Entry
Name
galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase;
GlfT2
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactofuranose:beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 4-beta/5-beta-D-galactofuranosyltransferase
Reaction(IUBMB)
28 UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 28 UDP + [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
Reaction(KEGG)
Substrate
UDP-alpha-D-galactofuranose [CPD:
C03733 ];
beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
Product
UDP [CPD:
C00015 ];
[beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol
Comment
Isolated from Mycobacterium tuberculosis. The enzyme adds approximately twenty-eight galactofuranosyl residues with alternating 1->5 and 1->6 links forming a galactan domain with approximately thirty galactofuranosyl residues. Involved in the formation of the cell wall in mycobacteria.
History
EC 2.4.1.288 created 2012
Pathway
ec00572 Arabinogalactan biosynthesis - Mycobacterium
Orthology
K16650 galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase
Genes
CHJ : NCTC10426_01362(glfT2)
KRO : BVG79_00198 BVG79_01971(glfT)
SCLO : SCLO_1028110 SCLO_1028180
APT : APA01_17560 APA01_17600
APW : APA42C_17560 APA42C_17600
APF : APA03_17560 APA03_17600
APU : APA07_17560 APA07_17600
APG : APA12_17560 APA12_17600
APQ : APA22_17560 APA22_17600
APX : APA26_17560 APA26_17600
APZ : APA32_17560 APA32_17600
APK : APA386B_687 APA386B_691
ASV : WG31_09060 WG31_09080
APOM : CPF11_11490 CPF11_11515
ATO : CIW82_07080 CIW82_10385
AASC : A4S02_07000 A4S02_07015
ACET : DS739_08915 DS739_08935
AOY : EOV40_008315 EOV40_008740
COQ : D9V35_07685 D9V35_07715
COMM : GN303_07475 GN303_07505
TPI : TREPR_2536 TREPR_2539
OLO : ADJ70_05840 ADJ70_12120
PCAT : Pcatena_07330(rfbF_1) Pcatena_12040(rfbF_2)
ATB : J4859_04805 J4859_08465
MBO : BQ2027_MB3838C(glft2)
MMAE : MMARE11_51930(glfT)
MBAI : MB901379_04812(glfT2)
MHEK : JMUB5695_00208(glfT2)
MPHL : MPHLCCUG_00197(glfT2)
MTHN : 4412656_04410(glfT2)
MAUU : NCTC10437_05411(glfT2)
MMUC : C1S78_010205 C1S78_028065
MFLV : NCTC10271_00204(glfT2)
MSAL : DSM43276_00148(glfT2)
MTER : 4434518_04065(glfT)
CDIP : ERS451417_02233(glfT)
CUN : Cul210932_2174(glfT)
CUQ : Cul210931_2128(glfT)
CUJ : CUL131002_2083c(glfT)
COA : DR71_1179 DR71_969(glfT2)
CLW : CLAC_00535 CLAC_11830
CMIN : NCTC10288_00189(glfT)
CXE : FOB82_04915 FOB82_06025
CRL : NCTC7448_00626(glfT)
CCYS : SAMEA4530656_2856(glfT2)
CAMC : I6I65_07050 I6I65_08040
CFY : I6L56_07980 I6L56_08915
CAUI : CAURIS_10515(glfT2)
CAUS : CAURIC_00995(glfT1)
CHAN : CHAN_00620(glfT1) CHAN_13235(glfT3)
NFA : NFA_1770(glfT) NFA_2140
NFR : ERS450000_04024(glfT2_2) ERS450000_04062(glfT2_3)
NCY : NOCYR_0133 NOCYR_0169
NBR : O3I_000690 O3I_000895
NNO : NONO_c01390 NONO_c01750
NSL : BOX37_00715 BOX37_00955
NSR : NS506_00779 NS506_00828
NTP : CRH09_00770 CRH09_00965
NOZ : DMB37_21710 DMB37_21915
NOD : FOH10_30590 FOH10_30845
NAH : F5544_00790 F5544_01015
NAD : NCTC11293_00913(glfT2_1) NCTC11293_00958(glfT2_2)
NWL : NWFMUON74_01170(glfT2) NWFMUON74_01540
NIE : KV110_00675 KV110_00880
NTC : KHQ06_06690 KHQ06_06910
NHU : H0264_01845 H0264_02165
NYA : LTV02_30600 LTV02_30860
NGP : LTT66_13515 LTT66_13760
NSPU : IFM12276_65590(glfT2) IFM12276_66060
NYU : D7D52_24970 D7D52_25190
RHA : RHA1_ro04054 RHA1_ro04109
RER : RER_02120(glfT) RER_02550
REB : XU06_01080 XU06_01300
RQI : C1M55_01085 C1M55_01280
ROP : ROP_39320(glfT) ROP_39720
ROA : Pd630_LPD00451 Pd630_LPD00507
RPY : Y013_17415 Y013_17585
RBY : CEJ39_03810 CEJ39_03990
RAV : AAT18_01470 AAT18_01630
RHW : BFN03_16900 BFN03_17135
RRZ : CS378_17650 CS378_17810
RHU : A3Q40_03621(glfT2_1) A3Q40_03648(glfT2_2)
RHQ : IM25_07360 IM25_07520 IM25_23725
RHOD : AOT96_11640 AOT96_11860
RRT : 4535765_00212(glfT2_1) 4535765_00247(glfT2_2)
RCR : NCTC10994_02445(glfT2_1) NCTC10994_02471(glfT2_2)
RTM : G4H71_08950 G4H71_09160
RKO : JWS14_22175 JWS14_22430
RGO : KYT97_20665 KYT97_20850
ROZ : CBI38_02185 CBI38_02465
RPSK : JWS13_22515 JWS13_22770
RGOR : NMQ04_00795 NMQ04_00950
RHOP : D8W71_02410 D8W71_02590
RHOO : RA302_01140 RA302_01305
RHOU : KZJ41_01445 KZJ41_01605
RHOW : A4U64_23145 A4U64_23305
RHOJ : JVH1_15915 JVH1_16185
RHOS : QWW67_18785 QWW67_18945
RHOQ : QWW98_18795 QWW98_18955
RHOY : QNA09_25525 QNA09_25685
RHOH : CPI83_27620 CPI83_27840
RHOX : RBB84_21995 RBB84_22160 RBB84_22525
RFA : A3L23_02021(glfT2_1) A3L23_02060(glfT2_2)
RHS : A3Q41_01302(glfT2_1) A3Q41_01342(glfT2_2)
PSOW : ABI214_12750 ABI214_13025
WHR : OG579_10610 OG579_11405
GPO : GPOL_c04080 GPOL_c04450
GOC : CXX93_02165 CXX93_08895
GOI : LK459_07675 LK459_07830
GSI : P5P27_13355 P5P27_20025
SPIN : KV203_00875 KV203_01045
DTM : BJL86_0224 BJL86_0257
DIT : C3V38_07635 C3V38_07740
DIZ : CT688_01425 CT688_01515
DPC : A6048_01460 A6048_01575
DLU : A6035_01810 A6035_01910
DKN : NHB83_01350 NHB83_01460
DCD : VYL96_01550 VYL96_01655
CBQ : AL705_03935 AL705_04205
TOY : FO059_02140 FO059_02230
SLUO : PS467_34320 PS467_34435
AMAU : DSM26151_09130(glfT2)
AAGI : NCTC2676_1_02028(glfT2)
AJR : N2K98_07365 N2K98_12210
RSA : RSal33209_1617(glfT)
KVR : CIB50_0002258(glfT2)
BFA : Bfae_20840 Bfae_26380
BRX : BH708_06630 BH708_09720
BRV : CFK39_02775 CFK39_05620
BGG : CFK41_03335 CFK41_06235
BRZ : CFK38_05465 CFK38_08515
TEH : GKE56_00665 GKE56_00710
PAUS : NCTC13651_00096(glfT2)
NAQU : ENKNEFLB_03322(glfT2)
SEN : SACE_0166 SACE_5733 SACE_5734
AMQ : AMETH_0245 AMETH_5592
AACD : LWP59_00915 LWP59_00960
AMOG : QRX60_10255 QRX60_30165 QRX60_36510
ACOR : LCL61_05770 LCL61_18700
PSEA : WY02_17115 WY02_17130
PSEE : FRP1_25630 FRP1_25645
PSEH : XF36_24925 XF36_24935
PSEQ : AD006_04810 AD006_04825
PECQ : AD017_12630 AD017_12645
PHH : AFB00_10305 AFB00_10340
PAUT : Pdca_01750(glfT2) Pdca_01780
PBRO : HOP40_07225 HOP40_07235
PPEL : H6H00_07640 H6H00_07645
PSDS : K1T35_00650 K1T35_00665
SSYI : EKG83_00710 EKG83_00715
KPHY : AOZ06_00985 AOZ06_01160
ACTU : Actkin_00153(glfT2_1) Actkin_00154(glfT2_2)
CROS : N8J89_00765 N8J89_00770
ACTY : OG774_19345 OG774_19415
BDE : BDP_2042(rfbF) BDP_2053(rfbF)
CCUR : IAR63_13890 IAR63_16405
SCYS : NIES4073_33410 NIES4073_33550 NIES4073_34620
CTHE : Chro_3133 Chro_3134
» show all
Taxonomy
Reference
Authors
Rose NL, Zheng RB, Pearcey J, Zhou R, Completo GC, Lowary TL
Title
Development of a coupled spectrophotometric assay for GlfT2, a bifunctional mycobacterial galactofuranosyltransferase.
Journal
Sequence
Reference
Authors
May JF, Splain RA, Brotschi C, Kiessling LL
Title
A tethering mechanism for length control in a processive carbohydrate polymerization.
Journal
Sequence
Reference
Authors
Wheatley RW, Zheng RB, Richards MR, Lowary TL, Ng KK
Title
Tetrameric structure of the GlfT2 galactofuranosyltransferase reveals a scaffold for the assembly of mycobacterial Arabinogalactan.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.288