| Entry |
|
|---|
| Name |
UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase;
neoK (gene name)
|
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
|
|---|
| Sysname |
UDP-N-acetyl-alpha-D-glucosamine:ribostamycin N-acetylglucosaminyltransferase
|
|---|
| Reaction(IUBMB) |
UDP-N-acetyl-alpha-D-glucosamine + ribostamycin = UDP + 2'''-acetyl-6'''-hydroxyneomycin C [RN: R08900]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
UDP-N-acetyl-alpha-D-glucosamine [CPD: C00043];
ribostamycin [CPD: C01759]
|
|---|
| Product |
UDP [CPD: C00015];
2'''-acetyl-6'''-hydroxyneomycin C
|
|---|
| Comment |
Involved in biosynthesis of the aminoglycoside antibiotic neomycin. Requires a divalent metal ion, optimally Mg2+, Mn2+ or Co2+.
|
|---|
| History |
EC 2.4.1.285 created 2012
|
|---|
| Pathway |
| ec00524 | Neomycin, kanamycin and gentamicin biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K13556 | UDP-N-acetyl-D-glucosamine:ribostamycin N-acetyl-D-glucosaminyltransferase |
|
|---|
| Genes |
|
|---|
| Reference |
|
|---|
| Authors |
Yokoyama K, Yamamoto Y, Kudo F, Eguchi T |
|---|
| Title |
Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.285 |
|
|---|
