KEGG   ENZYME: 2.4.1.311
Entry
EC 2.4.1.311                Enzyme                                 
Name
chloroorienticin B synthase;
GtfA
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-L-4-epi-vancosamine:desvancosaminyl-vancomycin vancosaminyltransferase
Reaction(IUBMB)
dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin = dTDP + chloroorienticin B [RN:R10595]
Reaction(KEGG)
R10595
Substrate
dTDP-beta-L-4-epi-vancosamine [CPD:C12321];
desvancosaminyl-vancomycin [CPD:C20720]
Product
dTDP [CPD:C00363];
chloroorienticin B [CPD:C20721]
Comment
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.4.1.311 created 2013
Pathway
ec01055  Biosynthesis of vancomycin group antibiotics
Orthology
K16440  chloroorienticin B synthase
Genes
AJA: AJAP_32100
AMYB: BKN51_41460
AROO: NQK81_15470
ACOR: LCL61_00200
AMYE: MJQ72_33955
AMYS: CVV72_21575
KUT: JJ691_70460
AAUR: V5P93_001188(knm16)
AOU: ACTOB_006487
Reference
1  [PMID:12874381]
  Authors
Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM
  Title
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway.
  Journal
Proc Natl Acad Sci U S A 100:9238-43 (2003)
DOI:10.1073/pnas.1233577100
  Sequence
[ag:CAA11774]
Reference
2  [PMID:15070728]
  Authors
Lu W, Oberthur M, Leimkuhler C, Tao J, Kahne D, Walsh CT
  Title
Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin.
  Journal
Proc Natl Acad Sci U S A 101:4390-5 (2004)
DOI:10.1073/pnas.0400277101
  Sequence
[ag:CAA11774]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.311
IUBMB Enzyme Nomenclature: 2.4.1.311
ExPASy - ENZYME nomenclature database: 2.4.1.311
BRENDA, the Enzyme Database: 2.4.1.311

  All links  
Protein sequence (7)   
   UniProt (6)   
   SWISS-PROT (1)   
All databases (7)   

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