KEGG ENZYME: 2.4.1.275

ENZYME: 2.4.1.275

Entry

EC 2.4.1.275 Enzyme

Name

neolactotriaosylceramide beta-1,4-galactosyltransferase;
beta4Gal-T4;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase;
lactotriaosylceramide beta-1,4-galactosyltransferase (incorrect)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase

Reaction(IUBMB)

UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05977 R09755]

Reaction(KEGG)

R05977(G) R09755

Substrate

UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]

Product

UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04922]

History

EC 2.4.1.275 created 2011, modified 2013

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec01100

Metabolic pathways

Orthology

K07969

beta-1,4-galactosyltransferase 4

Genes

HSA:	8702(B4GALT4)

PTR:	100608173(B4GALT4)

PPS:	100994562(B4GALT4)

GGO:	101146705(B4GALT4)

PON:	100443591(B4GALT4)

NLE:	100600025(B4GALT4)

MCC:	711983(B4GALT4)

MCF:	102142820(B4GALT4)

CSAB:

103228234(B4GALT4)

RRO:	104657610(B4GALT4)

RBB:	108531771(B4GALT4)

CJC:	100402903(B4GALT4)

SBQ:	101029385(B4GALT4)

MMU:	56375(B4galt4)

MCAL:

110311536(B4galt4)

MPAH:

110329539(B4galt4)

RNO:	303923(B4galt4)

MUN:	110555392(B4galt4)

CGE:	100689435(B4galt4)

NGI:	103741937(B4galt4)

HGL:	101723638(B4galt4)

CCAN:

109694543(B4galt4)

OCU:	100357504(B4GALT4)

TUP:	102470291(B4GALT4)

CFA:	608143(B4GALT4)

VVP:	112913456(B4GALT4)

AML:	100481658(B4GALT4)

UMR:	103678795(B4GALT4)

UAH:	113251830(B4GALT4)

ORO:	101385802(B4GALT4)

ELK:

111150160

FCA:	101100325(B4GALT4)

PTG:	102966539(B4GALT4)

PPAD:

109266428(B4GALT4)

AJU:	106980243(B4GALT4)

BTA:	511328(B4GALT4)

BOM:	102279871(B4GALT4)

BIU:	109576562(B4GALT4)

BBUB:

102407421(B4GALT4)

CHX:	102190262(B4GALT4)

OAS:	101104949(B4GALT4)

CFR:	102522848(B4GALT4)

CDK:	105090333(B4GALT4)

BACU:

103005928(B4GALT4)

LVE:	103084555(B4GALT4)

OOR:	101278923(B4GALT4)

DLE:	111166843(B4GALT4)

PCAD:

102977710(B4GALT4)

ECB:	100071082(B4GALT4)

EPZ:	103547412(B4GALT4)

EAI:	106823399(B4GALT4) 106840352

MYB:	102243483(B4GALT4)

MYD:	102775104(B4GALT4)

MNA:	107527210(B4GALT4)

HAI:	109386911(B4GALT4)

DRO:	112320685(B4GALT4)

PALE:

102879802(B4GALT4)

RAY:	107508361(B4GALT4)

MJV:	108408457(B4GALT4)

LAV:	100662008(B4GALT4)

TMU:

101352100

MDO:	100015888(B4GALT4)

SHR:	100933479(B4GALT4)

PCW:	110208058(B4GALT4)

OAA:	114817430(B4GALT4)

GGA:	418341(B4GALT4)

MGP:	100547867(B4GALT4)

CJO:	107320407(B4GALT4)

NMEL:

110399397(B4GALT4)

APLA:

101792176(B4GALT4)

ACYG:

106037583(B4GALT4)

TGU:	100230291(B4GALT4)

LSR:	110480885(B4GALT4)

SCAN:

103827100(B4GALT4)

GFR:	102034782(B4GALT4)

FAB:	101809954(B4GALT4)

PHI:	102108146(B4GALT4)

PMAJ:

107205999(B4GALT4)

CCAE:

111939072(B4GALT4)

CCW:	104687053(B4GALT4)

ETL:	114055096(B4GALT4)

FPG:	101915659(B4GALT4)

FCH:	102051115(B4GALT4)

CLV:	102093764(B4GALT4)

EGZ:	104126497(B4GALT4)

NNI:	104008639(B4GALT4)

ACUN:

113483816(B4GALT4)

PADL:

103921433(B4GALT4)

AAM:	106490705(B4GALT4)

ASN:	102370808(B4GALT4)

AMJ:	102569919(B4GALT4)

PSS:	102453780(B4GALT4)

CMY:	102946330(B4GALT4)

CPIC:

101953425(B4GALT4)

ACS:	100553568(b4galt4)

PVT:	110074021(B4GALT4)

PBI:	103068176(B4GALT4)

PMUR:

107287653(B4GALT4)

TSR:	106549008(B4GALT4)

PMUA:

114595809(B4GALT4)

GJA:	107106045(B4GALT4)

XLA:	108707823(b4galt4.L) 444709(b4galt4.S)

XTR:	100488464(b4galt4)

NPR:	108797173(B4GALT4)

DRE:	492760(b4galt4)

SRX:	107719754 107752248(b4galt4)

SANH:

107662077 107702948

SGH:	107557767(b4galt4) 107576632

CCAR:

109059855 109105806

IPU:	108260163(b4galt4)

PHYP:

113531354(b4galt4)

AMEX:

103042661(b4galt4)

EEE:	113587379(b4galt4)

TRU:	101061200(b4galt4)

TNG:	GSTEN00019044G001

LCO:	104935626(b4galt4)

NCC:	104965999(b4galt4)

MZE:	101466383(b4galt4)

ONL:	100692349(b4galt4)

OLA:	101164915(b4galt4)

XMA:	102221477(b4galt4)

XCO:	114152935(b4galt4)

PRET:

103475412(b4galt4)

CVG:	107096681(b4galt4)

NFU:	107386424(b4galt4)

KMR:	108237029(b4galt4)

ALIM:

106526137(b4galt4)

AOCE:

111587187(b4galt4)

CSEM:

103395579

POV:	109628818(b4galt4)

LCF:	108893526(b4galt4)

SDU:	111234517(b4galt4)

SLAL:

111666268(b4galt4)

HCQ:	109517999(b4galt4)

BPEC:

110158487(b4galt4)

MALB:

109959384(b4galt4)

SASA:

106563608(b4galt4) 106603047

OTW:	112228922 112231206(b4galt4)

SALP:

111950662 111964307(b4galt4)

ELS:	105010876(b4galt4)

SFM:	108924680(b4galt4)

PKI:	111838050(b4galt4)

LCM:	102355454 102358769

CMK:	103185094(b4galt4)

RTP:	109921819(b4galt4)

CIN:

100182391

» show all

Reference

1 [PMID:9792633]

Authors

Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H

Title

Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis.

Journal

J Biol Chem 273:29331-40 (1998)
DOI:10.1074/jbc.273.45.29331

Sequence

[hsa:8702]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.275

IUBMB Enzyme Nomenclature:

2.4.1.275

ExPASy - ENZYME nomenclature database:

2.4.1.275

BRENDA, the Enzyme Database:

2.4.1.275

DBGET integrated database retrieval system