KEGG   ENZYME: 2.4.1.355Help
Entry
EC 2.4.1.355                Enzyme                                 

Name
poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase;
TarS
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12014]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]
Product
UDP [CPD:C00015];
4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21849]
Comment
Involved in the biosynthesis of poly(ribitol-phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-beta-D-glucosamine to the OH group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.70 [poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase].
History
EC 2.4.1.355 created 2018
Orthology
K22708  poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase
Genes
KLW: DA718_00520
EBT: EBL_c14550
PCI: PCH70_02990
SULR: B649_05475
CAMP: CFT03427_1561
BSL: A7A1_1164
BSUS: Q433_19525
BJS: MY9_3617
BACY: QF06_16230
BGI: BGM20_11975
SAU: SA0248
SAV: SAV0258
SAW: SAHV_0257
SAM: MW0234
SAS: SAS0235
SAR: SAR0255
SAC: SACOL0243
SAE: NWMN_0192
SAD: SAAV_0226
SUZ: MS7_0248
SUG: SAPIG0271
SAUA: SAAG_00739
SAUS: SA40_0216
SAUU: SA957_0231
SAUG: SA268_0228
SAUF: X998_0234
SAB: SAB0197
SAUB: C248_0246
SAUM: BN843_2570
SAUC: CA347_265
SAUR: SABB_01594
SAUI: AZ30_01295
SAUD: CH52_04435
SAMS: NI36_01190
SSP: SSP0357
 » show all
Taxonomy
Reference
1  [PMID:14085356]
  Authors
NATHENSON SG, STROMINGER JL
  Title
ENZYMATIC SYNTHESIS OF N-ACETYLGLUCOSAMINYLRIBITOL LINKAGES IN TEICHOIC ACID FROM STAPHYLOCOCCUS AUREUS, STRAIN COPENHAGEN.
  Journal
J Biol Chem 238:3161-9 (1963)
Reference
2  [PMID:23027967]
  Authors
Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S
  Title
Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.
  Journal
Proc Natl Acad Sci U S A 109:18909-14 (2012)
DOI:10.1073/pnas.1209126109
  Sequence
Reference
3  [PMID:27973583]
  Authors
Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC
  Title
Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid beta-glycosyltransferase Involved in Methicillin Resistance.
  Journal
PLoS Pathog 12:e1006067 (2016)
DOI:10.1371/journal.ppat.1006067
  Sequence
[sav:SAV0258]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.355
IUBMB Enzyme Nomenclature: 2.4.1.355
ExPASy - ENZYME nomenclature database: 2.4.1.355
BRENDA, the Enzyme Database: 2.4.1.355

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