KEGG   ENZYME: 2.4.1.355
Entry
EC 2.4.1.355                Enzyme                                 
Name
poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase;
TarS
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12014 R12872]
Reaction(KEGG)
R12014 R12872(G);
(other) R12316(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]
Product
UDP [CPD:C00015];
4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21849]
Comment
Involved in the biosynthesis of poly(ribitol-phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-beta-D-glucosamine to the OH group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.70 [poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase].
History
EC 2.4.1.355 created 2018
Pathway
ec00552  Teichoic acid biosynthesis
Orthology
K22708  poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase
Genes
CIEAN232_28805
DICDpoa569_001459
GLECJD39_07375
ASIASU2_10100
ASSASU1_10145 ASU1_10580
AIOEXH44_04330
PSENPNC201_05825(epsJ1)
AMBAMBAS45_17130
PMESFX988_03852
HPIZGYM47_11390
NCINCTC10296_00789
NBCH3L91_00635
NMUSH7A79_1834
AQSDKK66_11295
RPIRpic_4742
RPFRpic12D_3665
RINACS15_5110
CFTCFF04554_1611
CFVCFVI03293_1633
CFXCFV97608_1736
CFZCSG_17420
CAMRCAQ16704_0308
CARMCARM_0274
SDOSD1155_02180 SD1155_02185
BSRI33_0250
BSYI653_17410
BSNBSn5_12650
BSXC663_3461(ggaB2)
BHTDIC78_13220
BMOJHC660_34600(ggaB)
BWDCT694_28360
BMQBMQ_1135
HMNHM131_05055
PBUTDTO10_26550
PPSRI6J18_19380
SAUSA0248
SAVSAV0258
SAWSAHV_0257
SAHSaurJH1_0249
SAJSaurJH9_0243
SAMMW0234
SASSAS0235
SARSAR0255
SACSACOL0243
SAXUSA300HOU_0269
SAASAUSA300_0252
SAOSAOUHSC_00228
SAENWMN_0192
SADSAAV_0226
SUUM013TW_0239
SUVSAVC_01030
SUJSAA6159_00235
SUKSAA6008_00232
SUCECTR2_219
SUTSAT0131_00251
SUQHMPREF0772_10244
SUZMS7_0248
SUDST398NM01_0271
SUXSAEMRSA15_02170
SUWSATW20_02600
SUGSAPIG0271
SUFSARLGA251_02220
SAUASAAG_00739
SAUERSAU_000202
SAUNSAKOR_00237
SAUSSA40_0216
SAUUSA957_0231
SAUGSA268_0228
SAUZSAZ172_0261
SAUTSAI1T1_2001990
SAUJSAI2T2_1001990
SAUKSAI3T3_1001990
SAUQSAI4T8_1001990
SAUVSAI7S6_1001990
SAUWSAI5S5_1001980
SAUXSAI6T6_1001990
SAUYSAI8T7_1001990
SAUFX998_0234
SABSAB0197
SUYSA2981_0258
SAUBC248_0246
SAUMBN843_2570
SAUCCA347_265
SAURSABB_01594
SAUIAZ30_01295
SAUDCH52_04435
SAMSNI36_01190
SUHSAMSHR1132_02260
SHASH0140
SHHShL2_00067
SSPSSP0076 SSP0357 SSP1599
SCASCA_0056
SLGSLGD_00394 SLGD_02320
SLNSLUG_03900 SLUG_22380
SSDSPSINT_2186
SWAA284_02040 A284_02045
SPASSTP1_0982 STP1_0983
SXYBE24_03100 BE24_10195
SXLSXYLSMQ121_0385 SXYLSMQ121_1643 SXYLSMQ121_2494
SXOSXYL_00388 SXYL_01717 SXYL_02674
SHUSHYC_01840
SCAPAYP1020_1653(epsJ)
SSCHLH95_01700
SAGQEP23_08260
SEQOSE1039_21940
SSIFAL483_09605 AL483_11825
SCVA4G25_07460
SPETCEP67_07300 CEP67_08460
SCOHBZ166_12515
SKLC7J89_02005 C7J89_03600
SHOMEGX58_04760
SMUSC7J88_04410
SCARDWB96_02360
SCHRDWB92_01660
SARLSAP2_04730
SPICSAMEA4384060_2471
SSHNCTC13712_00204
SDBCNQ82_00765
SLLOISP08_02345
SSCUCEP64_08335
SFFFOB90_06095
SSTESAMEA4384403_0141(kfoC)
MLENH3V22_00815
MVTI6J10_02375
SHVAAT16_03725
LGZNCTC10812_02570(hyaD_2)
PLYCGXP70_04285
LMELEUM_1424
LMMMI1_06285
LMKLMES_1202
LKILKI_08580
LECLGMK_03595
LGEC269_03420
LSUA6B45_06730
ETHCK496_09710
EREEUBREC_2520
ERTEUR_26180
ERAERE_07940
CGVCGLAU_09175(epsJ)
CSTRCBE89_04500
SGBWQO_10750
SSXSACTE_2001 SACTE_2668
SVLStrvi_8388
SRCM271_29740 M271_29755
SMALSMALA_3088
SSOII1A49_19315
SFASfla_4283
SBHSBI_06509
SDVBN159_1018 BN159_5402 BN159_5703
STRPF750_2426
SFISFUL_2168
SCIB446_32755
SLCSL103_04410
SXISXIM_15270 SXIM_49020
STRCAA958_25165
SPRISPRI_4935
SCZABE83_24680
SCXAS200_06040 AS200_43755
SRWTUE45_00552(epsH_1) TUE45_03194(epsH_3)
SRNA4G23_01674(epsJ_1)
SGSAVL59_21235
STSIA4E84_37930 A4E84_38975
SCADDN051_03245 DN051_05915
SLSSLINC_2987 SLINC_2996 SLINC_3051 SLINC_3284 SLINC_7751
SAUOBV401_19010
SVUB1H20_28805
SGVB1H19_16490
SLAUSLA_3568 SLA_5891
SALJSMD11_0634
STROSTRMOE7_15485
SNZDC008_31550
SGEDWG14_00906(epsH_1) DWG14_03000(epsJ_1) DWG14_05579(epsH_2) DWG14_05588(epsJ_3) DWG14_08205(epsJ_4)
SLKSLUN_13185
SGDELQ87_02770 ELQ87_15565
SCYAEJ357_02990 EJ357_15525
SGZC0216_08910 C0216_13325
SVNCP980_04260 CP980_07705
SHAWCEB94_38070
SRKFGW37_24995
SFICEIZ62_22250
SGALCP966_11960 CP966_12030
SPADDVK44_08985
SFYGFH48_17080
SAQUEJC51_17055 EJC51_17115 EJC51_19180 EJC51_41640
SRIMCP984_25200
SSUBCP968_08290 CP968_33610
SFUGCNQ36_02615 CNQ36_11770
STSUB7R87_09295
SCHACP983_02895 CP983_24855 CP983_28720
SCOECP976_15095 CP976_39315
STUIGCM10017668_04160
SATAC5746_17790
SCYGS1361_36200(epsH2)
SFEUIM697_20735
SLIAHA039_24005
SCALI6J39_28655
SPRACP972_32870
SDDD9753_03105
KABB7C62_09645
KITCFP65_2593
LXLKDY119_02624
LXYO159_15590
MIPAXH82_08125
MICRBMW26_01195
MFOLDXT68_01315
MWAE4K62_17210
MPRTET475_00800 ET475_11915
MOYCVS54_00314(epsJ_1)
MCAWF6J84_07730
MLZF6J85_16225
SALDFVA74_05210
LEULeucomu_09005
LEBG7066_06150
LVIG7068_15475
LINSG7067_08130
AGGC1N71_12925
ARLAFL94_17660
ARYATC04_09325
ACRYAC20117_19765
ACITHPK19_20700
AAIAARI_34170
GARAOZ07_07630 AOZ07_17870
GPRJQN66_07610
BFABfae_26480 Bfae_26500
BRXBH708_09755 BH708_09765
BRVCFK39_05660 CFK39_05665
BGGCFK41_03300
PHWG7075_00215
SERJSGUI_1221
BLINBLSMQ_3086
BLUTEW640_07375
BCAUI6G59_00200 I6G59_00225
MIKFOE78_12125
MICGGJV80_09125
MUZH4N58_17580
TFUTfu_2173
STRREKD16_04850(epsH)
SROSros_0992 Sros_8518
TBITbis_0511
STPStrop_1692 Strop_2081
SAQSare_1690
MAUMicau_2094 Micau_2815
MILML5_2201 ML5_5581
MICBMicB006_4385 MicB006_5153 MicB006_5919
MTUACSH63_10990 CSH63_14330
MICHFJK98_03075
MTEMGCE86_03970
MCABHXZ27_03165
MSAGGCM10017556_48200
VMAVAB18032_00450
MCRAID554_03195 ID554_19765
ASEACPL_2131
ACTSACWT_2009
PLABC6361_18995 C6361_29015
PLATC6W10_06425 C6W10_28685
VERHUT12_27720
NAVJQS30_15080
MRUmru_1264
MSIMsm_1324 Msm_1545
MMILsm9_2261
MELMetbo_0914
MFCBRM9_0685
MSUBBK009_06240
METOCIT02_10745
 » show all
Reference
1  [PMID:14085356]
  Authors
NATHENSON SG, STROMINGER JL
  Title
ENZYMATIC SYNTHESIS OF N-ACETYLGLUCOSAMINYLRIBITOL LINKAGES IN TEICHOIC ACID FROM STAPHYLOCOCCUS AUREUS, STRAIN COPENHAGEN.
  Journal
J Biol Chem 238:3161-9 (1963)
Reference
2  [PMID:23027967]
  Authors
Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S
  Title
Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.
  Journal
Proc Natl Acad Sci U S A 109:18909-14 (2012)
DOI:10.1073/pnas.1209126109
  Sequence
Reference
3  [PMID:27973583]
  Authors
Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC
  Title
Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid beta-glycosyltransferase Involved in Methicillin Resistance.
  Journal
PLoS Pathog 12:e1006067 (2016)
DOI:10.1371/journal.ppat.1006067
  Sequence
[sav:SAV0258]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.355
IUBMB Enzyme Nomenclature: 2.4.1.355
ExPASy - ENZYME nomenclature database: 2.4.1.355
BRENDA, the Enzyme Database: 2.4.1.355

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