Entry
Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating);
elongation 3beta-GalNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to beta-D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->3)-[N-acetyl-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase;
B3GNT3 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] = UDP + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] [RN:
R04636 R05901 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Product
UDP [CPD:
C00015 ];
3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Comment
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.
History
EC 2.4.1.146 created 1984, modified 2018
Orthology
K07970 beta-1,3-N-acetylglucosaminyltransferase 3
Genes
MCC : 114674034(B3GNT3) 719221
PKL : 118722609 118725871(B3GNT3)
SHON : 118975180 118975182
AJM : 119043950 119046818(B3GNT3) 119046819
PDIC : 114503731 114503735
PHAS : 123828315 123828458
TALA : 116963233 122153644
PMUR : 107285005 107285006 107296837(B3GNT3) 114922368
XLA : 108703715(b3gnt3.2.S) 108711807 734264(b3gnt3.2.L)
XTR : 100145701(b3gnt3.2) 100380117(b3gnt3.1) 100494334 101733889 116409851
NPR : 108790801 108793753 108803023
RTEM : 120909662 120909687 120914440 120933672 120933692
BBUF : 120989390(B3GNT3) 121009144
BGAR : 122919843 122920562(B3GNT3)
DRE : 100002020(b3gnt3.2) 561172(b3gnt3.4)
SANH : 107665060 107700302(b3gnt3)
CCAR : 109083431 109099585
CAUA : 113049247 113077616 113099571
IPU : 108265513 108265849 108266016 108266017
SMEO : 124399388 124400092 124400431
TFD : 113634256 113634260 113642616 113642617 113642618 113642619 113642620 125146324
TNG : GSTEN00019098G001 GSTEN00019099G001 GSTEN00019100G001
LCO : 104935378 109139021(b3gnt3) 109139346 109139347
ELY : 117253529 117263620 117264498
PLEP : 121941118 121952728
MSAM : 119900537 119900538 119900539 119917039
CUD : 121512695 121519212 121519214 121519215
ONL : 100700249 100710618 102077342(b3gnt3)
OAU : 116328445 116328458 116331915 116333906
OLA : 101163432 101173163 101173646 101175309
OML : 112138882 112139123 112142676 112142717 112150918 112150945
XMA : 102222047 102226121 102235218(b3gnt3) 111606492
XCO : 114137712 114137713 114150430 114151525 114152730
XHE : 116713044 116713045 116725213 116725996 116727933
PRET : 103463427 103463431 103475708 103476783
PFOR : 103129919 103129923 103133540 103133955
PLAI : 106937802 106937900 106947686 106955559
PMEI : 106906127 106914022 106914028 106914127
GAF : 122838849 122838850 122842547 122845157
CVG : 107095630 107103340(b3gnt3) 107103343 107103671 107104833
CTUL : 119773651 119786226 119786238 119787603 119787742 119790866
GMU : 124858982 124873366 124874498 124876850
NFU : 107376009 107386572 107392806
KMR : 108234252 108234256 108243045 108247418 119616708
ALIM : 106519220 106519221 106533410
NWH : 119407675 119407676 119420122 119430271
CSEM : 103395334 103395738 103395759 103399385
SSEN : 122780488 122781014 122781015
HHIP : 117760258 117760259 117760260 117760575 117760577
SDU : 111218271(b3gnt3) 111235274
SLAL : 111669970(b3gnt3) 111670022
XGL : 120790634 120791330 120802899
SASA : 106573871(b3gnt3) 106578060 106613654
OTW : 112250760(b3gnt3.4) 112252159
OGO : 123996683 123998437 124007935
ELS : 105007499 105011432(b3gnt3) 105031420
AANG : 118221742 118226430
PSPA : 121301356 121301670
ARUT : 117401222 117966163 117966195 117966263 117966282 117966310 117968039 117972057
» show all
Taxonomy
Reference
Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
Journal
Reference
Authors
Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K
Title
Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.146