KEGG ENZYME: 2.4.1.170

ENZYME: 2.4.1.170

Entry

EC 2.4.1.170                Enzyme

Name

isoflavone 7-O-glucosyltransferase;
uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase;
UDPglucose-favonoid 7-O-glucosyltransferase;
UDPglucose:isoflavone 7-O-glucosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase

Reaction(IUBMB)

UDP-glucose + an isoflavone = UDP + an isoflavone 7-O-beta-D-glucoside [RN:R07332]

Reaction(KEGG)

R07332 > R02932 R06795 R07718 R07720 R07729 R07740 R07753

Substrate

UDP-glucose [CPD:C00029];
isoflavone [CPD:C00799]

Product

UDP [CPD:C00015];
isoflavone 7-O-beta-D-glucoside [CPD:C04074]

Comment

The 4'-methoxy isoflavones biochanin A and formononetin and, more slowly, the 4'-hydroxyisoflavones genistein and daidzein, can act as acceptors. The enzyme does not act on isoflavanones, flavones, flavanones, flavanols or coumarins.

History

EC 2.4.1.170 created 1989

Pathway

ec00943

Isoflavonoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13263

isoflavone 7-O-glucosyltransferase

Genes

GMX:	100101902(IF7GT) 100776806(UGT8) 100777343(UGT7)

GSJ:	114389413 114389415 114390098

PVU:	PHAVU_004G104200g

VRA:

106763357

VAR:	108344639(AdGt-5) 108344857

VUN:	114181375 114181452

VUM:	124822034 124822864

APRC:

113867100

Reference

1 [PMID:6458246]

Authors

Koster J, Barz W.

Title

UDP-glucose:isoflavone 7-O-glucosyltransferase from roots of chick pea (Cicer arietinum L.).

Journal

Arch Biochem Biophys 212:98-104 (1981)
DOI:10.1016/0003-9861(81)90347-7

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.170

IUBMB Enzyme Nomenclature:

2.4.1.170

ExPASy - ENZYME nomenclature database:

2.4.1.170

BRENDA, the Enzyme Database:

2.4.1.170

CAS:	97089-62-8

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