KEGG   ENZYME: 2.4.1.141Help
Entry
EC 2.4.1.141                Enzyme                                 

Name
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase;
UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase;
uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase;
N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase;
UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-alpha-D-glucosaminyl-diphosphodolichol 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol [RN:R04494 R05970]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
History
EC 2.4.1.141 created 1984
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K07432  beta-1,4-N-acetylglucosaminyltransferase
K07441  beta-1,4-N-acetylglucosaminyltransferase
Genes
HSA: 199857(ALG14) 79868(ALG13)
PTR: 107966173(ALG13) 457040(ALG14)
PPS: 100990755(ALG13) 100992703(ALG14)
GGO: 101137154(ALG14) 101148710(ALG13)
PON: 100436390(ALG13) 100455462(ALG14)
NLE: 100595268(ALG13) 100600552(ALG14)
MCC: 706590(ALG13) 709630(ALG14)
MCF: 102126813(ALG14) 102144424(ALG13)
CSAB: 103224397(ALG14) 103232498(ALG13)
RRO: 104668599(ALG13) 104679535(ALG14)
CJC: 100396426(ALG14) 100398580(ALG13)
SBQ: 101028324(ALG13) 101028635(ALG14)
MMU: 320302(Glt28d2) 66789(Alg14) 67574(Alg13)
RNO: 108349244 300284(Alg13) 362031(Alg14)
CGE: 100754023(Alg13) 100773644(Alg14) 103160092
NGI: 103734638(Alg14) 103750014(Alg13)
HGL: 101699062(Alg14) 101703332 101710153(Alg13)
CCAN: 109686566(Alg14) 109699129
OCU: 100342997(ALG13) 100344143 100350419(ALG14)
TUP: 102468314(ALG13) 102475630 102492813(ALG14)
CFA: 481021(ALG13) 612241(ALG14)
AML: 100465309(ALG14) 100482253(ALG13)
UMR: 103669353(ALG14) 103679737(ALG13)
ORO: 101366864(ALG13) 101366876(ALG14)
FCA: 101095959(ALG13) 101101491(ALG14)
PTG: 102959335(ALG14) 102961075(ALG13)
AJU: 106968085(ALG14) 106985605(ALG13)
BTA: 107132045 506537(ALG14) 515282(ALG13)
BOM: 102270741(ALG14) 102276206(ALG13)
PHD: 102318722(ALG14) 102332892(ALG13)
CHX: 102177857(ALG14) 102184887(ALG13) 106503782
OAS: 101108526(ALG14) 101109593(ALG13)
SSC: 100157203(ALG14) 100523348(ALG13)
CFR: 102512320(ALG14) 102522108(ALG13)
CDK: 105085181(ALG14) 105103129(ALG13)
BACU: 103003872 103012926(ALG14)
LVE: 103077315 103078885(ALG13) 103089740(ALG14)
OOR: 101276556(ALG14) 101277624(ALG13)
ECB: 100058111(ALG14) 100058763(ALG13)
EAI: 106828111(ALG14) 106845125(ALG13)
MYB: 102254266(ALG14) 102258525(ALG13)
MYD: 102751504(ALG14) 102759147(ALG13)
RSS: 109437546(ALG14) 109438119(ALG13) 109439458
PALE: 102886591(ALG13) 102898603(ALG14)
LAV: 100660224(ALG14) 100668269(ALG13) 111752896
MDO: 100032901(ALG14) 100619965 103098000(ALG13)
OAA: 100076310
GGA: 422339(ALG13) 424484(ALG14)
MGP: 100544608(ALG14) 100551113(ALG13)
CJO: 107312757(ALG13) 107317356(ALG14)
APLA: 101801124(ALG13) 106016835(ALG14)
ACYG: 106038522(ALG13)
TGU: 100224572 100227409(ALG14)
GFR: 102034219 106631791(ALG13) 106631845(ALG14)
FAB: 101806675(ALG13) 101812517(ALG14)
PMAJ: 107203702(ALG13) 107208139(ALG14)
CCW: 104691725(ALG13) 104695359(ALG14)
FPG: 101918867(ALG13) 106112499(ALG14)
FCH: 106630808(ALG13) 106631554(ALG14)
CLV: 102091651(ALG13) 106145756(ALG14)
EGZ: 104135702(ALG13)
AAM: 106494783(ALG13)
ASN: 102379050 102382162(ALG13) 102383859(ALG14)
AMJ: 102562578 102573320(ALG13) 102575534(ALG14)
PSS: 102450756 102456842(ALG14) 102463607(ALG13)
CMY: 102932605(ALG14) 102943936(ALG13)
CPIC: 101934505(ALG13) 101942502(ALG14)
ACS: 100554968(alg13) 100561366(alg14)
PVT: 110074353(ALG13) 110076479(ALG14)
PBI: 103050004(ALG13) 103051408(ALG14)
GJA: 107112248(ALG14) 107123373
XLA: 108698403 108714370(alg14.L) 108715652(alg14.S) 431927(alg13.L)
XTR: 100145625(alg13) 100379745(alg14) 549862(alg13)
DRE: 436733(zgc:92907) 450072(alg14) 557181(alg13)
IPU: 100528959(alg13) 108270360(alg14) 108278514
TRU: 101068635 101069700(alg14) 101076588(alg13)
LCO: 104925550(alg13) 104926057(alg14) 104938128
NCC: 104960679(alg13) 104961634(alg14)
OLA: 101163283(alg14) 101163552 110015738(alg13)
PRET: 103471662(alg13) 103473139 103482219(alg14)
NFU: 107378296(alg13) 107382622(alg14) 107393843
CSEM: 103376842(alg14) 103383283 103390848(alg13)
HCQ: 109516663(alg13) 109516976(alg14)
LCM: 102360056(ALG14) 102362046 102366720(ALG13)
CMK: 103174640(alg14) 103179571(alg13)
DME: Dmel_CG14512(CG14512) Dmel_CG6308
DSI: Dsimw501_GD17960(Dsim_GD17960) Dsimw501_GD24820(Dsim_GD24820)
AME: 726253(GB14344) 726726
NVI: 100115468
DNX: 107171464
CEL: CELE_M02B7.4(algn-14) CELE_R10D12.12(algn-13)
LJA: Lj0g3v0304719.1(Lj0g3v0304719.1) Lj0g3v0304719.2(Lj0g3v0304719.2) Lj1g3v0416160.1(Lj1g3v0416160.1) Lj1g3v0416160.2(Lj1g3v0416160.2) Lj2g3v2017600.1(Lj2g3v2017600.1)
DOSA: Os02t0467700-01(Os02g0467700) Os03t0423200-01(Os03g0423200)
ATS: 109762009(LOC109762009) 109772813(LOC109772813) 109774664(LOC109774664)
ZMA: 100217271 100274149 100280032(IDP1988) 100285424(AY110060)
SCE: YBR070C(ALG14) YGL047W(ALG13)
KMX: KLMA_40126(ALG14) KLMA_50144(ALG13)
NCS: NCAS_0A10730(NCAS0A10730) NCAS_0C05680(NCAS0C05680)
NDI: NDAI_0A05570(NDAI0A05570) NDAI_0H00440(NDAI0H00440)
TPF: TPHA_0A03940(TPHA0A03940) TPHA_0K01930(TPHA0K01930)
TBL: TBLA_0B09870(TBLA0B09870) TBLA_0I02050(TBLA0I02050)
TDL: TDEL_0D03370(TDEL0D03370) TDEL_0E05670(TDEL0E05670)
KAF: KAFR_0F03110(KAFR0F03110) KAFR_0H01320(KAFR0H01320)
CAL: CAALFM_C100810WA(CaO19.6025) CAALFM_C210790CA(CaO19.5363)
SLB: AWJ20_3915(ALG13)
NCR: NCU03344
NTE: NEUTE1DRAFT123317(NEUTE1DRAFT_123317)
ANI: AN5736.2
ANG: ANI_1_2882014(An01g09110)
SPO: SPAC56E4.02c(alg13) SPAC5D6.06c(alg14)
ABP: AGABI1DRAFT97972(AGABI1DRAFT_97972)
ABV: AGABI2DRAFT148978(AGABI2DRAFT_148978)
MGL: MGL_4144
DDI: DDB_G0290339(ugt1)
DFA: DFA_03817(ugt1)
EHI: EHI_049660(21.t00050)
PCB: PCHAS_031060(PC000472.04.0) PCHAS_122490(PC302316.00.0)
TPV: TP02_0515
BBO: BBOV_II005640(18.m10008) BBOV_IV004090(23.m06545)
CPV: cgd7_4930
SMIN: v1.2.034275.t1(symbB.v1.2.034275.t1)
TCR: 504071.90
 » show all
Taxonomy
Reference
1  [PMID:6215245]
  Authors
Sharma CB, Lehle L, Tanner W.
  Title
Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast.
  Journal
Eur J Biochem 126:319-25 (1982)
DOI:10.1111/j.1432-1033.1982.tb06781.x
Reference
2  [PMID:192724]
  Authors
Turco SJ, Heath EC.
  Title
Glucuronosyl-N-acetylglucosaminyl pyrophosphoryldolichol. Formation in SV40-transformed human lung fibroblasts and biosynthesis in rat lung microsomal preparations.
  Journal
J Biol Chem 252:2918-28 (1977)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.141
IUBMB Enzyme Nomenclature: 2.4.1.141
ExPASy - ENZYME nomenclature database: 2.4.1.141
BRENDA, the Enzyme Database: 2.4.1.141
CAS: 75536-54-8

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