KEGG   ENZYME: 2.4.1.322Help
Entry
EC 2.4.1.322                Enzyme                                 

Name
devancosaminyl-vancomycin vancosaminetransferase;
devancosaminyl-vancomycin TDP-vancosaminyltransferase;
GtfD;
dTDP-beta-L-vancomycin:desvancosaminyl-vancomycin beta-L-vancosaminetransferase;
desvancosaminyl-vancomycin vancosaminetransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-beta-L-vancomycin:devancosaminyl-vancomycin beta-L-vancosaminetransferase
Reaction(IUBMB)
dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin [RN:R10833]
Reaction(KEGG)
Substrate
dTDP-beta-L-vancosamine [CPD:C12322];
devancosaminyl-vancomycin [CPD:C20720]
Product
dTDP [CPD:C00363];
vancomycin [CPD:C06689]
Comment
The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin.
History
EC 2.4.1.322 created 2014
Pathway
ec01055  Biosynthesis of vancomycin group antibiotics
Orthology
K16443  desvancosaminyl-vancomycin vancosaminetransferase
Genes
AOI: AORI_1486
Taxonomy
Reference
1  [PMID:11294642]
  Authors
Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT
  Title
Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.
  Journal
Biochemistry 40:4745-55 (2001)
DOI:10.1021/bi010050w
  Sequence
Reference
2  [PMID:15122882]
  Authors
Mulichak AM, Lu W, Losey HC, Walsh CT, Garavito RM
  Title
Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands.
  Journal
Biochemistry 43:5170-80 (2004)
DOI:10.1021/bi036130c
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.322
IUBMB Enzyme Nomenclature: 2.4.1.322
ExPASy - ENZYME nomenclature database: 2.4.1.322
BRENDA, the Enzyme Database: 2.4.1.322

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