Entry
Name
galactosylxylosylprotein 3-beta-galactosyltransferase;
galactosyltransferase II;
uridine diphosphogalactose-galactosylxylose galactosyltransferase;
UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:
R05927 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:
C00052 ];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Product
UDP [CPD:
C00015 ];
[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [CPD:
C04825 ]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.134 created 1984, modified 2002
Pathway
ec00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Orthology
K00734 galactosylxylosylprotein 3-beta-galactosyltransferase
Genes
MORG : 121443545 121448529(B3galt6)
ODA : 120862075 120880627(B3GALT6)
OVR : 110124951(B3GALT6) 139031112
RAY : 107503893 107510710(B3GALT6)
PRUF : 121358335(B3GALT6) 121358342
XLA : 108696563(b3galt6.L) 108697636(b3galt6.S)
GSH : 117348732(B3GALT6) 117354194
SANH : 107680432 107699339
CCAR : 109066899(b3galt6) 109098579
CAUA : 113055100 113069397
CGIB : 127968611 128022598
MASI : 127426325 127428241
SASA : 106582684 106593203
STRU : 115151055 115207362
OCLA : 139369926 139414204
SALP : 111970598 112080947
PSPA : 121329263 121329297
ARUT : 117425319 117972756
BFO : 118410806 118411359 118430418
BBEL : 109464793 109466855 109479943
SCLV : 120341313 120341315
SPU : 115921698 115924557 585022 753784
LPIC : 129276301 129276314 129276703
APLC : 110979066 110979076
ARUN : 117302355 117302507
AAMU : 139950268 139950269
DME : Dmel_CG8734(beta3GalTII)
DSI : Dsimw501_GD27981(Dsim_GD27981)
DYA : Dyak_GE22868(Dyak_beta3galt6)
DVI : 6627305(beta3GalTII)
CVJ : 135952300(beta3GalTII)
CGIG : 122403002 122403764
COBS : 139103660(Beta3galtii)
TLN : 139814452(Beta3galtii)
PMEC : 138942402 138942430
LHU : 105669725(beta3GalTII)
NPT : 124217079(beta3GalTII)
TMOL : 138131435(beta3GalTII)
ESIM : 136418428(beta3GalTII)
EFOR : 136348491(beta3GalTII)
BPHI : 137929323(beta3GalTII)
SGRE : 126295406 126295408
PPOI : 119096713 119097867
RSAN : 119389641 119389643
CEL : CELE_Y110A2AL.14(sqv-2)
CBR : CBG_19617(Cbr-sqv-2)
BMY : BM_BM7274(Bma-sqv-2)
RPHI : 132720046 132756340
AQU : 100637620 100640622 105313401 105313426 105316663
» show all
Taxonomy
Reference
Authors
Robinson JA, Robinson HC.
Title
Initiation of chondroitin sulphate synthesis by beta-D-galactosides. Substrates for galactosyltransferase II.
Journal
Reference
Authors
Schwartz NB, Roden L.
Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
Journal
J Biol Chem 250:5200-7 (1975)
Reference
Authors
Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD
Title
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.134
CAS: 56626-21-2 56626-19-8