KEGG   ENZYME: 2.4.1.311Help
Entry
EC 2.4.1.311                Enzyme                                 

Name
chloroorienticin B synthase;
GtfA
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-L-4-epi-vancosamine:desvancosaminyl-vancomycin vancosaminyltransferase
Reaction(IUBMB)
dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin = dTDP + chloroorienticin B [RN:R10595]
Reaction(KEGG)
Substrate
dTDP-beta-L-4-epi-vancosamine [CPD:C12321];
desvancosaminyl-vancomycin [CPD:C20720]
Product
dTDP [CPD:C00363];
chloroorienticin B [CPD:C20721]
Comment
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.4.1.311 created 2013
Pathway
ec01055  Biosynthesis of vancomycin group antibiotics
Orthology
K16440  chloroorienticin B synthase
Genes
AJA: AJAP_32100
Taxonomy
Reference
1  [PMID:12874381]
  Authors
Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM
  Title
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway.
  Journal
Proc Natl Acad Sci U S A 100:9238-43 (2003)
DOI:10.1073/pnas.1233577100
  Sequence
Reference
2  [PMID:15070728]
  Authors
Lu W, Oberthur M, Leimkuhler C, Tao J, Kahne D, Walsh CT
  Title
Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin.
  Journal
Proc Natl Acad Sci U S A 101:4390-5 (2004)
DOI:10.1073/pnas.0400277101
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.311
IUBMB Enzyme Nomenclature: 2.4.1.311
ExPASy - ENZYME nomenclature database: 2.4.1.311
BRENDA, the Enzyme Database: 2.4.1.311

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