Entry
Name
glucosylceramide beta-1,4-galactosyltransferase;
lactosylceramide synthase;
uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase;
UDP-Gal:glucosylceramide beta1->4galactosyltransferase;
GalT-2 (misleading);
UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:
R03354 R06276 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:
C00052 ];
beta-D-glucosyl-(1<->1)-ceramide [CPD:
C01190 ]
Product
UDP [CPD:
C00015 ];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:
C01290 ]
Comment
Involved in the synthesis of several different major classes of glycosphingolipids.
History
EC 2.4.1.274 created 2011
Pathway
Orthology
K07553 beta-1,4-galactosyltransferase 6
K09905 beta-1,4-galactosyltransferase 5
Genes
HSA : 9331(B4GALT6) 9334(B4GALT5)
PTR : 458324(B4GALT5) 468512(B4GALT6)
PPS : 100982032(B4GALT5) 100993210(B4GALT6)
GGO : 101150116(B4GALT5) 101152268(B4GALT6)
PON : 100441410(B4GALT5) 100455489(B4GALT6)
NLE : 100589590(B4GALT6) 100592572(B4GALT5)
HMH : 116460911(B4GALT5) 116468636(B4GALT6)
MCC : 706068(B4GALT6) 713891(B4GALT5)
MCF : 102123897(B4GALT5) 102126845(B4GALT6)
MTHB : 126941555 126964387
MNI : 105468047(B4GALT6) 105470699(B4GALT5)
CSAB : 103222574(B4GALT6) 103244553(B4GALT5)
CATY : 105585404(B4GALT5) 105592613(B4GALT6)
PANU : 101014914(B4GALT5) 101025962(B4GALT6)
TGE : 112611304(B4GALT6) 112632991(B4GALT5)
MLEU : 105535338(B4GALT6) 105548961(B4GALT5)
RRO : 104676080(B4GALT6) 104678530(B4GALT5)
RBB : 108519203(B4GALT6) 108539459(B4GALT5)
TFN : 117064015(B4GALT6) 117068899(B4GALT5)
PTEH : 111521000(B4GALT5) 111539603(B4GALT6)
CANG : 105502381(B4GALT5) 105505443(B4GALT6)
CJC : 100393875(B4GALT5) 100415155(B4GALT6)
SBQ : 101033869(B4GALT6) 101034546(B4GALT5)
CIMI : 108282152(B4GALT6) 108305339(B4GALT5)
CSYR : 103264306(B4GALT5) 103275965(B4GALT6)
MMUR : 105866471(B4GALT5) 105881093(B4GALT6)
LCAT : 123621689(B4GALT6) 123622706(B4GALT5)
PCOQ : 105818615(B4GALT5) 105820141(B4GALT6)
OGA : 100948995(B4GALT6) 100950401(B4GALT5)
MMU : 56336(B4galt5) 56386(B4galt6)
MCAL : 110284797(B4galt6) 110285803(B4galt5) 110302535
MPAH : 110318407(B4galt5) 110333156(B4galt6)
RNO : 362275(B4galt5) 65196(B4galt6)
MCOC : 116079058 116086887(B4galt6) 116091423(B4galt5)
ANU : 117702699(B4galt5) 117719807(B4galt6)
MUN : 110541438(B4galt6) 110548985(B4galt5)
CGE : 100689347(B4galt5) 100689438(B4galt6)
MAUA : 101836499(B4galt6) 101842355(B4galt5)
PROB : 127223436(B4galt5) 127234987(B4galt6)
PLEU : 114692662(B4galt5) 114704987(B4galt6)
MORG : 121441861 121453396 121460149(B4galt5)
MFOT : 126487408 126497158
AAMP : 119814578(B4galt6) 119815815(B4galt5)
NGI : 103730564(B4galt6) 103735557(B4galt5)
HGL : 101699877(B4galt5) 101726172(B4galt6)
CPOC : 100715716(B4galt6) 100734895(B4galt5)
CCAN : 109690522(B4galt5) 109701903(B4galt6)
DORD : 105984681(B4galt6) 105991655(B4galt5)
DSP : 122104416(B4galt6) 122127904(B4galt5)
NCAR : 124965709 124977364
OPI : 101524874(B4GALT5) 101526710(B4GALT6)
TUP : 102469566(B4GALT6) 102487471(B4GALT5)
GVR : 103588045(B4GALT6) 103589805(B4GALT5)
CFA : 485920(B4GALT5) 490499(B4GALT6)
CLUD : 112647909(B4GALT6) 112674102(B4GALT5)
VVP : 112918803(B4GALT6) 112931866(B4GALT5)
VLG : 121478017(B4GALT5) 121494504(B4GALT6)
AML : 100466298(B4GALT5) 100474316(B4GALT6)
UMR : 103663257(B4GALT6) 103669839(B4GALT5)
UAH : 113253319(B4GALT6) 113258702(B4GALT5)
UAR : 123775920(B4GALT5) 123782004(B4GALT6)
MPUF : 101671088(B4GALT5) 101692575(B4GALT6)
NVS : 122902951(B4GALT6) 122915987(B4GALT5)
ORO : 101382280(B4GALT5) 101384375(B4GALT6)
EJU : 114204947(B4GALT6) 114225493(B4GALT5)
ZCA : 113912792(B4GALT6) 113937254(B4GALT5)
MLX : 118004689(B4GALT6) 118023959(B4GALT5)
NSU : 110576721(B4GALT5) 110577055(B4GALT6)
FCA : 101081792(B4GALT5) 101088368(B4GALT6)
PYU : 121020094(B4GALT5) 121033035(B4GALT6)
PCOO : 112868292(B4GALT6) 112869118(B4GALT5)
PBG : 122467287(B4GALT5) 122470679(B4GALT6)
LRUF : 124503167 124517623
PTG : 102951837(B4GALT5) 102972031(B4GALT6)
PPAD : 109272301(B4GALT5) 109276438(B4GALT6)
AJU : 106983835(B4GALT6) 106986025(B4GALT5)
HHV : 120230436(B4GALT5) 120246827(B4GALT6)
BTA : 282407(B4GALT5) 524460(B4GALT6)
BOM : 102267802(B4GALT6) 102279000(B4GALT5)
BIU : 109567725(B4GALT5) 109577926(B4GALT6)
BBUB : 102396931(B4GALT5) 102404598(B4GALT6)
BBIS : 104980320(B4GALT6) 104985112(B4GALT5)
CHX : 102172079(B4GALT5) 102182084(B4GALT6)
OAS : 101114836(B4GALT6) 101116670(B4GALT5)
ODA : 120869086(B4GALT5) 120881176(B4GALT6)
CCAD : 122425740(B4GALT6) 122448098(B4GALT5)
SSC : 100517222(B4GALT6) 100522653(B4GALT5)
CFR : 102503599(B4GALT6) 102521524(B4GALT5)
CBAI : 105062500(B4GALT6) 105071973(B4GALT5)
CDK : 105086692(B4GALT6) 105087901(B4GALT5)
VPC : 102529234(B4GALT6) 102541730(B4GALT5)
BACU : 103018697(B4GALT5) 103020724(B4GALT6)
LVE : 103088100(B4GALT6) 103089475(B4GALT5)
OOR : 101285566(B4GALT5) 101289197 101289247(B4GALT6)
DLE : 111172038 111181500 111181502(B4GALT6) 111186650(B4GALT5)
PCAD : 102983948(B4GALT5) 102988052 102988809(B4GALT6)
PSIU : 116739283(B4GALT6) 116739917(B4GALT5) 116756886
NASI : 112402964(B4GALT5) 112407878 112408363(B4GALT6)
ECB : 100052209(B4GALT6) 100071419(B4GALT5)
EPZ : 103540749(B4GALT5) 103561393(B4GALT6)
EAI : 106825757(B4GALT5) 106833968(B4GALT6)
MYB : 102248931(B4GALT5) 102262835(B4GALT6)
MYD : 102754818(B4GALT6) 102772655(B4GALT5)
MMYO : 118663498(B4GALT6) 118663504(B4GALT5)
MLF : 102421492(B4GALT5) 102435641(B4GALT6)
MNA : 107524153(B4GALT6) 107540613(B4GALT5)
PKL : 118707626(B4GALT5) 118707975(B4GALT6)
HAI : 109375981(B4GALT6) 109381829(B4GALT5)
DRO : 112304173(B4GALT5) 112322928(B4GALT6)
SHON : 118977575(B4GALT6) 118996480(B4GALT5)
AJM : 119064067(B4GALT6) 119065211(B4GALT5)
PDIC : 114506456(B4GALT5) 114507078(B4GALT6)
PHAS : 123814992(B4GALT5) 123826319(B4GALT6)
MMF : 118618300(B4GALT6) 118618530(B4GALT5)
RFQ : 117011893(B4GALT6) 117015908(B4GALT5)
PALE : 102890757(B4GALT6) 102894851(B4GALT5)
PGIG : 120587185(B4GALT6) 120603784(B4GALT5)
PVP : 105293348(B4GALT6) 105296057(B4GALT5)
RAY : 107510330(B4GALT5) 107521759(B4GALT6)
MJV : 108391984(B4GALT5) 108394376
TOD : 119236370(B4GALT5) 119243120(B4GALT6)
SARA : 101549969(B4GALT6) 101552406(B4GALT5)
LAV : 100668075(B4GALT5) 100675072(B4GALT6)
ETF : 101641477(B4GALT5) 101654910(B4GALT6)
DNM : 101424789(B4GALT6) 101447257(B4GALT5)
MDO : 100023227(B4GALT5) 100024039(B4GALT6)
GAS : 123237131(B4GALT5) 123239177(B4GALT6)
SHR : 100919571(B4GALT6) 100921485(B4GALT5)
AFZ : 127543917 127548897 127560758
PCW : 110206639(B4GALT5) 110212527(B4GALT6)
OAA : 100076187(B4GALT5) 100084861(B4GALT6)
GGA : 107054826(B4GALT5) 421092(B4GALT6)
PCOC : 116242234(B4GALT6) 116242422(B4GALT5)
MGP : 100539947(B4GALT5) 100544705(B4GALT6)
CJO : 107310112(B4GALT6) 107323248(B4GALT5)
NMEL : 110394044(B4GALT6) 110408219(B4GALT5)
APLA : 101798368(B4GALT5) 101801239(B4GALT6)
ACYG : 106037605(B4GALT6) 106041421(B4GALT5)
AFUL : 116485870(B4GALT6) 116495624(B4GALT5)
TGU : 100219705(B4GALT5) 100224001(B4GALT6)
LSR : 110468127(B4GALT6) 110475226(B4GALT5)
SCAN : 103818902(B4GALT5) 103827214(B4GALT6)
PMOA : 120507101(B4GALT5) 120512143(B4GALT6)
OTC : 121333184(B4GALT6) 121343067(B4GALT5)
PRUF : 121359018(B4GALT6) 121359539(B4GALT5)
GFR : 102032390(B4GALT5) 102041264(B4GALT6)
FAB : 101811130(B4GALT6) 101813501(B4GALT5)
PHI : 102111801(B4GALT6) 102112117(B4GALT5)
PMAJ : 107200037(B4GALT6) 107213389(B4GALT5)
CCAE : 111924903(B4GALT6) 111938416(B4GALT5)
CCW : 104687783(B4GALT5) 104690421(B4GALT6)
CBRC : 103618246(B4GALT5) 103625477(B4GALT6)
ETL : 114057195(B4GALT6) 114067284(B4GALT5)
ZAB : 102063166(B4GALT6) 102069547(B4GALT5)
SVG : 106851951(B4GALT6) 106853032(B4GALT5)
FPG : 101914158(B4GALT6) 101916927(B4GALT5)
FCH : 102051198(B4GALT6) 102056539(B4GALT5)
CLV : 102094654(B4GALT5) 102095761(B4GALT6)
EGZ : 104126868(B4GALT6) 104132163(B4GALT5)
NNI : 104013108(B4GALT5) 104019778(B4GALT6)
PLET : 104615247(B4GALT6) 104618969(B4GALT5)
PCRI : 104025656(B4GALT5) 104034231
ACUN : 113477021(B4GALT6) 113487641(B4GALT5)
TALA : 104359199(B4GALT5) 104369487(B4GALT6)
PADL : 103919346(B4GALT5) 103923152(B4GALT6)
AFOR : 103901720(B4GALT5) 103904215(B4GALT6)
ACHC : 115339725(B4GALT5) 115340417(B4GALT6)
HLE : 104833212(B4GALT5) 104836034(B4GALT6)
AGEN : 126045484 126047162
CSTI : 104556704(B4GALT5) 104557429(B4GALT6)
EHS : 104504074 104516155(B4GALT5)
CMAC : 104485597(B4GALT6) 104486665(B4GALT5)
MUI : 104537527(B4GALT6) 104544210(B4GALT5)
FGA : 104082009 104083900(B4GALT5)
GSTE : 104253916 104263764
LDI : 104341264 104348550(B4GALT5)
OHA : 104328841(B4GALT5) 104329170(B4GALT6)
NNT : 104408248(B4GALT5) 104410167(B4GALT6)
SHAB : 115609688(B4GALT6) 115615327(B4GALT5)
DPUB : 104302701(B4GALT5) 104309117(B4GALT6)
PGUU : 104467398(B4GALT6) 104470568(B4GALT5)
CPEA : 104389643(B4GALT5) 104396985(B4GALT6)
AVIT : 104272589(B4GALT5) 104276668(B4GALT6)
CVF : 104287299(B4GALT6) 104293928(B4GALT5)
CUCA : 104057407(B4GALT5) 104059961(B4GALT6)
TEO : 104379306(B4GALT5) 104383498(B4GALT6)
BRHI : 104488418(B4GALT6) 104497025(B4GALT5)
AAM : 106484361 106484570(B4GALT6)
AROW : 112961832(B4GALT5) 112976326
NPD : 112949631(B4GALT5) 112956170(B4GALT6)
TGT : 104567240(B4GALT6) 104573775(B4GALT5)
SCAM : 104141724(B4GALT5) 104153546(B4GALT6)
ASN : 102368658(B4GALT6) 102380386(B4GALT5)
AMJ : 102558728(B4GALT6) 102565981(B4GALT5)
CPOO : 109318277(B4GALT6) 109318737(B4GALT5)
GGN : 109292381(B4GALT5) 109304142(B4GALT6)
PSS : 102447941(B4GALT5) 102452701(B4GALT6)
CMY : 102935373(B4GALT6) 102946090(B4GALT5)
CPIC : 101947429(B4GALT6) 101952199(B4GALT5)
TST : 117873447(B4GALT6) 117885757(B4GALT5)
CABI : 116827623(B4GALT6) 116838657(B4GALT5)
MRV : 120380228(B4GALT5) 120398036(B4GALT6)
ACS : 100564858(b4galt6) 100565899(b4galt5)
PVT : 110071795(B4GALT5) 110077648(B4GALT6)
SUND : 121928249(B4GALT5) 121930151(B4GALT6)
PBI : 103051698(B4GALT6) 103068190(B4GALT5)
PMUR : 107290823(B4GALT5) 107292806(B4GALT6)
CTIG : 120303835(B4GALT6) 120311575(B4GALT5)
TSR : 106537705(B4GALT6) 106539563(B4GALT5)
PGUT : 117663568(B4GALT5) 117672737(B4GALT6)
VKO : 123020446(B4GALT6) 123028448(B4GALT5)
PMUA : 114599623(B4GALT5) 114600656(B4GALT6)
ZVI : 118088344(B4GALT5) 118090012(B4GALT6)
HCG : 128322798(B4GALT5) 128324192(B4GALT6)
XLA : 108695277(b4galt6.S) 108702589 446703(b4galt5.L) 779435(b4galt6.L)
XTR : 548965(b4galt6) 549139(b4galt5)
NPR : 108786088(B4GALT6) 108803987
RTEM : 120918947(B4GALT5) 120940949(B4GALT6)
BBUF : 121001670(B4GALT6) 121005224(B4GALT5)
BGAR : 122938951(B4GALT6) 122941855(B4GALT5)
DRE : 393912(b4galt6) 724080(b4galt5)
SRX : 107712262 107712895 107725076 107736963
SANH : 107656676 107656727 107684873 107687169
SGH : 107566184 107571685 107588895
CCAR : 109046457 109048314 109052535 109113385
CAUA : 113040991 113063269 113068671 113121064
CGIB : 127938496 127944703 127983997 128011176
PPRM : 120491838(b4galt5) 120493721(b4galt6)
MAMB : 125259723(b4galt5) 125279139(b4galt6)
CIDE : 127501846 127505180
MASI : 127410394 127416439 127418927 127419795
IPU : 108258006(b4galt6) 108276341(b4galt5)
PHYP : 113545358(b4galt6) 113545592
SMEO : 124377165(b4galt6) 124398942(b4galt5)
TFD : 113649366(b4galt5) 113664015(b4galt6)
AMEX : 103033026 103035788(b4galt6)
TRU : 101064617(b4galt5) 101067520
TNG : GSTEN00019813G001 GSTEN00032619G001 GSTEN00033176G001
CGOB : 115006814(b4galt6) 115010532
ELY : 117253778(b4galt6) 117258398(b4galt5)
EFO : 125891080(b4galt5) 125895600(b4galt6)
PLEP : 121946794(b4galt5) 121965841(b4galt6)
SLUC : 116058871(b4galt6) 116062195(b4galt5)
ECRA : 117947486(b4galt5) 117949979(b4galt6)
ESP : 116692553 116695199(b4galt6)
PFLV : 114559421 114561163(b4galt6)
GAT : 120823438(b4galt6) 120829421(b4galt5)
PPUG : 119216244(b4galt6) 119222091(b4galt5)
MSAM : 119901318 119905400(b4galt5) 119906655
CUD : 121511953(b4galt6) 121517477(b4galt5)
ALAT : 119022148(b4galt5) 119028352(b4galt6)
OAU : 116320842(b4galt6) 116324748(b4galt5)
OML : 112136811(b4galt6) 112159165(b4galt5)
AOCE : 111569631 111574206
MCEP : 125009674(b4galt6) 125023939(b4galt5)
CSEM : 103385452 103399846(b4galt6)
POV : 109625355 109635241(b4galt5)
SSEN : 122761233(b4galt5) 122780999(b4galt6)
HHIP : 117760771(b4galt6) 117765102(b4galt5)
HSP : 118110788(b4galt5) 124854667(b4galt6)
LCF : 108889482(b4galt5) 108900672(b4galt6)
SLAL : 111668978 111671660
XGL : 120790947(b4galt6) 120804180(b4galt5)
BPEC : 110161219 110164585
MALB : 109952542(b4galt6) 109964632
SASA : 106560385 106566571 106584194
STRU : 115158619 115168513 115192303
OTW : 112222355(b4galt5) 112250024 112251295(b4galt6)
OMY : 110492517(b4galt5) 110521745 110524642(b4galt6)
OGO : 123996722(b4galt6) 124038071 124045602(b4galt5)
ONE : 115102006 115108597 115145403
SALP : 111971166 111975431
SNH : 120041225(b4galt5) 120052627 120055009
CCLU : 121533898 121538624 121540492 121545315
ELS : 105011876(b4galt6) 105013936
SFM : 108926445 108931694 108937008(b4galt5) 108937701
PKI : 111835933 111837084 111845994 111850147
AANG : 118208096(b4galt5) 118226143(b4galt6) 118233856
LOC : 102685687(b4galt5) 102687566
PSPA : 121298219 121313482 121314428 121319320(b4galt5)
ARUT : 117394518 117399277 117423234 117427114
PSEX : 120514576(b4galt5) 120530290(b4galt6)
LCM : 102348772(B4GALT6) 102355822(B4GALT5)
CMK : 103172840 103179660(b4galt6)
RTP : 109910835 109912806(b4galt5)
CPLA : 122548824(b4galt6) 122560075
SPU : 100893324 105437633 105439145 105447297 115918527 115923678 115925825 576421 576438 583786 585175 585604 586027 587517 588598 589658 592897 755711
APLC : 110977972 110977985 110979041 110980926 110981330 110986643
MCAF : 127714380 127715856
» show all
Taxonomy
Reference
Authors
Chatterjee S, Castiglione E
Title
UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.
Journal
Sequence
Reference
Authors
Trinchera M, Fiorilli A, Ghidoni R
Title
Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase.
Journal
Reference
Authors
Chatterjee S, Ghosh N, Khurana S
Title
Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney.
Journal
J Biol Chem 267:7148-53 (1992)
Sequence
Reference
Authors
Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N
Title
Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.
Journal
Sequence
Reference
Authors
Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N
Title
cDNA cloning and expression of human lactosylceramide synthase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.274