Entry
Name
lipopolysaccharide N-acetylmannosaminouronosyltransferase;
ManNAcA transferase;
uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase;
UDP-N-acetyl-beta-D-mannosaminouronate:lipid I N-acetyl-beta-D-mannosaminouronosyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-mannosaminouronate:lipid I N-acetyl-alpha-D-mannosaminouronosyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-mannosaminouronate + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:
R04477 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-mannosaminouronate;
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:
C01289 ]
Product
UDP [CPD:
C00015 ];
N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Comment
Involved in the biosynthesis of common antigen in Enterobacteriaceae.
History
EC 2.4.1.180 created 1990, modified 2011
Orthology
K02852 UDP-N-acetyl-D-mannosaminouronate:lipid I N-acetyl-D-mannosaminouronosyltransferase
Genes
ECOO : ECRM13514_4855(wecG)
ECOH : ECRM13516_4640(wecG)
EDJ : ECDH1ME8569_3677(rffM)
ECOI : ECOPMV1_04128(tagA)
REE : electrica_04894(tagA)
RTG : NCTC13098_07028(tagA)
CLAP : NCTC11466_04433(tagA)
KIE : NCTC12125_03602(tagA)
AHN : NCTC12129_04758(rffM_1)
METY : MRY16398_54480(wecG)
PSHI : SAMEA2665130_3004(tagA)
SMW : SMWW4_v1c01820(rffM)
SFJ : SAMEA4384070_0135(tagA)
SOF : NCTC11214_01918(tagA)
SSAR : SSARUM_000133(rffM)
PAQU : DMB82_0019200(rffM)
PARL : PEC302110_01640(wecG)
DIC : Dpoa569_000264(rffM)
TPTY : NCTC11468_03531(tagA)
PHEI : NCTC12003_03728(tagA)
PRJ : NCTC6933_03742(tagA)
LRI : NCTC12151_03582(tagA)
ALIG : NCTC10568_01896(wecG)
MSHE : MAALD49_25760(wecG)
RBS : RHODOSMS8_03375(wecG)
PCAG : NCTC12856_02055(tagA)
BUY : D8S85_03805 D8S85_16550
SPON : HME9304_01554(wecG)
» show all
Taxonomy
Reference
Authors
Barr K, Ward S, Meier-Dieter U, Mayer H, Rick PD
Title
Characterization of an Escherichia coli rff mutant defective in transfer of N-acetylmannosaminuronic acid (ManNAcA) from UDP-ManNAcA to a lipid-linked intermediate involved in enterobacterial common antigen synthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.180