KEGG   ENZYME: 2.4.1.275Help
Entry
EC 2.4.1.275                Enzyme                                 

Name
neolactotriaosylceramide beta-1,4-galactosyltransferase;
beta4Gal-T4;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase;
lactotriaosylceramide beta-1,4-galactosyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05977 R09755]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04922]
History
EC 2.4.1.275 created 2011, modified 2013
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K07969  beta-1,4-galactosyltransferase 4
Genes
HSA: 8702(B4GALT4)
PTR: 100608173(B4GALT4)
PPS: 100994562(B4GALT4)
GGO: 101146705(B4GALT4) 109026348
PON: 100443591(B4GALT4)
NLE: 100600025(B4GALT4)
MCC: 711983(B4GALT4)
MCF: 102142820(B4GALT4)
CSAB: 103228234(B4GALT4)
RRO: 104657610(B4GALT4)
RBB: 108531771(B4GALT4)
CJC: 100402903(B4GALT4)
SBQ: 101029385(B4GALT4)
MMU: 56375(B4galt4)
MCAL: 110311536(B4galt4)
MPAH: 110329539(B4galt4)
RNO: 303923(B4galt4)
MUN: 110555392(B4galt4)
CGE: 100689435(B4galt4)
NGI: 103741937(B4galt4)
HGL: 101723638(B4galt4)
CCAN: 109694543(B4galt4)
OCU: 100357504(B4GALT4)
TUP: 102470291(B4GALT4)
CFA: 608143(B4GALT4)
VVP: 112913456(B4GALT4)
AML: 100481658(B4GALT4)
UMR: 103678795(B4GALT4)
UAH: 113251830(B4GALT4)
ORO: 101385802(B4GALT4)
FCA: 101100325(B4GALT4)
PTG: 102966539(B4GALT4)
AJU: 106980243(B4GALT4)
BTA: 511328(B4GALT4)
BOM: 102279871(B4GALT4)
BIU: 109576562(B4GALT4)
BBUB: 102407421(B4GALT4)
PHD: 102340702(B4GALT4)
CHX: 102190262(B4GALT4)
OAS: 101104949(B4GALT4)
CFR: 102522848(B4GALT4)
CDK: 105090333(B4GALT4)
BACU: 103005928(B4GALT4)
LVE: 103084555(B4GALT4)
OOR: 101278923(B4GALT4)
DLE: 111166843(B4GALT4)
PCAD: 102977710(B4GALT4)
ECB: 100071082(B4GALT4)
EPZ: 103547412(B4GALT4)
EAI: 106823399(B4GALT4) 106840352
MYB: 102243483(B4GALT4)
MYD: 102775104(B4GALT4)
MNA: 107527210(B4GALT4)
HAI: 109386911(B4GALT4)
RSS: 109446346(B4GALT4)
DRO: 112320685(B4GALT4)
PALE: 102879802(B4GALT4)
RAY: 107508361(B4GALT4)
LAV: 100662008(B4GALT4)
TMU: 101352100
MDO: 100015888(B4GALT4)
SHR: 100933479(B4GALT4)
PCW: 110208058(B4GALT4)
OAA: 114817430(B4GALT4)
GGA: 418341(B4GALT4)
MGP: 100547867(B4GALT4)
CJO: 107320407(B4GALT4)
NMEL: 110399397(B4GALT4)
APLA: 101792176(B4GALT4)
ACYG: 106037583(B4GALT4)
TGU: 100230291(B4GALT4)
LSR: 110480885(B4GALT4)
SCAN: 103827100(B4GALT4)
GFR: 102034782(B4GALT4)
FAB: 101809954(B4GALT4)
PHI: 102108146(B4GALT4)
PMAJ: 107205999(B4GALT4)
CCAE: 111939072(B4GALT4)
CCW: 104687053(B4GALT4)
ETL: 114055096(B4GALT4)
FPG: 101915659(B4GALT4)
FCH: 102051115(B4GALT4)
CLV: 102093764(B4GALT4)
EGZ: 104126497(B4GALT4)
NNI: 104008639(B4GALT4)
ACUN: 113483816(B4GALT4)
PADL: 103921433(B4GALT4)
AAM: 106490705(B4GALT4)
ASN: 102370808(B4GALT4)
AMJ: 102569919(B4GALT4)
PSS: 102453780(B4GALT4)
CMY: 102946330(B4GALT4)
CPIC: 101953425(B4GALT4)
ACS: 100553568(b4galt4)
PVT: 110074021(B4GALT4)
PBI: 103068176(B4GALT4)
PMUR: 107287653(B4GALT4)
GJA: 107106045(B4GALT4)
XLA: 108707823(b4galt4.L) 444709(b4galt4.S)
XTR: 100488464(b4galt4)
NPR: 108797173(B4GALT4)
DRE: 492760(b4galt4)
SRX: 107719754 107752248(b4galt4)
SANH: 107662077 107702948
SGH: 107557767(b4galt4) 107576632
CCAR: 109059855 109097081 109105806
IPU: 108260163(b4galt4)
PHYP: 113531354(b4galt4)
AMEX: 103042661(b4galt4)
EEE: 113587379(b4galt4)
TRU: 101061200(b4galt4)
TNG: GSTEN00019044G001
LCO: 104935626(b4galt4)
NCC: 104965999(b4galt4)
MZE: 101466383(b4galt4)
OLA: 101164915(b4galt4)
XMA: 102221477(b4galt4)
XCO: 114152935(b4galt4)
PRET: 103475412(b4galt4)
NFU: 107386424(b4galt4)
KMR: 108237029(b4galt4)
AOCE: 111587187(b4galt4)
CSEM: 103395579
POV: 109628818(b4galt4)
LCF: 108893526(b4galt4)
SDU: 111234517(b4galt4)
HCQ: 109517999(b4galt4)
BPEC: 110158487(b4galt4)
MALB: 109959384(b4galt4)
SASA: 106563608(b4galt4) 106603047
OTW: 112228922 112231206(b4galt4)
SALP: 111950662 111964307(b4galt4)
ELS: 105010876(b4galt4)
SFM: 108924680(b4galt4)
PKI: 111838050(b4galt4)
LCM: 102355454 102358769
CMK: 103185094(b4galt4)
PRAP: 110995450
DPX: DAPPUDRAFT_335532
LAK: 106153459
SHX: MS3_01473
OVI: T265_03525
 » show all
Taxonomy
Reference
1  [PMID:9792633]
  Authors
Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H
  Title
Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid  biosynthesis.
  Journal
J Biol Chem 273:29331-40 (1998)
DOI:10.1074/jbc.273.45.29331
  Sequence
[hsa:8702]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.275
IUBMB Enzyme Nomenclature: 2.4.1.275
ExPASy - ENZYME nomenclature database: 2.4.1.275
BRENDA, the Enzyme Database: 2.4.1.275

  All links  
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (4)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (1499)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (154)   
   KEGG MGENES (758)   
   RefGene (586)   
Protein sequence (16)   
   UniProt (6)   
   SWISS-PROT (4)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
All databases (1536)   

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