KEGG   ENZYME: 2.4.1.275
Entry
EC 2.4.1.275                Enzyme                                 

Name
neolactotriaosylceramide beta-1,4-galactosyltransferase;
beta4Gal-T4;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase;
lactotriaosylceramide beta-1,4-galactosyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05977 R09755]
Reaction(KEGG)
R05977(G) R09755
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04922]
History
EC 2.4.1.275 created 2011, modified 2013
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K07969  beta-1,4-galactosyltransferase 4
Genes
HSA: 8702(B4GALT4)
PTR: 100608173(B4GALT4)
PPS: 100994562(B4GALT4)
GGO: 101146705(B4GALT4)
PON: 100443591(B4GALT4)
NLE: 100600025(B4GALT4)
MCC: 711983(B4GALT4)
MCF: 102142820(B4GALT4)
CSAB: 103228234(B4GALT4)
CATY: 105589723(B4GALT4)
PANU: 101019227(B4GALT4)
RRO: 104657610(B4GALT4)
RBB: 108531771(B4GALT4)
TFN: 117083477(B4GALT4)
PTEH: 111543736(B4GALT4)
CJC: 100402903(B4GALT4)
SBQ: 101029385(B4GALT4)
MMUR: 105879930(B4GALT4)
MMU: 56375(B4galt4)
MCAL: 110311536(B4galt4)
MPAH: 110329539(B4galt4)
RNO: 303923(B4galt4)
MCOC: 116085906(B4galt4)
MUN: 110555392(B4galt4)
CGE: 100689435(B4galt4)
PLEU: 114701494(B4galt4)
NGI: 103741937(B4galt4)
HGL: 101723638(B4galt4)
CCAN: 109694543(B4galt4)
OCU: 100357504(B4GALT4)
TUP: 102470291(B4GALT4)
CFA: 608143(B4GALT4)
VVP: 112913456(B4GALT4)
VLG: 121471564(B4GALT4)
AML: 100481658(B4GALT4)
UMR: 103678795(B4GALT4)
UAH: 113251830(B4GALT4)
ORO: 101385802(B4GALT4)
ELK: 111150160
MPUF: 101682220(B4GALT4)
EJU: 114214700(B4GALT4)
MLX: 118007075(B4GALT4)
FCA: 101100325(B4GALT4)
PYU: 121026811 121026814
PTG: 102966539(B4GALT4)
PPAD: 109266428(B4GALT4)
AJU: 106980243(B4GALT4)
HHV: 120223122(B4GALT4)
BTA: 511328(B4GALT4)
BOM: 102279871(B4GALT4)
BIU: 109576562(B4GALT4)
BBUB: 102407421(B4GALT4)
CHX: 102190262(B4GALT4)
OAS: 101104949(B4GALT4)
ODA: 120871334(B4GALT4)
CCAD: 122445575(B4GALT4)
CFR: 102522848(B4GALT4)
CBAI: 105081587(B4GALT4)
CDK: 105090333(B4GALT4)
BACU: 103005928(B4GALT4)
LVE: 103084555(B4GALT4)
OOR: 101278923(B4GALT4)
DLE: 111166843(B4GALT4)
PCAD: 102977710(B4GALT4)
ECB: 100071082(B4GALT4)
EPZ: 103547412(B4GALT4)
EAI: 106823399(B4GALT4) 106840352
MYB: 102243483(B4GALT4)
MYD: 102775104(B4GALT4)
MMYO: 118677233(B4GALT4)
MNA: 107527210(B4GALT4)
HAI: 109386911(B4GALT4)
DRO: 112320685(B4GALT4)
SHON: 118986581(B4GALT4)
AJM: 119059204(B4GALT4)
MMF: 118617345(B4GALT4)
PALE: 102879802(B4GALT4)
PGIG: 120586651(B4GALT4)
RAY: 107508361(B4GALT4)
MJV: 108408457(B4GALT4)
TOD: 119257499(B4GALT4)
LAV: 100662008(B4GALT4)
TMU: 101352100
MDO: 100015888(B4GALT4)
SHR: 100933479(B4GALT4)
PCW: 110208058(B4GALT4)
OAA: 114817430(B4GALT4)
GGA: 418341(B4GALT4)
PCOC: 116242431(B4GALT4)
MGP: 100547867(B4GALT4)
CJO: 107320407(B4GALT4)
NMEL: 110399397(B4GALT4)
APLA: 101792176(B4GALT4)
ACYG: 106037583(B4GALT4)
TGU: 100230291(B4GALT4)
LSR: 110480885(B4GALT4)
SCAN: 103827100(B4GALT4)
PMOA: 120506431(B4GALT4)
GFR: 102034782(B4GALT4)
FAB: 101809954(B4GALT4)
PHI: 102108146(B4GALT4)
PMAJ: 107205999(B4GALT4)
CCAE: 111939072(B4GALT4)
CCW: 104687053(B4GALT4)
ETL: 114055096(B4GALT4)
FPG: 101915659(B4GALT4)
FCH: 102051115(B4GALT4)
CLV: 102093764(B4GALT4)
EGZ: 104126497(B4GALT4)
NNI: 104008639(B4GALT4)
ACUN: 113483816(B4GALT4)
PADL: 103921433(B4GALT4)
AAM: 106490705(B4GALT4)
NPD: 112951788(B4GALT4)
ASN: 102370808(B4GALT4)
AMJ: 102569919(B4GALT4)
CPOO: 109319251(B4GALT4)
GGN: 109304505(B4GALT4)
PSS: 102453780(B4GALT4)
CMY: 102946330(B4GALT4)
CPIC: 101953425(B4GALT4)
TST: 117886849(B4GALT4)
CABI: 116825981
ACS: 100553568(b4galt4)
PVT: 110074021(B4GALT4)
PBI: 103068176(B4GALT4)
PMUR: 107287653(B4GALT4)
TSR: 106549008(B4GALT4)
PGUT: 117662153(B4GALT4)
PMUA: 114595809(B4GALT4)
ZVI: 118085493(B4GALT4)
GJA: 107106045(B4GALT4)
XLA: 108707823(b4galt4.L) 444709(b4galt4.S)
XTR: 100488464(b4galt4)
NPR: 108797173(B4GALT4)
DRE: 492760(b4galt4)
SRX: 107719754 107752248(b4galt4)
SANH: 107662077 107702948
SGH: 107557767(b4galt4) 107576632
CCAR: 109059855 109105806
CAUA: 113086208 113094244
IPU: 108260163(b4galt4)
PHYP: 113531354(b4galt4)
AMEX: 103042661(b4galt4)
EEE: 113587379(b4galt4)
TRU: 101061200(b4galt4)
TNG: GSTEN00019044G001
LCO: 104935626(b4galt4)
NCC: 104965999(b4galt4)
CGOB: 115018943
ELY: 117271675(b4galt4)
PLEP: 121953054(b4galt4)
SLUC: 116064910(b4galt4)
ECRA: 117956097(b4galt4)
PFLV: 114566193(b4galt4)
GAT: 120822075(b4galt4)
MSAM: 119895361(b4galt4)
CUD: 121518801(b4galt4)
MZE: 101466383(b4galt4)
ONL: 100692349(b4galt4)
OAU: 116336153(b4galt4)
OLA: 101164915(b4galt4)
OML: 112142420(b4galt4)
XMA: 102221477(b4galt4)
XCO: 114152935(b4galt4)
XHE: 116728667(b4galt4)
PRET: 103475412(b4galt4)
CVG: 107096681(b4galt4)
CTUL: 119778358(b4galt4)
NFU: 107386424(b4galt4)
KMR: 108237029(b4galt4)
ALIM: 106526137(b4galt4)
AOCE: 111587187(b4galt4)
CSEM: 103395579
POV: 109628818(b4galt4)
LCF: 108893526(b4galt4)
SDU: 111234517(b4galt4)
SLAL: 111666268(b4galt4)
XGL: 120802943(b4galt4)
HCQ: 109517999(b4galt4)
BPEC: 110158487(b4galt4)
MALB: 109959384(b4galt4)
SASA: 106563608(b4galt4) 106603047
OTW: 112228922 112231206(b4galt4)
OMY: 110510090(b4galt4) 110534104
SALP: 111950662 111964307(b4galt4)
SNH: 120021475 120057301
ELS: 105010876(b4galt4)
SFM: 108924680(b4galt4)
PKI: 111838050(b4galt4)
AANG: 118235907(b4galt4)
LOC: 102693001(b4galt4)
PSPA: 121302655 121321209
ARUT: 117405908 117972656
LCM: 102355454 102358769
CMK: 103185094(b4galt4)
RTP: 109921819(b4galt4)
CIN: 100182391
NLU: 120350325
GAE: 121388902
PMAX: 117339209
 » show all
Reference
1  [PMID:9792633]
  Authors
Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H
  Title
Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis.
  Journal
J Biol Chem 273:29331-40 (1998)
DOI:10.1074/jbc.273.45.29331
  Sequence
[hsa:8702]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.275
IUBMB Enzyme Nomenclature: 2.4.1.275
ExPASy - ENZYME nomenclature database: 2.4.1.275
BRENDA, the Enzyme Database: 2.4.1.275

  All links  
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (4)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (1539)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (213)   
   KEGG MGENES (739)   
   RefGene (586)   
Protein sequence (53)   
   UniProt (17)   
   SWISS-PROT (14)   
   RefSeq(pep) (22)   
DNA sequence (24)   
   RefSeq(nuc) (24)   
Protein domain (4)   
   InterPro (4)   
All databases (1635)   

Download RDF
DBGET integrated database retrieval system