KEGG   ENZYME: 2.4.1.134
Entry
EC 2.4.1.134                Enzyme                                 

Name
galactosylxylosylprotein 3-beta-galactosyltransferase;
galactosyltransferase II;
uridine diphosphogalactose-galactosylxylose galactosyltransferase;
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:R05927]
Reaction(KEGG)
R05927(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [CPD:C04825]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.134 created 1984, modified 2002
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00734  galactosylxylosylprotein 3-beta-galactosyltransferase
Genes
HSA: 126792(B3GALT6)
PTR: 457187(B3GALT6)
PPS: 100971409(B3GALT6)
PON: 112135480(B3GALT6)
NLE: 115833053(B3GALT6)
MCC: 703713(B3GALT6)
MCF: 102115188(B3GALT6)
CSAB: 103225816(B3GALT6)
CATY: 105572458(B3GALT6)
PANU: 101003310(B3GALT6)
RRO: 104673226(B3GALT6)
RBB: 108544195(B3GALT6)
TFN: 117093480(B3GALT6)
PTEH: 111526850(B3GALT6)
CJC: 100387131(B3GALT6)
MMUR: 105877638(B3GALT6)
MMU: 117592(B3galt6)
MCAL: 110292468(B3galt6)
MPAH: 110322882(B3galt6)
RNO: 298690(B3galt6)
MCOC: 116097170(B3galt6)
MUN: 110560227(B3galt6)
CGE: 100767598(B3galt6)
PLEU: 114708248(B3galt6)
NGI: 103749737(B3galt6)
HGL: 101721217(B3galt6)
CCAN: 109681028(B3galt6)
OCU: 103351814(B3GALT6)
TUP: 102502785(B3GALT6)
CFA: 664717(B3GALT6)
VVP: 112926057(B3GALT6)
VLG: 121500774(B3GALT6)
AML: 100473227(B3GALT6)
UMR: 103682080(B3GALT6)
UAH: 113270686(B3GALT6)
ORO: 101364618(B3GALT6)
ELK: 111154922
MPUF: 101677593(B3GALT6)
EJU: 114213404(B3GALT6)
MLX: 118020133(B3GALT6)
FCA: 105259949(B3GALT6)
PYU: 121017977(B3GALT6)
PBG: 122479773(B3GALT6)
PTG: 102964488(B3GALT6)
PPAD: 109273914(B3GALT6)
AJU: 106978137 113599162(B3GALT6)
HHV: 120242505(B3GALT6)
BTA: 522406(B3GALT6)
BOM: 102265005(B3GALT6)
BIU: 109570568(B3GALT6)
BBUB: 102406953(B3GALT6)
CHX: 102191357(B3GALT6)
OAS: 101105768(B3GALT6)
ODA: 120862075 120880627(B3GALT6)
CCAD: 122452078(B3GALT6)
SSC: 100523125(B3GALT6)
CFR: 102522264(B3GALT6)
CBAI: 105071076(B3GALT6)
CDK: 105105583(B3GALT6)
LVE: 103085660(B3GALT6)
OOR: 101276763(B3GALT6)
DLE: 111187245(B3GALT6)
PCAD: 112065327(B3GALT6)
ECB: 100146417(B3GALT6)
EPZ: 103558570(B3GALT6)
EAI: 106845197(B3GALT6)
MMYO: 118655568(B3GALT6)
MNA: 107543692(B3GALT6)
HAI: 109391146(B3GALT6)
SHON: 118998221(B3GALT6)
AJM: 119050524(B3GALT6)
MMF: 118643408(B3GALT6)
PALE: 102879449(B3GALT6)
PGIG: 120614084(B3GALT6)
RAY: 107503893 107510710(B3GALT6)
MJV: 108409072(B3GALT6)
TOD: 119236531(B3GALT6)
LAV: 100659349(B3GALT6)
TMU: 101342110
MDO: 100024991(B3GALT6)
SHR: 116422871(B3GALT6)
PCW: 110201068(B3GALT6)
OAA: 100074836(B3GALT6)
GGA: 428185(B3GALT6)
PCOC: 116242558(B3GALT6)
MGP: 104914138(B3GALT6)
CJO: 107323501(B3GALT6)
NMEL: 110408704(B3GALT6)
APLA: 101798225(B3GALT6)
ACYG: 106044272(B3GALT6)
TGU: 100225099(B3GALT6)
LSR: 110474385(B3GALT6)
SCAN: 103820901(B3GALT6)
PMOA: 120511127(B3GALT6)
FAB: 101808759(B3GALT6)
PHI: 102108353(B3GALT6)
PMAJ: 107213734(B3GALT6)
CCAE: 111938482(B3GALT6)
CCW: 104693401(B3GALT6)
ETL: 114071242(B3GALT6)
FPG: 101913380(B3GALT6)
FCH: 102056999(B3GALT6)
CLV: 102096830(B3GALT6)
EGZ: 104133398(B3GALT6)
NNI: 104009059(B3GALT6)
ACUN: 113487982(B3GALT6)
PADL: 103918023(B3GALT6)
AAM: 106495555(B3GALT6)
AROW: 112970105(B3GALT6)
NPD: 112957393(B3GALT6)
DNE: 112983500(B3GALT6)
ASN: 102373206(B3GALT6)
AMJ: 102571760(B3GALT6)
CPOO: 109314423(B3GALT6)
GGN: 109293554(B3GALT6)
PSS: 102452076(B3GALT6)
CMY: 102942046(B3GALT6)
CPIC: 101943011(B3GALT6)
TST: 117867974(B3GALT6)
CABI: 116824600(B3GALT6)
PVT: 110073136(B3GALT6)
PBI: 103049964(B3GALT6)
PMUR: 107298347(B3GALT6)
TSR: 106541052(B3GALT6)
PGUT: 117675860(B3GALT6)
PMUA: 114602507(B3GALT6)
ZVI: 118087931(B3GALT6)
GJA: 107110843(B3GALT6)
XLA: 108696563(b3galt6.L) 108697636(b3galt6.S)
XTR: 548849(b3galt6)
NPR: 108784315(B3GALT6)
DRE: 572324(b3galt6)
IPU: 108255271(b3galt6)
PHYP: 113539477(b3galt6)
AMEX: 103027814(b3galt6)
EEE: 113585544(b3galt6)
TRU: 777996(b3galt6)
LCO: 104939272(b3galt6)
NCC: 104942072(b3galt6)
CGOB: 115008833(b3galt6)
ELY: 117256359(b3galt6)
PLEP: 121953859(b3galt6)
SLUC: 116067467(b3galt6)
ECRA: 117943739(b3galt6)
PFLV: 114554241(b3galt6)
GAT: 120835278(b3galt6)
MSAM: 119886187(b3galt6)
CUD: 121529149(b3galt6)
MZE: 101485514(b3galt6)
ONL: 100693145(b3galt6)
OAU: 116326550(b3galt6)
OLA: 100049392(b3galt6)
OML: 112145073(b3galt6)
XMA: 102230525(b3galt6)
XCO: 114136114(b3galt6)
XHE: 116710500(b3galt6)
PRET: 103464912(b3galt6)
CVG: 107101435(b3galt6)
CTUL: 119791815(b3galt6)
NFU: 107385557(b3galt6)
KMR: 108246845(b3galt6)
ALIM: 106513334(b3galt6)
AOCE: 111587882(b3galt6)
CSEM: 103386136(b3galt6)
POV: 109629160(b3galt6)
LCF: 108884066(b3galt6)
SDU: 111221818(b3galt6)
SLAL: 111667675(b3galt6)
XGL: 120807316(b3galt6)
HCQ: 109522223(b3galt6)
BPEC: 110165823(b3galt6)
MALB: 109956258(b3galt6)
ELS: 105007424(b3galt6)
SFM: 108938192(b3galt6)
PKI: 111853658(b3galt6)
AANG: 118210577(b3galt6)
LOC: 102694517(b3galt6)
LCM: 102355255(B3GALT6)
CMK: 103187433(b3galt6)
RTP: 109918536(b3galt6)
CIN: 778996(b3galt6)
SCLV: 120341313
SKO: 100367674
DME: Dmel_CG8734(beta3GalTII)
DER: 6543072
DSE: 6608207
DSI: Dsimw501_GD27981(Dsim_GD27981)
DYA: Dyak_GE22868(Dyak_beta3galt6)
DSR: 110182817
DPO: Dpse_GA28758(Dpse_beta3galt6)
DPE: 6597933
DMN: 108162389
DWI: 6644411
DGR: 6566393
DAZ: 108610340
DNV: 115562853
DHE: 111592079
DVI: 6627305
CCAT: 101456591
MDE: 101899820
LCQ: 111679243
ACOZ: 120959582
AARA: 120901636
AAG: 5568811
AALB: 109419591
CPII: 120425909
AME: 102655877
ACER: 108003457
BIM: 100740262
BBIF: 117214488
BTER: 100644667
CCAL: 108622599
OBB: 114880076
MGEN: 117222654
NMEA: 116425873
SOC: 105194992
MPHA: 105829197
AEC: 105155005
ACEP: 105626882
PBAR: 105426350
VEM: 105566820
HST: 105186112
DQU: 106745352
CFO: 105255994
FEX: 115243790
LHU: 105669725
PGC: 109857902
OBO: 105284463
PCF: 106788423
NVI: 100680242
CSOL: 105359846
MDL: 103571274
CCIN: 107266373
TCA: 656431
DPA: 109534754
ATD: 109599054
AGB: 108910758
LDC: 111509085
NVL: 108563522
APLN: 108735776
PPYR: 116170377
OTU: 111424934
BMOR: 101740645
BMAN: 114247960
MSEX: 115449198
BANY: 112045668
PMAC: 106712341
PPOT: 106107973
PXU: 106117241
PRAP: 111001912
ZCE: 119830168
HAW: 110383736
TNL: 113493565
PXY: 105386738
DNX: 107164501
BTAB: 109035941
DCI: 103514882
CLEC: 106670905
HHAL: 106686435
NLU: 111047956
ZNE: 110831323
CSEC: 111867039
FCD: 110850766
DMK: 116916453
HAME: 121879271
HAZT: 108667009
EAF: 111700018
VDE: 111249317
VJA: 111270592
TUT: 107368691
DPTE: 113794377
CSCU: 111625572
PTEP: 107448329
SDM: 118186131
CEL: CELE_Y110A2AL.14(sqv-2)
CBR: CBG19617(Cbr-sqv-2)
BMY: BM_BM7274(Bma-sqv-2)
PCAN: 112556227
BGT: 106065403
GAE: 121390616
CRG: 105340554
MYI: 110450118
PMAX: 117344584
OBI: 106882295
LAK: 106161537
HMG: 100208936
PALZ: 118058471
 » show all
Reference
1  [PMID:3924029]
  Authors
Robinson JA, Robinson HC.
  Title
Initiation of chondroitin sulphate synthesis by beta-D-galactosides. Substrates for galactosyltransferase II.
  Journal
Biochem J 227:805-14 (1985)
DOI:10.1042/bj2270805
Reference
2  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J Biol Chem 250:5200-7 (1975)
Reference
3  [PMID:11551958]
  Authors
Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD
  Title
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).
  Journal
J Biol Chem 276:48189-95 (2001)
DOI:10.1074/jbc.M107339200
  Sequence
[hsa:126792] [mmu:117592]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.134
IUBMB Enzyme Nomenclature: 2.4.1.134
ExPASy - ENZYME nomenclature database: 2.4.1.134
BRENDA, the Enzyme Database: 2.4.1.134
CAS: 56626-21-2 56626-19-8

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