KEGG   ENZYME: 2.4.1.331
Entry
EC 2.4.1.331                Enzyme                                 

Name
8-demethyltetracenomycin C L-rhamnosyltransferase;
elmGT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-beta-L-rhamnose:8-demethyltetracenomycin C 3-alpha-L-rhamnosyltransferase
Reaction(IUBMB)
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [RN:R10955]
Reaction(KEGG)
R10955
Substrate
dTDP-beta-L-rhamnose [CPD:C03319];
8-demethyltetracenomycin C [CPD:C12379]
Product
dTDP [CPD:C00363];
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [CPD:C20974]
Comment
Isolated from Streptomyces olivaceus Tu2353. Involved in elloramycin biosynthesis. In vitro it can also utilize other 6-deoxy D- or L-hexoses.
History
EC 2.4.1.331 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19566  8-demethyltetracenomycin C L-rhamnosyltransferase
Reference
1  [PMID:11306350]
  Authors
Blanco G, Patallo EP, Brana AF, Trefzer A, Bechthold A, Rohr J, Mendez C, Salas JA
  Title
Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.
  Journal
Chem Biol 8:253-63 (2001)
DOI:10.1016/S1074-5521(01)00010-2
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.331
IUBMB Enzyme Nomenclature: 2.4.1.331
ExPASy - ENZYME nomenclature database: 2.4.1.331
BRENDA, the Enzyme Database: 2.4.1.331

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