dTDP-beta-L-rhodosamine:aklavinone 7-alpha-L-rhodosaminyltransferase (configuration-inverting)
dTDP-beta-L-rhodosamine + aklavinone = dTDP + aclacinomycin T [RN:
Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-beta-L-fucose. Involved in the biosynthesis of other aclacinomycins.
EC 18.104.22.1686 created 2014, modified 2015
ec01057 Biosynthesis of type II polyketide products
ec01110 Biosynthesis of secondary metabolites
K15946 aklavinone 7-alpha-L-rhodosaminyltransferase
Lu W, Leimkuhler C, Gatto GJ Jr, Kruger RG, Oberthur M, Kahne D, Walsh CT
AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.
Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D
Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.
ExPASy - ENZYME nomenclature database: 22.214.171.1246