KEGG   ENZYME: 2.4.1.313
Entry
EC 2.4.1.313                Enzyme                                 

Name
protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase;
B3GALNT2
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl-threonyl-[protein] 3-beta-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [RN:R10620 R12292]
Reaction(KEGG)
R10620 R12292(G);
(other) R07614(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20723]
Product
UDP [CPD:C00015];
3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20734]
Comment
The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor [1]. The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.
History
EC 2.4.1.313 created 2013
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K09654  beta-1,3-N-acetylgalactosaminyltransferase 2
Genes
HSA: 148789(B3GALNT2)
PTR: 469715(B3GALNT2)
PPS: 100978307(B3GALNT2)
GGO: 101140966(B3GALNT2)
PON: 100443319(B3GALNT2)
NLE: 100589286(B3GALNT2)
MCC: 711550(B3GALNT2)
MCF: 102146449(B3GALNT2)
CSAB: 103230797(B3GALNT2)
RRO: 104679172(B3GALNT2)
RBB: 108522205(B3GALNT2)
CJC: 100413278(B3GALNT2)
SBQ: 101046032(B3GALNT2)
MMU: 97884(B3galnt2)
MCAL: 110307761(B3galnt2)
MPAH: 110333891(B3galnt2)
RNO: 291212(B3galnt2)
MUN: 110558133(B3galnt2)
CGE: 100768564(B3galnt2)
NGI: 103745134(B3galnt2)
HGL: 101697517(B3galnt2)
CCAN: 109692618(B3galnt2)
OCU: 100352278(B3GALNT2)
TUP: 102477401(B3GALNT2)
CFA: 479196(B3GALNT2)
VVP: 112927402(B3GALNT2)
AML: 100484405(B3GALNT2)
UMR: 103661896(B3GALNT2)
UAH: 113259001(B3GALNT2)
ORO: 101372831(B3GALNT2)
ELK: 111160534
FCA: 101085750(B3GALNT2)
PTG: 102961022(B3GALNT2)
PPAD: 109248879(B3GALNT2)
AJU: 106982543(B3GALNT2)
BTA: 100125310(B3GALNT2)
BOM: 102280720(B3GALNT2)
BIU: 109553768(B3GALNT2)
BBUB: 102403318(B3GALNT2)
CHX: 102178329(B3GALNT2)
OAS: 101116957(B3GALNT2)
SSC: 100620910(B3GALNT2)
CFR: 102506122(B3GALNT2) 102522922
CDK: 116147114
BACU: 103018636(B3GALNT2)
LVE: 103083400(B3GALNT2)
OOR: 101271023(B3GALNT2)
DLE: 111163939(B3GALNT2)
PCAD: 102976716(B3GALNT2)
ECB: 100058647(B3GALNT2)
EPZ: 103547683(B3GALNT2)
EAI: 106834710(B3GALNT2)
MYB: 102240384(B3GALNT2)
MYD: 102762905(B3GALNT2)
MNA: 107527201(B3GALNT2)
HAI: 109387715(B3GALNT2)
DRO: 112306100(B3GALNT2)
PALE: 102897229(B3GALNT2)
RAY: 107520055(B3GALNT2)
MJV: 108401878(B3GALNT2)
LAV: 100663890(B3GALNT2)
TMU: 101358044
MDO: 100617587(B3GALNT2)
SHR: 100921524(B3GALNT2)
PCW: 110217849(B3GALNT2)
OAA: 100081648(B3GALNT2)
GGA: 430770(B3GALNT2)
MGP: 100538415(B3GALNT2)
CJO: 107311372(B3GALNT2)
NMEL: 110396188(B3GALNT2)
APLA: 101803248(B3GALNT2)
ACYG: 106048080(B3GALNT2)
TGU: 100218422(B3GALNT2)
LSR: 110468868(B3GALNT2)
SCAN: 103818567(B3GALNT2)
GFR: 102040498(B3GALNT2)
FAB: 101813810(B3GALNT2)
PHI: 102113102(B3GALNT2)
PMAJ: 107201263(B3GALNT2)
CCAE: 111927067(B3GALNT2)
CCW: 104684442(B3GALNT2)
ETL: 114066550(B3GALNT2)
FPG: 101914116(B3GALNT2)
FCH: 102053282(B3GALNT2)
CLV: 102094245(B3GALNT2)
EGZ: 104131046(B3GALNT2)
NNI: 104019876(B3GALNT2)
ACUN: 113477903(B3GALNT2)
PADL: 103921275(B3GALNT2)
AAM: 106486759(B3GALNT2)
ASN: 102378749(B3GALNT2)
AMJ: 102570410(B3GALNT2)
PSS: 102458995(B3GALNT2)
CMY: 102938135(B3GALNT2)
CPIC: 101933681(B3GALNT2)
ACS: 100557470(b3galnt2)
PVT: 110075614(B3GALNT2)
PBI: 103057702(B3GALNT2)
PMUR: 107288312(B3GALNT2)
TSR: 106538193(B3GALNT2)
PMUA: 114594411(B3GALNT2)
GJA: 107117761(B3GALNT2)
XLA: 431874(b3galnt2.L)
XTR: 496641(b3galnt2)
NPR: 108802270(B3GALNT2)
DRE: 553716(b3galnt2)
SANH: 107667096 107691207(b3galnt2)
SGH: 107557719(b3galnt2)
IPU: 108263411(b3galnt2)
PHYP: 113541960(b3galnt2)
AMEX: 103030528(b3galnt2)
EEE: 113577753(b3galnt2)
LCO: 104934548(b3galnt2)
NCC: 104960299(b3galnt2)
MZE: 101477300(b3galnt2)
ONL: 100693767(b3galnt2)
OLA: 101169879(b3galnt2)
XMA: 102234069(b3galnt2)
XCO: 114138582(b3galnt2)
PRET: 103477261(b3galnt2)
CVG: 107087799(b3galnt2)
NFU: 107375431(b3galnt2)
KMR: 108240630(b3galnt2)
ALIM: 106515875(b3galnt2)
AOCE: 111573739(b3galnt2)
CSEM: 103387616(b3galnt2)
POV: 109642026(b3galnt2)
LCF: 108885798(b3galnt2)
SDU: 111220668(b3galnt2)
SLAL: 111659007(b3galnt2)
HCQ: 109516187(b3galnt2)
BPEC: 110157249(b3galnt2)
MALB: 109962360(b3galnt2)
SASA: 106578767(b3galnt2)
OTW: 112237453(b3galnt2)
SALP: 112071951(b3galnt2)
ELS: 105006091(b3galnt2)
SFM: 108926991 108933762(b3galnt2)
PKI: 111835667 111856374(b3galnt2)
LCM: 102359133(B3GALNT2)
CMK: 103178875(b3galnt2)
BFO: 118425673
CIN: 100184607
SPU: 100893207
APLC: 110978840
SKO: 100372327
BTAB: 109031387
CLEC: 106672465
ZNE: 110828299
PVM: 113806206
TUT: 107363544
DPTE: 113790809
CSCU: 111636005
PTEP: 107441986
PCAN: 112570564
CRG: 105332774
MYI: 110454356
OBI: 106876718
NVE: 5507055
EPA: 110233214
ADF: 107345723
AMIL: 114965109
PDAM: 113667536
SPIS: 111330956
DGT: 114516906
HMG: 100200949
 » show all
Reference
1  [PMID:14724282]
  Authors
Hiruma T, Togayachi A, Okamura K, Sato T, Kikuchi N, Kwon YD, Nakamura A, Fujimura K, Gotoh M, Tachibana K, Ishizuka Y, Noce T, Nakanishi H, Narimatsu H
  Title
A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc.
  Journal
J Biol Chem 279:14087-95 (2004)
DOI:10.1074/jbc.M310614200
  Sequence
[hsa:148789]
Reference
2  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science 341:896-9 (2013)
DOI:10.1126/science.1239951
  Sequence
[hsa:148789]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.313
IUBMB Enzyme Nomenclature: 2.4.1.313
ExPASy - ENZYME nomenclature database: 2.4.1.313
BRENDA, the Enzyme Database: 2.4.1.313

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