KEGG   ENZYME: 2.4.1.146Help
Entry
EC 2.4.1.146                Enzyme                                 

Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating);
elongation 3beta-GalNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to beta-D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->3)-[N-acetyl-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase;
B3GNT3 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] = UDP + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] [RN:R04636 R05901]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Product
UDP [CPD:C00015];
3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Comment
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.
History
EC 2.4.1.146 created 1984, modified 2018
Orthology
K07970  beta-1,3-N-acetylglucosaminyltransferase 3
Genes
HSA: 10331(B3GNT3)
PTR: 455847(B3GNT3)
PPS: 100982986(B3GNT3)
GGO: 101151557(B3GNT3)
PON: 100433243(B3GNT3)
NLE: 100596245(B3GNT3)
MCC: 719221
MCF: 102134304(B3GNT3)
CSAB: 103234153(B3GNT3)
RRO: 104660961(B3GNT3)
RBB: 108534279(B3GNT3)
CJC: 100404385(B3GNT3)
SBQ: 101033879(B3GNT3)
MMU: 72297(B3gnt3)
MCAL: 110299618(B3gnt3)
MPAH: 110337004(B3gnt3)
RNO: 290638(B3gnt3)
MUN: 110549208(B3gnt3)
CGE: 100773213(B3gnt3)
NGI: 103726889(B3gnt3)
HGL: 101713138(B3gnt3)
CCAN: 109698339(B3gnt3)
TUP: 102472378(B3GNT3) 102476277
CFA: 484831(B3GNT3)
VVP: 112913174(B3GNT3)
AML: 100473756(B3GNT3)
UMR: 103675168(B3GNT3)
UAH: 113256690(B3GNT3)
ORO: 101368545(B3GNT3)
FCA: 101092089(B3GNT3)
PTG: 102965987(B3GNT3)
AJU: 106969093(B3GNT3)
BTA: 784997(B3GNT3)
BOM: 102281061(B3GNT3)
BIU: 109560822(B3GNT3)
BBUB: 102400108(B3GNT3)
CHX: 102171777(B3GNT3)
OAS: 101113066(B3GNT3)
SSC: 100518473(B3GNT3)
CFR: 102512477(B3GNT3)
CDK: 105101856(B3GNT3)
BACU: 103012961(B3GNT3)
LVE: 103080965(B3GNT3)
OOR: 101282171(B3GNT3)
DLE: 111166586(B3GNT3)
ECB: 100146466(B3GNT3)
EPZ: 103542315(B3GNT3)
EAI: 106830835(B3GNT3)
MYB: 102254606(B3GNT3)
MYD: 102767713(B3GNT3)
MNA: 107535321(B3GNT3)
HAI: 109382386(B3GNT3)
RSS: 109450104(B3GNT3)
DRO: 112305269(B3GNT3)
PALE: 102882932(B3GNT3)
LAV: 100673587(B3GNT3)
MDO: 100010637(B3GNT3)
SHR: 100920625(B3GNT3)
PCW: 110223495(B3GNT3)
OAA: 100086714(B3GNT3)
MGP: 100549756(B3GNT3)
CJO: 107325454(B3GNT3)
ACYG: 106048207(B3GNT3)
FPG: 106112886(B3GNT3)
FCH: 102054592(B3GNT3)
CLV: 102095902(B3GNT3)
EGZ: 104124478(B3GNT3)
NNI: 104013696(B3GNT3)
AAM: 106486607
ASN: 102373956(B3GNT3)
AMJ: 106737906(B3GNT3)
PSS: 102443521(B3GNT3)
CMY: 102944348(B3GNT3)
CPIC: 101936651(B3GNT3)
PVT: 110072506(B3GNT3)
PBI: 103061136(B3GNT3)
PMUR: 107296837(B3GNT3)
GJA: 107120629(B3GNT3)
XLA: 108703715 108711807 734264
XTR: 100145701(b3gnt3) 100494334
NPR: 108790801 108793753 108803023
DRE: 100002020(b3gnt3.2) 561172(b3gnt3.4)
SRX: 107755313
SANH: 107665060 107700302(b3gnt3)
SGH: 107599054
CCAR: 109083431 109099585
IPU: 108265513(b3gnt3) 108265849 108266016 108266017
PHYP: 113525137(b3gnt3)
AMEX: 103026573(b3gnt3)
EEE: 113587291 113587962
TRU: 101072648(b3gnt3)
TNG: GSTEN00019098G001 GSTEN00019099G001 GSTEN00019100G001
LCO: 104935378 109139021(b3gnt3) 109139346 109139347
NCC: 104958016
MZE: 101474209 105940915
OLA: 101163432 101173163 101173646 101175309
XMA: 102222047 102226121 102235218(b3gnt3) 111606492
XCO: 114137712 114137713 114150430 114151525 114152730
PRET: 103463427 103463431 103475708 103476783
NFU: 107376009 107386572 107392806
KMR: 108234252 108234256(b3gnt3) 108243045 108247418
CSEM: 103395334 103395738 103395759 103399385
LCF: 108881191 108893170
SDU: 111218271(b3gnt3) 111235274
HCQ: 109519123(b3gnt3)
BPEC: 110160181
MALB: 109958356
SASA: 106573871(b3gnt3) 106578060 106613654
OTW: 112250760
SALP: 111953012(b3gnt3)
ELS: 105007499 105011432(b3gnt3) 105031420
SFM: 108930515(b3gnt3)
PKI: 111860178(b3gnt3)
LCM: 102345207(B3GNT3)
CMK: 103181970(b3gnt3)
 » show all
Taxonomy
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr Res 120:3-16 (1983)
DOI:10.1016/0008-6215(83)88002-1
Reference
2  [PMID:11042166]
  Authors
Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K.
  Title
Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.
  Journal
J Biol Chem 276:3498-507 (2001)
DOI:10.1074/jbc.M004800200
  Sequence
[hsa:10331]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.146
IUBMB Enzyme Nomenclature: 2.4.1.146
ExPASy - ENZYME nomenclature database: 2.4.1.146
BRENDA, the Enzyme Database: 2.4.1.146
CAS: 87927-99-9

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Chemical substance (8)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (4)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (206)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (162)   
   KEGG MGENES (2)   
   RefGene (41)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (2)   
   RefSeq(pep) (5)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
All databases (233)   

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