KEGG   ENZYME: 2.4.1.304
Entry
EC 2.4.1.304                Enzyme                                 
Name
UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase;
WfeD;
UDP-Gal:GlcNAc-R 1,4-Gal-transferase;
UDP-Gal:GlcNAc-pyrophosphate-lipid beta-1,4-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-1,4-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + beta-D-Gal-(1->4)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol [RN:R10433]
Reaction(KEGG)
R10433
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]
Product
UDP [CPD:C00015];
beta-D-Gal-(1->4)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol [CPD:C20618]
Comment
The enzyme is involved in the the biosynthesis of the O-polysaccharide repeating unit of the bacterium Shigella boydii B14. The activity is stimulated by Mn2+ or to a lesser extent by Mg2+, Ca2+, Ni2+ or Pb2+.
History
EC 2.4.1.304 created 2013
Orthology
K21364  UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,4-galactosyltransferase
Genes
ELNNRG857_10355
ELFLF82_350
VROBSZ04_22135
PPRPBPRA2677
SHMShewmr7_1395
SEURFM038_015500
PPISB1L02_14610
PTUPTUN_a0641
PSENPNC201_02750(wfeD)
PAGAPAGA_a0486
PXIJ5O05_07210
PVBJ5X90_03360
PSAZPA25_03780
PSPIPS2015_1756
 » show all
Reference
1  [PMID:21057010]
  Authors
Xu C, Liu B, Hu B, Han Y, Feng L, Allingham JS, Szarek WA, Wang L, Brockhausen I
  Title
Biochemical characterization of UDP-Gal:GlcNAc-pyrophosphate-lipid beta-1,4-Galactosyltransferase WfeD, a new enzyme from Shigella boydii type 14 that catalyzes the second step in O-antigen repeating-unit synthesis.
  Journal
J Bacteriol 193:449-59 (2011)
DOI:10.1128/JB.00737-10
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.304
IUBMB Enzyme Nomenclature: 2.4.1.304
ExPASy - ENZYME nomenclature database: 2.4.1.304
BRENDA, the Enzyme Database: 2.4.1.304

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