KEGG   ENZYME: 2.4.1.337Help
Entry
EC 2.4.1.337                Enzyme                                 

Name
1,2-diacylglycerol 3-alpha-glucosyltransferase;
mgs (gene name);
UDP-glucose:diacylglycerol glucosyltransferase;
UDP-glucose:1,2-diacylglycerol glucosyltransferase;
uridine diphosphoglucose-diacylglycerol glucosyltransferase;
UDP-glucose-diacylglycerol glucosyltransferase;
UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase;
UDP-glucose:1,2-diacyl-sn-glycerol 3-D-glucosyltransferase;
1,2-diacylglycerol 3-glucosyltransferase (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:1,2-diacyl-sn-glycerol 3-alpha-D-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol [RN:R10850]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
UDP [CPD:C00015];
1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol [CPD:C06364]
Comment
The enzyme from the bacterium Acholeplasma laidlawii, which lacks a cell wall, produces the major non-bilayer lipid in the organism. The enzyme from the bacterium Agrobacterium tumefaciens acts under phosphate deprivation, generating glycolipids as surrogates for phospholipids. The enzyme belongs to the GT4 family of configuration-retaining glycosyltransferases. Many diacylglycerols with long-chain acyl groups can act as acceptors. cf. EC 2.4.1.336, monoglucosyldiacylglycerol synthase.
History
EC 2.4.1.337 created 2015
Pathway
ec00561  Glycerolipid metabolism
ec01100  Metabolic pathways
Orthology
K19002  1,2-diacylglycerol 3-alpha-glucosyltransferase
Genes
RCU: 8283514
EAS: Entas_2804
BUF: D8682_24075
SFO: Z042_01980
PCD: C2E16_13640
LAB: LA76x_3061
LAQ: GLA29479_125
LCP: LC55x_3094
LGU: LG3211_2133
LEZ: GLE_2075
LEM: LEN_2938
VAN: VAA_01123
PALI: A3K91_0724
ILO: IL0120
MAQ: Maqu_3009
MHC: MARHY2948
MAD: HP15_2896
GNI: GNIT_2597
MICC: AUP74_02649(mgs)
MICT: FIU95_08925(mgs)
LPH: LPV_1887
LPO: LPO_1662
LPM: LP6_1610
LPP: lpp1602
LPC: LPC_1061
LPA: lpa_02358(rfaG)
LPE: lp12_1570
LFA: LFA_0143
LOK: Loa_01866
LCJ: NCTC11976_00592(mgtA_1)
MEJ: Q7A_705
TEE: Tel_03140
TGR: Tgr7_1999
HCH: HCH_03962
CSA: Csal_2773
HEL: HELO_1566
SVA: SVA_0742
PUT: PT7_0189
MMB: Mmol_1695
MEH: M301_0256
MEP: MPQ_1874
GCA: Galf_2337
EBA: ebA5576
DSU: Dsui_1835
AZO: azo0965
AZA: AZKH_0861
AOA: dqs_1039
HMS: HMU07320
CAVI: CAV_0146
HYO: NNO_0452
NAM: NAMH_1659
GME: Gmet_1496
PCA: Pcar_2860
PPRF: DPRO_0629
DBA: Dbac_1187
DRT: Dret_2128
SCL: sce1028
SAT: SYN_00036
CID: P73_0719
ERF: FIU90_02035(kanE2)
BBAT: Bdt_0679(capM1)
BBW: BDW_02475
BBAC: EP01_17830
AFR: AFE_1427
BCL: ABC1852
LMO: lmo2555
LMOE: BN418_3022
LMOB: BN419_3035
LMOD: LMON_2570
LMOW: AX10_06845
LMOM: IJ09_12025
LMP: MUO_12755
LMOX: AX24_10725
LMQ: LMM7_2597
LMS: LMLG_2758
LMOK: CQ02_12965
LIN: lin2700
LWE: lwe2505
LSG: lse_2461
LIV: LIV_2469
LGZ: NCTC10812_02558(pimB_3)
LLA: L190226(ywaG)
LLK: LLKF_2386(ywaG)
LLT: CVCAS_2172(ywaG)
LLS: lilo_2118(ywaG)
LLX: NCDO2118_2245(ywaG)
LLM: llmg_2421
LLC: LACR_2441
LLR: llh_12415
LLW: kw2_2198
LLJ: LG36_2077(ywaG)
LGR: LCGT_1839
LGV: LCGL_1860
SPY: SPy_0516
SPYA: A20_0471(ywaG)
SPS: SPs1489
SPF: SpyM51444
SPYH: L897_02320
SPN: SP_1076
SPD: SPD_0961
SPR: spr0982
SPW: SPCG_1204
SJJ: SPJ_1014
SPX: SPG_0997
SNT: SPT_1119
SND: MYY_1123
SPNN: T308_05210
SPV: SPH_1164
SPP: SPP_1082
SNP: SPAP_1117
SAG: SAG0710
SAN: gbs0683
SAK: SAK_0836
SGC: A964_0710(ugtP)
SAGM: BSA_8000
SAGI: MSA_8520
SAGR: SAIL_8550
SAGP: V193_03325
SAGC: DN94_03325
SAGE: EN72_04295
SAGG: EN73_03995
SAGN: W903_0796
SMU: SMU_1588c
SMUA: SMUFR_1378
STC: str0570
STL: stu0570
STE: STER_0611
STN: STND_0568
STW: Y1U_C0546
STHE: T303_03995
SSA: SSA_1574
SSI: SSU1199
SUP: YYK_05725
SSUY: YB51_3050
SSUT: TL13_0629(lafA)
SSUI: T15_0601(ugtP)
SGO: SGO_0775
SEZ: Sez_1406
SEQ: SZO_05510
SEZO: SeseC_01819(ugtP)
SEQU: Q426_02085
SEU: SEQ_1593
SUB: SUB0539
SDS: SDEG_0548
SDA: GGS_0524
SDC: SDSE_0578
SGT: SGGB_1579
SMB: smi_0995
SOR: SOR_1157
STK: STP_0344
STB: SGPB_1463
SCF: Spaf_1482
SSR: SALIVB_1519(spt14)
STF: Ssal_01594(ugtP)
STJ: SALIVA_0578(SPT14)
SMN: SMA_1586
SIF: Sinf_1420
SIE: SCIM_0673
SIB: SIR_0932
SIU: SII_0949
SANG: SAIN_0677
SANC: SANR_0688
SANS: DK43_06740
SCG: SCI_1180
SCON: SCRE_1121
SCOS: SCR2_1121
SIK: K710_1447
SLU: KE3_1523
STRN: SNAG_1157(mgs)
LPL: lp_1275
LPJ: JDM1_1078
LPZ: Lp16_0985
LJO: LJ_1772
LJH: LJP_1530c
LAC: LBA0444
LAD: LA14_0471
LAF: SD55_0470(lafA)
LSA: LCA_0461
LSL: LSL_0390(rfaG)
LSI: HN6_00323(rfaG)
LSJ: LSJ_0376(rfaG)
LDB: Ldb1838
LBU: LBUL_1710
LDL: LBU_0785
LBR: LVIS_1550
LCA: LSEI_0861
LPAP: LBPC_0755
LCB: LCABL_09270(rfaG)
LCS: LCBD_0913
LCE: LC2W_0916
LGA: LGAS_1589
LRE: Lreu_1323
LRF: LAR_1254
LRT: LRI_0644
LHE: lhv_0467
LHL: LBHH_0421
LHV: lhe_1609
LHH: LBH_1453
LHD: HUO_03430
LFE: LAF_1384
LFR: LC40_0885
LFF: LBFF_1505
LRH: LGG_00825(rfaG)
LRG: LRHM_0791
LRL: LC705_00819(rfaG)
LRA: LRHK_849
LBH: Lbuc_1628
LKE: WANG_0144
LRM: LRC_06990
LSN: LSA_10380
LAE: LBAT_0490
PPE: PEPE_0612
PPEN: T256_03290
PCE: PECL_1222
EFA: EF2890
EFL: EF62_2986
EFS: EFS1_2298
EFN: DENG_02788(ugtP)
EFQ: DR75_1583
EFM: M7W_1440
EHR: EHR_14255
ECAS: ECBG_00754
EMU: EMQU_0957
EDU: LIU_05720
MPS: MPTP_0565
MPX: MPD5_1351
THL: TEH_19450(mgs)
OOE: OEOE_0648
LME: LEUM_0387
LMM: MI1_01670
LMK: LMES_0326
LCI: LCK_00379
LKI: LKI_05600
WKO: WKK_01935
WCE: WS08_0219
WCT: WS74_0219
WSO: WSWS_01110(bgsB)
CRN: CAR_c23920(tuaC)
CML: BN424_2419(rfaG) BN424_2460(rfaG-2)
CARC: NY10_68
CAE: SMB_G2571(mgtA) SMB_G3635
HHW: NCTC503_01926(mgtA_2)
ESU: EUS_12930
BPB: bpr_I0134
CPRO: CPRO_04910(mgs)
ERT: EUR_08530
SWO: Swol_0965
SLP: Slip_0834
SALQ: SYNTR_1089
DRM: Dred_1800
DAE: Dtox_2141
PTH: PTH_1384(RfaG)
DAU: Daud_1106
ELM: ELI_3817
OVA: OBV_10400(mgs)
TMR: Tmar_1195
CHY: CHY_1041
MTHO: MOTHE_c10970(mgs)
MTHZ: MOTHA_c11850(mgs)
ADG: Adeg_1032
TPZ: Tph_c12950(mgtA)
FMA: FMG_0876
APR: Apre_0159
ERH: ERH_0631
LPIL: LIP_1170
MFR: MFE_01500(rfaG)
MFP: MBIO_0218
MCM: MCAL160_0736(rfaG)
POY: PAM_008(rfaG)
PML: ATP_00083(rfaG)
PSOL: S284_02790(rfaG)
ACL: ACL_0487
ABRA: BN85311040(ALmgs)
APAL: BN85410350
AOC: Aocu_06320(lafA)
MBJ: KQ51_00541(mgs)
ROP: ROP_55070
MOO: BWL13_02711(mgs)
ARM: ART_3047
AAU: AAur_1499
BLIN: BLSMQ_1886
DCO: SAMEA4475696_0403(cotSA)
TFU: Tfu_2257
STRR: EKD16_02860(mgs) EKD16_06985(pimB4)
AMN: RAM_01025
AMYY: YIM_01070(pimA1)
ACTI: UA75_21660
ACAD: UA74_21180
AHG: AHOG_18675(mgs)
AFS: AFR_17905
BLJ: BLD_0858(rfaG2)
BLN: Blon_1936
BLON: BLIJ_2008
BLF: BLIF_0527
BLL: BLJ_0588
BLB: BBMN68_851(rfaG2)
BLM: BLLJ_0509
BLG: BIL_13340
BDE: BDP_0728
BDN: BBDE_0697
BBRU: Bbr_0601
BBRE: B12L_0511
BBRV: B689b_0597
BBRJ: B7017_0552
BBRC: B7019_0556
BBRN: B2258_0556
BBRS: BS27_0592
BBRD: BBBR_0530
BCAT: BBCT_0528
BPSC: BBPC_0579
NSH: GXM_07828
NSP: BMF81_04445(mgs)
CTHE: Chro_4808
ATM: ANT_20930
TTJ: TTHA0882
TAQ: TO73_1068
MRB: Mrub_1223
OTE: Oter_0790
TTF: THTE_2345
FMR: Fuma_04635(mgtA)
PBU: L21SP3_00746(mfpsA) L21SP3_01070(mgtA)
PBP: STSP1_00211(pimB) STSP1_01099(mgtA)
ALUS: STSP2_03343(mgtA)
BBUR: L144_02215
BGA: BG0463
BGB: KK9_0471
BGN: BgCN_0469
BAFT: P612_02305
BAFE: BAFK78_452
BCHI: OY14_02245
BTU: BT0454
BHR: BH0454
BDU: BDU_453
BRE: BRE_456
BCW: Q7M_460
BMIY: RJ61_02215
BPAK: X966_02275
BANE: N187_02205
TDE: TDE2034
LBA: Lebu_0344
SMF: Smon_0825
AFD: Alfi_2999
DORI: FH5T_18640
SLI: Slin_4362
FLM: MY04_1049
CTAK: 4412677_01088(pimB_1)
TLE: Tlet_0508
FNO: Fnod_1696
MARN: LN42_02515
DTN: DTL3_0645
KOL: Kole_0752
MINF: MESINF_1034(RfaG)
ASAC: ATHSA_1816
MOX: DAMO_2999
BBGW: UT28_C0001G0809(mgtA)
GAH: GAH_01461
MEAR: Mpt1_c11890(mshA1)
MARC: AR505_1787
ABI: Aboo_0792
TON: TON_0417
THM: CL1_0272
MBAK: MSBR3_2754
MMA: MM_0649
MMAC: MSMAC_0662
MTHR: MSTHT_2370
MTHE: MSTHC_0910
MMET: MCMEM_2093
MPL: Mpal_1997
MPD: MCP_0042
MEZ: Mtc_0426
RCI: RCIX1060
HUT: Huta_0088
HTI: HTIA_0045
HLA: Hlac_1234
HTU: Htur_3516
NAT: NJ7G_0978
SID: M164_0660
SIH: SiH_0467
STEP: IC006_2210
POG: Pogu_2059
MARH: Mia14_0917
PSYT: DSAG12_00646(treT_1)
 » show all
Taxonomy
Reference
1  [PMID:8995384]
  Authors
Karlsson OP, Dahlqvist A, Vikstrom S, Wieslander A
  Title
Lipid dependence and basic kinetics of the purified 1,2-diacylglycerol 3-glucosyltransferase from membranes of Acholeplasma laidlawii.
  Journal
J Biol Chem 272:929-36 (1997)
DOI:10.1074/jbc.272.2.929
Reference
2  [PMID:12911309]
  Authors
Li L, Storm P, Karlsson OP, Berg S, Wieslander A
  Title
Irreversible binding and activity control of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii at an anionic lipid bilayer surface.
  Journal
Biochemistry 42:9677-86 (2003)
DOI:10.1021/bi034360l
Reference
3  [PMID:11294844]
  Authors
Berg S, Edman M, Li L, Wikstrom M, Wieslander A
  Title
Sequence properties of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii membranes. Recognition of a large group of lipid glycosyltransferases in eubacteria and archaea.
  Journal
J Biol Chem 276:22056-63 (2001)
DOI:10.1074/jbc.M102576200
  Sequence
[acl:ACL_0487]
Reference
4  [PMID:24558041]
  Authors
Semeniuk A, Sohlenkamp C, Duda K, Holzl G
  Title
A bifunctional glycosyltransferase from Agrobacterium tumefaciens synthesizes monoglucosyl and glucuronosyl diacylglycerol under phosphate deprivation.
  Journal
J Biol Chem 289:10104-14 (2014)
DOI:10.1074/jbc.M113.519298
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.337
IUBMB Enzyme Nomenclature: 2.4.1.337
ExPASy - ENZYME nomenclature database: 2.4.1.337
BRENDA, the Enzyme Database: 2.4.1.337

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