KEGG   ENZYME: 2.4.1.348
Entry
EC 2.4.1.348                Enzyme                                 
Name
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase;
WbdC
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11937]
Reaction(KEGG)
R11937
Substrate
GDP-alpha-D-mannose [CPD:C00096];
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]
Product
GDP [CPD:C00035];
alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21780]
Comment
The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a.
History
EC 2.4.1.348 created 2017
Orthology
K12995  O-antigen biosynthesis alpha-1,3-mannosyltransferase
Genes
ECXEcHS_A2166
ECRECIAI1_2097(wbdC)
SBGSBG_0618(wbdC)
SBZA464_691
SBVN643_03115
KPJN559_1774
KVAKvar_1572
KPEKPK_1682
KVDKR75_26270
KVQSP68_06415
KQUAVR78_21660
KLWDA718_09860
PGELG71_13045
TCIA7K98_13140
PVACHC248_00500(kanE)
 » show all
Reference
1  [PMID:22875852]
  Authors
Greenfield LK, Richards MR, Li J, Wakarchuk WW, Lowary TL, Whitfield C
  Title
Biosynthesis of the polymannose lipopolysaccharide O-antigens from Escherichia coli serotypes O8 and O9a requires a unique combination of single- and multiple-active site mannosyltransferases.
  Journal
J Biol Chem 287:35078-91 (2012)
DOI:10.1074/jbc.M112.401000
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.348
IUBMB Enzyme Nomenclature: 2.4.1.348
ExPASy - ENZYME nomenclature database: 2.4.1.348
BRENDA, the Enzyme Database: 2.4.1.348

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