KEGG ENZYME: 2.4.1.165

ENZYME: 2.4.1.165

Entry

EC 2.4.1.165                Enzyme

Name

N-acetylneuraminylgalactosylglucosyl-glucoside beta-1,4-N-acetylgalactosaminyltransferase;
B4GALNT2 (gene name);
uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (incorrect);
UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 4-beta-N-acetylgalactosaminyltransferase (incorrect);
UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-N-acetylgalactosaminyltransferase (incorrect);
N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (incorrect)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-N-acetyl-alpha-D-galactosamine:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R 4-beta-N-acetylgalactosaminyltransferase

Reaction(IUBMB)

UDP-N-acetyl-alpha-D-galactosamine + an alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R = UDP + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [RN:R13540]

Reaction(KEGG)

R13540;
(other) R07609(G) R13169(G)

Substrate

UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [CPD:C23067]

Product

UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [CPD:C23068]

Comment

Requires Mn2+. The enzyme, found in mammals, is only active with substrates containing (2->3) linked sialic acid residues [2,3]. It is active with glycoproteins, but not with gangliosides. The enzyme is involved in synthesis of the blood group antigen Sda.

History

EC 2.4.1.165 created 1989, modified 2025

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

Orthology

K09655

beta-1,4-N-acetylgalactosaminyltransferase 2

Genes

HSA:	124872(B4GALNT2)

PTR:	750651(B4GALNT2)

PPS:	100993176(B4GALNT2)

GGO:	101133400(B4GALNT2)

PON:	100452106(B4GALNT2)

PPYG:

129017973(B4GALNT2)

NLE:	100584131(B4GALNT2)

HMH:	116474348(B4GALNT2)

SSYN:

129470670(B4GALNT2)

MCC:	700278(B4GALNT2)

MCF:	102140714(B4GALNT2)

MTHB:

126939898

MNI:	105472338(B4GALNT2)

CSAB:

103243634(B4GALNT2)

CATY:

105579713(B4GALNT2)

PANU:

103878756(B4GALNT2)

TGE:	112609766(B4GALNT2)

MLEU:

105553290(B4GALNT2)

RRO:	104659716(B4GALNT2)

RBB:	108516422(B4GALNT2)

TFN:	117066485(B4GALNT2)

PTEH:

111537285(B4GALNT2)

CANG:

105524586(B4GALNT2)

CJC:	100394954(B4GALNT2)

SBQ:	101047697(B4GALNT2)

CIMI:

108312234(B4GALNT2)

ANAN:

105717090(B4GALNT2)

CSYR:

103262840 103266014(B4GALNT2)

MMUR:

105885085(B4GALNT2)

LCAT:

123620749(B4GALNT2)

PCOQ:

105823692(B4GALNT2)

OGA:	100945875(B4GALNT2)

MMU:	14422(B4galnt2)

MCAL:

110305800(B4galnt2)

MPAH:

110332464(B4galnt2)

RNO:	688155(B4galnt2)

MCOC:

116077756(B4galnt2)

ANU:	117711504(B4galnt2)

ASYL:

127694350(B4galnt2)

MUN:	110553435(B4galnt2)

CGE:	100760696(B4galnt2)

MAUA:

101840281(B4galnt2)

PROB:

127220887(B4galnt2)

PLEU:

114692976(B4galnt2)

MORG:

121456595(B4galnt2)

MFOT:

126510513

AAMP:

119813190(B4galnt2)

NGI:	103738359(B4galnt2)

HGL:	101720363(B4galnt2)

CPOC:

100717731(B4galnt2)

CCAN:

109691409(B4galnt2)

DORD:

106003007(B4galnt2)

DSP:	122103322(B4galnt2)

PLOP:

125366013(B4galnt2)

NCAR:

124979279

MMMA:

107150668(B4galnt2)

ITI:	101965220(B4galnt2)

OCU:

100349858

OPI:	101525207(B4GALNT2)

TUP:	102492408(B4GALNT2)

GVR:	103595067(B4GALNT2)

CFA:	491067(B4GALNT2)

CLUD:

112655627(B4GALNT2)

VVP:	112918129(B4GALNT2)

VLG:	121472646(B4GALNT2)

NPO:	129512654(B4GALNT2)

AML:	100483832(B4GALNT2)

UMR:	103661027(B4GALNT2)

UAH:	113265596(B4GALNT2)

UAR:	123802836(B4GALNT2)

ELK:

111151756

LLV:

125086927

MPUF:

101675259(B4GALNT2)

MNP:	132003431(B4GALNT2)

MLK:	131816003(B4GALNT2)

NVS:	122906604(B4GALNT2)

ORO:	101364754(B4GALNT2)

EJU:	114201174(B4GALNT2)

ZCA:	113908180(B4GALNT2)

MLX:	118025137(B4GALNT2)

NSU:	110593110(B4GALNT2)

LWW:	102738801(B4GALNT2)

FCA:	101080338(B4GALNT2)

PYU:	121045173(B4GALNT2)

PCOO:

112854054(B4GALNT2)

PBG:	122484673(B4GALNT2)

PVIV:

125158697(B4GALNT2)

LRUF:

124512811

LGF:	123602915(B4GALNT2)

AJU:

106985153

PTG:	102954559(B4GALNT2)

PUC:

125927656

PLEZ:

122205862(B4GALNT2)

HHV:	120229055(B4GALNT2)

BTA:	508108(B4GALNT2)

BOM:	102271213(B4GALNT2)

BIU:	109574430(B4GALNT2)

BBUB:

102409195(B4GALNT2)

BBIS:

104990837(B4GALNT2)

CHX:	102190989(B4GALNT2)

OAS:	101119323(B4GALNT2)

BTAX:

128065431(B4GALNT2)

CSUM:

138083635(B4GALNT2)

ODA:	120866627(B4GALNT2)

CCAD:

122442981(B4GALNT2)

MREE:

136149100(B4GALNT2)

OVR:	110123360(B4GALNT2)

MBEZ:

129544284(B4GALNT2)

SSC:	100621328(B4GALNT2)

CFR:	102520340(B4GALNT2)

CBAI:

105073324(B4GALNT2)

CDK:	105095770(B4GALNT2)

VPC:	102530244(B4GALNT2)

BACU:

103015006(B4GALNT2)

BMUS:

118886811(B4GALNT2)

LVE:	103068562(B4GALNT2)

OOR:	101285231(B4GALNT2)

LALB:

132511907(B4GALNT2)

DLE:	111166349(B4GALNT2)

PCAD:

102980068(B4GALNT2)

PSIU:

116745715(B4GALNT2)

PPHC:

136139071(B4GALNT2)

NASI:

112399287(B4GALNT2)

ECB:	100069631(B4GALNT2)

EPZ:	103551068(B4GALNT2)

EAI:	106826472(B4GALNT2)

MYB:	102252110(B4GALNT2)

MYD:	102775387(B4GALNT2)

MMYO:

118672372(B4GALNT2)

MLF:	102419850(B4GALNT2)

MDT:	132218861(B4GALNT2)

MYUM:

138994109(B4GALNT2)

PKL:	118726475(B4GALNT2)

EFUS:

103297171(B4GALNT2)

MNA:	107539166(B4GALNT2)

DRO:	112316219(B4GALNT2)

SHON:

118978108(B4GALNT2)

AJM:	119052633(B4GALNT2)

PDIC:

114503198(B4GALNT2)

PHAS:

123817365(B4GALNT2)

MMF:	118634490(B4GALNT2)

PPAM:

129080115(B4GALNT2)

HAI:	109380657(B4GALNT2)

RFQ:	117012636(B4GALNT2)

PALE:

102881429(B4GALNT2)

PGIG:

120611271(B4GALNT2)

PVP:	105307237(B4GALNT2)

RAY:	107517594(B4GALNT2)

MJV:	108391052(B4GALNT2)

TOD:	119231558(B4GALNT2)

SETR:

125997603(B4GALNT2)

LAV:	100672250(B4GALNT2)

TMU:

101354263

ETF:	101662994(B4GALNT2)

DNM:	101418561(B4GALNT2)

MDO:	100021386(B4GALNT2)

GAS:	123246179(B4GALNT2)

SHR:	100921350 100921873(B4GALNT2)

AFZ:	127560292 127561358

PCW:

110215651

TVP:	118848533(B4GALNT2)

PBRV:

138143210

OAA:	100076912(B4GALNT2)

TACU:

119934664(B4GALNT2)

PSS:	102448246(B4GALNT2)

CMY:	102939794 102940015

CCAY:

125626861(B4GALNT2)

DCC:	119849007 119849119

CABI:

116831452 116831453

MRV:	120392291 120392292

ACS:	100552596(b4galnt2) 100565535

ASAO:

132779617(B4GALNT2)

PVT:	110090873(B4GALNT2)

SUND:

121934641(B4GALNT2)

PMUR:

107282587(B4GALNT2)

CTIG:

120303475(B4GALNT2)

TSR:	106555947(B4GALNT2)

PGUT:

117665010(B4GALNT2)

APRI:

131197496(B4GALNT2)

PTEX:

113442998(B4GALNT2)

NSS:	113413410(B4GALNT2)

VKO:	123030499(B4GALNT2)

PMUA:

114608016(B4GALNT2)

PRAF:

128400835(B4GALNT2)

ZVI:	118094607(B4GALNT2)

GJA:	107108709 107108710(B4GALNT2)

STOW:

125445013(B4GALNT2)

EMC:	129338596(B4GALNT2)

XLA:	108700822 108702178

XTR:	100493488(b4galnt2)

NPR:	108799378(B4GALNT2)

RTEM:

120918334 120919515 120919550 120919555

ACAT:

141113338 141114242 141114250 141114251

BBUF:

121005890(B4GALNT2)

BGAR:

122940234(B4GALNT2)

DTC:	141086579(B4GALNT2)

PWL:	138295302(B4GALNT2)

MUO:	115481846(B4GALNT2)

GSH:	117347101(B4GALNT2)

SRX:

107754353

SANH:

107686962

SGH:

107566245

CCAR:

109071575

CAUA:

113066559 113066561 113085423

LCO:

104932218

ELY:

117268954

SLUC:

116045072

MSAM:

119882287(b4galnt2.2) 119882316

MZE:	101475242 101476126 101486764 105941471 112429840 112431557

ONL:	100694685 100694946 100695216 100695479 100695743 100696269 102076897 106097693 109201126

OAU:	116311602 116318746 116324465 116335536 116335537 120440038

LCF:	108898568 108898575 108902147

BPEC:

110159932 110171949 110174521

SASA:

106600851 106607533

OTW:	112225910 112258535

OMY:	110486154 118936293

SALP:

111981463

ARUT:

117433359

PSEX:

120517257

CMK:	103189117 103189126

RTP:	109931404 109936785

CPLA:

122539634 122539925 122539926

HOC:	132830701 132830756 132830757 132830758 132830759 132830803 132830825

LERI:

129710332

BFO:	118419014 118425165

BBEL:

109463753 109470494 109474375 109474381 109474913

SKO:	100367375 100367530 100367716 100375110 100375254 100375406 100375852 100376775 100377750 102802651 102802769 102803988 102806872

PFLL:

139120955 139125369 139129896 139130499 139132233 139132256 139132257 139133505 139151170 139152619 139152700

» show all

Reference

1 [PMID:2425965]

Authors

Piller F, Blanchard D, Huet M, Cartron JP.

Title

Identification of a alpha-NeuAc-(2----3)-beta-D-galactopyranosyl N-acetyl-beta-D-galactosaminyltransferase in human kidney.

Journal

Carbohydr Res 149:171-84 (1986)
DOI:10.1016/S0008-6215(00)90376-8

Reference

2 [PMID:3106337]

Authors

Takeya A, Hosomi O, Kogure T.

Title

Identification and characterization of UDP-GalNAc: NeuAc alpha 2-3Gal beta 1-4Glc(NAc) beta 1-4(GalNAc to Gal)N-acetylgalactosaminyltransferase in human blood plasma.

Journal

J Biochem (Tokyo) 101:251-9 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121898

Reference

3 [PMID:1445260]

Authors

Dohi T, Nishikawa A, Ishizuka I, Totani M, Yamaguchi K, Nakagawa K, Saitoh O, Ohshiba S, Oshima M.

Title

Substrate specificity and distribution of UDP-GalNAc:sialylparagloboside N-acetylgalactosaminyltransferase in the human stomach.

Journal

Biochem J 288 ( Pt 1):161-5 (1992)
DOI:10.1042/bj2880161

Reference

4 [PMID:12678917]

Authors

Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A

Title

Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.

Journal

Biochem J 373:369-79 (2003)
DOI:10.1042/BJ20021892

Sequence

[hsa:124872]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.165

IUBMB Enzyme Nomenclature:

2.4.1.165

ExPASy - ENZYME nomenclature database:

2.4.1.165

BRENDA, the Enzyme Database:

2.4.1.165

CAS:	109136-50-7

All links

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