Entry
Name
phosphatidylinositol N-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase;
uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase (configuration-retaining)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [RN:
R02654 R05916 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
1-phosphatidyl-1D-myo-inositol [CPD:
C01194 ]
Product
UDP [CPD:
C00015 ];
6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol [CPD:
C01288 ]
Comment
Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.
History
EC 2.4.1.198 created 1992, modified 2002
Pathway
ec00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Orthology
K03857 phosphatidylinositol N-acetylglucosaminyltransferase subunit A
Genes
HMH : 116478056 116811529(PIGA)
CIMI : 108291893(PIGA) 108317974
MCAL : 110286445(Piga) 110307754
CGE : 100773712(Piga) 103164275
MAUA : 101835839 101839386(Piga)
PROB : 127218189(Piga) 127231625
PLEU : 114691192 114705718(Piga)
MORG : 121438256 121439399(Piga)
MFOT : 126510032 126512721
AAMP : 119805331(Piga) 119810784
NGI : 103740293(Piga) 103748332
PKL : 118719116 118719853(PIGA)
SANH : 107655498 107663925
CCAR : 109083992 109102471
CAUA : 113053179 113108689 113108728
CGIB : 127965548 128019891
SASA : 106582142 106586684
STRU : 115156316 115161209(piga)
OTW : 112225407 112241735(piga)
OMY : 110502009 110520488(piga)
OGO : 124044152(piga) 124045361
SALP : 111959891 111979350
SNH : 120057976(piga) 120064181
CCLU : 121536503(piga) 121571619
PSPA : 121320621 121327612
ARUT : 117406946 117973041
DSI : Dsimw501_GD25445(Dsim_GD25445)
RZE : 108356065 108373675 108378741
CGIG : 122401711 122404234
PPYR : 116172766 116172767
SGRE : 126295336 126314407
DPTE : 113791909 113794469
CEL : CELE_D2085.6(piga-1)
BMY : BM_BM3057(Bma-piga-1)
DPOL : 127831716 127840032
CSAT : 104772990 104780360 104790763
BNA : 106370718 106372585 106433521
GMX : 100775466 100796055 102660604
PVU : PHAVU_002G226400g PHAVU_005G132400g
CCAJ : 109810496 109811631
APRC : 113853815 113859890
PSAT : 127087075 127100415
LJA : Lj3g3v1101750.1(Lj3g3v1101750.1) Lj3g3v1101750.2(Lj3g3v1101750.2)
ADU : 107458810 107467947 107467967 107470539 107491675
AIP : 107606035 107613317 107634639
AHF : 112703049 112712659 112717762 112733460 112765621 112772688 112791443
LANG : 109340239 109358503
PMUM : 103321375 103329217
PAVI : 110759000 110765051
QSU : 111984257 111985546 112035648
SIND : 105155752 105155762
SSPL : 121767298 121770559
PSOM : 113288136 113302437
DOSA : Os07t0270950-01(Os07g0270950)
TAES : 123071155 123102953 123111111 123120101
LPER : 127332561 127344625
PVIR : 120659809 120660658 120667977 120695643
PHAI : 112879674 112880068
SMO : SELMODRAFT_406541(PigA)
NCS : NCAS_0C01170(NCAS0C01170)
NDI : NDAI_0K01180(NDAI0K01180) NDAI_0K01440(NDAI0K01440)
TPF : TPHA_0D01420(TPHA0D01420)
TBL : TBLA_0D01250(TBLA0D01250)
TDL : TDEL_0A06480(TDEL0A06480)
KAF : KAFR_0B03120(KAFR0B03120)
KNG : KNAG_0J01900(KNAG0J01900)
CAL : CAALFM_CR04040CA(SPT14)
NTE : NEUTE1DRAFT146852(NEUTE1DRAFT_146852)
ANG : ANI_1_2946014(An01g09910)
ABP : AGABI1DRAFT78057(AGABI1DRAFT_78057)
ABV : AGABI2DRAFT208693(AGABI2DRAFT_208693)
SCM : SCHCO_02637671(SCHCODRAFT_02637671)
MSYM : MSY001_2597(SPT14) MSY001_2598
MLR : MELLADRAFT_32231 MELLADRAFT_32491
EHI : EHI_105870(9.t00084)
PTM : GSPATT00001670001 GSPATT00014161001 GSPATT00028092001
FCY : FRACYDRAFT_185201(PIGA1)
PSOJ : PHYSODRAFT_255961 PHYSODRAFT_256568 PHYSODRAFT_258052 PHYSODRAFT_262753 PHYSODRAFT_263738 PHYSODRAFT_515380
» show all
Taxonomy
Reference
Authors
Doering TL, Masterson WJ, Englund PT, Hart GW.
Title
Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine.
Journal
J Biol Chem 264:11168-73 (1989)
Reference
Authors
Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T.
Title
The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.
Journal
Reference
Authors
Watanabe R, Murakami Y, Marmor MD, Inoue N, Maeda Y, Hino J, Kangawa K, Julius M, Kinoshita T
Title
Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.198