KEGG   ENZYME: 2.4.1.165
Entry
EC 2.4.1.165                Enzyme                                 
Name
N-acetylneuraminylgalactosylglucosyl-glucoside beta-1,4-N-acetylgalactosaminyltransferase;
B4GALNT2 (gene name);
uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (incorrect);
UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 4-beta-N-acetylgalactosaminyltransferase (incorrect);
UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-(2->3)-alpha-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-N-acetylgalactosaminyltransferase (incorrect);
N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + an alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R = UDP + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [RN:R13540]
Reaction(KEGG)
R13540;
(other) R07609(G) R13169(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [CPD:C23067]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R [CPD:C23068]
Comment
Requires Mn2+. The enzyme, found in mammals, is only active with substrates containing (2->3) linked sialic acid residues [2,3]. It is active with glycoproteins, but not with gangliosides. The enzyme is involved in synthesis of the blood group antigen Sda.
History
EC 2.4.1.165 created 1989, modified 2025
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
Orthology
K09655  beta-1,4-N-acetylgalactosaminyltransferase 2
Genes
HSA124872(B4GALNT2)
PTR750651(B4GALNT2)
PPS100993176(B4GALNT2)
GGO101133400(B4GALNT2)
PON100452106(B4GALNT2)
PPYG129017973(B4GALNT2)
NLE100584131(B4GALNT2)
HMH116474348(B4GALNT2)
SSYN129470670(B4GALNT2)
MCC700278(B4GALNT2)
MCF102140714(B4GALNT2)
MTHB126939898
MNI105472338(B4GALNT2)
CSAB103243634(B4GALNT2)
CATY105579713(B4GALNT2)
PANU103878756(B4GALNT2)
TGE112609766(B4GALNT2)
MLEU105553290(B4GALNT2)
RRO104659716(B4GALNT2)
RBB108516422(B4GALNT2)
TFN117066485(B4GALNT2)
PTEH111537285(B4GALNT2)
CANG105524586(B4GALNT2)
CJC100394954(B4GALNT2)
SBQ101047697(B4GALNT2)
CIMI108312234(B4GALNT2)
ANAN105717090(B4GALNT2)
CSYR103262840 103266014(B4GALNT2)
MMUR105885085(B4GALNT2)
LCAT123620749(B4GALNT2)
PCOQ105823692(B4GALNT2)
OGA100945875(B4GALNT2)
MMU14422(B4galnt2)
MCAL110305800(B4galnt2)
MPAH110332464(B4galnt2)
RNO688155(B4galnt2)
MCOC116077756(B4galnt2)
ANU117711504(B4galnt2)
ASYL127694350(B4galnt2)
MUN110553435(B4galnt2)
CGE100760696(B4galnt2)
MAUA101840281(B4galnt2)
PROB127220887(B4galnt2)
PLEU114692976(B4galnt2)
MORG121456595(B4galnt2)
MFOT126510513
AAMP119813190(B4galnt2)
NGI103738359(B4galnt2)
HGL101720363(B4galnt2)
CPOC100717731(B4galnt2)
CCAN109691409(B4galnt2)
DORD106003007(B4galnt2)
DSP122103322(B4galnt2)
PLOP125366013(B4galnt2)
NCAR124979279
MMMA107150668(B4galnt2)
ITI101965220(B4galnt2)
OCU100349858
OPI101525207(B4GALNT2)
TUP102492408(B4GALNT2)
GVR103595067(B4GALNT2)
CFA491067(B4GALNT2)
CLUD112655627(B4GALNT2)
VVP112918129(B4GALNT2)
VLG121472646(B4GALNT2)
NPO129512654(B4GALNT2)
AML100483832(B4GALNT2)
UMR103661027(B4GALNT2)
UAH113265596(B4GALNT2)
UAR123802836(B4GALNT2)
ELK111151756
LLV125086927
MPUF101675259(B4GALNT2)
MNP132003431(B4GALNT2)
MLK131816003(B4GALNT2)
NVS122906604(B4GALNT2)
ORO101364754(B4GALNT2)
EJU114201174(B4GALNT2)
ZCA113908180(B4GALNT2)
MLX118025137(B4GALNT2)
NSU110593110(B4GALNT2)
LWW102738801(B4GALNT2)
FCA101080338(B4GALNT2)
PYU121045173(B4GALNT2)
PCOO112854054(B4GALNT2)
PBG122484673(B4GALNT2)
PVIV125158697(B4GALNT2)
LRUF124512811
LGF123602915(B4GALNT2)
AJU106985153
PTG102954559(B4GALNT2)
PUC125927656
PLEZ122205862(B4GALNT2)
HHV120229055(B4GALNT2)
BTA508108(B4GALNT2)
BOM102271213(B4GALNT2)
BIU109574430(B4GALNT2)
BBUB102409195(B4GALNT2)
BBIS104990837(B4GALNT2)
CHX102190989(B4GALNT2)
OAS101119323(B4GALNT2)
BTAX128065431(B4GALNT2)
CSUM138083635(B4GALNT2)
ODA120866627(B4GALNT2)
CCAD122442981(B4GALNT2)
MREE136149100(B4GALNT2)
OVR110123360(B4GALNT2)
MBEZ129544284(B4GALNT2)
SSC100621328(B4GALNT2)
CFR102520340(B4GALNT2)
CBAI105073324(B4GALNT2)
CDK105095770(B4GALNT2)
VPC102530244(B4GALNT2)
BACU103015006(B4GALNT2)
BMUS118886811(B4GALNT2)
LVE103068562(B4GALNT2)
OOR101285231(B4GALNT2)
LALB132511907(B4GALNT2)
DLE111166349(B4GALNT2)
PCAD102980068(B4GALNT2)
PSIU116745715(B4GALNT2)
PPHC136139071(B4GALNT2)
NASI112399287(B4GALNT2)
ECB100069631(B4GALNT2)
EPZ103551068(B4GALNT2)
EAI106826472(B4GALNT2)
MYB102252110(B4GALNT2)
MYD102775387(B4GALNT2)
MMYO118672372(B4GALNT2)
MLF102419850(B4GALNT2)
MDT132218861(B4GALNT2)
MYUM138994109(B4GALNT2)
PKL118726475(B4GALNT2)
EFUS103297171(B4GALNT2)
MNA107539166(B4GALNT2)
DRO112316219(B4GALNT2)
SHON118978108(B4GALNT2)
AJM119052633(B4GALNT2)
PDIC114503198(B4GALNT2)
PHAS123817365(B4GALNT2)
MMF118634490(B4GALNT2)
PPAM129080115(B4GALNT2)
HAI109380657(B4GALNT2)
RFQ117012636(B4GALNT2)
PALE102881429(B4GALNT2)
PGIG120611271(B4GALNT2)
PVP105307237(B4GALNT2)
RAY107517594(B4GALNT2)
MJV108391052(B4GALNT2)
TOD119231558(B4GALNT2)
SETR125997603(B4GALNT2)
LAV100672250(B4GALNT2)
TMU101354263
ETF101662994(B4GALNT2)
DNM101418561(B4GALNT2)
MDO100021386(B4GALNT2)
GAS123246179(B4GALNT2)
SHR100921350 100921873(B4GALNT2)
AFZ127560292 127561358
PCW110215651
TVP118848533(B4GALNT2)
PBRV138143210
OAA100076912(B4GALNT2)
TACU119934664(B4GALNT2)
PSS102448246(B4GALNT2)
CMY102939794 102940015
CCAY125626861(B4GALNT2)
DCC119849007 119849119
CABI116831452 116831453
MRV120392291 120392292
ACS100552596(b4galnt2) 100565535
ASAO132779617(B4GALNT2)
PVT110090873(B4GALNT2)
SUND121934641(B4GALNT2)
PMUR107282587(B4GALNT2)
CTIG120303475(B4GALNT2)
TSR106555947(B4GALNT2)
PGUT117665010(B4GALNT2)
APRI131197496(B4GALNT2)
PTEX113442998(B4GALNT2)
NSS113413410(B4GALNT2)
VKO123030499(B4GALNT2)
PMUA114608016(B4GALNT2)
PRAF128400835(B4GALNT2)
ZVI118094607(B4GALNT2)
GJA107108709 107108710(B4GALNT2)
STOW125445013(B4GALNT2)
EMC129338596(B4GALNT2)
XLA108700822 108702178
XTR100493488(b4galnt2)
NPR108799378(B4GALNT2)
RTEM120918334 120919515 120919550 120919555
ACAT141113338 141114242 141114250 141114251
BBUF121005890(B4GALNT2)
BGAR122940234(B4GALNT2)
DTC141086579(B4GALNT2)
PWL138295302(B4GALNT2)
MUO115481846(B4GALNT2)
GSH117347101(B4GALNT2)
SRX107754353
SANH107686962
SGH107566245
CCAR109071575
CAUA113066559 113066561 113085423
LCO104932218
ELY117268954
SLUC116045072
MSAM119882287(b4galnt2.2) 119882316
MZE101475242 101476126 101486764 105941471 112429840 112431557
ONL100694685 100694946 100695216 100695479 100695743 100696269 102076897 106097693 109201126
OAU116311602 116318746 116324465 116335536 116335537 120440038
LCF108898568 108898575 108902147
BPEC110159932 110171949 110174521
SASA106600851 106607533
OTW112225910 112258535
OMY110486154 118936293
SALP111981463
ARUT117433359
PSEX120517257
CMK103189117 103189126
RTP109931404 109936785
CPLA122539634 122539925 122539926
HOC132830701 132830756 132830757 132830758 132830759 132830803 132830825
LERI129710332
BFO118419014 118425165
BBEL109463753 109470494 109474375 109474381 109474913
SKO100367375 100367530 100367716 100375110 100375254 100375406 100375852 100376775 100377750 102802651 102802769 102803988 102806872
PFLL139120955 139125369 139129896 139130499 139132233 139132256 139132257 139133505 139151170 139152619 139152700
 » show all
Reference
1  [PMID:2425965]
  Authors
Piller F, Blanchard D, Huet M, Cartron JP.
  Title
Identification of a alpha-NeuAc-(2----3)-beta-D-galactopyranosyl N-acetyl-beta-D-galactosaminyltransferase in human kidney.
  Journal
Carbohydr Res 149:171-84 (1986)
DOI:10.1016/S0008-6215(00)90376-8
Reference
2  [PMID:3106337]
  Authors
Takeya A, Hosomi O, Kogure T.
  Title
Identification and characterization of UDP-GalNAc: NeuAc alpha 2-3Gal beta 1-4Glc(NAc) beta 1-4(GalNAc to Gal)N-acetylgalactosaminyltransferase in human blood plasma.
  Journal
J Biochem (Tokyo) 101:251-9 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121898
Reference
3  [PMID:1445260]
  Authors
Dohi T, Nishikawa A, Ishizuka I, Totani M, Yamaguchi K, Nakagawa K, Saitoh O, Ohshiba S, Oshima M.
  Title
Substrate specificity and distribution of UDP-GalNAc:sialylparagloboside N-acetylgalactosaminyltransferase in the human stomach.
  Journal
Biochem J 288 ( Pt 1):161-5 (1992)
DOI:10.1042/bj2880161
Reference
4  [PMID:12678917]
  Authors
Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A
  Title
Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain.
  Journal
Biochem J 373:369-79 (2003)
DOI:10.1042/BJ20021892
  Sequence
[hsa:124872]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.165
IUBMB Enzyme Nomenclature: 2.4.1.165
ExPASy - ENZYME nomenclature database: 2.4.1.165
BRENDA, the Enzyme Database: 2.4.1.165
CAS: 109136-50-7

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