| Entry |
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| Name |
phosphatidyl-myo-inositol alpha-mannosyltransferase;
mannosyltransferase PimA;
PimA;
guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase (ambiguous)
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
GDP-alpha-D-mannose:1-phosphatidyl-1D-myo-inositol 2-alpha-D-mannosyltransferase (configuration-retaining)
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| Reaction(IUBMB) |
GDP-alpha-D-mannose + 1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol [RN: R11702 R12038]
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| Reaction(KEGG) |
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| Substrate |
GDP-alpha-D-mannose [CPD: C00096];
1-phosphatidyl-1D-myo-inositol [CPD: C01194]
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| Product |
GDP [CPD: C00035];
2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol [CPD: C21606]
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| Comment |
Requires Mg2+. The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs).
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| History |
EC 2.4.1.345 created 2017
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| Pathway |
| ec00571 | Lipoarabinomannan (LAM) biosynthesis |
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| Orthology |
| K08256 | phosphatidyl-myo-inositol alpha-mannosyltransferase |
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| Genes |
| ADE: | Adeh_2418 Adeh_3504 Adeh_4147 |
| ACP: | A2cp1_1540 A2cp1_3661 A2cp1_4300 |
| AFW: | Anae109_1460 Anae109_4290 |
| ANK: | AnaeK_1445 AnaeK_3592 AnaeK_4278 |
| MBO: | BQ2027_MB2642C(pimA) |
| MMAE: | MMARE11_20350(pimA) |
| MBAI: | MB901379_01929(pimA) |
| MHEK: | JMUB5695_02979(pimA) |
| MPHL: | MPHLCCUG_03040(pimA_4) |
| MTHN: | 4412656_02663(pimA_1) |
| MAUU: | NCTC10437_02393(pimA) |
| MFLV: | NCTC10271_03012(pimA) |
| MSAL: | DSM43276_02615(pimA_2) |
| MTER: | 4434518_02322(pimA) |
| CDIP: | ERS451417_01400(pimA) |
| CMIN: | NCTC10288_01082(pimA) |
| CRL: | NCTC7448_02033(pimA) |
| CCYS: | SAMEA4530656_0969(pimA) |
| NFR: | ERS450000_00344(pimA_1) |
| NAD: | NCTC11293_03465 NCTC11293_05069(pimA_3) |
| NWL: | NWFMUON74_29090(pimA) |
| RRT: | 4535765_02115(pimA_1) |
| RCR: | NCTC10994_00750(pimA_1) |
| TPUL: | TPB0596_26710(pimA) |
| SAMB: | SAM23877_1576(pimA) |
| SLE: | sle_55860(sle_55860) |
| SHUN: | DWB77_06227(pimA_2) |
| LXL: | KDY119_01909(pimA) KDY119_02514 KDY119_02788 |
| DAY: | FV141_06120 FV141_09830 |
| YIM: | J5M86_03760 J5M86_08185 |
| XYA: | ET471_02255 ET471_14725 |
| SKE: | Sked_05020 Sked_17450 |
| CEZ: | CBP52_00815 CBP52_05305 |
| CPAL: | F1D97_07675 F1D97_12170 |
| DCO: | SAMEA4475696_1639(pimA) |
| AUS: | IPK37_02590 IPK37_16990 |
| DEM: | LGT36_004575 LGT36_013815 |
| CGRN: | 4412665_01260(pimA) |
| PAUS: | NCTC13651_01031(pimA) |
| ACTU: | Actkin_01957(pimA_1) |
| ACTN: | L083_6074 L083_7331 |
| PFLA: | Pflav_006090 Pflav_043290 Pflav_084150 |
| PSUU: | Psuf_046800 Psuf_062980 |
| TBW: | NCTC13354_00166(pimA_1) |
| AHW: | NCTC11636_00266(pimA) |
| AIR: | NCTC12972_00755(pimA) |
| ASLA: | NCTC11923_02016(pimA_1) |
| AVC: | NCTC10951_00667(pimA_1) |
| BLA: | BLA_0946(pimA) BLA_1345 |
| BLC: | Balac_0824 Balac_1101 |
| BLT: | Balat_0824 Balat_1101 |
| BNM: | BALAC2494_00144 BALAC2494_00298 |
| BANI: | Bl12_0771 Bl12_1024 |
| BANL: | BLAC_04220 BLAC_05545 |
| BNI: | BANAN_04070 BANAN_05420 |
| BANM: | EN10_04175 EN10_05580 |
| BAST: | BAST_0796 BAST_0972 |
| BCOR: | BCOR_0682 BCOR_0827 |
| BII: | BINDI_0623 BINDI_0767 |
| BACT: | AB656_01400 AB656_02215 |
| BCHO: | BcFMB_07280 BcFMB_08500 |
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| Reference |
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| Authors |
Kordulakova J, Gilleron M, Mikusova K, Puzo G, Brennan PJ, Gicquel B, Jackson M |
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| Title |
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gu X, Chen M, Wang Q, Zhang M, Wang B, Wang H |
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| Title |
Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Giganti D, Albesa-Jove D, Urresti S, Rodrigo-Unzueta A, Martinez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM |
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| Title |
Secondary structure reshuffling modulates glycosyltransferase function at the membrane. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Rodrigo-Unzueta A, Martinez MA, Comino N, Alzari PM, Chenal A, Guerin ME |
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| Title |
Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.345 |
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