KEGG   ENZYME: 2.4.1.201
Entry
EC 2.4.1.201                Enzyme                                 
Name
alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase;
MGAT4C (gene name);
N-acetylglucosaminyltransferase VI;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI;
uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI;
mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase;
GnTVI;
GlcNAc-T VI;
UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->2)]-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] [RN:R05992]
Reaction(KEGG)
R05992(G);
(other) R04642
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Product
UDP [CPD:C00015];
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Comment
Requires a high concentration of Mn2+ for maximal activity. The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus. It transfers GlcNAc in beta1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by beta linkages. No homologous enzyme appears to exist in mammals.
History
EC 2.4.1.201 created 1992, modified 2001, modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K13748  alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase C
Genes
HSA25834(MGAT4C)
PTR467085(MGAT4C)
PPS100992134(MGAT4C)
GGO101151757(MGAT4C)
PON100455323(MGAT4C)
NLE100584226(MGAT4C)
MCC700450(MGAT4C) 705617
MCF101866242(MGAT4C) 102131925
MTHB126931328 126939017
CSAB103230293 103238817(MGAT4C)
CATY105581112(MGAT4C)
PANU101006452(MGAT4C) 103878644
TGE112634753(MGAT4C)
RRO104655963(MGAT4C)
RBB108535046(MGAT4C) 108545046
TFN117074698 117089664(MGAT4C)
PTEH111522678 111537602(MGAT4C)
CJC100413583(MGAT4C)
SBQ101043109(MGAT4C)
CSYR103257393(MGAT4C)
MMUR105860669(MGAT4C)
LCAT123627103 123639471(MGAT4C)
OGA100951828(MGAT4C)
MMU67569(Mgat4c)
MCAL110303902(Mgat4c)
MPAH110326810(Mgat4c)
RNO299756(Mgat4c)
MCOC116075661(Mgat4c)
MUN110566104(Mgat4c)
CGE100760589(Mgat4c)
MAUA101839717(Mgat4c)
PLEU114702912(Mgat4c)
MORG121462823(Mgat4c)
MFOT126497500
AAMP119803698(Mgat4c)
NGI103726602(Mgat4c)
HGL101708499 101725010(Mgat4c)
CPOC100726416(Mgat4c)
CCAN109700961(Mgat4c)
DORD105986819(Mgat4c)
DSP122119207(Mgat4c)
NCAR124983496
OCU100339976(MGAT4C) 100340174
OPI101532607(MGAT4C)
TUP102467784(MGAT4C)
CFA100682872 475418(MGAT4C)
CLUD112654324(MGAT4C) 112667035
VVP112914890(MGAT4C) 112934545
VLG121481334(MGAT4C)
AML100465193(MGAT4C)
UMR103660061(MGAT4C)
UAH113256203(MGAT4C)
UAR123780946(MGAT4C)
ELK111142256 111150946
LLV125107947
MPUF101692691(MGAT4C)
ORO101369336(MGAT4C)
EJU114211065(MGAT4C)
ZCA113923149(MGAT4C)
MLX117998923(MGAT4C)
NSU110577992 123324832(MGAT4C)
FCA109501701(MGAT4C)
PYU121040665(MGAT4C)
PBG122472359(MGAT4C)
LRUF124500980
PTG102971513(MGAT4C)
PPAD109258125(MGAT4C)
AJU106976669(MGAT4C)
HHV120243391(MGAT4C)
BTA539661(MGAT4C)
BOM102269061(MGAT4C)
BIU109558955(MGAT4C)
BBUB102410250(MGAT4C)
CHX102169257(MGAT4C) 102172500
OAS101108733(MGAT4C)
ODA120855467 120858418(MGAT4C)
CCAD122427462(MGAT4C)
SSC414851(MGAT4C)
CFR102503714(MGAT4C)
CBAI105072000(MGAT4C)
CDK105084877(MGAT4C)
VPC102544620(MGAT4C)
BACU103004161(MGAT4C)
LVE103080459(MGAT4C)
OOR101281932(MGAT4C)
DLE111163584(MGAT4C)
PCAD102984869(MGAT4C)
PSIU116760966(MGAT4C)
ECB100051064(MGAT4C) 100065011
EPZ103555117 103558210(MGAT4C)
EAI106838333(MGAT4C) 106840148
MYB102240623 102253362(MGAT4C)
MYD102757109 102769462(MGAT4C)
MMYO118651197(MGAT4C)
MLF102439378(MGAT4C)
MNA107526839(MGAT4C) 107536007
PKL118729987(MGAT4C)
HAI109387992(MGAT4C)
DRO112304367(MGAT4C) 112318900
SHON118974878(MGAT4C) 119003929
AJM119059021(MGAT4C) 119060798
PDIC114514085(MGAT4C)
PHAS123813526(MGAT4C)
MMF118624483(MGAT4C)
RFQ117028036(MGAT4C)
PALE102882602(MGAT4C)
PGIG120607266(MGAT4C)
PVP105293222(MGAT4C)
RAY107508696(MGAT4C)
MJV108404809(MGAT4C)
TOD119248274(MGAT4C)
SARA101538424(MGAT4C)
LAV100654846(MGAT4C) 104845928
TMU101341397 101345845
DNM101433730(MGAT4C)
MDO100015496 100020942(MGAT4C) 103102801
GAS123247432 123250138(MGAT4C)
SHR100932381(MGAT4C) 105750316
PCW110213170(MGAT4C) 110219622
OAA100081053(MGAT4C) 100091422
GGA395415(MGAT4C) 427873(MGAT4C)
PCOC116226659(MGAT4C) 116238699
MGP100541955(MGAT4C) 100550363
CJO107311189(MGAT4C) 107324722
NMEL110388150 110397617(MGAT4C)
APLA101791726(MGAT4C) 101799353
ACYG106041520(MGAT4C) 106045877
AFUL116498846 116502268(MGAT4C)
TGU100228531(MGAT4C)
LSR110469164 110469371(MGAT4C)
SCAN103813418(MGAT4C) 103822368
PMOA120497272 120499839(MGAT4C)
OTC121338661(MGAT4C) 121345499
PRUF121357264(MGAT4C) 121365391
GFR102034112(MGAT4C) 102043367
FAB101809036(MGAT4C) 101815032
PHI102103698 102110314(MGAT4C)
PMAJ107205204(MGAT4C) 107214888
CCAE111933425(MGAT4C) 111939621
CCW104692465 104698425(MGAT4C)
CBRC103616484 103622221(MGAT4C)
ETL114064493(MGAT4C) 114068544
ZAB102060851(MGAT4C) 102065237
ACHL103800029 103803128(MGAT4C)
FPG101914300(MGAT4C) 101916943
FCH102045721(MGAT4C) 102049618
CLV102088784(MGAT4C) 102089679
EGZ104121996 104132945(MGAT4C)
NNI104011085 104022863(MGAT4C)
PLET104620368 104626072(MGAT4C)
PCRI104029440 104038220(MGAT4C)
ACUN113488971 113491133(MGAT4C)
TALA104358634(MGAT4C) 104368412
PADL103916497 103918099(MGAT4C)
AFOR103901055 103904111(MGAT4C)
ACHC115334914 115336341(MGAT4C)
HALD104319221(MGAT4C) 104322250
CCRI104159024 104168708(MGAT4C)
CSTI104553832(MGAT4C) 104558892
EHS104510491(MGAT4C) 104515806
CMAC104482953 104483079(MGAT4C)
MUI104541795 104545966(MGAT4C)
FGA104072594 104078423(MGAT4C)
GSTE104256197 104258709(MGAT4C)
LDI104347639 104350418(MGAT4C)
MNB103779020 103780585(MGAT4C)
OHA104337055 104339130(MGAT4C)
NNT104407922 104408059(MGAT4C)
DPUB104305179
PGUU104467001 104467598(MGAT4C)
ACAR104522314 104527197(MGAT4C)
AVIT104271804(MGAT4C) 104277772
CVF104283161 104284338(MGAT4C)
AAM106485644 106488510(MGAT4C)
AROW112965031(MGAT4C) 112965061
NPD112956234(MGAT4C) 112959176
TGT104568398(MGAT4C) 104572580
DNE112981455(MGAT4C) 112983858
SCAM104139253 104143849(MGAT4C)
ASN102374657(MGAT4C) 102376706 102378177
AMJ102560247 102563452 102575494(MGAT4C)
CPOO109315437(MGAT4C) 109317586 109320931
GGN109295775(MGAT4C) 109299068
PSS102446260(MGAT4C) 102460254 102462087
CMY102934016 102938060 102941733(MGAT4C)
CPIC101936161 101937266 101947319(MGAT4C)
TST117869141(MGAT4C) 117876834
CABI116831643 116837314 116838998(MGAT4C)
MRV120395885(MGAT4C) 120404645 120405061
ACS100556708 100561638(mgat4c) 100562892
PVT110070064(MGAT4C) 110073381 110080923
SUND121919615 121927656 121930305(MGAT4C)
PBI103052083(MGAT4C) 103056592 103067082
PMUR107289197(MGAT4C) 107289270 107291092
CTIG120297010 120306691 120318027(MGAT4C)
TSR106543329 106545375 106548707(MGAT4C)
PGUT117655823(MGAT4C) 117663738 117665346
VKO123021414 123031944 123036175(MGAT4C)
PMUA114599446 114605745(MGAT4C)
ZVI118087646 118089492 118091132(MGAT4C)
GJA107107839 107111720 107123105(MGAT4C)
STOW125432431 125434718(MGAT4C)
XLA108710250(mgat4c.L) 108713740(mgat4g.L) 108715280(mgat4g.S)
XTR100486336(mgat4c) 100489718
NPR108785666 108792416(MGAT4C)
RTEM120916984 120932064(MGAT4C)
BBUF120980409 120983210(MGAT4C)
BGAR122920881 122925844(MGAT4C)
DRE100333333(mgat4c) 492796(zgc:101663)
SRX107709235 107730506(mgat4c) 107740326 107746337
SANH107672194 107673483 107686247(mgat4c) 107697032
SGH107553950 107554219 107566074 107583810
CCAR109076300 109099101 109100200 109109693
CAUA113041006 113061513 113094049 113118293
PPRM120473933(zgc:101663) 120493289(mgat4c)
MAMB125254447(mgat4c) 125260201(zgc:101663)
IPU108263961 108275769(zgc:101663) 124627963
PHYP113534472(mgat4c) 113545614
SMEO124395386(mgat4c) 124399071(zgc:101663)
TFD113650708(zgc:101663) 113652306(mgat4c)
AMEX103027198(mgat4c) 103036431
EEE113587801 113592123(mgat4c)
TRU101064767 101066579(mgat4c) 105418847
TNGGSTEN00012385G001 GSTEN00025653G001 GSTEN00025676G001
LCO104922610(mgat4c) 104925119 104933748
NCC104945386 104948068
CGOB115009692 115010151(mgat4c) 115010597
ELY117258290(zgc:101663) 117262063 117262816(mgat4c)
EFO125886748(mgat4c) 125887690 125892001
PLEP121946530(zgc:101663) 121950129 121950657(mgat4c)
SLUC116046844(mgat4c) 116046857 116058000
ECRA117947186(zgc:101663) 117949041(mgat4c)
ESP116693217 116693629 116694239(mgat4c)
PFLV114558668 114560033 114560790(mgat4c)
GAT120809353 120809461(mgat4c) 120828980
PPUG119196245(mgat4c) 119196346 119223297
MSAM119894451(mgat4c) 119905770
CUD121515449(mgat4c) 121515710 121516959
ALAT119022130(zgc:101663) 119024189 119025165
MZE101472188 101483483 106675125(mgat4c)
ONL100693195 100694611 100704471
OAU116314008 116314030 116322804(zgc:101663)
OLA101156719(mgat4c) 101173858 101175155
OML112152399 112152418 112159708(zgc:101663)
XMA102218707 102222649(mgat4c) 102226325
XCO114146072 114150652 114162050(mgat4c)
XHE116708141(mgat4c) 116724208 116737181
PRET103465731 103465750(mgat4c) 103466943
PFOR103147598(mgat4c) 103147605 103150232
PLAI106946939(mgat4c) 106952455 106955720
PMEI106920731 106930831(mgat4c) 106932588
GAF122831579 122835165(mgat4c) 122835691
CVG107093796 107099730(mgat4c) 107100989
CTUL119775468 119798056(mgat4c) 119799214
GMU124858877(mgat4c) 124876318 124879350
NFU107388342(mgat4c) 107391540 107395515
KMR108244220 108244231(mgat4c) 108249187(zgc:101663)
ALIM106523019 106526858(mgat4c) 106529854
NWH119415392 119415443(mgat4c) 119417207(zgc:101663)
AOCE111571046(mgat4c) 111576346 111582021
MCEP125008130(zgc:101663) 125014350 125015384(mgat4c)
CSEM103380004 103384716 103398884(mgat4c)
POV109623979 109624028(mgat4c) 109630602
SSEN122775946 122776438(mgat4c) 122776933
HHIP117762789 117763482(mgat4c) 117765390
HSP118109043(mgat4c) 118109797 118110945(zgc:101663)
LCF108880860(mgat4c) 108880875 108899620
SDU111222525(mgat4c) 111229827 111237016
SLAL111647753 111659931 111672170(mgat4c)
XGL120793480 120793483 120803652
HCQ109528599 109530880 109530900(mgat4c)
BPEC110155136(mgat4c) 110162118
MALB109956382 109956477(mgat4c) 109969969
BSPL114857063 114857320 114858890(zgc:101663)
SASA106561603 106573111 106573155
STRU115152337 115152344 115168743 115197568 115197585
OTW112218868(mgat4c) 112219151 112221479 112252660 112253389
OMY110492713 110499683(mgat4c) 110499798 110524434 110524488
OGO123997662 124004004 124018217 124018671 124033449
ONE115108992 115109671 115115583 115122670 115133953
SALP111952907 111952978 111962732 111962745
SNH120053306 120053529 120061718 120065888 120065895
CCLU121531248 121531288 121531664 121545306 121577038
ELS105007116 105026418 105030750
SFM108918691 108928190 108931472
PKI111835193(mgat4c) 111855285
AANG118207630 118215556 118218736 118232199(mgat4c)
LOC102687023(mgat4c) 102690465
PSPA121299730 121300191 121318495(mgat4c) 121320295 121330096
ARUT117414479 117419564(mgat4c) 117428212 117965983
LCM102346343 102347820(MGAT4C)
CMK103175065 103179072 103185333(mgat4c)
RTP109910955(mgat4c) 109914242 109915501
BFO118413034 118413212 118413214
BBEL109469451 109469461 109469462 109474455 109474456 109474458 109474568
SPU105441386 580331
APLC110974061 110984449 110984711 110984722 110985805 110985807 110985808
SKO100372236
FCD110856945
PJA122265764
PCHN125044079
HAME121868829
PCLA123768461
PTRU123512426
HAZT108665683
LSM121113635
PPOI119098206
CSCU111636137
SDM118180358
LGILOTGIDRAFT_172688
PCAN112559553 112575653
GAE121382652 121383354
HRF124126230 124152739 124152785
HRJ124255965 124255977 124262739
CRG105320882 105324375 105324376 105325491 105330470 105338504 105338576 105340894 105342679 117680994 117683793 117683794 117683795 117683796
MYI110443458 110447857 110453151 110454675 110459894 110463378 110463896
PMAX117329199 117335820 117335983 117336373 117336392 117336407 117336523 117336524 117341467
MMER123535723 123536079 123536118 123536693 123536846 123537118
LAK106152265 106160495 106164659 106172365 106172639 106174249 106176399
NVE5503815 5513696 5517229 5517300 5521811
EPA110232308 110243200 110244311
ATEN116288335 116305189 116305197
ADF107328532 107333160 107333161 107336078 107344550 107347979 107348679 107352963
AMIL114947664 114949509 114959622 114969084 114969085 114969910 114971341
PDAM113678682 113681400 113681963 113682042 113682084 113686241
SPIS111319180 111325502 111325529 111328500 111328729
DGT114517430 114519996 114519998 114524837 114527166 114542530
XEN124441719 124441720 124442975 124443219 124443220 124443221 124446286
TADTRIADDRAFT_32367 TRIADDRAFT_51821 TRIADDRAFT_55928 TRIADDRAFT_61341
APROF751_5773
MBRMONBRDRAFT_30843
SREPTSG_02232
SMINv1.2.033022.t1(symbB.v1.2.033022.t1)
 » show all
Reference
1  [PMID:2525556]
  Authors
Brockhausen I, Hull E, Hindsgaul O, Schachter H, Shah RN, Michnick SW, Carver JP.
  Title
Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc beta 1-6 (GlcNAc beta 1-2)Man alpha-R (GlcNAc to Man) beta-4-N-acetylglucosaminyltransferase VI.
  Journal
J Biol Chem 264:11211-21 (1989)
Reference
2  [PMID:10903319]
  Authors
Taguchi T, Ogawa T, Inoue S, Inoue Y, Sakamoto Y, Korekane H, Taniguchi N
  Title
Purification and characterization of UDP-GlcNAc: GlcNAcbeta 1-6(GlcNAcbeta 1-2)Manalpha 1-R [GlcNAc to Man]-beta 1, 4-N-acetylglucosaminyltransferase VI from hen oviduct.
  Journal
J Biol Chem 275:32598-602 (2000)
DOI:10.1074/jbc.M004673200
  Sequence
[gga:395415]
Reference
3  [PMID:10962001]
  Authors
Sakamoto Y, Taguchi T, Honke K, Korekane H, Watanabe H, Tano Y, Dohmae N, Takio K, Horii A, Taniguchi N
  Title
Molecular cloning and expression of cDNA encoding chicken UDP-N-acetyl-D-glucosamine (GlcNAc): GlcNAcbeta 1-6(GlcNAcbeta 1-2)- manalpha 1-R[GlcNAc to man]beta 1,4N-acetylglucosaminyltransferase VI.
  Journal
J Biol Chem 275:36029-34 (2000)
DOI:10.1074/jbc.M005860200
  Sequence
[gga:395415]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.201
IUBMB Enzyme Nomenclature: 2.4.1.201
ExPASy - ENZYME nomenclature database: 2.4.1.201
BRENDA, the Enzyme Database: 2.4.1.201
CAS: 119699-68-2

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