KEGG   ENZYME: 2.4.1.180
Entry
EC 2.4.1.180                Enzyme                                 
Name
lipopolysaccharide N-acetylmannosaminouronosyltransferase;
ManNAcA transferase;
uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase;
UDP-N-acetyl-beta-D-mannosaminouronate:lipid I N-acetyl-beta-D-mannosaminouronosyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-mannosaminouronate:lipid I N-acetyl-alpha-D-mannosaminouronosyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-mannosaminouronate + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R04477]
Reaction(KEGG)
R04477
Substrate
UDP-N-acetyl-alpha-D-mannosaminouronate;
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
Comment
Involved in the biosynthesis of common antigen in Enterobacteriaceae.
History
EC 2.4.1.180 created 1990, modified 2011
Orthology
K02852  UDP-N-acetyl-D-mannosaminouronate:lipid I N-acetyl-D-mannosaminouronosyltransferase
Genes
ECOb3794(rffM)
ECJJW3770(rffM)
ECDECDH10B_3984(rffM)
EBWBWG_3477(rffM)
ECOKECMDS42_3233(rffM)
ECEZ5306(wecG)
ECSECs_4728(wecG)
ECFECH74115_5228
ETWECSP_4843
ELXCDCO157_4465
EOIECO111_4621(rffM)
EOJECO26_4791(rffM)
EOHECO103_4369(rffM)
ECOOECRM13514_4855(wecG)
ECOHECRM13516_4640(wecG)
ESLO3K_24890
ESOO3O_00450
ESMO3M_24810
ECKEC55989_4267(rffM)
ECGE2348C_4096(rffM)
EOKG2583_4589(rffM)
ELRECO55CA74_22020
ELHETEC_4077
ECWEcE24377A_4307
EUNUMNK88_4604
ECPECP_3986
ENAECNA114_3933(wecG)
ECOSEC958_4257(rffM)
ECVAPECO1_2680(wecG)
ECOAAPECO78_22820
ECXEcHS_A4012
ECMEcSMS35_4159
ECYECSE_4078
ECRECIAI1_3982(rffM)
ECQECED1_4480(rffM)
EUMECUMN_4320(rffM)
ECTECIAI39_2992(rffM)
EOCCE10_4438(rffM)
EBRECB_03673(wecG)
EBLECD_03673(wecG)
EBEB21_03622(rffM)
EBDECBD_4244
ECIUTI89_C4352(rffM)
EIHECOK1_4241
ECZECS88_4218(rffM)
ECCc4716(wecG)
ELOEC042_4172(rffM)
ELNNRG857_18850
ESEECSF_3635
ECLEcolC_4208
EKOEKO11_4561
EKFKO11_03985(rffM)
EABECABU_c42740(rffM)
EDHEcDH1_4181
EDJECDH1ME8569_3677(rffM)
ELUUM146_19115
ELWECW_m4093(rffM)
ELLWFL_19985(rffM)
ELCi14_4309(wecG)
ELDi02_4309(wecG)
ELPP12B_c3925(wecG)
ELFLF82_1862(rffM)
ECOLLY180_19650
ECOIECOPMV1_04128(tagA)
ECOJP423_21000
EFEEFER_3709(rffM)
EALEAKF1_ch2142c
EMAC1192_16590
ESZFEM44_09710(rffM)
STYSTY3626(rffM)
STTt3368(rffM)
SEXSTBHUCCB_35520
SENTTY21A_17045
STMSTM3929(wecG)
SEOSTM14_4727(wecG)
SEVSTMMW_39041
SEYSL1344_3888(rffM)
SEMSTMDT12_C40830
SEJSTMUK_3915(wecG)
SEBSTM474_4107(wecG)
SEFUMN798_4266(rffM)
SETUSTU288_19830
SETCCFSAN001921_20785
SENRSTMDT2_38001(rffM)
SENDDT104_39471(rffM)
SENICY43_20570
SEENSE451236_01255
SPTSPA3769(rffM)
SEKSSPA3513
SPQSPAB_04874
SEISPC_4043(rffM)
SECSCH_3834(wecG)
SEHSeHA_C4258
SHBSU5_045
SENHCFSAN002069_12395
SEEHSEEH1578_05760
SEESNSL254_A4209
SENNSN31241_47930
SEWSeSA_A4140
SEASeAg_B4155
SENSQ786_19255
SEDSeD_A4317
SEGSG3514(wecG)
SELSPUL_3497(wecG)
SEGASPUCDC_3483(wecG)
SETSEN3734(wecG)
SENAAU38_19270
SENOAU37_19265
SENVAU39_19285
SENQAU40_21490
SENLIY59_19740
SENJCFSAN001992_14015
SEECCFSAN002050_02530
SEEBSEEB0189_022690
SEEPI137_16765
SENBBN855_40070
SENEIA1_19100
SENCSEET0819_03500
SESSARI_03724
SBGSBG_3472(rffM)
SBZA464_3989
SBVN643_17355
SALZEOS98_22690
SFLSF3869(wecG)
SFXS3891(wecG)
SFVSFV_3709(wecG)
SFESFxv_4215(rffM)
SFNSFy_5523
SFSSFyv_5588
SFTNCTC1_04181(tagA)
SSNSSON_3967(wecG)
SBOSBO_3806(wecG)
SBCSbBS512_E4126
SDYSDY_3953(wecG)
SDZAsd1617_05182
SHQA0259_00430
ENCECL_04992
ENLA3UG_22175
ECLGEC036_42980
ECLEECNIH2_01490
ECLNECNIH4_21935
ECLIECNIH5_01030
ECLXLI66_00870
ECLYLI62_01285
ECLZLI64_00945
ECLOENC_02090
EHMAB284_01230
EXFBFV63_00855
ECLAECNIH3_01035
ECLCECR091_01035
EAUDI57_19330
EKBBFV64_22675
ENOECENHK_21380
EECEcWSU1_04378(wecG)
ELGBH714_23075
ECANCWI88_21925
ERNBFV67_21315
ECLSLI67_023515
ECHGFY206_23635(rffM)
ESHC1N69_22190
ENTEnt638_3993
EASEntas_4276
ENRH650_16120
ENXNI40_021410
ENFAKI40_4796
LNICWR52_13450
EBGFAI37_07605(rffM)
ENDA4308_06310
ENZG0034_22290(rffM)
ENSHWQ15_09195(rffM)
ENKLOC22_11700(rffM)
EHUD5067_0000845(rffM)
EMORL6Y89_00690(rffM)
ENBELK40_21810
ESAESA_03765
CSKES15_3690(rffM)
CSZCSSP291_17425
CSJCSK29544_00723
CCONAFK62_01325
CDMAFK67_01295
CSIP262_05485
CMJAFK66_018805
CUIAFK65_00965
CMWAFK63_17325
CTUCTU_02310(wecG)
KPNKPN_04295(wecG)
KPUKP1_0157(wecG)
KPMKPHS_01420
KPPA79E_4893
KPHKPNIH24_00760
KPZKPNIH27_00775
KPVKPNIH29_00730
KPWKPNIH30_00765
KPYKPNIH31_00765
KPGKPNIH32_00770
KPCKPNIH10_00755
KPQKPR0928_00760
KPTVK055_3180
KPOKPN2242_24490
KPRKPR_0249(wecG)
KPJN559_4990
KPID364_21880
KPAKPNJ1_05298
KPSKPNJ2_05254
KPXPMK1_01782(tagA)
KPBFH42_17835
KPNEKU54_025925
KPNULI86_25805
KPNKBN49_4564(wecG)
KVAKvar_4933
KPEKPK_5384
KPKA593_11580
KVDKR75_09005
KVQSP68_15600
KOXKOX_07600
KOEA225_0163
KOYJ415_02150
KOMHR38_06185
KMIVW41_17920
KOKKONIH1_01050
KOCAB185_06170
KQUAVR78_05315
EAEEAE_07840
EARCCG32431
KQVB8P98_26810
KLLBJF97_00900
KLWDA718_28375
KARLGL98_24190(rffM)
KGRJJJ10_26695(rffM)
RORRORB6_17895
RONTE10_03075
RPLNB1209_26070
RAODSD31_24905
RTGNCTC13098_07028(tagA)
REEelectrica_04894(tagA)
CROROD_39521(rffM)
CKOCKO_00136
CFDCFNIH1_03870
CBRAA6J81_16810
CWECO701_21765
CYOCD187_23755
CPOTFOB25_11015(rffM)
CFQC2U38_25595
CSEDJY391_22075(rffM)
CAMAF384_20605
CAFAL524_03460
CIFAL515_01645
CFARCI104_24870
CIRC2U53_10185
CIEAN232_04035
CPARCUC49_19580
CTELGBC03_04825(rffM)
CITZE4Z61_16715(rffM)
CARSE1B03_01360(rffM)
EBTEBL_c37900
CNTJT31_11655
CEMLH23_06055
CENLH86_05990
CLAPNCTC11466_04433(tagA)
PGELG71_04960
ESCEntcl_4236
KLEAO703_00690
KSAC813_14550
KORAWR26_24210(rffM)
KRDA3780_25565
KCOBWI95_22845
KOTEH164_21510
KPSEIP581_00780(rffM)
KIENCTC12125_03602(tagA)
KASKATP_43460(wecG)
LAXAPT61_00895
LEIC2U54_03815
LEHC3F35_12680
LEEDVA44_22800
LERGNG29_22135(rffM)
LEAGNG26_21340(rffM)
LPNUKQ929_00195(rffM)
LAZA8A57_20790
LEFLJPFL01_4111
LEWDAI21_05265
BUFD8682_14665
BAGEBADSM9389_40020
BFTMNO13_23480(rffM)
SYMK6K13_22210(rffM)
METYMRY16398_54480(wecG)
AHNNCTC12129_04758(rffM_1)
ASUBNLZ15_21290(rffM)
YREHEC60_18725(rffM)
SGOEA8O29_021750(rffM)
KINAB182_24210
PDZHHA33_01215(rffM)
IZHFEM41_06615(rffM)
PSHISAMEA2665130_3004(tagA)
PSGCG163CM_34160(wecG)
EBFD782_4358
EBCC2U52_07170
EBUCUC76_14635
PSTSE05_20660
YPEYPO3855(rffM)
YPKy0373(wecG)
YPHYPC_0367(rffM)
YPAYPA_0163
YPNYPN_0108
YPMYP_3190(wecG)
YPPYPDSF_3473
YPGYpAngola_A0523
YPZYPZ3_3409(wecG)
YPTA1122_06535
YPDYPD4_3401(wecG)
YPXYPD8_3401(wecG)
YPWCH59_1798
YPJCH55_3155
YPVBZ15_3853
YPLCH46_1206
YPSYPTB0179(wecG)
YPOBZ17_2410
YPIYpsIP31758_0193
YPYYPK_4022
YPBYPTS_0191
YPQDJ40_2245
YPUBZ21_3530
YPRBZ20_1946
YPCBZ23_3802
YPFBZ19_3637
YENYE0180(wecG)
YEPYE105_C0183
YEYY11_33781
YELLC20_05062
YEWCH47_3305
YETCH48_1873
YEFFORC2_3918
YEEYE5303_41241(rffM)
YSIBF17_08890
YALAT01_2291
YFRAW19_3027
YINCH53_1983
YKRCH54_2761
YROCH64_2769
YRUBD65_1767
YRBUGYR_09360
YAKACZ76_10115
YMADA391_21950
YHID5F51_00955
YCAF0T03_00925(rffM)
YMOHRD69_04285(rffM)
SMARSM39_4328(rffM)
SMACSMDB11_4276(rffM)
SMWSMWW4_v1c01820(rffM)
SPESpro_0172
SRRSerAS9_0134
SRLSOD_c01280(wecG)
SRYM621_00640
SPLYQ5A_000735(wecG)
SRSSerAS12_0134
SRASerAS13_0133
SMAFD781_0140
SLQM495_00680
SERFL085_05280
SERSSERRSCBI_00760
SFWWN53_09260
SFGAV650_01725
SRZAXX16_0387
SERASer39006_003855
SERQCWC46_03855
SERMCLM71_00765
SQUE4343_15430(rffM)
SFJSAMEA4384070_0135(tagA)
SOFNCTC11214_01918(tagA)
SSURATE40_021585
SURIJ0X03_23175(rffM)
SRHZFO014_09250(rffM)
SENPKHA73_22480(rffM)
SFOZ042_12855
RAHRahaq_4253
RACEJHW33_15650(rffM)
RAQRahaq2_4366
RAAQ7S_21620
ROXBV494_17780
RVCJ9880_06775(rffM)
GQUAWC35_10735
EAMEGXP68_20340(rffM)
RBADH2866_08945(rffM)
ECAECA4200(wecG)
PATREV46_20950
PATOGZ59_42640(wecG)
PCTPC1_4000
PCCPCC21_039790
PCVBCS7_20005
PWAPecwa_4192
PPARA8F97_20520
PECW5S_4355
PWSA7983_06105
PPOABJK05_14990
PBRAB5S52_01205
PPUJE2566_20345(rffM)
PARII2D83_01265(rffM)
PAQUDMB82_0019200(rffM)
PVZOA04_42690(wecG)
PPAVLOZ86_02300(rffM)
PQUIG609_018930(rffM)
DDDDda3937_00277(rffM)
DZEDd1591_0167
DDCDd586_3890
DZCW909_18955
DSOA4U42_07590
CEDLH89_13895
DFNCVE23_20975
DDQDDI_3997
DAQDAQ1742_04236(rffM)
DICDpoa569_000264(rffM)
DDADd703_0212
BGJAWC36_20070
BRBEH207_16125
BNGEH206_01340
BIZHC231_01325(rffM)
LBQCKQ53_04150
LPOPI6N93_00955(rffM)
SGLSG2374
SODSant_0300(rffM)
PESSOPEG_0373(rffM)
SLIGGTU79_01555(rffM)
EAMEAMY_0182(wecG)
EAYEAM_0175(wecG)
ETAETA_02080(wecG)
EPYEpC_01960(wecG)
EPREPYR_00205(wecG)
EBIEbC_02050(wecG)
ERJEJP617_13940(wecG)
EGEEM595_3325(wecG)
EPECI789_17705
ERWIGN242_20150(rffM)
ETPLU633_24935(rffM)
ERPLJN55_22125(rffM)
PAMPANA_0158(wecG)
PLFPANA5342_4269(wecG)
PAJPAJ_3318(wecG)
PAQPAGR_g4120
PVAPvag_3393(wecG)
PAGGAL522_05100
PAOPat9b_0151
KLNLH22_01505
PANTPSNIH1_06325
PANPPSNIH2_16570
PAGCBEE12_07485
PSTWDSJ_22155
PALHB1H58_08570
PANSFCN45_00780(rffM)
PEYEE896_18345(rffM)
PDISD8B20_00635
PERLAC65_00430(rffM)
PGZC2E15_20315
PCDC2E16_19735
MINTC7M51_03207(wecG)
MTHIC7M52_03792(wecG)
TCIA7K98_18780
TPTYNCTC11468_03531(tagA)
PLUplu4651(wecG)
PLUMA4R40_23070
PAYPAU_04131(wecG)
PTTVY86_06545
PAKHB0X70_23510
PLUICE143_23550
PMRPMI3327(rffM)
PMIBBB2000_3359(rffM)
PVLAOB99_01055
PVGCRN77_03020
PHAUPH4a_08085
PROTBTA34_17860
PCOLF1325_01015(rffM)
PCIBF9282_01015(rffM)
PPEEI6G31_08360(rffM)
XBOXBJ1_4167(rffM)
XBVXBW1_4522(wecG)
XNEXNC1_0396(rffM)
XNMXNC2_0388(rffM)
XDOXDD1_0357(wecG)
XPOXPG1_3473(wecG)
XHOA9255_14175
XBUHGO23_18220(rffM)
PSIS70_11695
PSXDR96_841
PSTABGK56_14625
PRGRB151_042090(wecG)
PALACO695_05770
PHEINCTC12003_03728(tagA)
PRQCYG50_17690(rffM)
PRJNCTC6933_03742(tagA)
PVCG3341_18310(rffM)
PMAGJI723_18675(rffM)
MMKMU9_244
ANSArsFIN_02240(wecG)
AEDE3U36_04200(rffM)
AETLDL57_00995(rffM)
MWIMNY66_14780(rffM)
EICNT01EI_0101
ETRETAE_0112(wecG)
ETDETAF_0085
ETEETEE_1873
ETCETAC_00420
EDWQY76_02295
EDLAAZ33_00430(rffM)
EHOA9798_16270
HAVAT03_01750
HPARAL518_03855
OPODSM2777_02250
LPVHYN51_09695
PFQQQ39_17680
PRAGEKN56_00975
LRINCTC12151_03582(tagA)
HDUHD_1833(wecG)
HAPHAPS_1059(wecG)
HPAZK756_01480
HPASJL26_00605
HPAKJT17_09615
GLECJD39_10790
MHTD648_23610
MHQD650_2570
MHATB824_3630
MHXMHH_c03420(wecG)
MHAEF382_09245
MHAMJ450_05970
MHAOJ451_06990
MHALN220_12970
MHAQWC39_01290
MHAYVK67_01295
MVRX781_2210
MVIX808_19360
MVGX874_18140
MVEX875_1830
MGRAA4G16_10700
MBOSICJ55_03510(rffM)
APLAPL_1543(wecG)
APJAPJL_1571(wecG)
APAAPP7_1605(wecG)
ASIASU2_09915
ASSASU1_09960
AEUACEE_09180
AIOEXH44_07115(rffM)
ALIGNCTC10568_01896(wecG)
BTOWQG_3560
BTREF542_18400
BTRHF543_20280
BTRAF544_3970
OOIA6A10_01440
FCLA4G17_03560
PGBH744_2c2841
SSESsed_2965
SALGBS332_14655
SAESHBH39_11930
COMCMT41_10605
PIAPI2015_0483
FESHER31_10745
HALCEY643_02535
RHHE0Z06_09455
KKOKkor_0932
KSDKS2013_1446
KPDCW740_04290
BCIBIM45_421
CHACHAB381_1474
APAIAPAC_0714
DOVDSCO28_33280(wecG)
RBSRHODOSMS8_03375(wecG)
HDTHYPDE_29638
BLASBSY18_3070
GPOGPOL_c11150
BEGINE88_00326(wecG)
BSTEK6V31_12800
BVUBVU_0687 BVU_1547
PGIPG_0119
PGNPGN_0233
PGTPGTDC60_0396
PCAGNCTC12856_02055(tagA)
PSACPSM36_0191
PDIBDI_0042
PARCCI960_03310
PMERINE87_01599(wecG)
PGOLK6V26_13165
PJOLK449_10440
BUYD8S85_03805 D8S85_16550
AGDFRZ59_07205
FLLEI427_04645
MARTBTR34_12055
CLYCelly_1361
SPONHME9304_01554(wecG)
WIJBWZ20_06275
SHYRLA303_00370
 » show all
Reference
1  [PMID:3275612]
  Authors
Barr K, Ward S, Meier-Dieter U, Mayer H, Rick PD
  Title
Characterization of an Escherichia coli rff mutant defective in transfer of N-acetylmannosaminuronic acid (ManNAcA) from UDP-ManNAcA to a lipid-linked intermediate involved in enterobacterial common antigen synthesis.
  Journal
J Bacteriol 170:228-33 (1988)
DOI:10.1128/JB.170.1.228-233.1988
  Sequence
[eco:b3794]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.180
IUBMB Enzyme Nomenclature: 2.4.1.180
ExPASy - ENZYME nomenclature database: 2.4.1.180
BRENDA, the Enzyme Database: 2.4.1.180
CAS: 113478-30-1

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