| Entry |
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| Name |
sucrose-phosphate synthase;
UDP-glucose---fructose-phosphate glucosyltransferase;
sucrosephosphate---UDP glucosyltransferase;
UDP-glucose-fructose-phosphate glucosyltransferase;
SPS;
uridine diphosphoglucose-fructose phosphate glucosyltransferase;
sucrose 6-phosphate synthase;
sucrose phosphate synthetase;
sucrose phosphate-uridine diphosphate glucosyltransferase;
sucrose phosphate synthase;
UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
UDP-alpha-D-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase (configuration-retaining)
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| Reaction(IUBMB) |
UDP-alpha-D-glucose + D-fructose 6-phosphate = UDP + sucrose 6F-phosphate [RN: R00766 R06073]
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| Reaction(KEGG) |
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| Substrate |
UDP-alpha-D-glucose [CPD: C00029];
D-fructose 6-phosphate [CPD: C00085]
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| Product |
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| Comment |
Requires Mg2+ or Mn2+ for maximal activity [2]. The enzyme from Synechocystis sp. strain PCC 6803 is not specific for UDP-glucose as it can use ADP-glucose and, to a lesser extent, GDP-glucose as substrates [2]. The enzyme from rice leaves is activated by glucose 6-phosphate but that from cyanobacterial species is not [2]. While the reaction catalysed by this enzyme is reversible, the enzyme usually works in concert with EC 3.1.3.24, sucrose-phosphate phosphatase, to form sucrose, making the above reaction essentially irreversible [3]. The F in sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.
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| History |
EC 2.4.1.14 created 1961, modified 2008
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| Pathway |
| ec00500 | Starch and sucrose metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00696 | sucrose-phosphate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
MENDICINO J. |
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| Title |
Sucrose phosphate synthesis in wheat germ and green leaves. |
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| Journal |
J Biol Chem 235:3347-52 (1960) |
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| Reference |
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| Authors |
Curatti L, Folco E, Desplats P, Abratti G, Limones V, Herrera-Estrella L, Salerno G |
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| Title |
Sucrose-phosphate synthase from Synechocystis sp. strain PCC 6803: identification of the spsA gene and characterization of the enzyme expressed in Escherichia coli. |
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| Journal |
J Bacteriol 180:6776-9 (1998) |
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| Reference |
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| Authors |
Huber SC, Huber JL |
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| Title |
ROLE AND REGULATION OF SUCROSE-PHOSPHATE SYNTHASE IN HIGHER PLANTS. |
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| Journal |
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| Reference |
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| Authors |
Cumino A, Curatti L, Giarrocco L, Salerno GL |
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| Title |
Sucrose metabolism: Anabaena sucrose-phosphate synthase and sucrose-phosphate phosphatase define minimal functional domains shuffled during evolution. |
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| Journal |
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| Reference |
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| Authors |
Chua TK, Bujnicki JM, Tan TC, Huynh F, Patel BK, Sivaraman J |
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| Title |
The structure of sucrose phosphate synthase from Halothermothrix orenii reveals its mechanism of action and binding mode. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.4.1.14 |
| ExPASy - ENZYME nomenclature database: | 2.4.1.14 |
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