Entry
Name
phosphatidyl-myo-inositol dimannoside synthase;
mannosyltransferase PimB;
PimB;
guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-alpha-D-mannose:2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol 6-alpha-D-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
(1) GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [RN:
R11703 R12040 ];
(2) GDP-alpha-D-mannose + 2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [RN:
R11704 R12041 ]
Reaction(KEGG)
Substrate
GDP-alpha-D-mannose [CPD:
C00096 ];
2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [CPD:
C21606 ];
2-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol [CPD:
C21609 ]
Product
GDP [CPD:
C00035 ];
2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [CPD:
C21607 ];
2-O-(6-O-acyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol [CPD:
C21608 ]
Comment
Requires Mg2+. The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs).
History
EC 2.4.1.346 created 2017
Pathway
ec00571 Lipoarabinomannan (LAM) biosynthesis
Orthology
K13668 phosphatidyl-myo-inositol dimannoside synthase
Genes
ACUM : C9E88_002455 C9E88_003825
MICC : AUP74_00447(pimB_1) AUP74_02363(pimB_2)
TVI : Thivi_0136 Thivi_4065
THIP : N838_18105 N838_30105
TNI : TVNIR_0046(pimB_[H])
APRS : BI364_02665 BI364_14415
JAJ : EKL02_12450 EKL02_15185
URU : DSM104443_02788(mshA_3)
APET : ToN1_15740 ToN1_15830
AZI : AzCIB_3666 AzCIB_3674
NGL : RG1141_CH11680 RG1141_CH33730
NGG : RG540_CH11960 RG540_CH34550
MTW : CQW49_00750 CQW49_19900
PLEO : OHA_1_02180(pimB_1) OHA_1_02526(pimB_3)
TSV : DSM104635_00214(pimB_1)
RMM : ROSMUCSMR3_01261(pimB)
DAX : FDQ92_08880 FDQ92_11075
MMAS : MYMAC_001053 MYMAC_006889
MRM : A7982_07502 A7982_07729
MBO : BQ2027_MB2211C(pimb)
MSA : Mycsm_00921 Mycsm_03889
MBAI : MB901379_02937(pimB_2)
MHEK : JMUB5695_02169(pimB_1)
MPHL : MPHLCCUG_03319(pimB_1)
MTHN : 4412656_01856(pimB)
MAUU : NCTC10437_03437(pimB)
MPOF : MPOR_19710 MPOR_38570(pimB)
MFLV : NCTC10271_02003(pimB_1)
MSAL : DSM43276_01770(pimB_2)
MTER : 4434518_01643(pimB_2)
CDD : CDCE8392_1527(pimB')
CDIP : ERS451417_01644(pimB')
CUE : CULC0102_1654(pimB2)
CUN : Cul210932_1606(pimB2)
CUS : CulFRC11_1508(pimB2)
CUQ : Cul210931_1491(pimB2)
CUZ : Cul05146_1578(pimB2)
CUJ : CUL131002_1528c(pimB2)
CMIN : NCTC10288_00789(pimB')
CRL : NCTC7448_00034(PimB')
CCYS : SAMEA4530656_0709(PimB')
NFR : ERS450000_02396(pimB_1)
NAD : NCTC11293_02766(pimB_2)
RFA : A3L23_03917(pimB_2) A3L23_05001(pimB_3)
RRT : 4535765_02999(pimB')
RCR : NCTC10994_00019(pimB_1)
SCO : SCO2132(SC6G10.05c) SCO5681(SC5H4.05c)
SSX : SACTE_1563 SACTE_4840
SLV : SLIV_10220(pimB1) SLIV_27045(pimB2)
SAMB : SAM23877_2229(pimB)
SRW : TUE45_02663(pimB_1) TUE45_06404(pimB_3)
SLE : sle_50070(sle_50070)
SPAV : Spa2297_08770 Spa2297_24075
SKY : D0C37_03150 D0C37_06260 D0C37_25590
SALW : CP975_09380 CP975_25975
SLS : SLINC_2464 SLINC_8323
SNR : SNOUR_13495 SNOUR_29695(pimB)
SKA : CP970_12040 CP970_31995
SHAW : CEB94_11555 CEB94_14800
SFIC : EIZ62_08255 EIZ62_24445
SSEO : D0Z67_07515 D0Z67_22475
SATA : C5746_05905 C5746_11685
SHK : J2N69_09190 J2N69_26975
SRUG : F0345_06360 F0345_25600
SVIO : HWN34_05545 HWN34_23985
KAB : B7C62_07450 B7C62_08940
JTE : ASJ30_03610 ASJ30_08475
JLI : EXU32_02525 EXU32_05890
JME : EEW87_006790 EEW87_011155
NGV : CDO52_03710 CDO52_13790
STRR : EKD16_10065(pimB5) EKD16_11955(pimB6)
ACTW : F7P10_31255 F7P10_31325 F7P10_36355
FRA : Francci3_0171 Francci3_1284 Francci3_3098
FRE : Franean1_1819 Franean1_2131 Franean1_3857
FRI : FraEuI1c_1807 FraEuI1c_2230 FraEuI1c_2234 FraEuI1c_2240 FraEuI1c_4961
FAL : FRAAL0355 FRAAL2029 FRAAL5099
FSY : FsymDg_1680 FsymDg_3159
ACTA : C1701_04880 C1701_05495
ACTU : Actkin_01583(pimB_1)
MCAB : HXZ27_03425 HXZ27_23035
ACTN : L083_1913 L083_7327
PSUU : Psuf_012870 Psuf_014950
CATI : CS0771_68050 CS0771_74380
DVC : Dvina_05560 Dvina_44645
TBW : NCTC13354_01752(pimB)
AHW : NCTC11636_00090(pimB_1)
ERZ : ER308_00580 ER308_15460
SYY : SYNGTS_0352(slr1076)
SYT : SYNGTI_0352(slr1076)
SYS : SYNPCCN_0352(slr1076)
SYQ : SYNPCCP_0352(slr1076)
DFS : HGD76_02070 HGD76_18570
RRS : RoseRS_4446 RoseRS_4579
OBG : Verru16b_01985(pimB_1) Verru16b_02842(pimB_5)
VBH : CMV30_08570 CMV30_13645
VBS : EGM51_00500 EGM51_07980
RML : FF011L_51540(pimB_3)
MFF : MFFC18_29150(pimB_3)
ABAC : LuPra_01058(pimB_2) LuPra_03303(pimB_4)
BCEL : BcellWH2_00189(pimB_1)
RMG : Rhom172_1676 Rhom172_2756
STHA : NCTC11429_04913(pimB)
PROC : Ptc2401_00359(pimB_2)
CPRV : CYPRO_2393 CYPRO_2660
» show all
Taxonomy
Reference
Authors
Guerin ME, Kaur D, Somashekar BS, Gibbs S, Gest P, Chatterjee D, Brennan PJ, Jackson M
Title
New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis.
Journal
Sequence
Reference
Authors
Mishra AK, Batt S, Krumbach K, Eggeling L, Besra GS
Title
Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.
Journal
Sequence
Reference
Authors
Batt SM, Jabeen T, Mishra AK, Veerapen N, Krumbach K, Eggeling L, Besra GS, Futterer K
Title
Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.346