Entry
Name
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase;
MurG transferase;
UDP-N-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase;
UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol [RN:
R05662 R06173 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
Product
UDP [CPD:
C00015 ];
beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
Comment
The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, {iupac/misc/prenol#p6::click here}).
History
EC 2.4.1.227 created 2002
Pathway
Orthology
K02563 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Genes
CSAT : 104702077 104712992 104751230
MSYL : 126599368 126624953
PSOM : 113298063 113303127
TAES : 123069875 123078311
SMO : SELMODRAFT_121052(GT28A1)
ECOO : ECRM13514_0094(murG)
ECOH : ECRM13516_0097(murG)
ELR : ECO55CA74_00445(murG)
ECW : EcE24377A_0092(murG)
ECOA : APECO78_03900(murG)
EDJ : ECDH1ME8569_0087(murG)
ECOI : ECOPMV1_00093(murG)
SEM : STMDT12_C01280(murG)
SETC : CFSAN001921_16780(murG)
SEEN : SE451236_06655(murG)
SENH : CFSAN002069_08585(murG)
SEEH : SEEH1578_09670(murG)
SENJ : CFSAN001992_10365(murG)
SEEC : CFSAN002050_07085(murG)
SEEB : SEEB0189_018745(murG)
SENC : SEET0819_07520(murG)
REE : electrica_04243(murG)
RTG : NCTC13098_06204(murG)
CLAP : NCTC11466_03832(murG)
KIE : NCTC12125_02946(murG)
BAGE : BADSM9389_34590(murG)
AHN : NCTC12129_04164(murG_1)
METY : MRY16398_47280(murG)
PTF : PROFFT_A_01750(murG)
PSHI : SAMEA2665130_0388(murG)
YPG : YpAngola_A2918(murG)
YPI : YpsIP31758_3387(murG)
SMW : SMWW4_v1c07470(murG)
SERS : SERRSCBI_03435(murG)
SFJ : SAMEA4384070_0785(murG)
SOF : NCTC11214_00762(murG_1)
SSAR : SSARUM_000690(murG)
SERA : Ser39006_006165(murG)
PAQU : DMB82_0017165(murG)
PARL : PEC302110_33470(murG)
DIC : Dpoa569_000604(murG)
EHD : ERCIPSTX3056_385(murG)
BAPF : BUMPF009_CDS00378(murg)
BAPG : BUMPG002_CDS00379(murg)
BAPU : BUMPUSDA_CDS00378(murg)
BAPW : BUMPW106_CDS00379(murg)
TPTY : NCTC11468_03093(murG)
PHEI : NCTC12003_01246(murG)
PRJ : NCTC6933_02763(murG)
LRI : NCTC12151_02612(murG)
HIC : NTHIC486_01604(murG)
HPIT : NCTC13334_01199(murG)
HHZ : NCTC10839_01091(murG)
HAEG : NCTC8502_01262(murG)
PDAG : 4362423_00242(murG)
ADP : NCTC12871_01078(murG)
ALIG : NCTC10568_00020(murG)
ASEG : NCTC10977_00977(murG)
AVT : NCTC3438_00980(murG)
RPNE : NCTC8284_03143(murG_1)
PAET : NCTC13378_01314(murG)
XFU : XFF4834R_chr07830(murG)
XPH : XppCFBP6546_07540(murG)
XHD : LMG31886_35530(murG)
LLZ : LYB30171_02233(murG)
VAU : VANGNB10_cI2169c(murG)
VPL : SA104470976_00425(murG)
PAEB : NCGM1900_2242(murG)
PIX : RIN61_06850(murG) RIN61_18530
PVD : CFBP1590__1173(murG)
PPRC : PFLCHA0_c50360(murG)
PMUD : NCTC8068_04355(murG)
PFW : PF1751_v1c09070(murG)
PPUU : PputUW4_04503(murG)
PTRT : HU722_0005945(murG)
PTW : TUM18999_13410(murG)
PTAE : NCTC10697_00861(murG)
MSHE : MAALD49_08960(murG)
PSYC : DABAL43B_2329(murG)
MCAT : MC25239_00304(murG)
MCUN : NCTC10297_00841(murG)
SCAA : TUM17387_03640(murG)
PLZ : S4054249_18770(murG)
SALH : HMF8227_02470(murG)
CBS : COXBURSA331_A0224(murG)
LLG : 44548918_01711(murG)
LJR : NCTC11533_01885(murG)
LCJ : NCTC11976_02781(murG_1)
LWA : SAMEA4504053_1139(murG)
LSS : NCTC12082_00770(murG)
LADL : NCTC12735_01404(murG)
LANT : TUM19329_13680(murG)
MISZ : MishRS11D_06360(murG)
TIB : THMIRHAM_16530(murG)
TSE : THMIRHAS_19250(murG)
TZO : THMIRHAT_06570(murG)
TFRI : Thiofri_04395(murG)
TNI : TVNIR_2604(murG_[H])
GAI : IMCC3135_29180(murG_2)
THIC : TspCOW1_31480(murG)
HAAH : HALA3H3_950051(murG)
ALCA : ASALC70_01147(murG)
AEL : NCTC12917_03782(murG)
CHJ : NCTC10426_02278(murG)
CDIZ : CEDIAZO_03159(murG)
BTHG : MS2017_1159 MS2017_1175
NMM : NMBM01240149_1666(murG)
NMS : NMBM01240355_0431(murG)
NMQ : NMBM04240196_0430(murG)
NMZ : NMBNZ0533_1827(murG)
NMX : NMA510612_2328(murG)
NWE : SAMEA3174300_1586(murG)
NZO : SAMEA4504057_0382(murG)
NCI : NCTC10296_00539(murG)
NCZ : NCTC10294_01267(murG)
NANI : NCTC12227_02082(murG)
ECOR : SAMEA4412678_0476(murG)
BMV : BMASAVP1_A0472(murG)
BML : BMA10229_A1331(murG)
BPM : BURPS1710b_3545(murG)
BPL : BURPS1106A_3550(murG)
BDF : WI26_02340 WI26_03375
BUE : BRPE67_ACDS23650(murG)
BPLA : bpln_1g04340 bpln_2g14500
PLG : NCTC10937_01077(murG)
LMIR : NCTC12852_00832(murG)
BUO : BRPE64_ACDS24170(murG)
VTR : MYVALT_F_00080(murG)
BTRM : SAMEA390648700549(murG)
AXX : ERS451415_00805(murG)
LIM : L103DPR2_02752(murG)
LIH : L63ED372_02318(murG)
SMIO : CATMQ487_11990(murG)
URU : DSM104443_00678(murG)
UPL : DSM104440_00644(murG)
THAG : CKCBHOJB_00773(murG)
FPHO : SHINM1_017240(murG)
RTT : RTTH1527_01960(murG)
RTB : RTB9991CWPP_01970(murG)
RBS : RHODOSMS8_01896(murG)
SMEL : SM2011_c01866(murG)
SFD : USDA257_c45000(murG)
SAME : SAMCFNEI73_Ch2462(murG)
AGR : AGROH133_07429(murG)
ALF : CFBP5473_05535(murG)
AVV : RvVAT039_03520(murG)
AVF : RvVAR031_24200(murG)
ASAL : CFBP5507_09275(murG)
RPUS : CFBP5875_08910(murG)
ALEG : CFBP4996_08810(murG)
REC : RHECIAT_CH0002998(murG)
REL : REMIM1_CH02895(murG)
REP : IE4803_CH03072(murG)
REI : IE4771_CH03110(murG)
RTR : RTCIAT899_CH11360(murG)
RGA : RGR602_CH02496(murG)
RPHA : AMC79_CH03010(murG)
RLW : RlegWSM1455_14375(murG)
RBW : RLCC275e_14410(murG)
NEN : NCHU2750_14840(murG)
LAS : CLIBASIA_04995(murG)
BIO : BR141012304_11281(murG)
BSEP : HAP48_0002785(murG)
BCAN : BcanWSM471_29045(murG)
VGO : GJW-30_1_01844(murG)
BHS : BM1374165_01164(murG)
BBK : BARBAKC583_0947(murG)
BTX : BM1374166_01518(murG)
BEZ : NCTC12898_01030(murG)
MEA : Mex_1p0093 Mex_1p1016 Mex_1p3147(murG)
MDI : METDI0083 METDI1816 METDI3711(murG)
MEX : Mext_0202 Mext_1231 Mext_2941
MCH : Mchl_0145 Mchl_1393 Mchl_3168
MPO : Mpop_0286 Mpop_1172 Mpop_3124
MZA : B2G69_08390 B2G69_13435 B2G69_22275
META : Y590_00420 Y590_05200 Y590_14245
MAQU : Maq22A_1p31510 Maq22A_c12405(murG)
MPHY : MCBMB27_01973 MCBMB27_05493
MEE : DA075_01840 DA075_19315
METD : C0214_00945 C0214_05170 C0214_16295(murG)
METX : A3862_19005 A3862_28915
MMES : MMSR116_19920(murG) MMSR116_31340
MIND : mvi_37530(murG) mvi_56310
MTUN : MTUNDRAET4_1812(murG)
FIL : BN1229_v1_3986(murG)
FIY : BN1229_v1_3973(murG)
AUA : M673_15305 M673_16930
AALA : IGS74_09505(murG) IGS74_12210
AALM : LUX29_10560(murG) LUX29_14100
BVY : NCTC9239_00715(murG)
TSV : DSM104635_02827(murG)
RLI : RLO149_c025710(murG)
PHP : PhaeoP97_00929(murG)
PPIC : PhaeoP14_00881(murG)
SINL : DSM14862_01100(murG_1)
SPSE : SULPSESMR1_01942(murG)
RMM : ROSMUCSMR3_01030(murG)
AHT : ANTHELSMS3_04269(murG)
LALG : LentiSH36_01691(murG)
PMAU : CP157_02089(murG_1)
LVS : LOKVESSMR4R_01002(murG)
NGF : FRF71_01355(murG) FRF71_14375
SBIN : SBA_ch1_35010(murG)
SPAG : sphantq_01057(murG)
SFLA : SPHFLASMR4Y_00089(murG)
SPHJ : BSL82_02680 BSL82_08190
SAND : H3309_12485 H3309_13630(murG)
RGI : RGI145_03710 RGI145_13335
ROS : CTJ15_13665 CTJ15_23050
SHUM : STHU_05580 STHU_42600(murG)
SVC : STVA_07750 STVA_42490(murG)
ATI : AL072_08520 AL072_23125
AZM : DM194_07705(murG) DM194_23785
AZZ : DEW08_15970(murG) DEW08_26255
HTQ : FRZ44_11260(murG) FRZ44_40390
HPO : HMPREF4655_21344(murG)
HPX : HMPREF0462_1165(murG)
HPYA : HPAKL117_05435(murG)
HPYK : HPAKL86_02325(murG)
HCL : NCTC13205_00708(murG)
HSH : NHP194022_04110(murG)
HPUL : NCTC13154_01077(murG)
CJV : MTVDSCj20_1041(murG)
CFV : CFVI03293_0904(murG)
CAMP : CFT03427_0842(murG)
CCOC : CCON33237_0953(murG)
CLR : UPTC16701_0762(murG)
CLM : UPTC16712_0766(murG)
CAMR : CAQ16704_0791(murG)
CHV : CHELV3228_1438(murG)
CPIN : CPIN18020_0734(murG)
CAMZ : CVIC12175_0767(murG)
SMAB : LN246_01530(murG) LN246_14075(murG)
GEC : GEO60473_24870(murG)
GBN : GEOBRER4_04890(murG)
PPOR : JCM14722_12430(murG)
SUR : STAUR_6262(murG) STAUR_6639
CFUS : CYFUS_005601 CYFUS_007830
SCL : sce1027 sce1664(murG)
SCU : SCE1572_07375 SCE1572_10515
BAZ : BAMTA208_09540(murG)
BAE : BATR1942_05405(murG)
BSON : S101395_03214(murG)
BAN : BA_4049(murG1) BA_4477(murG2)
BAR : GBAA_4049(murG1) GBAA_4477(murG2)
BAH : BAMEG_0578(murG1) BAMEG_4511(murG2)
BAI : BAA_4075(murG1) BAA_4494(murG2)
BAX : H9401_3860 H9401_4270
BANT : A16_40550 A16_44720
BANS : BAPAT_3884 BAPAT_4294
BANH : HYU01_19800 HYU01_21840
BANV : DJ46_2749(murG) DJ46_3159(murG)
BCE : BC3748 BC3910 BC4249
BCA : BCE_3956(murG) BCE_4331(murG)
BCZ : BCE33L3669(murG) BCE33L4004(murG)
BCR : BCAH187_A3963(murG1) BCAH187_A4384(murG2)
BCB : BCB4264_A3848(murG) BCB4264_A4011(murG1) BCB4264_A4365(murG2)
BCU : BCAH820_3925(murG1) BCAH820_4273(murG2)
BCG : BCG9842_B0869(murG2) BCG9842_B1230(murG1) BCG9842_B1450(murG)
BCQ : BCQ_3696(murG) BCQ_4037(murG)
BCX : BCA_3845(murG) BCA_4014(murG1) BCA_4362(murG2)
BAL : BACI_c38660(murG1) BACI_c42170(murG2)
BCER : BCK_13910 BCK_15680(murG)
BCEF : BcrFT9_03029(murG) BcrFT9_03339
BTK : BT9727_3652(murG) BT9727_3994(murG)
BTL : BALH_3379(murG) BALH_3540 BALH_3849(murG)
BTB : BMB171_C3421(murG) BMB171_C3574(murG) BMB171_C3921(murG2)
BTT : HD73_4032 HD73_4194 HD73_4557
BTHR : YBT1520_19935 YBT1520_20775(murG) YBT1520_22600
BTHI : BTK_19835 BTK_20650(murG) BTK_22450
BTC : CT43_CH3690(murG) CT43_CH3911(murG) CT43_CH4267(murG2)
BTF : YBT020_18365 YBT020_19210(murG) YBT020_20955
BTM : MC28_2916(murG1) MC28_3132(murG1) MC28_3545(murG2)
BTG : BTB_c38220(murG4) BTB_c40380(murG1) BTB_c43940(murG2)
BTI : BTG_00640 BTG_27870 BTG_30215(murG)
BTN : BTF1_16800 BTF1_17850(murG) BTF1_19635
BTHT : H175_ch3749 H175_ch3973 H175_ch4337
BTHU : YBT1518_20555 YBT1518_21430(murG) YBT1518_23470
BTW : BF38_10(murG) BF38_5080(murG)
BTHY : AQ980_08555 AQ980_10370 AQ980_11185
BWE : BcerKBAB4_3517 BcerKBAB4_3737 BcerKBAB4_4107
BWW : bwei_0683 bwei_1044(murG) bwei_1212
BMYO : BG05_1765(murG) BG05_2114(murG) BG05_2277
BTY : Btoyo_0983 Btoyo_1155 Btoyo_1496
BMYC : DJ92_1001(murG) DJ92_1357(murG)
BBY : CY96_17840 CY96_18630 CY96_20440
BWD : CT694_20180 CT694_21030(murG) CT694_22885
BTRO : FJR70_12960(murG) FJR70_15055(murG)
BMOB : MLA2C4_19585 MLA2C4_20435(murG) MLA2C4_22235
BNT : GSN03_17655 GSN03_18485(murG) GSN03_20245
BPAC : LMD38_05715(murG) LMD38_07575(murG)
BPAN : NLJ82_18950(murG) NLJ82_20680(murG)
BALU : QRY64_21350 QRY64_22440(murG) QRY64_24185(murG)
BIF : N288_09205 N288_12055
BFD : NCTC4823_02570(murG)
BACI : B1NLA3E_06110(murG)
GST : HW35_12975 HW35_16330
BACA : FAY30_08725(murG) FAY30_26160
BARD : QRY57_19325(murG) QRY57_21015
BON : A361_09205 A361_13320
BKO : CKF48_01070(murG) CKF48_20800
CSUA : IM538_10380(murG) IM538_14410
CSOA : LIS82_10785(murG) LIS82_14595
CSPG : LS684_07740(murG) LS684_23855
PARG : PspKH34_36030(murG)
PRD : F7984_06370(murG) F7984_08035
NCM : QNK12_03235 QNK12_08640(murG)
MDG : K8L98_10485(murG) K8L98_14900
BLEN : NCTC4824_02751(murG_1) NCTC4824_02886(murG_2)
BOU : I5818_16260(murG) I5818_21225
GAJ : MY490_12735 MY490_15140(murG)
SAX : USA300HOU_1355(murG)
SUQ : HMPREF0772_11789(murG)
SUX : SAEMRSA15_12810(murG)
SUF : SARLGA251_13340(murG)
SAUT : SAI1T1_2010250(murG)
SAUJ : SAI2T2_1010270(murG)
SAUK : SAI3T3_1010260(murG)
SAUQ : SAI4T8_1010250(murG)
SAUV : SAI7S6_1010260(murG)
SAUW : SAI5S5_1010220(murG)
SAUX : SAI6T6_1010230(murG)
SAUY : SAI8T7_1010260(murG)
SDP : NCTC12225_01581(murG)
SPIC : SAMEA4384060_1511(murG)
SSH : NCTC13712_01410(murG)
SSIM : SAMEA4384339_1318(murG)
SSTE : SAMEA4384403_1359(murG)
LMOC : LMOSLCC5850_2097(murG)
LMW : LMOSLCC2755_2097(murG)
LMX : LMOSLCC2372_2102(murG)
LMZ : LMOSLCC2482_2093(murG)
LMON : LMOSLCC2376_1988(murG)
LMOS : LMOSLCC7179_2007(murG)
LMOO : LMOSLCC2378_2059(murG)
LMOY : LMOSLCC2479_2099(murG)
LMOT : LMOSLCC2540_2128(murG)
LMOA : LMOATCC19117_2055(murG)
LGZ : NCTC10812_00810(murG)
GMO : NCTC11323_00538(murG)
GHA : NCTC10459_01214(murG)
BBE : BBR47_23000 BBR47_38370(murG)
BAGR : BA6348_11950(murG) BA6348_17590
BRW : GOP56_09530(murG) GOP56_13910
BCHS : JNE38_11940 JNE38_19465(murG)
BPAB : PSE45_11390 PSE45_17680(murG)
BAYD : BSPP4475_06590(murG)
BREH : HP435_11930 HP435_18200(murG)
PPM : PPSC2_02885(murG1) PPSC2_16605(murG3)
PPO : PPM_0520(murG1) PPM_3355(murG3)
PPOL : X809_02350 X809_32680
PPQ : PPSQR21_005550(murG) PPSQR21_033500
PSAB : PSAB_06330 PSAB_17390
PAEF : R50345_23075 R50345_30125
PSTE : PSTEL_13945 PSTEL_19465
PAEJ : H70737_23130 H70737_29775
PBJ : VN24_15000 VN24_19590
PIH : UB51_03725 UB51_23820
PPEO : ABE82_02590 ABE82_16710
PYG : AWM70_06195 AWM70_11090 AWM70_11285
PDH : B9T62_01925 B9T62_23815(murG)
PCX : LPB68_05215 LPB68_09910
PVO : PVOR_11329 PVOR_17719
PPSC : EHS13_10730 EHS13_13265(murG)
PALB : EJC50_13310(murG) EJC50_28830
PCHI : PC41400_22805(murG)
PBK : Back11_25660(murG1) Back11_59250(murG2)
PRZ : GZH47_05645(murG) GZH47_21220
PLYC : GXP70_10615(murG) GXP70_25305
PSOP : KP014_10035 KP014_23980(murG)
PCEL : HUB94_01390(murG) HUB94_17560
PTHI : NDS46_09470(murG) NDS46_14485 NDS46_15315
PUI : PUW25_07340 PUW25_18475(murG)
PMAH : PTQ21_07515 PTQ21_27355(murG)
PDY : QJQ58_06595 QJQ58_12695(murG)
PWN : QNH46_09065 QNH46_16125(murG)
PSPN : L1F29_02500 L1F29_10415(murG)
PPOG : QPK24_06920 QPK24_17835(murG)
PAUN : MJA45_11015(murG) MJA45_24325
PNK : AASFL403_03680(murG)
PLZH : C0638_05010 C0638_16775(murG)
TCO : Theco_0234 Theco_2317
ANEU : PP175_07660 PP175_16930(murG)
COHN : KCTCHS21_40720(murG1)
SACA : FFV09_02780(murG) FFV09_06235
ACUR : JZ785_08775(murG) JZ785_23245
LFB : C1X05_02435 C1X05_11290(murG)
TVU : AB849_006320 AB849_009500(murG)
PABS : JIR001_20320(murG1)
SPYM : M1GAS476_1318(murG)
SPH : MGAS10270_Spy1268(murG)
SPI : MGAS10750_Spy1360(murG)
SPJ : MGAS2096_Spy1271(murG)
SPK : MGAS9429_Spy1247(murG)
STG : MGAS15252_1136(murG)
STZ : SPYALAB49_001234(murG)
SNV : SPNINV200_06090(murG)
SPNG : HMPREF1038_00714(murG)