KEGG   ENZYME: 2.4.1.335Help
Entry
EC 2.4.1.335                Enzyme                                 

Name
dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase;
AglC;
UDP-Glc-2,3-diNAcA glycosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate:dolichyl N-acetyl-alpha-D-glucosaminyl-phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase
Reaction(IUBMB)
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate + an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate = UDP + an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy-beta-D-glucuronsyl)-N-acetyl-alpha-D-glucosaminyl phosphate [RN:R11224]
Reaction(KEGG)
Substrate
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:C19725];
archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate [CPD:C04678]
Product
UDP [CPD:C00015];
archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy-beta-D-glucuronsyl)-N-acetyl-alpha-D-glucosaminyl phosphate [CPD:C21213]
Comment
The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain.
History
EC 2.4.1.335 created 2015
Orthology
K21305  dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase
Genes
MVO: Mvol_0744
PYC: TQ32_02885
TSI: TSIB_2026
THS: TES1_1885
TGY: X802_04105
THV: ADU37_CDS21890
Taxonomy
Reference
1  [PMID:23624439]
  Authors
Larkin A, Chang MM, Whitworth GE, Imperiali B
  Title
Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis.
  Journal
Nat Chem Biol 9:367-73 (2013)
DOI:10.1038/nchembio.1249
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.335
IUBMB Enzyme Nomenclature: 2.4.1.335
ExPASy - ENZYME nomenclature database: 2.4.1.335
BRENDA, the Enzyme Database: 2.4.1.335

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