Entry
Name
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase;
N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase;
heparan glucuronyltransferase II
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan [RN:
R07335 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucuronate [CPD:
C00167 ];
N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
Product
UDP [CPD:
C00015 ];
beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
Comment
Involved in the biosynthesis of heparin and heparan sulfate. Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase (EC
2.4.1.224 ) activity required for the synthesis of the heparan sulfate disaccharide repeats.
History
EC 2.4.1.225 created 2002
Pathway
ec00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Orthology
K02366 glucuronyl/N-acetylglucosaminyl transferase EXT1
K02367 glucuronyl/N-acetylglucosaminyl transferase EXT2
Genes
HSA : 2131(EXT1) 2132(EXT2)
PTR : 107976420(EXT1) 451140(EXT2)
PPS : 100975712(EXT2) 100985695(EXT1)
GGO : 101130563(EXT2) 109025298(EXT1)
PON : 100172450(EXT1) 100436160(EXT2)
PPYG : 129007272(EXT2) 129041970(EXT1)
NLE : 100597702(EXT1) 100604250(EXT2)
HMH : 116476325(EXT2) 116813541(EXT1)
SSYN : 129484203(EXT2) 129486743(EXT1)
MCC : 701488(EXT1) 715975(EXT2)
MCF : 101926231(EXT1) 102136104(EXT2)
MTHB : 126936267 126961556
MNI : 105468540(EXT1) 105471617(EXT2)
CSAB : 103236980 103237338(EXT1)
CATY : 105584539(EXT1) 105586840(EXT2)
PANU : 100137439(EXT1) 101019229(EXT2) 116272456 116272614
TGE : 112606187(EXT2) 112629920(EXT1)
MLEU : 105529083 105554777(EXT2)
RRO : 104658897(EXT1) 104673882(EXT2)
RBB : 108519255(EXT2) 108536176(EXT1)
TFN : 117079472(EXT1) 117081393(EXT2)
PTEH : 111544934(EXT2) 111551020(EXT1)
CANG : 105511053(EXT1) 105527086(EXT2)
CJC : 100386964(EXT1) 100400679(EXT2)
SBQ : 101039408(EXT2) 101053444(EXT1)
CIMI : 108304907(EXT2) 108305915(EXT1)
ANAN : 105710789(EXT1) 105717305
CSYR : 103260803 103263660 103264178 103272774
MMUR : 105863703(EXT1) 105885490(EXT2)
LCAT : 123642622(EXT2) 123645168(EXT1)
PCOQ : 105812176(EXT1) 105819145(EXT2)
OGA : 100943601(EXT1) 100949922(EXT2)
MMU : 14042(Ext1) 14043(Ext2)
MCAL : 110310432(Ext1) 110311448(Ext2)
MPAH : 110317782(Ext2) 110334870(Ext1)
RNO : 299907(Ext1) 311215(Ext2)
MCOC : 116082489(Ext1) 116090518(Ext2)
ASYL : 127667498(Ext1) 127685648(Ext2)
MUN : 110540376(Ext2) 110559447(Ext1)
CGE : 100689334(Ext1) 100751585(Ext2)
MAUA : 101826524(Ext1) 101842118(Ext2)
PROB : 127222213(Ext2) 127235391(Ext1)
PLEU : 114694845(Ext1) 114699729(Ext2)
MORG : 121440558(Ext2) 121461166(Ext1)
MFOT : 126491860 126504517
AAMP : 119814179(Ext2) 119822782(Ext1)
NGI : 103738135(Ext1) 103751554(Ext2)
HGL : 101706257(Ext1) 101715817(Ext2)
CPOC : 100712625(Ext2) 100716132(Ext1)
CCAN : 109686418 109702003
DORD : 105996073(Ext2) 105997725(Ext1)
DSP : 122100734(Ext2) 122102360(Ext1)
DMER : 138805958(Ext1) 138833960(Ext2)
PLOP : 125360972(Ext1) 125362321(Ext2)
NCAR : 124960112 124981119
MMMA : 107135778(Ext2) 107142875(Ext1)
ITI : 101964761(Ext2) 101972325(Ext1)
OPI : 101535829(EXT1) 101536088(EXT2)
TUP : 102467803(EXT1) 102487057(EXT2)
GVR : 103591115(EXT1) 103596582(EXT2)
CFA : 475989(EXT2) 482024(EXT1)
CLUD : 112662087(EXT1) 112663258(EXT2)
VVP : 112915941(EXT1) 112924118(EXT2)
VLG : 121498758(EXT1) 121501521(EXT2)
NPO : 129501308(EXT2) 129502436(EXT1)
AML : 100465258(EXT1) 105242037(EXT2)
UMR : 103661582(EXT1) 103672344(EXT2)
UAH : 113252791(EXT1) 113265012
UAR : 123797768(EXT1) 123799595(EXT2)
MPUF : 101672930(EXT2) 101691546(EXT1)
MNP : 132008192 132008356 132014249(EXT1)
MLK : 131811678(EXT2) 131826469(EXT1)
NVS : 122904351(EXT1) 122912861(EXT2)
ORO : 101366478(EXT2) 101382133(EXT1)
EJU : 114199089(EXT1) 114215287(EXT2)
ZCA : 113914556(EXT2) 113931105(EXT1)
MLX : 118015150(EXT1) 118015783(EXT2)
NSU : 110576283(EXT2) 110579220(EXT1)
LWW : 102741200(EXT1) 102744900(EXT2)
FCA : 101081362(EXT1) 101083620(EXT2)
PYU : 121042894(EXT1) 121043515(EXT2)
PCOO : 112859477(EXT1) 112865217(EXT2)
PBG : 122483728(EXT2) 122495739(EXT1)
PVIV : 125156370(EXT1) 125176532(EXT2)
LRUF : 124504734 124507771
LGF : 123585554(EXT1) 123601619(EXT2)
PTG : 102964333(EXT2) 102968916(EXT1)
PPAD : 109273237(EXT1) 109279210 109279211(EXT2)
PLEZ : 122201128(EXT2) 122211191(EXT1)
HHV : 120228461(EXT2) 120228668(EXT1)
BTA : 281151(EXT2) 538602(EXT1)
BOM : 102275740(EXT2) 102280308(EXT1)
BIU : 109568471(EXT1) 109569634(EXT2)
BBUB : 102389161(EXT2) 102407802(EXT1)
BBIS : 104982778(EXT2) 105005436(EXT1)
CHX : 102182243(EXT2) 102182809(EXT1)
OAS : 101110867(EXT2) 101114877(EXT1)
BTAX : 128059226(EXT1) 128060107(EXT2)
CSUM : 138088368(EXT1) 138092456(EXT2)
ODA : 120860718 120876908(EXT2) 120878901(EXT1)
CCAD : 122449196(EXT2) 122450981(EXT1)
MREE : 136144866(EXT1) 136174348(EXT2)
OVR : 110134498(EXT1) 110143371(EXT2)
MBEZ : 129554774(EXT2) 129559842(EXT1)
SSC : 100157655(EXT1) 100522362(EXT2)
CFR : 102508456(EXT1) 102514905(EXT2)
CBAI : 105076487(EXT2) 105082972(EXT1)
CDK : 105096148(EXT1) 105106838(EXT2)
VPC : 102535018(EXT1) 102542570(EXT2)
BACU : 102999728(EXT2) 103019432(EXT1)
BMUS : 118883288(EXT1) 118899308(EXT2)
LVE : 103078738(EXT1) 103091009(EXT2)
OOR : 101280958(EXT2) 101286251(EXT1)
LALB : 132508341(EXT1) 132525841(EXT2)
GMF : 115857516(EXT2) 115863179(EXT1)
DDP : 132413226(EXT1) 132429886(EXT2)
DLE : 111165183(EXT1) 111184011(EXT2)
PCAD : 102979294 102980097(EXT1)
PSIU : 116742524(EXT1) 116758175(EXT2)
PPHC : 136126635(EXT2) 136136846(EXT1)
NASI : 112397180(EXT1) 112402430(EXT2)
ECB : 100055879(EXT2) 100056983(EXT1)
EPZ : 103549478(EXT1) 103556459(EXT2)
EAI : 106839736(EXT1) 106843971(EXT2)
MYB : 102238781(EXT2) 102244714(EXT1)
MYD : 102765321(EXT1) 102767712(EXT2)
MMYO : 118665109(EXT2) 118670761(EXT1)
MLF : 102422014(EXT2) 102441376(EXT1)
MDT : 132219587(EXT1) 132241238(EXT2)
MYUM : 138993009(EXT1) 139018886(EXT2)
PKL : 118712503 118718227(EXT1)
EFUS : 103287659(EXT1) 103290862(EXT2)
MNA : 107525491(EXT2) 107533185(EXT1)
DRO : 112303473(EXT2) 112315333(EXT1)
SHON : 118988619(EXT1) 119002984(EXT2)
AJM : 119051826(EXT1) 119064418(EXT2)
PDIC : 114499874(EXT2) 114514407(EXT1)
PHAS : 123810129(EXT2) 123833269(EXT1)
MMF : 118627865(EXT2) 118631561(EXT1)
PPAM : 129081459(EXT2) 129084291(EXT1)
HAI : 109382533 109391972(EXT2)
RFQ : 117029882(EXT2) 117033795(EXT1)
PALE : 102890634(EXT2) 102891150(EXT1)
PGIG : 120595391(EXT1) 120606317
PVP : 105290068(EXT2) 105292239(EXT1)
RAY : 107507149(EXT1) 107511887(EXT2)
MJV : 108394755(EXT2) 108399086(EXT1)
TOD : 119238592(EXT1) 119255341(EXT2)
SARA : 101538625(EXT1) 101551336(EXT2)
SFUM : 130019692(EXT1) 130039404(EXT2)
SETR : 126009054(EXT1) 126017607(EXT2)
LAV : 100656016(EXT2) 100657623(EXT1)
ETF : 101661672(EXT1) 101662457(EXT2)
DNM : 101436351(EXT1) 101436915(EXT2)
MDO : 100010947(EXT2) 100025396(EXT1)
GAS : 123241026(EXTL1) 123241182(EXT1) 123252570 123252571
SHR : 100929895(EXT1) 105750949(EXT2)
AFZ : 127541352 127544392 127555663
PCW : 110200303(EXT1) 110223945(EXT2)
TVP : 118837393(EXTL1) 118851574(EXT1) 118854074(EXT2)
PBRV : 138154242(EXTL1) 138155837(EXT1) 138163852(EXT2)
MLAO : 141498309(EXT1) 141518476(EXT2)
OAA : 100078206(EXT1) 100079286(EXT2)
TACU : 119926593(EXT1) 119943353(EXT2)
GGA : 100858205(EXT1) 100859367(EXTL1) 425859(EXT2)
PCOC : 116227694(EXT1) 116229130(EXT2) 116230047(EXTL1)
MGP : 100542119(EXT1) 100545109 100551486(EXTL1)
CJO : 107310492(EXT1) 107314816(EXT2) 107324063(EXTL1)
TPAI : 128085844(EXT2) 128088342(EXTL1) 128090880(EXT1)
LMUT : 125691409(EXT1) 125694790(EXT2) 125703958(EXTL1)
NMEL : 110387476(EXTL1) 110395119(EXT1) 110401311(EXT2)
APLA : 101790687(EXT2) 101792373(EXT1) 119713596(EXTL1)
ACYG : 106037911(EXTL1) 106038456(EXT1) 106044125(EXT2)
CATA : 118250771(EXT2) 118252659(EXT1) 118255759(EXTL1)
AFUL : 116485915(EXT1) 116489660(EXT2) 116498028(EXTL1)
TGU : 100227900(EXT1) 100231605(EXT2) 115498288(EXTL1)
LSR : 110472037(EXT2) 110472893(EXTL1) 110479282(EXT1)
SCAN : 103814231(EXT1) 103823579(EXTL1) 103826716(EXT2)
PMOA : 120505159(EXT1) 120512558(EXT2) 120513889(EXTL1)
OTC : 121333361(EXT2) 121337462(EXT1) 121342741(EXTL1)
PRUF : 121349516(EXT2) 121351215(EXTL1) 121355356(EXT1)
ATRC : 139587404(EXT1) 139590224(EXT2) 139602929(EXTL1)
GFR : 102035022(EXTL1) 102040196(EXT2) 102043948(EXT1)
FAB : 101814666(EXT2) 101816822(EXT1) 101818678(EXTL1)
OMA : 130249178(EXT1) 130253844(EXT2) 130262245(EXTL1)
PHI : 102099981(EXT1) 102107359(EXT2) 102111356(EXTL1)
PMAJ : 107200137(EXT1) 107205846(EXT2) 107213996(EXTL1)
CCAE : 111925064(EXT1) 111930141(EXT2)
CCW : 104692676(EXT1) 104695274(EXT2)
CBRC : 103616910(EXTL1) 103620718(EXT2) 103623522(EXT1)
ACOE : 138105415(EXT1) 138111423(EXT2) 138122051(EXTL1)
ETL : 114057979(EXT1) 114064860(EXT2) 114070342(EXTL1)
ZAB : 102062154(EXT2) 102067827(EXT1)
ZLE : 135444634(EXT1) 135448536(EXT2) 135457261(EXTL1)
SVG : 106849477(EXT1) 106851532(EXT2) 106861906(EXTL1)
MMEA : 130572519(EXT2) 130574552(EXT1) 130583292(EXTL1)
HRT : 120753978(EXT2) 120758554(EXT1) 120763137(EXTL1)
SATI : 136362492(EXT2) 136371154(EXTL1) 136371196(EXT1)
CCIC : 134045040(EXT2) 134050503(EXT1) 134053734(EXTL1)
FPG : 101919384(EXT1) 101922176(EXTL1) 101923547(EXT2)
FCH : 102049940(EXT1) 102054426(EXT2) 102056866(EXTL1)
CCRI : 104157610(EXT2) 104162814(EXT1)
NNT : 104403804(EXT1) 104409474(EXT2)
SHAB : 115606439(EXT2) 115609772(EXT1) 115615978(EXTL1)
ACUN : 113476897(EXT1) 113480641(EXT2) 113488189(EXTL1)
TALA : 104365235(EXT1) 104367927(EXT2) 116964263(EXTL1)
ACHC : 115333408(EXT2) 115340329(EXT1) 115351760(EXTL1)
HLE : 104837180(EXTL1) 104837692(EXT1) 104839720(EXT2)
AGEN : 126047399 126049009 126049243
HHAR : 128139481(EXT2) 128141851(EXT1) 128152799(EXTL1)
GCL : 127012556 127017427 127025047
CSTI : 104550813(EXT2) 104555699 104561130
LDI : 104342773(EXT2) 104349538(EXT1)
DPUB : 104297238(EXT1) 104297453(EXT2) 104307496(EXTL1)
PPUS : 135180185(EXT2) 135181208(EXT1) 135190941(EXTL1)
AVIT : 104275926(EXT2) 104279093(EXT1)
BRHI : 104494174(EXT2) 104496894(EXT1)
EGZ : 104134053(EXT2) 104134955(EXTL1)
NNI : 104017847(EXTL1) 104018021(EXT1) 104019563(EXT2)
PCRI : 104037223(EXT2) 104037444
PCAO : 104039550(EXT2) 104049419
PADL : 103914958(EXT1) 103921685(EXT2)
AFOR : 103896426(EXTL1) 103897223(EXT1) 103897455(EXT2)
FGA : 104079754(EXT2) 104080655(EXT1)
CBOY : 140647417(EXT1) 140652706(EXT2) 140662177(EXTL1)
CLV : 102084082(EXTL1) 102085197(EXT2) 102091811(EXT1)
CNIC : 135986025(EXT1) 135989572(EXT2) 135997740(EXTL1)
MUI : 104538279(EXT2) 104542233 104542281(EXTL1)
PLET : 104618170 104619405(EXT2)
EHS : 104506250(EXT2) 104510203(EXT1)
CMAC : 104481663 104482061
CUCA : 104061521(EXTL1) 104066187(EXT1) 104067268(EXT2)
TEO : 104372233 104374413(EXT2)
BREG : 104639655 104641383(EXT1)
OHA : 104330168(EXT2) 104332486(EXT1)
CPEA : 104386715(EXT1) 104390387(EXT2) 104394116(EXTL1)
CVF : 104282894(EXT1) 104283937(EXTL1) 104295831(EXT2)
RTD : 128904733(EXT1) 128908421(EXT2) 128919015(EXTL1)
CRID : 134512216(EXT1) 134514692(EXT2) 134525323(EXTL1)
AAM : 106485009 106496271(EXT1) 106498294(EXT2) 106499622
AROW : 112960952(EXT1) 112964418(EXTL1) 112972955 112978433(EXT2)
NPD : 112943491(EXT2) 112948502(EXT1) 112950897(EXTL1)
TGT : 104565017(EXT2) 104573294
DNE : 112979229(EXT2) 112982032(EXTL1) 112989149(EXT1)
SCAM : 104149258(EXT2) 104150074(EXT1)
ASN : 102370729(EXT1) 102376854(EXTL1) 102379048(EXT2)
AMJ : 102560415(EXT1) 102562202(EXT2) 102575942(EXTL1)
CPOO : 109318544(EXTL1) 109321140(EXT2) 109321481(EXT1)
GGN : 109294162(EXTL1) 109298936(EXT2) 109299004(EXT1)
PSS : 102444477(EXT1) 102446763(EXT2)
CMY : 102929859(EXTL1) 102938478(EXT2) 102939595(EXT1)
CCAY : 125624786(EXTL1) 125632784(EXT1) 125634923 125638325(EXT2)
DCC : 119845550(EXTL1) 119852082(EXT1) 119852576 119857262(EXT2)
CPIC : 101946173(EXT1) 101949276(EXT2) 101953823(EXTL1) 103307378
TST : 117868243(EXTL1) 117873767(EXT1) 117876973(EXT2)
CABI : 116818811(EXT1) 116830766(EXT2) 116837997(EXTL1)
MRV : 120389310(EXTL1) 120398808(EXT1) 120404543(EXT2)
ACS : 100553800(extl1) 100555771(ext2) 100567014(ext1)
ASAO : 132768475(EXT2) 132775071(EXT1) 132780719(EXTL1)
PVT : 110076972(EXT1) 110081549(EXT2) 110084159(EXTL1)
SUND : 121915625(EXTL1) 121928875(EXT1) 121933481(EXT2)
PBI : 103048904 103054708 103062807(EXT2) 103067611(EXTL1)
PMUR : 107292260 107295666(EXTL1) 107302595(EXT2)
CTIG : 120307392(EXT1) 120307969(EXT2) 120314310(EXTL1)
TSR : 106538947 106539688(EXTL1) 106545012(EXT2)
PGUT : 117663388(EXTL1) 117665492(EXT2) 117668371(EXT1)
PCAE : 139311547(EXT2) 139314644(EXT1) 139320917(EXTL1)
APRI : 131187435(EXT2) 131196014(EXT1) 131204188(EXTL1)
PTEX : 113437525(EXTL1) 113438272(EXT1) 113440794(EXT2)
NSS : 113410220(EXT2) 113417566(EXTL1) 113427134(EXT1)
VKO : 123019173(EXT1) 123025901(EXTL1) 123026241(EXT2)
PMUA : 114596253(EXT2) 114601312(EXT1) 114601546(EXTL1)
PRAF : 128413518(EXT2) 128417122(EXT1) 128418730(EXTL1)
ZVI : 118085381(EXT2) 118086449(EXTL1) 118089708(EXT1)
HCG : 128323737(EXT1) 128333382(EXTL1) 128334415(EXT2)
GJA : 107110827(EXTL1) 107113379 107122615(EXT2)
STOW : 125426333(EXT2) 125434955(EXTL1) 125439498(EXT1)
EMC : 129324507(EXT2) 129333222(EXT1) 129343175(EXTL1)
XLA : 380140(ext2.L) 398214(ext1.L) 398750(ext2.S) 399115(ext1.S)
XTR : 100151709(ext2) 448393(ext1)
NPR : 108786158(EXT2) 108790563(EXT1)
RTEM : 120917049(EXT2) 120941479(EXT1)
ACAT : 141111936(EXT2) 141121746
BBUF : 120980295(EXT2) 121001066(EXT1)
BGAR : 122920720(EXT2) 122938154(EXT1)
DTC : 141092424(EXT2) 141101258(EXT1)
PWL : 138282773(EXT1) 138283745(EXT2) 138295359
MUO : 115464768 115468808(EXT2) 115479964(EXT1) 115480317(EXTL1)
GSH : 117352242(EXT2) 117355075(EXT1) 117357489 117365871(EXTL1)
DRE : 101885478 493780(ext2) 497279(ext1a) 497280(ext1b) 497281(ext1c)
SRX : 107706235(extl1) 107706241 107711539 107715577 107727350 107733302 107750554 107754264 107754269 107754691
SANH : 107654722 107654729 107659874 107671371 107671458 107683605 107685778 107688159(ext2) 107688215 107688378 107696533
SGH : 107558762 107562300 107586005 107592048(extl1) 107592050 107592164 107592487 107592940 107592945 107593432
CCAR : 109050531 109056569 109072430 109074535(ext2) 109075419 109075422 109084266 109102354 109109198 109109965
CAUA : 113052033 113062235 113062294 113062301 113063437 113073234 113083119 113105758 113115689 113119245 113119254 113121224
CGIB : 127935072 127935393 127938411 127962006 127975010 127978542 127979490 127983603 128017046 128030806
PTET : 122323313 122323527(ext1b) 122324020(ext1c) 122324433 122333980(ext1a) 122333996 122349070(ext2)
LROH : 127168414(ext2) 127178446(ext1a) 127181513(ext1b) 127181899(ext1c) 127182637
GRF : 141283190 141289835(ext1c) 141290019(ext1b) 141332070(ext2) 141342343(ext1a)
OMC : 131521901(ext1a) 131525465 131526332(ext1b) 131527582 131544219(ext2)
PPRM : 120468007(ext2) 120469966(ext1c) 120479262(ext1b) 120491188(ext1a) 120493730
RKG : 130078411(ext1a) 130096027 130102576(ext2)
MAMB : 125243241(ext1a) 125264629(ext2) 125275117(ext1b) 125275126 125278978
CIDE : 127497257 127497324 127500934 127501221 127502442 127515571
CERY : 137001981 137018674 137029879(ext2) 137037540(ext1b) 137037953(ext1a)
MASI : 127420630 127420631 127425512 127425513 127453101 127454129 127454839
TROS : 130551302 130556169(ext2) 130557989(ext1a) 130566509(ext1b) 130566756
TDW : 130415440(ext1b) 130415633 130425151(ext2) 130432903(ext1a) 130434877
MANU : 129441614(ext2) 129448753(ext1a) 129454424(ext1b) 129454464 141350479
PDAB : 135730873(ext2) 135750024 135779551 135779671(ext1b) 135789196(ext1a)
IPU : 108256617(ext1a) 108257122(ext1b) 108257140 108271344 108275270
IFU : 128599505(ext1a) 128600187 128600192(ext1b) 128613387(ext2) 128619295
PHYP : 113529295 113532714 113535947 113535988 113536365(ext2)
SMEO : 124375785(ext1b) 124375938 124390802(ext2) 124401370 124403868(ext1a)
TFD : 113643961(ext1c) 113649722(ext1a) 113654795 113661608(ext1b) 113663258(ext2)
TVC : 132837615 132839969(ext1a) 132845376(ext2) 132854431 132863853(ext1b)
CGAR : 128514201(ext1a) 128515110 128518772(ext1b) 128519636 128543008(ext2)
NGRA : 132867456(ext1a) 132881451 132899122(ext2) 132900716(ext1b) 132900723(ext1c)
TRN : 134300836(ext1a) 134320439 134331470(ext2) 134331573 134331607(ext1b)
AMEX : 103026919 103031914(ext1b) 103040053(ext1a) 103046596(ext2) 103047171
CMAO : 118798675(ext1a) 118805664(ext1b) 118805672 118815270 118818835(ext2)
EEE : 113575759(ext2) 113578814 113588018(ext1) 113591568 113591687
CHAR : 105891959 105897019 105904948(ext1b) 105907228(ext2) 105909063(ext1c)
SPIL : 134068817(ext2) 134072226 134072383(ext1b) 134082849 134097796
TRU : 101065654 101066048(ext2) 101072426 101072822 101075972
TFS : 130516284 130518042(ext1b) 130518113(ext1c) 130521281(ext2) 130532494
TNG : GSTEN00017827G001 GSTEN00032917G001 GSTEN00032935G001 GSTEN00035381G001 GSTEN00038113G001
LCO : 104919199(ext2) 104926220 104931682 104932462 104937142
NCC : 104945394 104949435 104961795(ext1) 104963025(ext2)
TBEN : 117471545(ext2) 117477648(ext1b) 117477663(ext1c) 117480396 117486878
CGOB : 115003439 115006327(ext2) 115015568 115016180 115021154
PGEO : 117439799 117454828(ext1b) 117455536 117460478 117467212(ext2)
GACU : 117535645 117537462 117542614 117545386(ext1c) 117547083(ext2)
EMAC : 134861875 134863486(ext2) 134874992 134875490(ext1b) 134876603
ELY : 117258719(ext2) 117263289(ext1b) 117263650 117265950 117270842
EFO : 125881736(ext2) 125893291 125897583 125904485 125904491(ext1b)
PLEP : 121945585 121955317 121958010(ext1b) 121958038 121960250(ext2)
SLUC : 116034014(ext2) 116035281 116047237(ext1c) 116047249(ext1b) 116066120
ECRA : 117943850(ext2) 117946948 117956425(ext1b) 117956791 117961813 117961814
ESP : 116688651(ext2) 116690738 116701186 116701221 116706523
PFLV : 114553112(ext2) 114557177 114567744 114567814 114572953
GAT : 120807940 120808600(ext2) 120810156 120826358(ext1b) 120826673(ext1c)
PPUG : 119195167 119197352 119219177(ext1b) 119219200(ext1c) 119229335(ext2)
AFB : 129096805(ext1c) 129097306(ext1b) 129101386(ext2) 129107479 129109669
CLUM : 117725979(ext2) 117727284 117738620(ext1c) 117739586(ext1b) 117745311
PSWI : 130192468(ext2) 130194589(ext1b) 130197680 130202948 130212600
CANA : 137784405(ext1c) 137784486(ext1b) 137785399 137799549 137803781(ext2)
CVE : 137870963 137872829(ext1b) 137872834(ext1c) 137887787(ext2) 137890907
MSAM : 119890106(ext2) 119897919 119907162 119907458(ext1b) 119908630 119909485
SCHU : 122862811 122863823 122863835(ext1b) 122875957(ext2) 122881559
CUD : 121513315 121513674(ext2) 121521338 121523384(ext1b) 121524170
SPUL : 138583866 138585160(ext2) 138608386(ext1b) 138608433(ext1c) 138612408
LMIX : 132973701(ext2) 132984283 132984747 132990662(ext1c) 132990897(ext1b)
ALAT : 119005988 119012419 119016449(ext1b) 119017160 119017615(ext2)
ASTR : 137592938(ext2) 137601901 137607673(ext1c) 137607811(ext1b) 137613916
MZE : 101464589 101473582(ext2) 101479111 101482519 101486492
ONL : 100695641(ext2) 100700775 100705583 100707723 109194193
OAU : 116309414 116318909 116318948(ext1b) 116322583 116327190(ext2)
OLA : 101163398(ext2) 101164181 101167217 101169374
OML : 112143494 112160904(ext2) 112162700(ext1b) 112162739(ext1c)
CSAI : 133418595 133426387 133460500(ext1c) 133461261(ext1b) 133461580(ext2)
XMA : 102217307 102217354 102230266 102234444(ext2) 102237506
XCO : 114141516 114142777(ext2) 114155469 114156156 114159116
XHE : 116716748 116718349(ext2) 116731149 116731796 116734657
PRET : 103457265 103462432(ext2) 103472886(ext1) 103473086 103478346
PFOR : 103131421 103135121 103139431(ext2) 103151922 103154987 103155379(ext1)
PLAI : 106951280 106953583(ext1) 106958190(ext2) 106961006 106964918
PMEI : 106907411 106923397(ext1) 106926106(ext2) 106928852
GAF : 122821865(ext2) 122825094 122831600 122843906(ext1b) 122844227(ext1c)
PPRL : 129354190(ext1b) 129357919 129367500 129369640(ext2) 129375284 129375722(ext1c)
CVG : 107082854 107085591(ext2) 107086154 107089629(ext1) 107094248 107094935
CTUL : 119772289(ext1c) 119775297 119777081 119778046(ext1b) 119782724(ext2)
GMU : 124865747 124866743(ext2) 124879655(ext1c) 124879738(ext1b) 124881887
NFU : 107377760 107378775 107381443(ext2) 107394502 107394966
KMR : 108228674(ext2) 108232308 108243943(ext1b) 108244864 108250176(ext1c)
ALIM : 106511501 106514225(ext1) 106527530 106530767(ext2) 106532427 106535689
NWH : 119418618 119425471 119425560(ext1c) 119427822(ext2)
AOCE : 111564587 111569354(ext1b) 111571373 111574611(ext2) 111589114
EJA : 138194481 138212049 138213084(ext2) 138214429 138214560(ext1b)
BFRE : 138617350 138617356(ext1b) 138617841 138620427(ext2) 138635816
MCEP : 125005111(ext2) 125016650 125019553(ext1b) 125019586
CSEM : 103378751(ext2) 103381137 103388612(ext1) 103393992 103394040
POV : 109632177(ext1) 109636768(ext2) 109639984 109642456 109643173 109644500
SSEN : 122772353(ext2) 122774807 122784514 122786453 122786792
SSOE : 131443931 131447169 131447311(ext1b) 131459935(ext2) 131471511
HHIP : 117758031 117758296(ext2) 117770077 117770079(ext1b) 117776501
HSP : 118099670 118109144(ext2) 118113668 118124559 118124711(ext1b)
PPLT : 128440274(ext2) 128449250 128459920 128461233(ext1b) 128461234
SMAU : 118290446 118291744(ext1b) 118292050 118302515(ext2) 118307214
LCF : 108888686 108889564(ext1b) 108889565 108889668 108889677 108891202
SDU : 111222995 111223271 111227735 111237872 111238419(ext2)
SLAL : 111654812(ext2) 111658101 111671857 111671874 111672565
XGL : 120784183 120786451(ext1b) 120786592(ext1c) 120788958 120794269(ext2)
HCQ : 109514394(ext2) 109518055 109518060 109523479 109529689(ext1)
SSCV : 125967040(ext2) 125975194 125986591(ext1b) 125986799 125990392
SBIA : 133496678 133498500(ext2) 133498505 133498911(ext1b) 133500493
PEE : 133395353 133395927(ext1c) 133399176(ext2) 133401231 133416989
PTAO : 133468229 133470740(ext1b) 133470770(ext2) 133471083(ext1c) 133479328
BPEC : 110153759 110156338 110171534 110172856(ext2) 110173279
ENY : 140359147 140362127(ext1b) 140362136(ext1c) 140373544 140380875(ext2)
MALB : 109952487 109958190 109958643 109958685 109965798(ext2) 109968834
BSPL : 114843138 114849466 114852235(ext2) 114865978(ext1b) 114866303(ext1c)
SJO : 128357971(ext2) 128366364 128374174(ext1b) 128374740(ext1c) 128376753
SSCO : 133983502 133984017(ext2) 133996159(ext1c) 133996406(ext1b) 133997938
GMH : 115534201 115535896 115553622(ext1) 115558722(ext2)
SASA : 100306779(ext1c) 100380322(ext2) 106570050 106571404 106588496 106588504 106594121 106597672 106607809
STRU : 115167097(ext2) 115173416 115173427 115174806 115175988 115175999 115187873 115187874 115192831
OTW : 112217339 112229926 112229932 112247034 112250171 112264222 112264884 112264892 121844920
OMY : 110487634 110488385 110496112(ext1b) 110496808(ext1c) 110506669 110511734 110522229 110526537 110529611
OGO : 123990750 123995089 124012587 124012858(ext1b) 124017649 124033638 124035622 124043635 124043639
ONE : 115107751 115112435(ext2) 115128292 115128299 115131708 115131715 115139415
OKI : 109866535 109881440 109882847 109884984 109888434 109901372 109903709 109907601 109907609
OKE : 118360328 118382370 118386898 118394191 118397690 118398284 118398659 118398931 118399209
OMM : 135520979 135550061(ext1c) 135550067 135550395 135552315 135552325(ext1b) 135557591 135557936
OCLA : 139373381 139373392 139385253 139392191 139392465 139394444 139407785 139411558 139415589
SALP : 111954432 111955132 111955294 111955814 111955850 111969484 111972462
SNH : 120019504 120022446 120022523 120024563 120027266 120027289 120040883 120049131
CCLU : 121542569 121548927 121552579 121571473 121571482 121585943 121586367(ext1b) 121586374(ext1c) 123484405 123484718
ELS : 105005807 105017786 105022258(ext2) 105023503 105027867
OEP : 134006853(ext1b) 134022951 134025059 134028538(ext2)
SFM : 108922050(ext1) 108928562 108931808 108934682(ext2) 108940524
PKI : 111836091 111840708(ext2) 111843930 111843931 111844061 111854291
AANG : 118215430(ext2) 118226079 118230580 118233246(ext1c) 118233844
AROT : 135241673(ext2) 135257546 135260459 135261178(ext1c) 135261797(ext1b)
CCOG : 133111858(ext2) 133128240 133130918 133136814(ext1b) 133137886(ext1c)
LOC : 102688650 102688999(ext1) 102689027(ext2) 102698389
PSPA : 121294359 121303296 121308213 121313281 121314898 121315561 121317487 121329636
ARUT : 117394872 117400267 117402503 117411447 117412720 117414200 117432282 117435140 117964062
PSEX : 120516821(ext1b) 120517016(ext2) 120517779 120526106
LCM : 102353460(EXT1) 102354369 102354854(EXTL1) 102363354(EXT2)
CMK : 103174976(ext2) 103179627 103184956 103185802
CPLA : 122549339 122558076(ext2) 122563602
HOC : 132811644 132824498(ext2) 132829949
LERI : 129696566 129697178 129705551(ext2) 129709842
HAKA : 140719730 140723062 140729660(ext2) 140733582
PMRN : 116942588 116945549(EXT2) 116951675
LRJ : 133340906 133349171 133351349(EXT2)
BBEL : 109479557 109480278
SCLV : 120335452 120335699
SPU : 100893938 115918716 577995
APLC : 110981069 110986223
ARUN : 117291505 117301143
AAMU : 139939320 139949667
AFIL : 140153402 140166308
SKO : 100313593 100372539 102809744
PFLL : 139115606 139116267
DME : Dmel_CG10117(ttv) Dmel_CG8433(sotv)
DSI : Dsimw501_GD11060(Dsim_GD11060) Dsimw501_GD25567(Dsim_GD25567)
DYA : Dyak_GE13596 Dyak_GE14097
DMN : 108159562 108159662 117190510
DMO : Dmoj_GI20737 Dmoj_GI20872
DNV : 108652943 115564114 115564922
DVI : 6624746(ttv) 6627192(sotv)
CCAT : 101453656 101460876
ALUD : 128868279 128868649
TDA : 119675557 119678265 119686355
SCAC : 106082419 106092647
CVJ : 135959583(ttv) 135960464(sotv)
ECOE : 129940208 129944140
CLON : 129605324 129608535
ACOZ : 120952216 120956752
AARA : 120901724 120906198
AMER : 121593113 121599408
ASTE : 118503312 118509916
AMAP : 126557170 126568738
AFUN : 125764791 125768269
AMOU : 128297376 128306730
AMRS : 128709589 128719291
AALI : 118459545 118467462
ACOS : 131269752 131271234
AALB : 109397881 109411435 109416900 109428863 115254192
ASUA : 134207535 134225952
CQU : CpipJ_CPIJ009765 CpipJ_CPIJ012734
CPII : 120424304 120429091
CBRI : 134831022 134832896
BCOO : 119078978 119081884
PPAP : 129798673 129806250
ACER : 107997927 107999513
ALAB : 122711993 122714818
AFLR : 100867904 100871709
BBIF : 117211962 117214192
BVAN : 117156137 117166073
BHUN : 126866545 126875259
BTER : 100643223 100650849
BAFF : 126925000 126926220
BPYO : 122571366 122577021
BPAS : 132908765 132915143
CCAL : 108622677 108627221
OBB : 114871565 114871663 114880970
MGEN : 117220187 117224160
NMEA : 116429461 116432549
CGIG : 122399622 122404430
MPHA : 105835292 105839250
ACEP : 105619491 105627211
ACOC : 108690991 108692927
MZT : 108720297(ttv) 108723591(sotv)
CCOA : 108776227 108781742
PBAR : 105425236 105427034
COBS : 139107146(Sotv) 139110955(Ttv)
TLN : 139808653(Ttv) 139810702(Sotv)
PMEC : 138936147(Sotv) 138944659(Ttv)
LHU : 105673709(sotv) 105675813(ttv)
PFUC : 122518599 122523426
VCRB : 124425504 124426496
CSOL : 105364815 105366129
CGLO : 123268665 123275072
CTYP : 141526832(Sotv) 141530673(Ttv)
AGIF : 122851929 122854354
CINS : 118067431 118074555
VCAN : 122407576 122409842
CCIN : 107262845 107267679
NPT : 124213539(ttv) 124217576(sotv)
AROA : 105685258 105688324
TMOL : 138134409(sotv) 138140297(ttv)
ESIM : 136410253(ttv) 136410316(sotv)
EFOR : 136345830(sotv) 136350422(ttv)
AGRG : 126743580 126748888
CSET : 123316160 123321334
HAXR : 123676507 123685656
NVL : 108557086 108557670 108558174
APLN : 108740927 108743766
PPYR : 116163081 116164508 116166831
BMOR : 101736061 101741346
BMAN : 114247002 114249440
MSEX : 115440710 115448364
DPL : KGM_203672 KGM_214517
BANY : 112046889 112047335
MCIX : 123658419 123669423
PMAC : 106708978 106709701
PPOT : 106100685 106105805
BPHI : 137926552(ttv) 137933708(sotv)
PRAP : 110993283 111003256
PNAP : 125049662 125056161
CCRC : 123696746 123705704
LSIN : 126966570 126974418
AAGE : 121730210 121733524
HAW : 110374076(ttv) 110376090
SLIU : 111353115 111357626
ATRA : 106135529 106137347
LGLY : 125225474 125229496
CSTB : 134744564 134755872
CFUM : 141436511 141438138(ttv)
CFEL : 113365782 113366316 113369841 113369842
CCRN : 123299680 123302491
ACOO : 126835201 126846336
BTAB : 109034604 109035894
CLEC : 106673227 106674189
HHAL : 106678975(sotv) 106681771
HVI : 124360669 124362624 124373510
PHU : Phum_PHUM455050 Phum_PHUM488440
TPAL : 117652175 117652466
CSEC : 111866884 111872464
PAME : 138703211(ttv) 138703622(sotv)
SGRE : 126297625 126352265
BROR : 134535068 134538741
HAMR : 139687455(ttv) 139691358(sotv)
DPX : DAPPUDRAFT_304945 DAPPUDRAFT_307216
DPZ : 124328499 124337515 124340498
AFRA : 136029889 136031246
PVM : 113802032(ttv) 113824640(sotv)
PCHN : 125032085 125036743
PMOO : 119592442 119596794
HAME : 121864489 121869478
PCLA : 123758376(sotv) 123769944(ttv)
PTRU : 123501535 123501664
ESN : 126984445 127005043 127005282
MRJ : 136831668 136842590(sotv)
PORN : 139746603(sotv) 139761079(ttv)
HAZT : 108671440 108677950
LSM : 121117496(sotv) 121121323(ttv)
PPOI : 119094444 119094445 119102599
RSAN : 119374094 119402119
TUT : 107361403 107367244 107371591 107371607
DPTE : 113789732 113796479
CSCU : 111630346 111639960
CVS : 136972765(sotv) 136988493(ttv)
PTEP : 107437365 107450714
ABRU : 129960529 129972503
LPOL : 106458350 106460090 106473945 106478475
PMEO : 129586373 129588086
NAI : NECAME_01875 NECAME_04728
BMY : BM_BM10349(Bma-rib-2) BM_BM3322(Bma-rib-1)
LOA : LOAG_05822 LOAG_08703
HRO : HELRODRAFT_119925 HELRODRAFT_186788
LGI : LOTGIDRAFT_124977 LOTGIDRAFT_199269
PVUL : 126808726 126831214
PCAN : 112561913 112565643
HRJ : 124270731 124276925 124282773
HASI : 137277473 137286532
HCRA : 139473685 139475282
CANU : 128181295 128183294
CVN : 111099932 111104029 111104189
PMAX : 117317139 117326975
AIRR : 138306122 138308614
MCAF : 127725165 127732091
MMER : 123539606 123552181
RPHI : 132715401 132752103
DPOL : 127850329 127857791
MAEA : 128205603 128238651
LAK : 106155252 106175986 106181741
SMM : Smp_146320.1 Smp_172060
SHX : MS3_00006818(EXT2_1)
OVI : T265_05866 T265_05932
LLON : 135487508 135502896
EPA : 110240280 110241454 110241460
ATEN : 116298104 116307177
ADF : 107336652 107336815 107358713
AMIL : 114957442 114961284 122957050
MCAZ : 138033585 138042617
MFOO : 138004449 138007574
PDAM : 113666284 113669827
SPIS : 111326534 111336973
TAD : TRIADDRAFT_1026 TRIADDRAFT_24279
SMO : SELMODRAFT_23945 SELMODRAFT_24030
PPP : 112279610 112280248 112280650 112281934 112282628 112290993 112294684
SRE : PTSG_07269 PTSG_10121
ACAN : ACA1_335890 ACA1_393390
FCY : FRACYDRAFT_160829 FRACYDRAFT_234481
» show all
Taxonomy
Reference
Authors
Senay C, Lind T, Muguruma K, Tone Y, Kitagawa H, Sugahara K, Lidholt K, Lindahl U, Kusche-Gullberg M.
Title
The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.
Journal
Sequence
Reference
Authors
Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K
Title
The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.225