KEGG   ENZYME: 2.4.1.134
Entry
EC 2.4.1.134                Enzyme                                 
Name
galactosylxylosylprotein 3-beta-galactosyltransferase;
galactosyltransferase II;
uridine diphosphogalactose-galactosylxylose galactosyltransferase;
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:R05927]
Reaction(KEGG)
R05927(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [CPD:C04825]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.134 created 1984, modified 2002
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00734  galactosylxylosylprotein 3-beta-galactosyltransferase
Genes
HSA126792(B3GALT6)
PTR457187(B3GALT6)
PPS100971409(B3GALT6)
PON112135480(B3GALT6)
NLE115833053(B3GALT6)
HMH116812768(B3GALT6)
MCC703713(B3GALT6)
MCF102115188(B3GALT6)
MTHB126952061
MNI105498306(B3GALT6)
CSAB103225816(B3GALT6)
CATY105572458(B3GALT6)
PANU101003310(B3GALT6)
TGE112625398(B3GALT6)
RRO104673226(B3GALT6)
RBB108544195(B3GALT6)
TFN117093480(B3GALT6)
PTEH111526850(B3GALT6)
CJC100387131(B3GALT6)
CIMI108313919(B3GALT6)
CSYR103250094(B3GALT6)
MMUR105877638(B3GALT6)
LCAT123636029(B3GALT6)
PCOQ105820907(B3GALT6)
OGA100958919(B3GALT6)
MMU117592(B3galt6)
MCAL110292468(B3galt6)
MPAH110322882(B3galt6)
RNO298690(B3galt6)
MCOC116097170(B3galt6)
ANU117708571(B3galt6)
MUN110560227(B3galt6)
CGE100767598(B3galt6)
MAUA101833181(B3galt6)
PROB127213542(B3galt6)
PLEU114708248(B3galt6)
MORG121443545 121448529(B3galt6)
MFOT126493175
AAMP119816893(B3galt6)
NGI103749737(B3galt6)
HGL101721217(B3galt6)
CPOC100730778(B3galt6)
CCAN109681028(B3galt6)
DORD106002935(B3galt6)
DSP122127349(B3galt6)
PLOP125354206(B3galt6)
NCAR124963718
MMMA107155460(B3galt6)
OCU103351814 127489283
OPI101521287(B3GALT6)
TUP102502785(B3GALT6)
CFA664717(B3GALT6)
CLUD112647021(B3GALT6)
VVP112926057(B3GALT6)
VLG121500774(B3GALT6)
NPO129496555(B3GALT6)
AML100473227(B3GALT6)
UMR103682080(B3GALT6)
UAH113270686(B3GALT6)
UAR123796089(B3GALT6)
ELK111154922
LLV125097488
MPUF101677593(B3GALT6)
MNP132001037(B3GALT6)
MLK131810351(B3GALT6)
NVS122899323(B3GALT6)
ORO101364618(B3GALT6)
EJU114213404(B3GALT6)
ZCA113928681(B3GALT6)
MLX118020133(B3GALT6)
NSU110575332(B3GALT6)
FCA105259949(B3GALT6)
PYU121017977(B3GALT6)
PCOO112864860(B3GALT6)
PBG122479773(B3GALT6)
LRUF124514991
PTG102964488(B3GALT6)
PPAD109273914(B3GALT6)
PUC125913244
AJU106978137 113599162
HHV120242505(B3GALT6)
BTA522406(B3GALT6)
BOM102265005(B3GALT6)
BIU109570568(B3GALT6)
BBUB102406953(B3GALT6)
BBIS104996102(B3GALT6)
CHX102191357(B3GALT6)
OAS101105768(B3GALT6)
BTAX128061558(B3GALT6)
ODA120862075 120880627(B3GALT6)
CCAD122452078(B3GALT6)
MBEZ129551405(B3GALT6)
SSC100523125(B3GALT6)
CFR102522264(B3GALT6)
CBAI105071076(B3GALT6)
CDK105105583(B3GALT6)
LVE103085660(B3GALT6)
OOR101276763(B3GALT6)
DLE111187245(B3GALT6)
PCAD112065327(B3GALT6)
PSIU116756707(B3GALT6)
ECB100146417(B3GALT6)
EPZ103558570(B3GALT6)
EAI106845197(B3GALT6)
MMYO118655568(B3GALT6)
MNA107543692(B3GALT6)
PKL118731977(B3GALT6)
EFUS103295354(B3GALT6)
HAI109391146(B3GALT6)
DRO112299603(B3GALT6)
SHON118998221(B3GALT6)
AJM119050524(B3GALT6)
PDIC114497174(B3GALT6)
PHAS123831877(B3GALT6)
MMF118643408(B3GALT6)
RFQ117026943(B3GALT6)
PPAM129079267(B3GALT6)
PALE102879449(B3GALT6)
PGIG120614084(B3GALT6)
RAY107503893 107510710(B3GALT6)
MJV108409072(B3GALT6)
TOD119236531(B3GALT6)
SARA101551557(B3GALT6)
LAV100659349(B3GALT6)
TMU101342110
ETF101640488(B3GALT6)
DNM101412993(B3GALT6)
MDO100024991(B3GALT6)
GAS123240111(B3GALT6)
SHR116422871(B3GALT6)
AFZ127556024
PCW110201068(B3GALT6)
OAA100074836(B3GALT6)
GGA428185(B3GALT6)
PCOC116242558(B3GALT6)
MGP104914138(B3GALT6)
CJO107323501(B3GALT6)
TPAI128085037(B3GALT6)
LMUT125703417(B3GALT6)
NMEL110408704(B3GALT6)
APLA101798225(B3GALT6)
ACYG106044272(B3GALT6)
CATA118253261(B3GALT6)
AFUL116497597(B3GALT6)
TGU100225099(B3GALT6)
LSR110474385(B3GALT6)
SCAN103820901(B3GALT6)
PMOA120511127(B3GALT6)
OTC121344105(B3GALT6)
PRUF121358335(B3GALT6) 121358342
FAB101808759(B3GALT6)
OMA130261658(B3GALT6)
PHI102108353(B3GALT6)
PMAJ107213734(B3GALT6)
CCAE111938482(B3GALT6)
CCW104693401(B3GALT6)
CBRC103622302(B3GALT6)
ETL114071242(B3GALT6)
ZAB102062738(B3GALT6)
ACHL103809603(B3GALT6)
SVG106858906(B3GALT6)
MMEA130588631(B3GALT6)
HRT120762285(B3GALT6)
FPG101913380(B3GALT6)
FCH102056999(B3GALT6)
CLV102096830(B3GALT6)
EGZ104133398(B3GALT6)
NNI104009059(B3GALT6)
PCRI104023992(B3GALT6)
PLET104620975(B3GALT6)
EHS104508150(B3GALT6)
PCAO104047856(B3GALT6)
ACUN113487982(B3GALT6)
TALA104355594(B3GALT6)
PADL103918023(B3GALT6)
AFOR103894783(B3GALT6)
ACHC115343036(B3GALT6)
HALD104312985(B3GALT6)
HLE104837931(B3GALT6)
AGEN126041894
GCL127024687
CCRI104154611(B3GALT6)
CSTI104562399(B3GALT6)
CMAC104479565(B3GALT6)
MUI104534116(B3GALT6)
BREG104642472(B3GALT6)
FGA104074823(B3GALT6)
GSTE104263956(B3GALT6)
LDI104339978(B3GALT6)
MNB103779504(B3GALT6)
OHA104336061(B3GALT6)
NNT104403522(B3GALT6)
SHAB115617565(B3GALT6)
DPUB104305940(B3GALT6)
PGUU104469478(B3GALT6)
ACAR104520744(B3GALT6)
CPEA104395466(B3GALT6)
AVIT104279118(B3GALT6)
CVF104290552(B3GALT6)
RTD128918509(B3GALT6)
CUCA104055619(B3GALT6)
TEO104372719(B3GALT6)
BRHI104496585(B3GALT6)
AAM106495555(B3GALT6)
AROW112970105(B3GALT6)
NPD112957393(B3GALT6)
TGT104569274(B3GALT6)
DNE112983500(B3GALT6)
SCAM104141997(B3GALT6)
ASN102373206(B3GALT6)
AMJ102571760(B3GALT6)
CPOO109314423(B3GALT6)
GGN109293554(B3GALT6)
PSS102452076(B3GALT6)
CMY102942046(B3GALT6)
CCAY125624374(B3GALT6)
DCC119845163(B3GALT6)
CPIC101943011(B3GALT6)
TST117867974(B3GALT6)
CABI116824600(B3GALT6)
MRV120387825(B3GALT6)
ASAO132764837(B3GALT6)
PVT110073136(B3GALT6)
SUND121937204(B3GALT6)
PBI103049964(B3GALT6)
PMUR107298347(B3GALT6)
CTIG120318999(B3GALT6)
TSR106541052(B3GALT6)
PGUT117675860(B3GALT6)
APRI131187139(B3GALT6)
PTEX113446182(B3GALT6)
NSS113421288(B3GALT6)
VKO123030942(B3GALT6)
PMUA114602507(B3GALT6)
PRAF128419734(B3GALT6)
ZVI118087931(B3GALT6)
HCG128338695(B3GALT6)
GJA107110843(B3GALT6)
STOW125445691(B3GALT6)
EMC129344414(B3GALT6)
XLA108696563(b3galt6.L) 108697636(b3galt6.S)
XTR548849(b3galt6)
NPR108784315(B3GALT6)
RTEM120915404(B3GALT6)
BBUF121004783(B3GALT6)
BGAR122926567(B3GALT6)
MUO115482650(B3GALT6)
GSH117348732(B3GALT6) 117354194
DRE572324(b3galt6)
SRX107714504 107751019
SANH107680432 107699339
SGH107555998 107592565
CCAR109066899 109098579
CAUA113055100 113069397
CGIB127968611 128022598
PTET122354624(b3galt6)
LROH127172694(b3galt6)
OMC131549749(b3galt6)
PPRM120473396(b3galt6)
RKG130071800(b3galt6)
MAMB125256819(b3galt6)
CIDE127522816
MASI127426325 127428241
TROS130571219(b3galt6)
TDW130410338(b3galt6)
MANU129427941(b3galt6)
IPU108255271
IFU128625233(b3galt6)
PHYP113539477(b3galt6)
SMEO124402544(b3galt6)
TFD113661931(b3galt6)
TVC132838247(b3galt6)
AMEX103027814(b3galt6)
CMAO118799964(b3galt6)
EEE113585544(b3galt6)
CHAR105898137(b3galt6)
TRU777996(b3galt6)
TFS130524102(b3galt6)
LCO104939272(b3galt6)
NCC104942072(b3galt6)
TBEN117486501(b3galt6)
CGOB115008833(b3galt6)
PGEO117447155(b3galt6)
GACU117547515(b3galt6)
ELY117256359(b3galt6)
EFO125886969(b3galt6)
PLEP121953859(b3galt6)
SLUC116067467(b3galt6)
ECRA117943739(b3galt6)
ESP116687782(b3galt6)
PFLV114554241(b3galt6)
GAT120835278(b3galt6)
PPUG119229718(b3galt6)
AFB129105330(b3galt6)
CLUM117731223(b3galt6)
MSAM119886187(b3galt6)
SCHU122868234(b3galt6)
CUD121529149(b3galt6)
ALAT119021203(b3galt6)
MZE101485514(b3galt6)
ONL100693145(b3galt6)
OAU116326550(b3galt6)
OLA100049392(b3galt6)
OML112145073(b3galt6)
XMA102230525(b3galt6)
XCO114136114(b3galt6)
XHE116710500(b3galt6)
PRET103464912(b3galt6)
PFOR103144356(b3galt6)
PLAI106955120(b3galt6)
PMEI106917398(b3galt6)
GAF122833643(b3galt6)
CVG107101435(b3galt6)
CTUL119791815(b3galt6)
GMU124856092(b3galt6)
NFU107385557(b3galt6)
KMR108246845(b3galt6)
ALIM106513334(b3galt6)
NWH119411667(b3galt6)
AOCE111587882(b3galt6)
MCEP125007439(b3galt6)
CSEM103386136(b3galt6)
POV109629160(b3galt6)
SSEN122767632(b3galt6)
HHIP117761446(b3galt6)
HSP118105344(b3galt6)
LCF108884066
SDU111221818(b3galt6)
SLAL111667675(b3galt6)
XGL120807316(b3galt6)
HCQ109522223(b3galt6)
SSCV125977869
SBIA133507190(b3galt6)
PEE133408663(b3galt6)
PTAO133483247(b3galt6)
BPEC110165823(b3galt6)
MALB109956258(b3galt6)
BSPL114856146(b3galt6)
SJO128355846(b3galt6)
SASA106582684 106593203
STRU115151055 115207362
OTW112221817 112254159
OMY110494759 110527712
OGO124002933 124021082
ONE115143517 115145326
OKI109890807 109899633
OKE118388200 118399919
SALP111970598 112080947
SNH120023840 120064928
CCLU121574770(b3galt6)
ELS105007424(b3galt6)
SFM108938192(b3galt6)
PKI111853658(b3galt6)
AANG118210577(b3galt6)
LOC102694517(b3galt6)
PSPA121329263 121329297
ARUT117425319 117972756
PSEX120530945(b3galt6)
LCM102355255(B3GALT6)
CMK103187433(b3galt6)
RTP109918536(b3galt6)
CPLA122540307
HOC132833608(b3galt6)
LERI129711531(b3galt6)
PMRN116946874(B3GALT6)
LRJ133351161(B3GALT6)
BFO118410806 118411359 118430418
BBEL109464793 109466855 109479943
CIN778996(b3galt6)
SCLV120341313 120341315
SPU115921698 115924557 585022 753784
LPIC129276301 129276314 129276703
APLC110979066 110979076
AJC117114774
SKO100367674
DMEDmel_CG8734(beta3GalTII)
DER6543072
DSE6608207
DSIDsimw501_GD27981(Dsim_GD27981)
DYADyak_GE22868(Dyak_beta3galt6)
DAN6502488
DSR110182817
DPO6902748
DPE6597933
DMN108162389
DWI6644411
DGR6566393
DMODmoj_GI17485
DAZ108610340
DNV115562853
DHE111592079
DVI6627305
CCAT101456591
BOD106615736
BDR105221813
RZE108365364 108374143
TDA119687357
MDE101899820
SCAC106084399
LCQ111679243
LSQ119609799
GFS119642715
ECOE129939432
HIS119653093
AGA1280132
ACOZ120959582
AARA120901636
AMER121595845
ASTE118512538
AFUN125763950
AMOU128301174
AALI118460973
AAG5568811
AALB109419591
CQUCpipJ_CPIJ010407
CPII120425909
CNS116341215
BCOO119078669
AME102655877
ACER108003457
ALAB122711455
ADR102680594
AFLR100865260
BIM100740262
BBIF117214488
BVK117242628
BVAN117161233
BTER100644667
BAFF126925321
BPYO122576443
BPAS132914476
FVI122527186
CCAL108622599
OBB114880076
MGEN117222654
NMEA116425873
CGIG122403002 122403764
SOC105194992
MPHA105829197
AEC105155005
ACEP105626882
PBAR105426350
VEM105566820
HST105186112
DQU106745352
CFO105255994
FEX115243790
LHU105669725
PGC109857902
OBO105284463
PCF106788423
PFUC122522484
VPS122634692
VCRB124430012
NVI100680242
CSOL105359846
TPRE106659421
LHT122499156
LBD127282005
MDL103571274
CGLO123261645
FAS105270274
DAM107035758
AGIF122859047
CINS118064670
VCAN122408940
CCIN107266373
DSM124409973
NPT124217079
NFB124180265
NLO107220329
NVG124303036
TCA656431
DPA109534754
SOY115889543
AGRG126736701
ATD109599054
CSET123311551
AGB108910758
LDC111509085
NVL108563522
APLN108735776
PPYR116170377
OTU111424934
BMOR101740645
BMAN114247960
MSEX115449198
DPLKGM_203077
BANY112045668
MJU123864867
NIQ126778792
VCD124537227
MCIX123664536
PMAC106712341
PPOT106107973
PXU106117241
PRAP111001912
PBX123717655
PNAP125061803
ZCE119830168
CCRC123700226
LSIN126971217
HAW110383736
HZE124641691
TNL113493565
SLIU111354696
OFU114352165
PXY105386738
PGW126378464
CCRN123293455
API100168819 100574538
DNX107164501
AGS114128883 114128889
RMD113556535 113559464
ACOO126838762
DVT126894137
BTAB109035941
DCI103514882
CLEC106670905
HHAL106686435
NLU111047956
HVI124359504
MQU128993435
PHUPhum_PHUM361650
FOC113218242
TPAL117643550
ZNE110831323
CSEC111867039
SGRE126295406 126295408
IEL124164070
FCD110850766
DPXDAPPUDRAFT_65862
DMK116916453
DPZ124328348
PVM113821037 113821051
PJA122248394
PCHN125029043
PMOO119574129
HAME121879271
PCLA123756098
CQD128686351
PTRU123517004
ESN127000022
HAZT108667009
EAF111700018
LSM121114049
TCF131886829
PPOI119096713 119097867
DSV119446461 119446463
RSAN119389641 119389643
RMP119180578 119180586
VDE111249317
VJA111270592
TUT107368691
DPTE113794377
DFR124497317
CSCU111625572
PTEP107448329
UDV129229567
SDM118186131
LPOL106473282
CELCELE_Y110A2AL.14(sqv-2)
CBRCBG_19617(Cbr-sqv-2)
CRQGCK72_006770
NAINECAME_13336
BMYBM_BM7274(Bma-sqv-2)
LOALOAG_03680
HROHELRODRAFT_169080
LGILOTGIDRAFT_125392
PVUL126827177
PCAN112556227
BGT106065403
GAE121390616
HRF124111204
HRJ124265859
CRG105340554
CVN111138398
CANU128189218
OED125663861
MYI110450118
PMAX117344584
MCAF127720574
MMER123527630
RPHI132720046 132756340
DPOL127832442
OBI106882295
OSN115224526
LAK106161537
NVE5501668
EPA110240882
ATEN116295325
ADF107328872
AMIL114971432
PDAM113675377
SPIS111320722
DGT114526059
XEN124446513
HMG100208936
HSY130636358
AQU100637620 100640622 105313401 105313426 105316663
PALZ118058471
MBRMONBRDRAFT_23896
SREPTSG_02498
FCYFRACYDRAFT_267815
 » show all
Reference
1  [PMID:3924029]
  Authors
Robinson JA, Robinson HC.
  Title
Initiation of chondroitin sulphate synthesis by beta-D-galactosides. Substrates for galactosyltransferase II.
  Journal
Biochem J 227:805-14 (1985)
DOI:10.1042/bj2270805
Reference
2  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J Biol Chem 250:5200-7 (1975)
Reference
3  [PMID:11551958]
  Authors
Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD
  Title
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).
  Journal
J Biol Chem 276:48189-95 (2001)
DOI:10.1074/jbc.M107339200
  Sequence
[hsa:126792] [mmu:117592]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.134
IUBMB Enzyme Nomenclature: 2.4.1.134
ExPASy - ENZYME nomenclature database: 2.4.1.134
BRENDA, the Enzyme Database: 2.4.1.134
CAS: 56626-21-2 56626-19-8

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