Entry
Name
2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase;
uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase;
BX8;
BX9;
benzoxazinoid glucosyltransferase;
DIMBOA glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-beta-D-glucosyltransferase
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one = UDP + (2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [RN:
R04579 ];
(2) UDP-alpha-D-glucose + 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one = UDP + (2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [RN:
R07426 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:
C00029 ];
2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one [CPD:
C04720 ];
2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one [CPD:
C15770 ]
Product
UDP [CPD:
C00015 ];
(2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [CPD:
C04831 ];
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [CPD:
C15772 ]
Comment
The enzyme is involved in the detoxification of the benzoxazinoids DIBOA (2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one) and DIMBOA (2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) which are stored as the respective non-toxic glucosides in the vacuoles in some plants, most commonly from the family of Poaceae (grasses). Benzoxazinoids are known to exhibit antimicrobial, antifeedant, and antiinsecticidal effects and are involved in the interaction of plants with other plants, insects, or microorganisms.
History
EC 2.4.1.202 created 1992, modified 2012
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K13227 UDP-glucosyltransferase BX8/BX9
Genes
DOSA : Os11t0444000-01(Os11g0444000)
ATS : 109735346 109736907 109754422
TDC : 119314690 119315414 119328279 119330805 119334371 119336035 119336866 119340106 119341052 119349903 119349904
TAES : 100682422 123147887 123150283 123150314 123159126 123160005 123167683 123172831
ZMA : 100274317 100277344 103632152
SITA : 101752637 101753321 101778310 101780325
PVIR : 120644461 120644612 120684540 120684928 120696099
» show all
Taxonomy
Reference
Authors
Bailey BA, Larson RL
Title
Hydroxamic Acid glucosyltransferases from maize seedlings.
Journal
Sequence
Reference
Authors
von Rad U, Huttl R, Lottspeich F, Gierl A, Frey M.
Title
Two glucosyltransferases are involved in detoxification of benzoxazinoids in maize.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.202