KEGG ENZYME: 2.4.1.149

ENZYME: 2.4.1.149

Entry

EC 2.4.1.149 Enzyme

Name

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase;
poly-N-acetyllactosamine extension enzyme;
Galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase;
UDP-GlcNAc:GalR beta-D-3-N-acetylglucosaminyltransferase;
N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase;
UDP-GlcNAc:Galbeta1->4GlcNAcbeta-Rbeta1->3-N-acetylglucosaminyltransferase;
GnTE;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase;
beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine 3-beta-N-acetyl-D-glucosaminyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R 3-beta N-acetylglucosaminyltransferase (configuration-inverting)

Reaction(IUBMB)

UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R [RN:R02789]

Reaction(KEGG)

R02789 > R04659 R05974(G) R05975(G)

Substrate

UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R [CPD:C00694]

Product

UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R [CPD:C04890]

Comment

Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on glycoproteins, glycolipids, and oligosaccharides.

History

EC 2.4.1.149 created 1984 (EC 2.4.1.163 created 1989, incorporated 2016), modified 2016

Pathway

ec00533

Glycosaminoglycan biosynthesis - keratan sulfate

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec01100

Metabolic pathways

Orthology

K00741

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

K07970

beta-1,3-N-acetylglucosaminyltransferase 3

K07971

beta-1,3-N-acetylglucosaminyltransferase 4

Genes

HSA:	10331(B3GNT3) 10678(B3GNT2) 79369(B3GNT4)

PTR:	455847(B3GNT3) 744166(B3GNT4) 745838(B3GNT2)

PPS:	100973625(B3GNT2) 100982200(B3GNT4) 100982986(B3GNT3)

GGO:	101126374(B3GNT4) 101130700(B3GNT2) 101151557(B3GNT3)

PON:	100433243(B3GNT3) 100437574(B3GNT4) 100461200(B3GNT2)

NLE:	100585350(B3GNT4) 100596245(B3GNT3) 100607325(B3GNT2)

MCC:	693396(B3GNT2) 702023(B3GNT4) 719221

MCF:	102134304(B3GNT3) 102136094(B3GNT2) 102138868(B3GNT4)

CSAB:

103220181(B3GNT2) 103234153(B3GNT3) 103239303(B3GNT4)

RRO:	104660961(B3GNT3) 104666296(B3GNT4) 104666963(B3GNT2)

RBB:	108517019(B3GNT2) 108534279(B3GNT3) 108541058(B3GNT4)

CJC:	100385332 100402866(LRRC43) 100404385(B3GNT3) 100407247(B3GNT2)

SBQ:	101033879(B3GNT3) 101041127(B3GNT4) 101043174(B3GNT2) 104650627

MMU:	231727(B3gnt4) 53625(B3gnt2) 72297(B3gnt3)

MCAL:

110294452(B3gnt4) 110299618(B3gnt3) 110304431(B3gnt2)

MPAH:

110312862(B3gnt4) 110330666(B3gnt2) 110337004(B3gnt3)

RNO:	288752(B3gnt4) 290638(B3gnt3) 305571(B3gnt2)

MUN:	110539904(B3gnt2) 110545326(B3gnt4) 110549208(B3gnt3)

CGE:	100766691(B3gnt2) 100769077(B3gnt4) 100773213(B3gnt3)

NGI:	103726889(B3gnt3) 103739056(B3gnt4) 103743255(B3gnt2)

HGL:	101697436(B3gnt4) 101713138(B3gnt3) 101714518 101723595(B3gnt2)

CCAN:

109684612(B3gnt4) 109698339(B3gnt3) 109698721(B3gnt2)

OCU:	100342947(B3GNT2) 103345065(B3GNT4)

TUP:	102471847(B3GNT2) 102472378(B3GNT3) 102476277 102485148(B3GNT4)

CFA:	474611(B3GNT2) 484831(B3GNT3) 486255(B3GNT4)

VVP:	112913174(B3GNT3) 112915284(B3GNT2) 112935241(B3GNT4)

AML:	100473756(B3GNT3) 100480301(B3GNT4) 100484275(B3GNT2)

UMR:	103661263(B3GNT4) 103671308(B3GNT2) 103675168(B3GNT3)

UAH:	113245108(B3GNT2) 113256690(B3GNT3) 113266926(B3GNT4)

ORO:	101368545(B3GNT3) 101372054(B3GNT4) 101381726(B3GNT2)

ELK:	111144118 111148065 111156471

FCA:	101080523(B3GNT2) 101092089(B3GNT3) 101092795(B3GNT4)

PTG:	102953748(B3GNT2) 102965987(B3GNT3) 102969555(B3GNT4)

PPAD:

109247961(B3GNT3) 109256689(B3GNT2) 109277706(B3GNT4)

AJU:	106967555(B3GNT4) 106969093(B3GNT3) 106973472(B3GNT2)

BTA:	515585(B3GNT2) 534619(B3GNT4) 784997(B3GNT3)

BOM:	102270553 102277608 102278923(B3GNT4) 102281061(B3GNT3) 102285789(B3GNT2)

BIU:	109560124 109560822(B3GNT3) 109566200(B3GNT2) 109568239 109571378(B3GNT4)

BBUB:

102394827 102397471 102400108(B3GNT3) 102400497(B3GNT2) 102405446(B3GNT4) 102410358

CHX:	102168846(B3GNT4) 102171777(B3GNT3) 102172908(B3GNT2)

OAS:	101102267(B3GNT4) 101113066(B3GNT3) 101117403(B3GNT2)

SSC:	100518473(B3GNT3) 100524195(B3GNT2) 100736645(B3GNT4)

CFR:	102506509(B3GNT2) 102512477(B3GNT3) 102519695(B3GNT4)

CDK:	105097252(B3GNT2) 105101856(B3GNT3)

BACU:

103010834(B3GNT4) 103012961(B3GNT3) 103013589(B3GNT2) 103018714

LVE:	103079240(B3GNT2) 103080965(B3GNT3) 103086312(B3GNT4)

OOR:	101277117(B3GNT4) 101282171(B3GNT3) 101290494(B3GNT2)

DLE:	111166586(B3GNT3) 111183111 111186581(B3GNT2) 111186885(B3GNT4)

PCAD:

102976518(B3GNT4) 102980178 102981094(B3GNT2) 102989486(B3GNT3) 112063850

ECB:	100060158(B3GNT4) 100064405(B3GNT2) 100146466(B3GNT3)

EPZ:	103541201(B3GNT4) 103542315(B3GNT3) 103566217(B3GNT2)

EAI:	106828376(B3GNT2) 106830835(B3GNT3) 106842309(B3GNT4)

MYB:	102254606(B3GNT3) 102258133(B3GNT4) 106723541(B3GNT2)

MYD:	102762333(B3GNT2) 102767713(B3GNT3) 102772504(B3GNT4)

MNA:	107535321(B3GNT3) 107537907(B3GNT2) 107541840(B3GNT4)

HAI:	109377910(B3GNT2) 109382386(B3GNT3) 109386073(B3GNT4)

DRO:	112297890(B3GNT2) 112305269(B3GNT3) 112310866(B3GNT4)

PALE:

102879999(B3GNT2) 102882932(B3GNT3) 102898492(B3GNT4)

RAY:	107515228(B3GNT4) 107519880(B3GNT2) 107521817(B3GNT3)

MJV:	108388013(B3GNT3) 108390388(B3GNT4) 108393417(B3GNT2)

LAV:	100656431(B3GNT2) 100667062(B3GNT4) 100673587(B3GNT3)

TMU:	101351176 101354980

MDO:	100010637(B3GNT3) 100022055(B3GNT4) 100031891(B3GNT2)

SHR:	100920625(B3GNT3) 100928418(B3GNT2) 100929127(B3GNT4)

PCW:	110196776(B3GNT4) 110207715(B3GNT2) 110223495(B3GNT3)

OAA:	100074841(B3GNT4) 100078191(B3GNT2) 100086714(B3GNT3)

GGA:	100858043(B3GNT4) 421286(B3GNT2)

MGP:	100540421(B3GNT2) 100545749(B3GNT4) 100549756(B3GNT3)

CJO:	107310873(B3GNT2) 107321114(B3GNT4) 107325454(B3GNT3)

NMEL:

110388735(B3GNT3) 110395871(B3GNT2) 110406488(B3GNT4)

APLA:

101793948(B3GNT2)

ACYG:

106031126(B3GNT4) 106045606(B3GNT2) 106048207(B3GNT3)

TGU:	100217506(B3GNT2) 100226631(B3GNT4)

LSR:	110474867(B3GNT2) 110478150(B3GNT4)

SCAN:

103818157(B3GNT4) 103821345(B3GNT2)

GFR:	102031557(B3GNT4) 102038254(B3GNT2)

FAB:	101811159(B3GNT4) 101811829(B3GNT2)

PHI:	102101528(B3GNT4) 102107608(B3GNT2)

PMAJ:

107202442(B3GNT2) 107211771(B3GNT4)

CCAE:

111926547(B3GNT2) 111936404(B3GNT4)

CCW:	104688690(B3GNT4) 104696618(B3GNT2)

ETL:	114054988(B3GNT4) 114067254(B3GNT2)

FPG:	101910333(B3GNT2) 101917583(B3GNT4) 106112886(B3GNT3)

FCH:	102047111(B3GNT2) 102054592(B3GNT3) 102054954(B3GNT4)

CLV:	102085751(B3GNT2) 102087378(B3GNT4) 102095902(B3GNT3)

EGZ:	104122740(B3GNT4) 104124478(B3GNT3) 104129481(B3GNT2)

NNI:	104013696(B3GNT3) 104014921(B3GNT2) 104020734(B3GNT4)

ACUN:

113478588(B3GNT2) 113486316(B3GNT4)

PADL:

103914568(B3GNT4) 103917425 103919575(B3GNT2)

AAM:	106486607 106495676(B3GNT4) 106499878(B3GNT2)

ASN:	102370599(B3GNT2) 102373956(B3GNT3) 102377528(B3GNT4)

AMJ:	102572682(B3GNT4) 102573235(B3GNT2) 106737906(B3GNT3)

PSS:	102443521(B3GNT3) 102444677(B3GNT4) 102453681 102460724(B3GNT2)

CMY:	102933292 102935807(B3GNT4) 102936051(B3GNT2) 102944348(B3GNT3)

CPIC:

101935467(B3GNT4) 101936651(B3GNT3) 101937115 101943630(B3GNT2) 103305821

ACS:	100554272(b3gnt2) 100566391(b3gnt4)

PVT:	110072506(B3GNT3) 110077488(B3GNT2) 110083863(B3GNT4)

PBI:	103052938(B3GNT2) 103061136(B3GNT3)

PMUR:

107284337(B3GNT2) 107296837(B3GNT3) 114922368

TSR:	106540975(B3GNT2) 106556824

PMUA:

114587060(B3GNT4) 114588656(B3GNT3) 114593513(B3GNT2)

GJA:	107115872(B3GNT4) 107120629(B3GNT3) 107121952(B3GNT2)

XLA:	108703715 108705729(b3gnt4.S) 108711807 108716744(b3gnt4.L) 414647(b3gnt2.L) 446358(b3gnt2.S) 734264

XTR:	100145701(b3gnt3.2) 100170561(b3gnt2) 100491670(b3gnt4) 100494334

NPR:	108786336(B3GNT2) 108787618(B3GNT4) 108790801 108793753 108803023

DRE:	100002020(b3gnt3.2) 561172(b3gnt3.4) 793362(b3gnt2b)

SRX:	107715381 107715967 107718504 107729991 107744608 107746084 107755313 107756177 107758521

SANH:

107660790 107665060 107669315 107670832 107689838 107699974 107700302(b3gnt3) 107700808 107703838

SGH:	107553573 107567918 107568313 107576349 107577595 107580023 107583559 107598544 107599054

CCAR:

109056641 109070406 109071360 109071950 109083431 109088493 109097101 109097262 109099585 109101636 109108015

IPU:	108259010 108265513(b3gnt3) 108265849 108266016 108266017 108268832 108269904 108278533

PHYP:

113525137(b3gnt3) 113529240 113537243 113541733 113544975

AMEX:

103026573(b3gnt3) 103035833 103036752 103037893(b3gnt2) 103046039

EEE:	113573371 113579668 113582170 113586023 113587291 113587962

TRU:	101061479 101071706 101072648(b3gnt3) 101079085(b3gnt2)

TNG:	GSTEN00007808G001 GSTEN00008464G001 GSTEN00018713G001 GSTEN00019098G001 GSTEN00019099G001 GSTEN00019100G001

LCO:	104918524(b3gnt2) 104920611 104928418 104931834 104935378 109139021(b3gnt3) 109139346 109139347

NCC:	104942322 104958016 104960895 104963443(b3gnt2) 104965223

MZE:	101464351 101467932 101470823(b3gnt2) 101474209 101481391 105940915

ONL:	100692524 100700249 100700614 100709040 100710618 100712515(b3gnt2) 102077342(b3gnt3) 109194920

OLA:	101159027 101159277 101162771 101163432 101168731 101173163 101173646 101173680 101175309

XMA:	102221480 102222047 102226121 102230398 102233570 102235218(b3gnt3) 102237208 111606492

XCO:	114137712 114137713 114138355 114139733 114145440 114149550 114150430 114151525 114152730

PRET:

103463427 103463431 103469913(b3gnt2) 103471046 103473546 103475708 103476501 103476783

CVG:	107088646(b3gnt2) 107090155 107090158 107094038 107095630 107098520 107103340(b3gnt3) 107103343 107103671 107104833

NFU:	107376009 107376053 107381105 107382280 107386572 107392806 107396549

KMR:	108232657 108234252 108234256(b3gnt3) 108237942 108242584 108243045 108247096 108247418

ALIM:

106513597 106519220 106519221 106530507 106533410 106535648(b3gnt2)

AOCE:

111567613 111571528 111576549(b3gnt3) 111585264

CSEM:

103387698(b3gnt2) 103390298 103391297 103391307 103395334 103395738 103395759 103399385

POV:	109626316 109627895 109636623(b3gnt3) 109642350(b3gnt2) 109643979

LCF:	108873134 108878744 108881191 108882532 108886059 108893170

SDU:	111218271(b3gnt3) 111226778 111227437 111232960 111235274 111237484

SLAL:

111646513 111648851 111650548 111651808 111655742 111669085 111669970(b3gnt3) 111670022

HCQ:	109515786 109518316 109519123(b3gnt3) 109526674(b3gnt2)

BPEC:

110153939 110153952 110155984(b3gnt2) 110157057 110160181 110160193

MALB:

109957496 109958356 109960726 109961182(b3gnt2)

SASA:

106563486 106564859 106573871(b3gnt3) 106575107 106577323 106578060 106580367(b3gnt4) 106585823 106593461 106594957 106595399 106600605 106604396 106613654

OTW:	112221173 112230368 112231332 112250760 112254009 112255914 112262877(b3gnt4) 112265228

SALP:

111953012(b3gnt3) 111958228(b3gnt4) 111959039 111964175 111965529 111967089 111971025 112077816 112080874

ELS:	105007499 105008367 105010962 105011432(b3gnt3) 105021532 105026101(b3gnt4) 105026740 105031420

SFM:	108920231 108921069 108926975 108930515(b3gnt3) 108933745 108934765(b3gnt4)

PKI:	111834566 111835114 111836464(b3gnt4) 111850811(b3gnt2) 111859614 111860178(b3gnt3)

LCM:	102345207(B3GNT3) 102350925 102359554(B3GNT2) 102362021(B3GNT4) 106704705

CMK:	103173573 103177950(b3gnt2) 103181970(b3gnt3) 103184281 103184282

RTP:	109910452 109918138 109925703 109931612(b3gnt4) 109937760

DPX:	DAPPUDRAFT_314109

BMY:

Bm1_50875

LOA:	LOAG_16500

CRG:

105333708

» show all

Reference

1 [PMID:6219989]

Authors

van den Eijnden DH, Winterwerp H, Smeeman P, Schiphorst WE.

Title

Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.

Journal

J Biol Chem 258:3435-7 (1983)

Reference

2 [PMID:6238026]

Authors

Basu M, Basu S.

Title

Biosynthesis in vitro of Ii core glycosphingolipids from neolactotetraosylceramide by beta 1-3- and beta 1-6-N-acetylglucosaminyltransferases from mouse T-lymphoma.

Journal

J Biol Chem 259:12557-62 (1984)

Reference

3 [PMID:3160874]

Authors

Takeya A, Hosomi O, Kogure T.

Title

The presence of N-acetyllactosamine and lactose: beta (1-3)N-acetylglucosaminyltransferase activity in human urine.

Journal

Jpn J Med Sci Biol 38:1-8 (1985)

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