KEGG   ENZYME: 2.4.1.310
Entry
EC 2.4.1.310                Enzyme                                 
Name
vancomycin aglycone glucosyltransferase;
GtfB (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:vancomycin aglycone 48-O-beta-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + vancomycin aglycone = UDP + devancosaminyl-vancomycin [RN:R10594]
Reaction(KEGG)
R10594
Substrate
UDP-alpha-D-glucose [CPD:C00029];
vancomycin aglycone [CPD:C20719]
Product
UDP [CPD:C00015];
devancosaminyl-vancomycin [CPD:C20720]
Comment
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.4.1.310 created 2013
Pathway
ec01055  Biosynthesis of vancomycin group antibiotics
Orthology
K16444  vancomycin aglycone glucosyltransferase
Genes
LGULG3211_2060(gtfB)
LEZGLE_1936
LEMLEN_3062
SURSTAUR_4277
AGEAA314_00618
CFUSCYFUS_000252
SCLsce8970(gtfE)
SCUSCE1572_48875
PAUUE8A73_008730
SAMYDB32_007987
BOIBLM15_03940
MIVC4E04_17165
CMBCSW64_17500
HNEHNE_2384
SPAPH3Z74_00855 H3Z74_10395
ACELacsn021_15630
MPAMAP_2871c
MAOMAP4_0937
MAVIRC58_04605
MAVMAV_3653
MITOCO_25740
MIAOCU_25590
MIDMIP_03577
MYOOEM_24180
MCHIAN480_13525
MIROCQ_24300
MMANMMAN_03190
MSAMycsm_04809
MULMUL_4949
MMIMMAR_0148
MMAEMMARE11_01350
MMMW7S_12435
MLIMULP_00133
MSHGMSG_01769
MFJMFLOJ_14760
MSTOMSTO_16320
MSIMMSIM_05540
MCOOMCOO_08500 MCOO_10290
MBAIMB901379_00113
MPSEMPSD_01460
MNED174_23150
MYNMyAD_22700
MRHMycrhN_1486 MycrhN_5442
MMORMMOR_38890
MCEEMCEL_38310
NBRO3I_020415 O3I_022455
NSLBOX37_16920
NSRNS506_05801(gtfB)
NWLNWFMUON74_19990 NWFMUON74_30120
NHUH0264_29045
NYALTV02_04980
RHARHA1_ro03522
ROAPd630_LPD07907
RHUA3Q40_02053
GORKTR9_1827
SHYSHJG_1904
SHOSHJGH_1669
SRCM271_06890
SCTSCAT_p1593(rgt)
SCYSCATT_p01310
SBHSBI_02990
SVESVEN_3444
SALSSLNWT_2781 SLNWT_4757
STREGZL_07987
SLCSL103_17190
SPRISPRI_5993
SRWTUE45_pSRc_0432(TUE45_pSRTUE45c_0432)
SRNA4G23_03608
SALWCP975_15810
SGMGCM10017557_01070 GCM10017557_03400
SCADDN051_04670
SLSSLINC_0863
SNRSNOUR_36265
SSIAA7J05_01405
SGVB1H19_02020
SALFSMD44_04791
SALJSMD11_6659 SMD11_6727
SLXSLAV_16635(novM1) SLAV_35915(novM2)
SFKKY5_7970 KY5_7986
SGEDWG14_00394(aknK)
SLKSLUN_38755
SGDELQ87_34360
SCYAEJ357_09080
SNQCP978_01590
SKACP970_42930
SFICEIZ62_01765 EIZ62_14495
SAQUEJC51_30950 EJC51_40985
SBYH7H31_16795
SCOECP976_19455
SBATG4Z16_02265
SNFJYK04_00799(gtfB)
SPLACP981_09155 CP981_33240
SATAC5746_37480
SLIAHA039_31000
SVDCP969_00880
SAUHSU9_005065
SFBCP974_19545
SMOBJ7W19_11085
SPEUCGZ69_06345
SROIIAG44_03180 IAG44_35960
SMAOCAG99_18345
SGOBtest1122_05295
SINEKI385_00245 KI385_04200 KI385_41035
SLFJEQ17_42820
SDECL3078_24150
KITCFP65_7138
LMOIVV02_12065
MICGGJV80_02950
TFLRPIT_10355
KFLKfla_0374
KQIF1D05_22545
TCUTcur_2526
ACTWF7P10_15695
SROSros_5179
NOABKM31_42295
NCXNocox_13400(noc25)
NGNLCN96_07825
FREFranean1_5814
SACGFDZ84_31065
AMDAMED_3957 AMED_5501
AMNRAM_20165 RAM_28035
AMMAMES_3910 AMES_5434
AMZB737_3910 B737_5434
AOIAORI_1487 AORI_3038 AORI_6511
AJAAJAP_06410 AJAP_12965 AJAP_32080 AJAP_32090 AJAP_32095
AMQAMETH_1868
AMYBBKN51_26020 BKN51_41465 BKN51_41470 BKN51_41480
AMYYYIM_26400(novM3)
AORISD37_07860 SD37_26075 SD37_33685
AMIAmir_3897
SESPBN6_44490(gtuS1-3) BN6_68280(gtuS1-1)
SSYIEKG83_16745 EKG83_30910
KALKALB_3316 KALB_7082
KPHYAOZ06_14195 AOZ06_27475 AOZ06_46940 AOZ06_50140
LEDBBK82_23920
ACTAC1701_00030
PMADBAY61_20630
MAUMicau_2443
MILML5_5919
MICBMicB006_3073
MCABHXZ27_03580 HXZ27_05415
ASEACPL_4499(gtfE)
AFSAFR_23425
ACTSACWT_4370
DVCDvina_39180
GLYK3N28_18315 K3N28_22670
ATQGH723_03540 GH723_03545
TOQHCG51_11195
VBHCMV30_01090
ROOG5S37_27010
VBAIMCC26134_08695
GBAJ421_6182
PGINFRZ67_17255
 » show all
Reference
1  [PMID:11294642]
  Authors
Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT
  Title
Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.
  Journal
Biochemistry 40:4745-55 (2001)
DOI:10.1021/bi010050w
Reference
2  [PMID:11470430]
  Authors
Mulichak AM, Losey HC, Walsh CT, Garavito RM
  Title
Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.
  Journal
Structure 9:547-57 (2001)
DOI:10.1016/S0969-2126(01)00616-5
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.310
IUBMB Enzyme Nomenclature: 2.4.1.310
ExPASy - ENZYME nomenclature database: 2.4.1.310
BRENDA, the Enzyme Database: 2.4.1.310

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