242
SOC105199296
MPHA105831588
AEC105152211
ACEP105621491
PBAR105432394
VEM105557328
HST105184864
DQU106749752
CFO105259486
FEX115240461
LHU105672626
PGC109861759
OBO105280118
PCF106789089
PFUC122519167
VPS122632161
NVI100120002
CSOL105366360
TPRE106658409
MDL103570181
CGLO123274927
FAS105267090
DAM107037242
AGIF122847346
CCIN107268680
TCA662423
DPA109542053
SOY115886688
ATD109599091
CSET123313724
AGB108913888
LDC111517279
NVL108563065
APLN108732470
PPYR116176826
OTU111427602
BMOR101735491 101735627
BMAN114241485 114241539
MSEX115447086
DPLKGM_206283
BANY112044001
PMAC106715865
PPOT106106003
PRAP110991476
ZCE119837768
HAW110381565
TNL113495145
OFU114355401
PXY105398823
API100159143
DNX107164425
AGS114130494
RMD113552740
BTAB109037025 109039279 109040034
DCI103512140
CLEC106662520
HHAL106682624
NLU111051545
PHUPhum_PHUM457130
FOC113212726
ZNE110834722
CSEC111873817
FCD110848119
DPXDAPPUDRAFT_48345
PVM113811151
PJA122262323
PCHN125039725
HAME121872064
PCLA123757924
PTRU123515088
HAZT108669115
EAF111716031
ISCIscW_ISCW003979
DSV119450995
RSAN119404767
RMP119180766
VDE111248646 111250068
VJA111268066 111269797
TUT107362732
DFR124492866
CSCU111635429
PTEP107438664 107447873
SDM118185197
CELCELE_R10E11.4(sqv-3)
CBRCBG_09970(Cbr-sqv-3)
LOALOAG_01756
NAINECAME_16363
TSPTsp_04693
HROHELRODRAFT_133632
LGILOTGIDRAFT_211278
PCAN112564096
BGT106059572
GAE121382675
HRF124135420
HRJ124264556
CRG105349030
MYI110455947 110455951 110462331 110462968
PMAX117339302 117341887
MMER123546488
OBI106876853
OSN115232486
LAK106166791 106169021
SMMSmp_210290
NVE5521053
EPA110251303
ATEN116292869
ADF107327698
AMIL114960238
PDAM113673687
SPIS111320677
DGT114516073
XEN124444352
HMG100206713
TADTRIADDRAFT_61457
AQU100633202
APROF751_6798
MISMICPUN_64091
MPPMICPUCDRAFT_38613
SREPTSG_07984
EHXEMIHUDRAFT_197820 EMIHUDRAFT_197985
GTTGUITHDRAFT_160848
 » show all
Reference
1  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J Biol Chem 250:5200-7 (1975)
Reference
2  [PMID:10438455]
  Authors
Okajima T, Yoshida K, Kondo T, Furukawa K
  Title
Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
  Journal
J Biol Chem 274:22915-8 (1999)
DOI:10.1074/jbc.274.33.22915
  Sequence
[hsa:11285]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.133
IUBMB Enzyme Nomenclature: 2.4.1.133
ExPASy - ENZYME nomenclature database: 2.4.1.133
BRENDA, the Enzyme Database: 2.4.1.133
CAS: 52227-72-2

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