KEGG   ENZYME: 2.4.1.255
Entry
EC 2.4.1.255                Enzyme                                 

Name
protein O-GlcNAc transferase;
O-GlcNAc transferase;
OGTase;
O-linked N-acetylglucosaminyltransferase;
uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase;
protein O-linked beta-N-acetylglucosamine transferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-alpha-acetyl-D-glucosamine:[protein]-3-O-N-acetyl-beta-D-glucosaminyl transferase
Reaction(IUBMB)
(1) UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine [RN:R09304 R09676];
(2) UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine [RN:R09677]
Reaction(KEGG)
R09304(G) R09676 R09677
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
[protein]-L-serine [CPD:C02189];
[protein]-L-threonine [CPD:C19803]
Product
UDP [CPD:C00015];
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine [CPD:C19802];
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine [CPD:C19804]
Comment
Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins.
History
EC 2.4.1.255 created 2011
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K09667  protein O-GlcNAc transferase
K18134  EGF domain-specific O-GlcNAc transferase
Genes
HSA: 285203(EOGT) 8473(OGT)
PTR: 465702(OGT) 494220(EOGT)
PPS: 100970968(EOGT) 100989146(OGT)
GGO: 101130943(EOGT) 101140533(OGT)
PON: 100440288(EOGT)
NLE: 100591966(OGT) 100597324(EOGT)
MCC: 696742(EOGT) 698268(OGT)
MCF: 101866582(OGT) 102115709(EOGT)
CSAB: 103227871(EOGT) 103232164(OGT)
CATY: 105585669(EOGT) 105586111(OGT)
PANU: 101012718(OGT) 101016739(EOGT)
RRO: 104664903(OGT) 104677919(EOGT)
RBB: 108520117(EOGT) 108527587(OGT)
TFN: 117077238(OGT) 117083114(EOGT)
PTEH: 111533476(EOGT) 111535675(OGT)
CJC: 100386886(OGT) 100390811(EOGT)
SBQ: 101045971(OGT) 101048286(EOGT)
MMUR: 105855308(OGT) 105857800(EOGT)
MMU: 101351(Eogt) 108155(Ogt)
MCAL: 110286164(Ogt) 110295728(Eogt)
MPAH: 110313595(Ogt) 110316878(Eogt)
RNO: 26295(Ogt) 494219(Eogt)
MCOC: 116087255(Ogt) 116099312(Eogt)
MUN: 110540923(Ogt) 110551653(Eogt)
CGE: 100757071(Eogt) 100768670(Ogt)
PLEU: 114681773(Eogt) 114686372 114708645(Ogt)
NGI: 103729142(Eogt) 103751946(Ogt)
HGL: 101710902 101715607(Eogt) 101721730(Ogt)
CCAN: 109691372(Eogt) 109699231(Ogt)
OCU: 100342123(EOGT) 100354727(OGT)
TUP: 102479359(OGT) 102499112(EOGT)
CFA: 480955(OGT) 494221(EOGT)
VVP: 112907620(OGT) 112909151(EOGT)
VLG: 121482787(OGT) 121494734(EOGT)
AML: 100475282(OGT) 100479105(EOGT)
UMR: 103674238(EOGT) 103682584(OGT)
UAH: 113245624(OGT) 113257067(EOGT)
ORO: 101369290(OGT) 101370331(EOGT)
MPUF: 101678699(EOGT) 101686183(OGT)
EJU: 114202321(OGT) 114214651(EOGT)
MLX: 118004860(EOGT) 118026025(OGT)
FCA: 101089680(EOGT) 101094162(OGT)
PYU: 121016738(EOGT)
PTG: 102959921(EOGT) 102964072(OGT)
PPAD: 109254620(OGT) 109279033(EOGT)
AJU: 106975137(EOGT) 106982362(OGT)
HHV: 120242887(EOGT) 120246039(OGT)
BTA: 508782(EOGT) 532053(OGT)
BOM: 102279900(EOGT) 102286677(OGT)
BIU: 109555132 109576379(EOGT)
BBUB: 102397041(OGT) 102414295(EOGT)
CHX: 102176741(EOGT) 102187305(OGT)
OAS: 101106996(OGT) 101117114(EOGT)
ODA: 120868409(EOGT) 120881991(OGT)
CCAD: 122425130(EOGT) 122434635(OGT)
SSC: 100155485(EOGT) 664652(OGT)
CFR: 102516733(OGT) 102521209(EOGT)
CBAI: 105066587(EOGT) 105083681(OGT)
CDK: 105087990(OGT) 105095255(EOGT)
BACU: 103018912(EOGT) 103019745 103020800(OGT)
LVE: 103071794(EOGT) 103073601(OGT)
OOR: 101276173(EOGT) 101282914(OGT)
DLE: 111167771(OGT) 111174202(EOGT)
ECB: 100053493(EOGT) 100056148(OGT)
EPZ: 103542615(OGT) 103550858(EOGT)
EAI: 106827921(EOGT) 106828870(OGT)
MYB: 102245549(OGT) 102247874(EOGT)
MYD: 102751826(EOGT) 102773180(OGT)
MMYO: 118653673(OGT) 118667903(EOGT)
MNA: 107530428(EOGT) 107532885(OGT)
HAI: 109385597(OGT) 109392531(EOGT)
DRO: 112300108(OGT) 112301247(EOGT)
SHON: 118983428(EOGT) 118994977(OGT)
AJM: 119035393(OGT) 119038283(EOGT)
MMF: 118617510 118633463(EOGT) 118636576(OGT)
PALE: 102879009(EOGT) 102890872(OGT)
PGIG: 120585395(OGT) 120593712(EOGT)
RAY: 107497451(EOGT) 107513897(OGT)
MJV: 108395819(EOGT) 108396625(OGT)
TOD: 119230907(EOGT) 119246084(OGT)
LAV: 100662852(OGT) 100671086(EOGT)
MDO: 100011073(OGT) 100618477(EOGT)
SHR: 100929019(OGT) 100931735(EOGT)
PCW: 110201103(OGT) 110222535(EOGT)
OAA: 100078373(EOGT) 103169766(OGT)
GGA: 422203(OGT) 426961(EOGT)
PCOC: 116229585(OGT) 116237062(EOGT)
MGP: 100538830(OGT) 100550764(EOGT)
CJO: 107312490(OGT) 107319994(EOGT)
NMEL: 110403357(OGT) 110404631(EOGT)
APLA: 101796788(EOGT) 101799851(OGT)
ACYG: 106035493(EOGT) 106037709(OGT)
TGU: 100224237(OGT) 100225538(EOGT)
LSR: 110472655(OGT) 110482002(EOGT)
SCAN: 103817084(EOGT) 103824224(OGT)
PMOA: 120495619(EOGT) 120506181(OGT)
GFR: 102042181(EOGT) 102044727(OGT)
FAB: 101808611(OGT) 101809614(EOGT)
PHI: 102112943(OGT) 102113990(EOGT)
PMAJ: 107203795(OGT) 107210283(EOGT)
CCAE: 111929384(OGT) 111934977(EOGT)
CCW: 104683359(EOGT) 104691638(OGT)
ETL: 114063090(EOGT) 114066210(OGT)
FPG: 101915918(OGT) 101923329(EOGT)
FCH: 102050428(EOGT) 102052264(OGT)
CLV: 102092523(OGT) 102092951(EOGT)
EGZ: 104124274(OGT) 104132663(EOGT)
NNI: 104012908(OGT) 104016922(EOGT)
ACUN: 113479886(OGT) 113484949(EOGT)
PADL: 103921788(EOGT) 103923339(OGT)
AAM: 106482679(OGT) 106494570(EOGT)
NPD: 112948669(OGT) 112958676(EOGT)
ASN: 102381905(EOGT) 102387350(OGT)
AMJ: 102575029(OGT) 102576718(EOGT)
CPOO: 109310957(OGT) 109311186(EOGT)
GGN: 109288985(EOGT) 109300549(OGT)
PSS: 102445994(OGT) 102448245(EOGT)
CMY: 102932353(OGT) 102946700(EOGT)
CPIC: 101937402(OGT) 101947597(EOGT)
TST: 117880423(EOGT) 117882853(OGT)
CABI: 116820412(EOGT) 116832838(OGT)
ACS: 100554805(eogt) 100561277(ogt)
PVT: 110080200(OGT) 110083322(EOGT)
PBI: 103048321(EOGT) 103059316(OGT)
PMUR: 107302642(EOGT) 107303237(OGT)
TSR: 106552555(OGT) 106553479(EOGT)
PGUT: 117679014(EOGT) 117679618(OGT)
PMUA: 114588797(OGT) 114591850(EOGT)
GJA: 107108561(OGT) 107121813(EOGT)
XLA: 443983(eogt.L) 447694(ogt.L)
XTR: 553157(ogt) 780148(eogt)
NPR: 108786181(EOGT) 108802573(OGT)
DRE: 337685(ogt.1) 652952(ogt.2) 798087(eogt)
SANH: 107663079(ogt) 107688794 107696816(eogt)
IPU: 108254783(eogt) 108268666(ogt)
PHYP: 113539733(eogt) 113542871(ogt)
AMEX: 103028765(ogt) 103044264(eogt)
EEE: 113576512(ogt) 113580746(eogt)
TRU: 101076057(ogt) 777950(eogt)
LCO: 104923189(ogt) 104933151(eogt)
NCC: 104944985 104952211(ogt)
CGOB: 115008895(eogt) 115014345(ogt)
ELY: 117256414(eogt) 117261344(ogt.1)
PLEP: 121948206(ogt.1) 121957264(eogt)
SLUC: 116035165(eogt) 116064459(ogt.1)
ECRA: 117943838(eogt) 117951278(ogt.1)
PFLV: 114554696(eogt) 114562335(ogt)
GAT: 120818201(ogt.1) 120835659(eogt)
MSAM: 119886715(eogt) 119889177(ogt.1) 119914073
CUD: 121516702(ogt.1) 121527996(eogt)
MZE: 101479094(ogt) 101484112(eogt)
ONL: 100697871(ogt) 100707880(eogt)
OAU: 116324555(ogt.1) 116330146(eogt)
OLA: 101164571(ogt) 101170339(eogt)
OML: 112145214(eogt) 112153091(ogt.1)
XMA: 102227742(ogt) 102236401(eogt)
XCO: 114136179(eogt) 114139527(ogt)
XHE: 116710007(eogt) 116714753(ogt)
PRET: 103465051(eogt) 103471170(ogt)
CVG: 107089044(ogt) 107091495(eogt)
CTUL: 119787775 119792481(ogt.1)
NFU: 107385431(eogt) 107395869(ogt)
KMR: 108240572(ogt.1) 108244079(eogt)
ALIM: 106515959(ogt) 106518517(eogt)
AOCE: 111565562(ogt) 111588777(eogt)
CSEM: 103386183(eogt) 103391144(ogt)
POV: 109626074(ogt) 109629413(eogt)
LCF: 108882891(ogt) 108885653(eogt)
SDU: 111221765(eogt) 111226555(ogt)
SLAL: 111652072(ogt) 111670901(eogt)
XGL: 120783495(eogt) 120785102(ogt.1)
HCQ: 109509878(eogt) 109515817(ogt)
BPEC: 110163678(ogt) 110165803(eogt)
MALB: 109956143(eogt) 109968379(ogt)
OMY: 110489148 110494507(eogt) 110504566(ogt.1)
SALP: 111968556(eogt) 111970572 112069184(ogt)
ELS: 105017304(eogt) 105025795(ogt)
PKI: 111834588(eogt) 111843708(ogt)
AANG: 118211084(eogt) 118222756(ogt.1)
LOC: 102685520(eogt) 102690404(ogt)
LCM: 102352761(EOGT) 102361281(OGT)
CMK: 103179783(eogt) 103189357(ogt)
RTP: 109933608(eogt) 109935524(ogt) 109936141
DME: Dmel_CG10392(sxc) Dmel_CG9867(Eogt)
DSI: Dsimw501_GD17889(Dsim_GD17889) Dsimw501_GD23152(Dsim_GD23152) Dsimw501_GD28381(Dsim_GD28381)
NVI: 100114611 100116809(Ogt)
SDM: 118204044
CEL: CELE_H12D21.10(H12D21.10) CELE_K04G7.3(ogt-1)
CBR: CBG11610 CBG16605(Cbr-ogt-1)
BMY: BM_BM4640(Bm4640) BM_BM4815(Bma-ogt-1)
EGL: EGR_08361
HMG: 100201589
ATH: AT3G04240(SEC) AT3G11540(SPY)
LJA: Lj5g3v0803050.1(Lj5g3v0803050.1) Lj5g3v1303350.1(Lj5g3v1303350.1) Lj5g3v1303350.2(Lj5g3v1303350.2)
JCU: 105635885
DOSA: Os02t0489550-00(Os02g0489550) Os08t0559300-01(Os08g0559300)
ZMA: 100191509(pco141552) 100381672(cl27878_1(278))
MNG: MNEG_0970
DDI: DDB_G0285263(spyA)
DFA: DFA_05779(spyA)
CPV: cgd1_1300
SMIN: v1.2.002533.t1(symbB.v1.2.002533.t1) v1.2.015572.t2(symbB.v1.2.015572.t2) v1.2.023338.t1(symbB.v1.2.023338.t1)
DKO: I596_1643
VAQ: FIV01_02260(yrrB)
MCA: MCA1509
AEH: Mlg_0699
CSA: Csal_1986
APAC: S7S_17190
SLIM: SCL_1574
SVA: SVA_1487
SALN: SALB1_1846
TBN: TBH_C0586
RSY: RSUY_33650(yrrB_2)
BGO: BM43_4753
BFN: OI25_2230
PNU: Pnuc_1827
BPT: Bpet3016
ODI: ODI_R2116
VEI: Veis_4399
DAC: Daci_0605
CTES: O987_02360
JAG: GJA_1948
CFU: CFU_3581
LCH: Lcho_1753
TIN: Tint_0323
THI: THI_0359
MMB: Mmol_0910
MEH: M301_0992
MEP: MPQ_2726
URU: DSM104443_01850(bepA_6)
ABRE: pbN1_23980
DAR: Daro_0785
TCL: Tchl_0404
GEO: Geob_0648
PPD: Ppro_3331
DPI: BN4_12635
DBA: Dbac_1874
DOL: Dole_1087
SCL: sce6916
RPE: RPE_2672
MDI: METDI3576
MEX: Mext_2809
MCH: Mchl_3037
MPO: Mpop_3854
META: Y590_13555
BID: Bind_0441
HDN: Hden_1151
ALB: AEB_P2985
ACR: Acry_0103
TXI: TH3_07240
PUF: UFO1_2904
PFT: JBW_01759
PMT: PMT_1811
AMR: AM1_1237
MPK: VL20_2464
CYT: cce_2852
CALH: IJ00_20345
TTR: Tter_2822
PUV: PUV_15350
OTE: Oter_0461
PIR: VN12_00870(yrrB_1) VN12_15170
RUL: UC8_02840
GMR: GmarT_02750(yrrB_1)
GPN: Pan110_03210(yrrB_1)
SDYN: Mal52_14920(yrrB_1) Mal52_29660(yrrB_3) Mal52_29670(yrrB_4) Mal52_29680 Mal52_61190(yrrB_8) Mal52_61200(yrrB_9) Mal52_61210(yrrB_10) Mal52_61220(yrrB_11) Mal52_61230(yrrB_12)
PLON: Pla110_27810(yrrB_4)
GES: VT84_38485(yrrB_3)
FTJ: FTUN_7357
ULI: ETAA1_31420(yrrB)
IPA: Isop_0879
AGV: OJF2_07990(yrrB_1) OJF2_10470 OJF2_62140(yrrB_8)
KST: KSMBR1_3635(rfe_5)
BIP: Bint_0207
ABAC: LuPra_02590(yrrB_3)
THYD: TTHT_0729
CCH: Cag_0732
PPH: Ppha_0641
 » show all
Reference
1  [PMID:18948359]
  Authors
Banerjee S, Robbins PW, Samuelson J
  Title
Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum.
  Journal
Glycobiology 19:331-6 (2009)
DOI:10.1093/glycob/cwn107
  Sequence
Reference
2  [PMID:18818698]
  Authors
Clarke AJ, Hurtado-Guerrero R, Pathak S, Schuttelkopf AW, Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM
  Title
Structural insights into mechanism and specificity of O-GlcNAc transferase.
  Journal
EMBO J 27:2780-8 (2008)
DOI:10.1038/emboj.2008.186
Reference
3  [PMID:16541109]
  Authors
Rao FV, Dorfmueller HC, Villa F, Allwood M, Eggleston IM, van Aalten DM
  Title
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.
  Journal
EMBO J 25:1569-78 (2006)
DOI:10.1038/sj.emboj.7601026
Reference
4  [PMID:1533623]
  Authors
Haltiwanger RS, Blomberg MA, Hart GW
  Title
Glycosylation of nuclear and cytoplasmic proteins. Purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase.
  Journal
J Biol Chem 267:9005-13 (1992)
Reference
5  [PMID:9083068]
  Authors
Lubas WA, Frank DW, Krause M, Hanover JA
  Title
O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats.
  Journal
J Biol Chem 272:9316-24 (1997)
DOI:10.1074/jbc.272.14.9316
  Sequence
[cel:CELE_K04G7.3] [hsa:8473]
Reference
6  [PMID:21240259]
  Authors
Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S
  Title
Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
  Journal
Nature 469:564-7 (2011)
DOI:10.1038/nature09638
  Sequence
[hsa:8473]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.255
IUBMB Enzyme Nomenclature: 2.4.1.255
ExPASy - ENZYME nomenclature database: 2.4.1.255
BRENDA, the Enzyme Database: 2.4.1.255

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