Entry
Name
dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase;
ALG6;
Dol-P-Glc:Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase;
dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dolichyl beta-D-glucosyl-phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 3-alpha-D-glucosyltransferase (configuration-inverting)
Reaction(IUBMB)
dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:
R06262 ]
Reaction(KEGG)
Substrate
dolichyl beta-D-glucosyl phosphate [CPD:
C01246 ];
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol;
dolichyl phosphate [CPD:
C00110 ]
Comment
The successive addition of three glucose residues by EC
2.4.1.267 , EC
2.4.1.265 (Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase) and EC
2.4.1.256 (Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly.
History
EC 2.4.1.267 created 2011, modified 2012
Pathway
Orthology
K03848 alpha-1,3-glucosyltransferase
Genes
PBRV : 138164904 138165272
PTEX : 113447949 113447998
XLA : 100049135(alg6.L) 446684(alg6.S)
SANH : 107692382 107704515
SGH : 107556552(alg6) 107591199
LPIC : 129270785 129270792
DSI : Dsimw501_GD23688(Dsim_GD23688)
RZE : 108355568 108368632 108379968
ASTE : 118509277 118515242
DPX : DAPPUDRAFT_218258 DAPPUDRAFT_69112
DMK : 116927453 116935921 123466536 123471299 123471323 123474060 123474269 123474270 123474271 123474272 123474273 123474274 123474275 123474276 123474277 123474392 123474393 123474394 123474662
PPOI : 119091745 119092664
CEL : CELE_C08B11.8(algn-6)
MAEA : 128213106 128214262
CSAT : 104719513 104724205 104732997
EUS : EUTSA_v10017711mg EUTSA_v10027717mg
CPAP : 110807251 110825437
HSYR : 120175146 120206756
AIP : 107609351 107609909 107646715
MSYL : 126603360 126631504
PALZ : 118029742 118055985
CILL : 122309307 122314192
CANN : 107841768 107860041
SSPL : 121775281 121777719
MING : 122057226 122062962
PSOM : 113288818 113289846 113301392
TAES : 123085758 123092243 123097582
MFLO : 136532007 136545305
PVIR : 120652487 120692071
SMO : SELMODRAFT_452924(GT57A1)
CGR : 2887464(GVI51_E02409)
NCS : NCAS_0D02160(NCAS0D02160)
NDI : NDAI_0C02630(NDAI0C02630)
TPF : TPHA_0J00350(TPHA0J00350)
TBL : TBLA_0G00970(TBLA0G00970)
TDL : TDEL_0G04470(TDEL0G04470)
KAF : KAFR_0A05070(KAFR0A05070)
KNG : KNAG_0F02890(KNAG0F02890)
LBG : 92206871(LODBEIA_P16750)
CAL : CAALFM_CR06900CA(ALG6)
YLI : 2911218(YALI2_D00340g)
NTE : NEUTE1DRAFT114446(NEUTE1DRAFT_114446)
SMP : 36391737(SMAC4_12740)
TATV : 25776409(TrAtP1_012259)
TASP : 36612816(TrAFT101_010447)
MBRN : 26246129(G6M90_00g085810)
PLJ : 28883510(PLICBS_000527)
CDET : 87939139(CDEST_02636)
BFU : BCIN_15g01740(Bcalg6)
PTRR : 6346207(PtrM4_137090)
ADAC : 96086819(ACET3X_006497)
LBC : LACBIDRAFT_399393(ALG6)
ABP : AGABI1DRAFT74153(AGABI1DRAFT_74153)
ABV : AGABI2DRAFT206973(AGABI2DRAFT_206973)
SCM : SCHCO_02615751(SCHCODRAFT_02615751)
FCY : FRACYDRAFT_193959(GT3)
EHX : EMIHUDRAFT_521937(ALG6-2) EMIHUDRAFT_521942(ALG6-1)
» show all
Taxonomy
Reference
Authors
Reiss G, te Heesen S, Zimmerman J, Robbins PW, Aebi M
Title
Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway.
Journal
Sequence
Reference
Authors
Runge KW, Huffaker TC, Robbins PW
Title
Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway.
Journal
J Biol Chem 259:412-7 (1984)
Reference
Authors
Westphal V, Xiao M, Kwok PY, Freeze HH
Title
Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.267