Entry
Name
lipid-A-disaccharide synthase;
lpxB (gene name);
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine 1-phosphate 2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosaminyltransferase
Reaction(IUBMB)
a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + a lipid X = UDP + a lipid A disaccharide [RN:
R04606 ]
Reaction(KEGG)
Substrate
UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine [CPD:
C22410 ];
lipid X [CPD:
C04824 ]
Product
Comment
Involved with EC
2.3.1.129 (acyl-[acyl-carrier-protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC
2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Gram-negative bacteria.
History
EC 2.4.1.182 created 1990, modified 2021
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K00748 lipid-A-disaccharide synthase
Genes
CSAT : 104747133 104766495 104790553
PSAT : 127076520 127138141 127138142
LJA : Lj3g3v0730090.2(Lj3g3v0730090.2) Lj3g3v0730090.3(Lj3g3v0730090.3)
NTA : 107764969 107789052 107795892
SSPL : 121797214 121798863
DOSA : Os01t0752600-01(Os01g0752600)
TAES : 123062074 123070798 123079189
PVIR : 120674397 120708062
SMO : SELMODRAFT_405438(GT19A1)
ECOO : ECRM13514_0190(lpxB)
ECOH : ECRM13516_0192(lpxB)
ELR : ECO55CA74_00890(lpxB)
ECW : EcE24377A_0186(lpxB)
ECOA : APECO78_04340(lpxB)
EDJ : ECDH1ME8569_0175(lpxB)
ECOI : ECOPMV1_00188(lpxB)
SEM : STMDT12_C02300(lpxB)
SETC : CFSAN001921_16260(lpxB)
SEEN : SE451236_07165(lpxB)
SENH : CFSAN002069_08000(lpxB)
SEEH : SEEH1578_10265(lpxB)
SENJ : CFSAN001992_09830(lpxB)
SEEC : CFSAN002050_07685(lpxB)
SEEB : SEEB0189_018160(lpxB)
SENC : SEET0819_08075(lpxB)
RTG : NCTC13098_06066(lpxB_1)
REE : electrica_04151(lpxB)
CLAP : NCTC11466_03745(lpxB)
KIE : NCTC12125_02842(lpxB)
METY : MRY16398_46170(lpxB)
AHN : NCTC12129_00978(lpxB)
PTF : PROFFT_A_03640(lpxB)
PSHI : SAMEA2665130_2477(lpxB)
YPG : YpAngola_A3422(lpxB)
YPI : YpsIP31758_1026(lpxB)
SMW : SMWW4_v1c38960(lpxB)
SERS : SERRSCBI_18860(lpxB)
SFJ : SAMEA4384070_3891(lpxB)
SOF : NCTC11214_02866(lpxB_2)
PAQU : DMB82_0015675(lpxB)
DIC : Dpoa569_002781(lpxB)
EHD : ERCIPSTX3056_197(lpxB)
TPTY : NCTC11468_03014(lpxB)
PHEI : NCTC12003_03043(lpxB)
PRJ : NCTC6933_03143(lpxB)
LRI : NCTC12151_00728(lpxB)
HIC : NTHIC486_01732(lpxB)
HPIT : NCTC13334_00943(lpxB)
HHZ : NCTC10839_00206(lpxB)
HAEG : NCTC8502_01195(lpxB)
PDAG : 4362423_01391(lpxB)
ADP : NCTC12871_01517(lpxB)
ALIG : NCTC10568_00008(lpxB_1)
ASEG : NCTC10977_00780(lpxB)
AVT : NCTC3438_00890(lpxB)
RPNE : NCTC8284_03741(lpxB)
PAET : NCTC13378_00347(lpxB)
XFU : XFF4834R_chr30890(lpxB)
XPH : XppCFBP6546_04365(lpxB)
XHD : LMG31886_29040(lpxB)
LLZ : LYB30171_01750(lpxB)
VAU : VANGNB10_cI2034c(lpxB)
VPL : SA104470976_00565(lpxB)
PAEB : NCGM1900_2633(lpxB)
PPUD : DW66_1149 DW66_1483
PVD : CFBP1590__4033(lpxB)
PPRC : PFLCHA0_c12090(lpxB)
PFW : PF1751_v1c12300(lpxB)
PPUU : PputUW4_01101(lpxB)
PTRT : HU722_0007475(lpxB)
PTW : TUM18999_46140(lpxB)
PTAE : NCTC10697_03444(lpxB)
PSYC : DABAL43B_1230(lpxB)
MCAT : MC25239_01137(lpxB)
MCUN : NCTC10297_01600(lpxB)
SCAA : TUM17387_27380(lpxB)
PLZ : S4054249_06680(lpxB)
SALH : HMF8227_02141(lpxB)
CBS : COXBURSA331_A0735(lpxB)
CEY : CleRT_04280(lpxB) CleRT_05720(lpxB)
LPN : lpg1371(lpxB) lpg2945(lpxB)
LPH : LPV_1484(lpxB) LPV_3324(lpxB)
LPO : LPO_1360(lpxB) LPO_3270(lpxB)
LPU : LPE509_00065 LPE509_01832
LPM : LP6_1352(lpxB) LP6_2980(lpxB)
LPF : lpl1322(lpxB) lpl2872(lpxB)
LPP : lpp1325(lpxB) lpp3014(lpxB)
LPC : LPC_0787(lpxB) LPC_3256(lpxB)
LPA : lpa_02021(lpxB) lpa_04311(lpxB)
LFA : LFA_1296(lpxB) LFA_3717(lpxB)
LHA : LHA_1809(lpxB) LHA_3167(lpxB)
LLG : 44548918_01133(lpxB)
LJR : NCTC11533_01295(lpxB)
LCJ : NCTC11976_00912(lpxB_1) NCTC11976_02469(lpxB_2)
LWA : SAMEA4504053_1544(lpxB)
LSS : NCTC12082_00500(lpxB)
LADL : NCTC12735_00898(lpxB)
LANT : TUM19329_16770(lpxB1) TUM19329_29600(lpxB2)
MISZ : MishRS11D_18850(lpxB)
TIB : THMIRHAM_12160(lpxB)
TSE : THMIRHAS_12770(lpxB)
TZO : THMIRHAT_13900(lpxB)
TNI : TVNIR_1897(lpxB_[H])
GAI : IMCC3135_25465(lpxB)
THIC : TspCOW1_05870(lpxB)
HSR : HSBAA_07520 HSBAA_07530
HAXI : HAALTHF_01280n HAALTHF_01290n
AEL : NCTC12917_03198(lpxB)
CHJ : NCTC10426_02247(lpxB)
CDIZ : CEDIAZO_01208(lpxB)
NMM : NMBM01240149_1886(lpxB)
NMS : NMBM01240355_0203(lpxB)
NMQ : NMBM04240196_0206(lpxB)
NMZ : NMBNZ0533_0203(lpxB)
NMX : NMA510612_0085(lpxB)
NWE : SAMEA3174300_1391(lpxB)
NZO : SAMEA4504057_0484(lpxB)
NCI : NCTC10296_00142(lpxB)
NCZ : NCTC10294_01717(lpxB)
NANI : NCTC12227_02052(lpxB)
ECOR : SAMEA4412678_0938(lpxB)
BMV : BMASAVP1_A2042(lpxB)
BML : BMA10229_A3269(lpxB)
BPM : BURPS1710b_2569(lpxB)
BPL : BURPS1106A_2479(lpxB)
BUE : BRPE67_ACDS11070(lpxB)
PLG : NCTC10937_01480(lpxB)
LMIR : NCTC12852_01667(lpxB)
BUO : BRPE64_ACDS12020(lpxB)
VTR : MYVALT_F_03060(lpxB)
BTRM : SAMEA390648703405(lpxB)
AXX : ERS451415_02493(lpxB)
LIM : L103DPR2_02045(lpxB)
LIH : L63ED372_01546(lpxB)
URU : DSM104443_01043(lpxB)
UPL : DSM104440_00952(lpxB)
FPHO : SHINM1_011200(lpxB)
RTT : RTTH1527_01515(lpxB)
RTB : RTB9991CWPP_01525(lpxB)
RBS : RHODOSMS8_00892(lpxB)
SMEL : SM2011_c02089(lpxB)
SFD : USDA257_c35470(lpxB)
SAME : SAMCFNEI73_Ch1638(lpxB)
AGR : AGROH133_05896(lpxB)
AVV : RvVAT039_00160(lpxB)
AVF : RvVAR031_21400(lpxB)
REC : RHECIAT_CH0002022(lpxB)
REL : REMIM1_CH01983(lpxB)
REP : IE4803_CH01981(lpxB)
REI : IE4771_CH02056(lpxB)
RTR : RTCIAT899_CH08550(lpxB)
RGA : RGR602_CH01817(lpxB)
RPHA : AMC79_CH02105(lpxB)
RLW : RlegWSM1455_08940(lpxB)
NGL : RG1141_CH15450(lpxB)
NEN : NCHU2750_20050(lpxB)
LAS : CLIBASIA_03290(lpxB)
BIO : BR141012304_11538(lpxB)
BSEP : HAP48_0040385(lpxB)
BCAN : BcanWSM471_21615(lpxB)
VGO : GJW-30_1_02820(lpxB)
BHS : BM1374165_00621(lpxB)
BBK : BARBAKC583_0594(lpxB)
BTX : BM1374166_00861(lpxB)
BEZ : NCTC12898_00799(lpxB)
MAQU : Maq22A_c20400(lpxB)
MMES : MMSR116_12455(lpxB)
FIL : BN1229_v1_2968(lpxB)
FIY : BN1229_v1_2949(lpxB)
BVY : NCTC9239_01868(lpxB)
TSV : DSM104635_02043(lpxB)
RLI : RLO149_c019600(lpxB)
PHP : PhaeoP97_01429(lpxB)
PPIC : PhaeoP14_01336(lpxB)
SINL : DSM14862_01347(lpxB)
SPSE : SULPSESMR1_01700(lpxB)
AHT : ANTHELSMS3_03604(lpxB)
LVS : LOKVESSMR4R_01410(lpxB)
AALK : LGT41_0013005(lpxB)
HPO : HMPREF4655_20729(lpxB)
HPX : HMPREF0462_0541(lpxB)
HCL : NCTC13205_00432(lpxB)
HSH : NHP194022_01960(lpxB)
HPUL : NCTC13154_00351(lpxB)
CJV : MTVDSCj20_0263(lpxB)
CFV : CFVI03293_0325(lpxB)
CAMP : CFT03427_0333(lpxB)
CCOC : CCON33237_1449(lpxB)
CLR : UPTC16701_1340(lpxB)
CLM : UPTC16712_1365(lpxB)
CAMR : CAQ16704_1379(lpxB)
CHV : CHELV3228_1399(lpxB)
CPIN : CPIN18020_1488(lpxB)
CAMZ : CVIC12175_0261(lpxB)
GBN : GEOBRER4_32870(lpxB)
DDN : DND132_1258 DND132_3280
PPOR : JCM14722_27180(lpxB)
VRM : 44547418_00559(lpxB)
VDN : NCTC11831_01403(lpxB)
DHO : Dia5BBH33_02560(lpxB)
MANA : MAMMFC1_02253(lpxB)
PFAC : PFJ30894_00849(lpxB)
SYR : SynRCC307_1815(lpxB)
SYX : SynWH7803_1955(lpxB)
SYP : SYNPCC7002_A0068(lpxB)
SYH : Syncc8109_2204(lpxB)
SYNW : SynWH8103_00642(lpxB)
CYI : CBM981_2016(lpxB) CBM981_2776(lpxB)
CMP : Cha6605_3562 Cha6605_3563
LET : O77CONTIG1_00243(lpxB)
CHON : NIES4102_19420(lpxB2)
CYT : cce_1829(lpxB2) cce_1830(lpxB1)
PAGH : NIES204_30470(lpxB)
CALN : NIES2098_20860(lpxB)
NSPH : BDGGKGIB_02607(lpxB_1)
STAN : STA3757_02940(lpxB)
CTLF : CTLFINAL_03485(lpxB)
CTLI : CTLINITIAL_03475(lpxB)
CTJT : CTJTET1_02150(lpxB)
CTFS : CTRC342_02170(lpxB)
CTHF : CTRC852_02185(lpxB)
CTCJ : CTRC943_02130(lpxB)
CTHJ : CTRC953_02130(lpxB)
CTMJ : CTRC966_02145(lpxB)
CTTJ : CTRC971_02135(lpxB)
CTJS : CTRC122_02165(lpxB)
OBG : Verru16b_00063(lpxB)
ABIW : Abiwalacus_24480(lpxB)
LAMB : KBB96_01360(lpxB) KBB96_18980(lpxB)
TRS : Terro_2311 Terro_2675
BTHO : Btheta7330_04252(lpxB)
BCEL : BcellWH2_03933(lpxB)
BFC : BacF7301_09865(lpxB)
PCRE : NCTC12858_01592(lpxB)
PCAG : NCTC12856_00264(lpxB)
PMZ : HMPREF0659_A6071(lpxB)
PDN : HMPREF9137_1750(lpxB)
POC : NCTC13071_00158(lpxB)
ACOU : A5CBH24_13400(lpxB)
ADA : A5CPEGH6_13750(lpxB)
SMIZ : 4412673_02071(lpxB)
SDJ : NCTC13534_02971(lpxB)
STHA : NCTC11429_05079(lpxB)
PSEZ : HME7025_01346(lpxB)
SPON : HME9304_00997(lpxB)
AALG : AREALGSMS7_00738(lpxB)
KOS : KORDIASMS9_00473(lpxB)
KAN : IMCC3317_23750(lpxB)
CGLE : NCTC11432_02794(lpxB)
CTAI : NCTC12078_02842(lpxB)
CTAK : 4412677_01275(lpxB_1) 4412677_02207(lpxB_2)
CHRJ : CHRYMOREF3P_2370(lpxB)
CJG : NCTC13459_01581(lpxB)
CANT : NCTC13489_02579(lpxB)
PTAN : CRYO30217_02338(lpxB)
PROC : Ptc2401_00432(lpxB)
ALAM : RT761_00351(lpxB_2)
» show all
Taxonomy
Reference
Authors
Ray BL, Painter G, Raetz CR.
Title
The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli.
Journal
J Biol Chem 259:4852-9 (1984)
Reference
Authors
Crowell DN, Reznikoff WS, Raetz CR.
Title
Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase.
Journal
Sequence
Reference
Authors
Metzger LE 4th, Raetz CR.
Title
Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein.
Journal
Reference
Authors
Bohl TE, Shi K, Lee JK, Aihara H.
Title
Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.182