KEGG   ENZYME: 2.4.1.292
Entry
EC 2.4.1.292                Enzyme                                 
Name
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase;
PglH
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol 4-alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
3 UDP-N-acetyl-alpha-D-galactosamine + GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol = 3 UDP + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Product
UDP [CPD:C00015];
[GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Comment
Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway.
History
EC 2.4.1.292 created 2012
Orthology
K17249  GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase
Genes
CJE: Cj1129c(pglH)
CJB: BN148_1129c(pglH)
CJJ: CJJ81176_1146(pglH)
CJU: C8J_1069(wlaC)
CJN: ICDCCJ07001_1086
CJI: CJSA_1071(pglH)
CJM: CJM1_1107(capM)
CJS: CJS3_1175(pglH)
CJP: A911_05470
CJEJ: N564_01097
CJEU: N565_01140
CJEN: N755_01133
CJEI: N135_01166
CJER: H730_06615
CJV: MTVDSCj20_1132(pglH)
CJY: QZ67_01207(pglH)
CJQ: UC78_1086(pglH)
CJL: PJ17_05785
CJW: PJ18_05600
CJR: CJE1271(pglH)
CJD: JJD26997_0592(pglH)
CJZ: M635_01350
CJX: BN867_11200
CFF: CFF8240_1385 CFF8240_1386
CFT: CFF04554_1400(pglH) CFF04554_1401
CFV: CFVI03293_1423(pglH) CFVI03293_1424
CFX: CFV97608_1523(pglH) CFV97608_1524
CFZ: CSG_15220 CSG_15230
CAMP: CFT03427_1348(pglH) CFT03427_1349
CFP: CR44_06820 CR44_06825
CCV: CCV52592_1215(pglH2) CCV52592_1216(pglH1)
CHA: CHAB381_0956 CHAB381_0958
CCO: CCC13826_0454(pglH1) CCC13826_0455(pglH2)
CCOC: CCON33237_1467(pglH1) CCON33237_1468(pglH2)
CLA: CLA_1251(pglH)
CLR: UPTC16701_1234(pglH)
CLM: UPTC16712_1252(pglH)
CLQ: UPTC4110_1236(pglH)
CLN: UPTC3659_1471(pglH)
CLL: CONCH_1202(pglH)
CCOL: BN865_09990
CCC: G157_03290
CCQ: N149_1070
CCF: YSQ_03325
CCY: YSS_06110
CCOI: YSU_03360
CCOF: VC76_05540(pglH_1)
CCOO: ATE51_01346(pglH)
CAJ: CIG1485E_1394(pglH) CIG1485E_1395
CIS: CINS_1216(pglH)
CVO: CVOL_1230(pglH)
CPEL: CPEL_1357(pglH)
CAMR: CAQ16704_1262(pglH)
CSM: CSUB8521_1438(pglH)
CSF: CSUB8523_1534(pglH)
CGRA: CGRAC_1492(pglH1) CGRAC_1494(pglH2)
CURE: CUREO_1377(pglH)
CHYO: CHH_0374 CHH_0375(pglH)
CHV: CHELV3228_0551(pglH)
CSPF: CSF_0895(pglH1) CSF_0897(pglH2)
CPIN: CPIN18020_0859(pglH)
CCUN: CCUN_1168(pglH)
CLX: CLAN_0351 CLAN_0352(pglH)
CAVI: CAV_0408(pglH)
CHW: A2J15_001335
CAMZ: CVIC12175_1313 CVIC12175_1314(pglH)
CAMY: CSUIS_0196 CSUIS_0197(pglH)
COJ: CORN_1321(pglH)
CUX: CUP3940_1140(pglH)
CRX: CRECT_1679(pglH)
CGEO: CGEO_1576(pglH1) CGEO_1578(pglH2)
CCOR: CCORG_0290(pglH)
CARM: CARM_1284(pglH)
CMUC: CMCT_0313(pglH1) CMCT_0314(pglH2)
CSHO: CSHOW_1521(pglH)
CINF: CINF_0320
CNV: CNZW441b_1132(pglH)
CVU: CVULP_0489(pglH)
CDEV: CIGN_1245(pglH) CIGN_1246
CCAQ: CCAL_1418(pglH1) CCAL_1419(pglH2)
 » show all
Reference
1  [PMID:16186480]
  Authors
Glover KJ, Weerapana E, Imperiali B
  Title
In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation.
  Journal
Proc Natl Acad Sci U S A 102:14255-9 (2005)
DOI:10.1073/pnas.0507311102
  Sequence
[cje:Cj1129c]
Reference
2  [PMID:19159314]
  Authors
Troutman JM, Imperiali B
  Title
Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions.
  Journal
Biochemistry 48:2807-16 (2009)
DOI:10.1021/bi802284d
  Sequence
[cje:Cj1129c]
Reference
3  [PMID:21606362]
  Authors
Borud B, Viburiene R, Hartley MD, Paulsen BS, Egge-Jacobsen W, Imperiali B, Koomey M
  Title
Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system.
  Journal
Proc Natl Acad Sci U S A 108:9643-8 (2011)
DOI:10.1073/pnas.1103321108
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.292
IUBMB Enzyme Nomenclature: 2.4.1.292
ExPASy - ENZYME nomenclature database: 2.4.1.292
BRENDA, the Enzyme Database: 2.4.1.292

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Gene (103)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (102)   
Protein sequence (616)   
   UniProt (356)   
   SWISS-PROT (1)   
   RefSeq(pep) (259)   
DNA sequence (4531)   
   RefSeq(nuc) (3327)   
   GenBank (649)   
   EMBL (555)   
Protein domain (2)   
   InterPro (2)   
All databases (5252)   

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