KEGG   ENZYME: 2.4.1.206
Entry
EC 2.4.1.206                Enzyme                                 

Name
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase;
LA2 synthase;
beta1->3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase;
lactosylceramide beta-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-N-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04493 R05971]
Reaction(KEGG)
R04493 R05971(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
History
EC 2.4.1.206 created 1992
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K03766  beta-1,3-N-acetylglucosaminyltransferase 5
Genes
HSA: 84002(B3GNT5)
PTR: 735383(B3GNT5)
PPS: 100978128(B3GNT5)
GGO: 101133247(B3GNT5)
PON: 100438226(B3GNT5)
NLE: 100600878(B3GNT5)
MCC: 705694(B3GNT5)
MCF: 102119427(B3GNT5)
CSAB: 103221160(B3GNT5)
RRO: 104664648(B3GNT5)
RBB: 108521055(B3GNT5)
CJC: 100411350(B3GNT5)
SBQ: 101035254(B3GNT5)
MMU: 108105(B3gnt5)
MCAL: 110311880(B3gnt5)
MPAH: 110329546(B3gnt5)
RNO: 116740(B3gnt5)
MUN: 110564996(B3gnt5)
CGE: 100757919(B3gnt5)
NGI: 103726553(B3gnt5)
HGL: 101723270(B3gnt5)
CCAN: 109700297(B3gnt5)
OCU: 100352940(B3GNT5)
TUP: 102489196(B3GNT5)
CFA: 102154559(B3GNT5)
VVP: 112926242(B3GNT5)
AML: 100477043(B3GNT5)
UMR: 103676097(B3GNT5)
UAH: 113254536(B3GNT5)
ORO: 101385310(B3GNT5)
ELK: 111151247
FCA: 101096409(B3GNT5)
PTG: 102956905(B3GNT5)
PPAD: 109275199(B3GNT5)
AJU: 106967357(B3GNT5)
BTA: 767899(B3GNT5)
BOM: 102284217(B3GNT5)
BIU: 109557599(B3GNT5)
BBUB: 102402441(B3GNT5)
CHX: 102189161(B3GNT5)
OAS: 101103203(B3GNT5)
SSC: 397599(B3GNT5)
CFR: 102514403(B3GNT5)
CDK: 105085901(B3GNT5)
BACU: 103015740(B3GNT5)
LVE: 103079181(B3GNT5)
OOR: 101288601(B3GNT5)
DLE: 111173504(B3GNT5)
PCAD: 102979892(B3GNT5)
ECB: 100058694(B3GNT5)
EPZ: 103558196(B3GNT5)
EAI: 106834539(B3GNT5)
MYB: 102250884(B3GNT5)
MYD: 102773368(B3GNT5)
MNA: 107541112(B3GNT5)
HAI: 109396440(B3GNT5)
DRO: 112305059(B3GNT5)
PALE: 102892817(B3GNT5)
RAY: 107507023(B3GNT5)
MJV: 108397663(B3GNT5)
LAV: 100672153(B3GNT5)
TMU: 101342861
MDO: 103100021(B3GNT5)
SHR: 100920203(B3GNT5)
PCW: 110204756(B3GNT5)
OAA: 100092498(B3GNT5)
GGA: 424960(B3GNT5)
MGP: 100544407(B3GNT5)
CJO: 107318134(B3GNT5)
NMEL: 110397816(B3GNT5)
APLA: 101791474(B3GNT5)
ACYG: 106032048(B3GNT5)
TGU: 100224977(B3GNT5)
LSR: 110477686(B3GNT5)
SCAN: 103815322(B3GNT5)
GFR: 102033487(B3GNT5)
FAB: 101810058(B3GNT5)
PHI: 102111086(B3GNT5)
PMAJ: 107208796(B3GNT5)
CCAE: 111933377(B3GNT5)
CCW: 104687996(B3GNT5)
ETL: 114059482(B3GNT5)
FPG: 101915210(B3GNT5)
FCH: 102047405(B3GNT5)
CLV: 102087227(B3GNT5)
EGZ: 104123298(B3GNT5)
NNI: 104019580(B3GNT5)
ACUN: 113483221(B3GNT5)
PADL: 103914981(B3GNT5)
AAM: 106482228(B3GNT5) 106490128
ASN: 102383416(B3GNT5)
AMJ: 102563242(B3GNT5)
PSS: 102462329(B3GNT5)
CMY: 102930607(B3GNT5)
CPIC: 101944344(B3GNT5)
ACS: 100560177(b3gnt5)
PVT: 110086058(B3GNT5)
PBI: 103056995(B3GNT5)
PMUR: 107299948(B3GNT5)
TSR: 106555717(B3GNT5)
PMUA: 114598037(B3GNT5)
GJA: 107117663(B3GNT5)
XLA: 446540(b3gnt5.S) 496364(b3gnt5.L)
XTR: 394849(b3gnt5)
NPR: 108791305(B3GNT5)
DRE: 336526(b3gnt5a) 791470(b3gnt5b)
IPU: 100528972(b3g5a) 108267178(b3gnt5)
LCO: 104920550
NCC: 104942412(b3gnt5)
MZE: 101475629(b3gnt5) 101479343
ONL: 100706077(b3gnt5) 102082918
OLA: 101164751(b3gnt5)
XMA: 102225193(b3gnt5) 102236464
PRET: 103464035 103479067(b3gnt5)
CVG: 107082590(b3gnt5)
KMR: 108238228(b3gnt5b) 108250604(b3gnt5a)
AOCE: 111581474(b3gnt5) 111588986
LCF: 108883761(b3gnt5) 108896980
SDU: 111228747(b3gnt5) 111231897
HCQ: 109520510(b3gnt5)
PKI: 111854663(b3gnt5) 111860520
LCM: 106702428(B3GNT5)
CMK: 103190900(b3gnt5)
RTP: 109915865(b3gnt5)
BFO: 118432074
CIN: 104265549
 » show all
Reference
1  [PMID:1825612]
  Authors
Gottfries J, Percy AK, Mansson JE, Fredman P, Wikstrand CJ, Friedman HS, Bigner DD, Svennerholm L.
  Title
Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas.
  Journal
Biochim Biophys Acta 1081:253-61 (1991)
DOI:10.1016/0005-2760(91)90279-Q
Reference
2  [PMID:2960671]
  Authors
Holmes EH, Hakomori S, Ostrander GK.
  Title
Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.
  Journal
J Biol Chem 262:15649-58 (1987)
Reference
3  [PMID:1901591]
  Authors
Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L.
  Title
Glycosphingolipid glycosyltransferases in human fetal brain.
  Journal
J Neurochem 56:1461-5 (1991)
DOI:10.1111/j.1471-4159.1991.tb02038.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.206
IUBMB Enzyme Nomenclature: 2.4.1.206
ExPASy - ENZYME nomenclature database: 2.4.1.206
BRENDA, the Enzyme Database: 2.4.1.206
CAS: 83682-80-8

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