KEGG   ENZYME: 2.4.1.252Help
Entry
EC 2.4.1.252                Enzyme                                 

Name
GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase;
GumH;
AceA;
alpha1,3-mannosyltransferase AceA
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [RN:R09733]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:C00096];
D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [CPD:C19856]
Product
GDP [CPD:C00035];
D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [CPD:C19855]
Comment
In the bacterium Gluconacetobacter xylinus (previously known as Acetobacter xylinum) the enzyme is involved in the biosynthesis of the exopolysaccharide acetan [1]. In Xanthomonas campestris the enzyme is involved in the biosynthesis of the exopolysaccharide xanthan [5].
History
EC 2.4.1.252 created 2011
Orthology
K13657  alpha-1,3-mannosyltransferase
Genes
XFA: XF_2364
XFT: PD_1391(gumH)
XFM: Xfasm12_1533
XFN: XfasM23_1477
XFF: XFLM_01095
XFL: P303_06670
XFS: D934_11050
XFH: XFHB_03280
XCC: XCC2448(gumH)
XCB: XC_1664
XCA: xcc-b100_1718(gumH)
XCP: XCR_2761(gumH)
XCV: XCV2781(gumH)
XAX: XACM_2561(gumH)
XAC: XAC2579(gumH)
XCI: XCAW_02260(gumH)
XFU: XFF4834R_chr26160(gumH)
XOO: XOO3173(gumH)
XOM: XOO3013(XOO3013)
XOP: PXO_01398(gumH)
XOR: XOC_1873(gumH)
XPH: XppCFBP6546_19500(XppCFBP6546P_19500)
PSD: DSC_06245
CJA: CJA_0620(gt4J-2)
CFU: CFU_2732(gumH)
CARE: LT85_2940(gumH)
AZO: azo2237(gumH)
AOA: dqs_2370
RET: RHE_CH04050(aceC)
REC: RHECIAT_CH0004338(aceC)
MAQU: Maq22A_1p38155(rfaG)
MCG: GL4_0201
SJP: SJA_C2-01960(gumH)
GDI: GDI2550(gumH)
GDJ: Gdia_0789
GXY: GLX_27840
GXL: H845_825
KEU: S101446_03152(gumH)
 » show all
Taxonomy
Reference
1  [PMID:10485283]
  Authors
Geremia RA, Roux M, Ferreiro DU, Dauphin-Dubois R, Lellouch AC, Ielpi L
  Title
Expression and biochemical characterisation of recombinant AceA, a bacterial alpha-mannosyltransferase.
  Journal
Mol Gen Genet 261:933-40 (1999)
  Sequence
[gxl:H845_825]
Reference
2  [PMID:11001941]
  Authors
Abdian PL, Lellouch AC, Gautier C, Ielpi L, Geremia RA
  Title
Identification of essential amino acids in the bacterial alpha -mannosyltransferase aceA.
  Journal
J Biol Chem 275:40568-75 (2000)
DOI:10.1074/jbc.M007496200
  Sequence
[gxl:H845_825]
Reference
3  [PMID:8759843]
  Authors
Petroni EA, Ielpi L
  Title
Isolation and nucleotide sequence of the GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase gene from Acetobacter xylinum.
  Journal
J Bacteriol 178:4814-21 (1996)
DOI:10.1128/JB.178.16.4814-4821.1996
  Sequence
[gxl:H845_825]
Reference
4  [PMID:10872841]
  Authors
Lellouch AC, Watt GM, Geremia RA, Flitsch SL
  Title
Phytanyl-pyrophosphate-linked substrate for a bacterial alpha-mannosyltransferase.
  Journal
Biochem Biophys Res Commun 272:290-2 (2000)
DOI:10.1006/bbrc.2000.2771
Reference
5  [PMID:9537354]
  Authors
Katzen F, Ferreiro DU, Oddo CG, Ielmini MV, Becker A, Puhler A, Ielpi L
  Title
Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence.
  Journal
J Bacteriol 180:1607-17 (1998)
  Sequence
[xcc:XCC2448]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.252
IUBMB Enzyme Nomenclature: 2.4.1.252
ExPASy - ENZYME nomenclature database: 2.4.1.252
BRENDA, the Enzyme Database: 2.4.1.252

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