KEGG   ENZYME: 2.4.1.338Help
Entry
EC 2.4.1.338                Enzyme                                 

Name
validoxylamine A glucosyltransferase;
vldK (gene name);
valG (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:validoxylamine-A 4'-O-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + validoxylamine A = UDP + validamycin A [RN:R11241]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
validoxylamine A [CPD:C17700]
Product
UDP [CPD:C00015];
validamycin A [CPD:C12112]
Comment
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.4.1.338 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K20438  validoxylamine A glucosyltransferase
Genes
SHY: SHJG_0282
SHO: SHJGH_0116
Taxonomy
Reference
1  [PMID:16632251]
  Authors
Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z.
  Title
Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.
  Journal
Chem Biol 13:387-97 (2006)
DOI:10.1016/j.chembiol.2006.02.002
  Sequence
[shy:SHJG_0282]
Reference
2  [PMID:18563934]
  Authors
Xu H, Minagawa K, Bai L, Deng Z, Mahmud T
  Title
Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A.
  Journal
J Nat Prod 71:1233-6 (2008)
DOI:10.1021/np800185k
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.338
IUBMB Enzyme Nomenclature: 2.4.1.338
ExPASy - ENZYME nomenclature database: 2.4.1.338
BRENDA, the Enzyme Database: 2.4.1.338

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