Entry
Name
D-inositol-3-phosphate glycosyltransferase;
mycothiol glycosyltransferases;
MshA;
UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP [RN:
R09634 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
1D-myo-inositol 3-phosphate [CPD:
C04006 ]
Product
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate [CPD:
C19761 ];
UDP [CPD:
C00015 ]
Comment
The enzyme, which belongs to the GT-B fold superfamily, catalyses the first dedicated reaction in the biosynthesis of mycothiol [1]. The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate [2]. A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate [3].
History
EC 2.4.1.250 created 2010
Orthology
K15521 D-inositol-3-phosphate glycosyltransferase
Genes
BUE : BRPE67_ECDS00300 BRPE67_ECDS01490
AXX : ERS451415_04217(mshA_3)
MASS : CR152_16740 CR152_19275
TPRO : Ga0080559_TMP2006 Ga0080559_TMP4534
PABY : Ga0080574_TMP1853 Ga0080574_TMP2156
AGE : AA314_03321 AA314_03322
PSYH : D0S48_01685 D0S48_08230
FWA : DCMF_12670 DCMF_25910
SAP : Sulac_2018 Sulac_2425
MAVI : RC58_02620 RC58_20345
MSA : Mycsm_00543 Mycsm_01319
MYV : G155_25745 G155_27815
MDX : BTO20_04985 BTO20_26465
MGRO : FZ046_09615(mshA) FZ046_09880
MNV : MNVI_22920(mshA) MNVI_32350
MNM : MNVM_13460(mshA) MNVM_29870
MBAI : MB901379_00694(mshA_1)
MHEK : JMUB5695_04173(mshA)
MKY : IWGMT90018_08150(mshA)
MCB : Mycch_0600 Mycch_2704
MFT : XA26_52200(mshA) XA26_56210
MPHL : MPHLCCUG_04512(mshA_2)
MTHN : 4412656_00583(mshA_1) 4412656_01154(mshA_2)
MDR : MDOR_03380(mshA) MDOR_08660
MAUU : NCTC10437_00686(mshA_2)
MMAG : MMAD_08500(mshA) MMAD_10440
MAIC : MAIC_12770 MAIC_30220 MAIC_48880(mshA)
MPSC : MPSYJ_02550(mshA) MPSYJ_37230 MPSYJ_37250
MARZ : MARA_30720 MARA_30760 MARA_31450(mshA)
MANY : MANY_47120(mshA) MANY_52350
MPOF : MPOR_11710(mshA) MPOR_32860
MMAT : MMAGJ_38150(mshA) MMAGJ_46920
MFG : K6L26_23555 K6L26_26935(mshA)
MFLV : NCTC10271_03900(mshA_1) NCTC10271_04486(mshA_2)
MCEE : MCEL_20710 MCEL_27120(mshA)
MMON : EWR22_03460(mshA) EWR22_06775
MGO : AFA91_00610 AFA91_30100
MHOL : K3U96_19680 K3U96_23155(mshA)
MSEN : K3U95_04620(mshA) K3U95_20745
MSAL : DSM43276_02013 DSM43276_03879(mshA)
MJD : JDM601_0475 JDM601_3079
MTER : 4434518_00470(mshA_1) 4434518_03068(mshA_2)
MHIB : MHIB_25100 MHIB_39990(mshA)
MHER : K3U94_02760(mshA) K3U94_17420
MVM : MJO54_02770(mshA) MJO54_17505
CDIP : ERS451417_00310(mshA)
COI : CPCIP5297_01380(mshA)
CUN : Cul210932_0316(mshA)
CUQ : Cul210931_0304(mshA)
CUJ : CUL131002_0302(mshA)
CHN : A605_01970 A605_05510
CMIN : NCTC10288_02245(mshA)
CRL : NCTC7448_01129(mshA_2)
CCYS : SAMEA4530656_2186(mshA_2)
NFA : NFA_23980 NFA_51920(mshA)
NFR : ERS450000_01702(mshA_2) ERS450000_04691(mshA_3)
NAD : NCTC11293_00121(mshA_1)
NWL : NWFMUON74_43720 NWFMUON74_66080(mshA)
NSPU : IFM12276_57710(mshA)
RER : RER_15810 RER_16170(mshA)
REB : XU06_07765 XU06_07960
RQI : C1M55_08015 C1M55_08190(mshA)
ROP : ROP_17450(mshA) ROP_18330
ROA : Pd630_LPD06250 Pd630_LPD06293
RAV : AAT18_19425 AAT18_23145
RFA : A3L23_00964(mshA_1) A3L23_02775(mshA_3)
RHS : A3Q41_00585(mshA_1) A3Q41_02388(mshA_3)
RHW : BFN03_12755 BFN03_12910
RHOD : AOT96_18390 AOT96_18565
RRT : 4535765_03708(mshA_1)
RCR : NCTC10994_03552(mshA_3)
RTM : G4H71_15115 G4H71_15465(mshA)
RANT : RHODO2019_01600(mshA)
TPUL : TPB0596_06290(mshA)
DIT : C3V38_01770 C3V38_03185(mshA)
SCO : SCO4204(2SCD46.18) SCO6185(SC2G5.06)
SHO : SHJGH_2019 SHJGH_4651
STRP : F750_1038 F750_3943(mshA)
SCI : B446_01245 B446_04870 B446_17845 B446_34050
SLV : SLIV_07210 SLIV_17355(mshA)
SCW : TU94_17975 TU94_26545
STRM : M444_00445 M444_16420
SAMB : SAM23877_3492(mshA) SAM23877_5916
SPRI : SPRI_1885 SPRI_4052
SCX : AS200_24960 AS200_42265
SRW : TUE45_01023(mshA_2) TUE45_04740(mshA_4)
STRF : ASR50_04035 ASR50_18260
SLE : sle_14930(sle_14930) sle_38490(sle_38490)
SRN : A4G23_00217(mshA_1) A4G23_02492(mshA_4)
STRT : A8713_14220 A8713_25755
STSI : A4E84_01850 A4E84_18365
SGM : GCM10017557_15200 GCM10017557_38500(mshA)
SPHW : NFX46_24620 NFX46_38195(mshA)
STRD : NI25_08455 NI25_21375
SSIA : A7J05_08155 A7J05_19405
SLX : SLAV_09105(mshA1) SLAV_17730(mshA2)
SGE : DWG14_00393(mshA_1) DWG14_04601(mshA_3)
SGD : ELQ87_20915(mshA) ELQ87_38410
SCYA : EJ357_07030 EJ357_21025(mshA)
SAST : CD934_01770 CD934_05570 CD934_13655(mshA)
SHAW : CEB94_02325 CEB94_18825(mshA)
SFIC : EIZ62_17745(mshA) EIZ62_30455
SBY : H7H31_05975 H7H31_19580
SRIM : CP984_08365 CP984_16360(mshA)
SSUB : CP968_02050 CP968_18445(mshA)
SCIN : CP977_01795 CP977_19015(mshA)
SFUG : CNQ36_15890(mshA) CNQ36_32400
SPAC : B1H29_07465 B1H29_20235
SCHA : CP983_23180(mshA) CP983_39665(mshA)
SGX : H4W23_21905(mshA) H4W23_22735
SCOE : CP976_20300(mshA) CP976_34435 CP976_40815
STUI : GCM10017668_31870(mshA) GCM10017668_56740
SHUN : DWB77_03632(mshA_1)
SFEU : IM697_03180(mshA) IM697_16445(mshA)
SDD : D9753_19245(mshA) D9753_32765
SACT : DMT42_18020(mshA) DMT42_30455
SGOB : test1122_07615 test1122_10690(mshA)
SRUG : F0345_15825(mshA) F0345_26105
STAA : LDH80_18005(mshA) LDH80_18665(mshA)
SCAE : IHE65_02280(mshA) IHE65_24480(mshA)
SXT : KPP03845_104150(mshA_3)
SDRZ : NEH16_01930 NEH16_14485(mshA)
SARG : HKX69_18795 HKX69_31740
SCY : SCATT_24860 SCATT_51370
KIT : CFP65_0979 CFP65_3319 CFP65_6027
STRI : C7M71_013285(mshA) C7M71_018220 C7M71_027475
CMH : VO01_13815 VO01_15230
CCAP : AES38_12965 AES38_14415
RTC : APU90_02210 APU90_06955
RTN : A6122_0944 A6122_2392
RIA : C7V51_01390 C7V51_14990
RFS : C1I64_10190 C1I64_12780 C1I64_18660
RTE : GSU10_02680 GSU10_05315
CART : PA27867_2304 PA27867_3163
MANT : BHD05_07725 BHD05_07870 BHD05_11795
ARR : ARUE_c01120 ARUE_c30420
ARZ : AUT26_00460 AUT26_14195
ARQ : BWQ92_08075 BWQ92_16875
ARN : CGK93_00775 CGK93_16520(mshA)
ARX : ARZXY2_3799 ARZXY2_789(mshA)
ACRY : AC20117_03440 AC20117_18480
ARTH : C3B78_02145 C3B78_13905(mshA)
AAGI : NCTC2676_1_01798(mshA_4) NCTC2676_1_03036(mshA_5)
ASUF : MNQ99_03345 MNQ99_10650(mshA)
AOD : Q8Z05_01360(mshA) Q8Z05_09850
PUE : FV140_00450 FV140_15790(mshA)
APN : Asphe3_04630 Asphe3_27440
PSNI : NIBR502771_02835 NIBR502771_11220(mshA)
PDEL : JCQ34_02025 JCQ34_13190(mshA)
GCR : GcLGCM259_1393 GcLGCM259_2538
KVR : CIB50_0000024(mshA_1)
SATK : SA2016_0690 SA2016_2813
YIM : J5M86_03755 J5M86_12460(mshA)
XYL : ET495_10525 ET495_10845(mshA) ET495_12880
XYA : ET471_03295(mshA) ET471_05180
CELZ : E5225_05835 E5225_14605
ORN : DV701_08505(mshA) DV701_09985
DCO : SAMEA4475696_0882(mshA)
PAUS : NCTC13651_00188(mshA)
TEZ : BKM78_08945 BKM78_09500
TLA : TLA_TLA_01804(mshA_1) TLA_TLA_01919(mshA_2)
RAIN : Rai3103_12345 Rai3103_14195
NBE : Back2_09760 Back2_13320(mshA)
NAQU : ENKNEFLB_00888(mshA_1)
MGG : MPLG2_0103 MPLG2_3560(mshA)
MUZ : H4N58_02805(mshA) H4N58_15680
AGRA : AGRA3207_005269(mshA)
NOW : GBF35_04135(mshA) GBF35_30330 GBF35_32280
FRE : Franean1_0851 Franean1_5882 Franean1_6162 Franean1_6548 Franean1_6549
FSY : FsymDg_1059 FsymDg_4081
FRI : FraEuI1c_6082 FraEuI1c_6341
AMQ : AMETH_0128 AMETH_0421
AMYC : CU254_01010(mshA) CU254_17790
AMYB : BKN51_07955 BKN51_34605 BKN51_36475
AORI : SD37_16280 SD37_38940
PHH : AFB00_01985 AFB00_14135
SESP : BN6_81180(gtuS4-21)
SSYI : EKG83_00295 EKG83_44765(mshA)
KBU : Q4V64_23780(mshA) Q4V64_41275
LED : BBK82_16700 BBK82_42565
ACTI : UA75_02230 UA75_10355 UA75_16430
ACAD : UA74_02220 UA74_05080 UA74_10385
AHG : AHOG_02170(mshA1) AHOG_09725(mshA2)
PMAD : BAY61_01880 BAY61_08260
ACTU : Actkin_06095(mshA_3)
STP : Strop_0331 Strop_1762 Strop_3722
MAU : Micau_5263 Micau_5680
MICB : MicB006_1730 MicB006_4277 MicB006_5122
MTUA : CSH63_28930(mshA) CSH63_31095
MICH : FJK98_09630 FJK98_10425 FJK98_27485 FJK98_29570(mshA)
MTEM : GCE86_05480 GCE86_20925 GCE86_23020(mshA)
MCAB : HXZ27_10625 HXZ27_11530 HXZ27_26425 HXZ27_28380(mshA)
MSAG : GCM10017556_15180 GCM10017556_19330(mshA) GCM10017556_43340 GCM10017556_45680
VMA : VAB18032_00060 VAB18032_01930 VAB18032_14340
MCRA : ID554_02665 ID554_09675 ID554_18340(mshA) ID554_20185
VER : HUT12_10460 HUT12_27345 HUT12_29495(mshA)
MENO : Jiend_34430(mshA) Jiend_38440
MCHL : PVK74_16545 PVK74_18545(mshA)
MFEU : H1D33_01795 H1D33_04310(mshA)
MPRN : Q3V37_09605(mshA) Q3V37_11610
MHAW : RMN56_14415(mshA) RMN56_16555
ASE : ACPL_2650 ACPL_6582 ACPL_7885
AMS : AMIS_50140 AMIS_63450 AMIS_76040(mshA)
ACTN : L083_4595 L083_6112 L083_7672
ACTS : ACWT_2896 ACWT_6451 ACWT_7754
ACTR : Asp14428_53180(mshA)
PLK : CIK06_10850 CIK06_26200(mshA)
PLAB : C6361_00275 C6361_11465(mshA) C6361_14520
PLAT : C6W10_08560(mshA) C6W10_10635 C6W10_21375
PFLA : Pflav_040290 Pflav_065820(mshA)
PSUU : Psuf_007810 Psuf_027800(mshA) Psuf_075450
PRY : Prubr_31560(mshA) Prubr_35420 Prubr_48060 Prubr_56830 Prubr_58330
CATI : CS0771_08970(mshA) CS0771_59910
CAI : Caci_5074 Caci_6395 Caci_7644 Caci_8224
ACTT : DDD63_00520 DDD63_00525
AVC : NCTC10951_00265(mshA_1)
ABAM : B1s21122_05810(mshA)
EKE : EK0264_15050 EK0264_19155
AQZ : KSP35_06620 KSP35_17465
DHI : LH044_08105 LH044_11680
CMP : Cha6605_0855 Cha6605_0857 Cha6605_5458
CYN : Cyan7425_1751 Cyan7425_2924
CEP : Cri9333_3742 Cri9333_4344
LEN : LEP3755_01000 LEP3755_07970 LEP3755_28800 LEP3755_56810
LET : O77CONTIG1_02192(mshA_1) O77CONTIG1_03884(mshA_7)
LBO : LBWT_24300 LBWT_5330
THEU : HPC62_13675 HPC62_22375
GLP : Glo7428_1199 Glo7428_3980
HAO : PCC7418_1738 PCC7418_2984
CYC : PCC7424_1935 PCC7424_3257
CYJ : Cyan7822_0598 Cyan7822_0795
OXY : HCG48_00920 HCG48_16470 HCG48_21320
OAC : Oscil6304_0821 Oscil6304_2012 Oscil6304_2973
MIC : Mic7113_0204 Mic7113_1043 Mic7113_5881 Mic7113_5916
GLJ : GKIL_0944(gmhA) GKIL_4105(mshA)
NON : NOS3756_22520 NOS3756_39620
NED : HUN01_30795 HUN01_32560 HUN01_33275
ANN : EH233_06180 EH233_24450
CALO : Cal7507_5994 Cal7507_6027
NSPH : BDGGKGIB_00910(mshA_2)
NCN : BZZ01_18090 BZZ01_29935
CTHE : Chro_2260 Chro_2932
PLP : Ple7327_1732 Ple7327_3145 Ple7327_3305
SCS : Sta7437_0828 Sta7437_0877
STAN : STA3757_05160 STA3757_10340
DEB : DehaBAV1_0142 DehaBAV1_0890
DMY : X793_00980 X793_04740
DUC : UCH007_02410 UCH007_08380
KBS : EPA93_20945 EPA93_21710
ULI : ETAA1_07230(mshA_3) ETAA1_63180(mshA_9)
AGV : OJF2_28890(cotSA_2) OJF2_33150(mshA_4)
» show all
Taxonomy
Reference
Authors
Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y
Title
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA).
Journal
Sequence
Reference
Authors
Newton GL, Ta P, Bzymek KP, Fahey RC
Title
Biochemistry of the initial steps of mycothiol biosynthesis.
Journal
Sequence
Reference
Authors
Vetting MW, Frantom PA, Blanchard JS
Title
Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.250