Entry
Name
dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase;
ALG10;
Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase;
dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dolichyl beta-D-glucosyl-phosphate:alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol alpha-1,2-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol [RN:
R06264 ]
Reaction(KEGG)
Substrate
dolichyl beta-D-glucosyl phosphate [CPD:
C01246 ];
alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
dolichyl phosphate [CPD:
C00110 ];
alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Comment
This eukaryotic enzyme performs the final step in the synthesis of the lipid-linked oligosaccharide, attaching D-glucose in an alpha-1,2-linkage to the outermost D-glucose in the long branch. The lipid-linked oligosaccharide is involved in N-linked protein glycosylation of selected asparagine residues of nascent polypeptide chains in eukaryotic cells.
History
EC 2.4.1.256 created 2011, modified 2012
Pathway
Orthology
K03850 alpha-1,2-glucosyltransferase
Genes
HSA : 144245(ALG10B) 84920(ALG10)
PTR : 451831(ALG10B) 735940(ALG10)
PPS : 100971669 103784887(ALG10B)
GGO : 101124291(ALG10B) 115930196(ALG10)
PON : 100459566(ALG10) 100462149(ALG10B)
PPYG : 129010277 129010447
HMH : 116472820(ALG10) 116481059(ALG10B)
SSYN : 129465464 129483164
XLA : 108711169(alg10.L) 432047(alg10.S)
SANH : 107666210 107689747
CCAR : 109069232 109072923
CAUA : 113057842 113098992
CGIB : 127956946 127972635
BPEC : 110161661 110173956
SASA : 106575988 106609113
STRU : 115179977 115198651(alg10)
OTW : 112214420 112216782(alg10)
OMY : 110490168(alg10) 110500280
OGO : 123994723(alg10) 124014144
OKE : 118366139(alg10) 118392261
SALP : 111951196 111951453
SNH : 120031965(alg10) 120049317
CCLU : 121555067 121581592
PSPA : 121318335 121319760
ARUT : 117415264(alg10) 117419566
DSI : Dsimw501_GD14291(Dsim_GD14291)
AALB : 109401118 115260171
BCOO : 119074883 119084462
PPOI : 119089901 119090622
CEL : CELE_T24D1.4(algn-10)
CBR : CBG_03825(Cbr-tag-179)
RPHI : 132752071 132753510
CSAT : 104708910 104734248 104768404
BNA : 106433531 106433532 106448826 106448834 125599921
PCIN : 129288042 129296220
MSYL : 126593576 126620252
NTA : 107796503 107825705 107826089
SSPL : 121795412 121798956
MING : 122067477 122082087
PSOM : 113309673 113344964
TAES : 123045956 123053822 123189691
PVIR : 120642432 120681852
PAUA : 133888456 133925538
NCOL : 116254944 116268050
SMO : SELMODRAFT_96516(GT59A1)
CGR : 2890660(GVI51_L06435)
NCS : NCAS_0F00630(NCAS0F00630)
NDI : NDAI_0D02500(NDAI0D02500)
TPF : TPHA_0A05070(TPHA0A05070)
TBL : TBLA_0B07410(TBLA0B07410)
TDL : TDEL_0G01240(TDEL0G01240)
KAF : KAFR_0B04220(KAFR0B04220)
KNG : KNAG_0A01600(KNAG0A01600)
SPAA : SPAPADRAFT_56279(ALG10)
LBG : 92208542(LODBEIA_P33460)
CAL : CAALFM_C305340WA(DIE2)
YLI : 2906680(YALI2_C00740g)
NTE : NEUTE1DRAFT128956(NEUTE1DRAFT_128956)
SMP : 10807154(SMAC4_03022)
PBEL : QC761_122490(ALG10)
PPSD : QC762_122490(ALG10)
PPSP : QC763_122490(ALG10)
PPSA : QC764_122490(ALG10)
FPOA : FPOAC1_011979(ALG10)
TATV : 25779934(TrAtP1_007434)
TASP : 36618314(TrAFT101_007961)
PLJ : 28888655(PLICBS_003824)
PTKZ : JDV02_000031(ALG10)
CDET : 87947139(CDEST_10639)
BFU : BCIN_15g04220(Bcdie2)
ALUC : AKAW2_21364S(ALG10)
CIM : CIMG_12056(CIMG07985)
PTRR : 6342600(PtrM4_088790)
ADAC : 96084393(ACET3X_004071)
LBC : LACBIDRAFT_399396(ALG10)
ABP : AGABI1DRAFT50659(AGABI1DRAFT_50659)
SCM : SCHCO_02609673(SCHCODRAFT_02609673)
PIF : PITG_03060 PITG_21941
» show all
Taxonomy
Reference
Authors
Burda P, Aebi M
Title
The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylation.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.256