KEGG ENZYME: 2.4.1.355

ENZYME: 2.4.1.355

Entry

EC 2.4.1.355                Enzyme

Name

poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase;
TarS

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-N-acetyl-alpha-D-glucosamine:4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)

Reaction(IUBMB)

n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12014 R12872]

Reaction(KEGG)

R12014 R12872(G);
(other) R12316(G)

Substrate

UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]

Product

UDP [CPD:C00015];
4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21849]

Comment

Involved in the biosynthesis of poly(ribitol-phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-beta-D-glucosamine to the OH group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.70 [poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase].

History

EC 2.4.1.355 created 2018

Pathway

ec00552

Teichoic acid biosynthesis

Orthology

K22708

poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase

Genes

HPIZ:

GYM47_11390

NCI:	NCTC10296_00789

NMUS:

H7A79_1834

AQS:	DKK66_11295

BSR:

I33_0250

BSN:	BSn5_12650

BAWR:

D9C22_19100 D9C22_19130

SA0248

SAV:

SAV0258

SAW:

SAHV_0257

SAH:	SaurJH1_0249

SAJ:	SaurJH9_0243

SAM:

MW0234

SAS:

SAS0235

SAR:

SAR0255

SAC:

SACOL0243

SAX:	USA300HOU_0269

SAA:	SAUSA300_0252

SAO:	SAOUHSC_00228

SAE:

NWMN_0192

SAD:

SAAV_0226

SUU:	M013TW_0239

SUV:	SAVC_01030

SUJ:	SAA6159_00235(tarS)

SUK:	SAA6008_00232

SUC:

ECTR2_219

SUT:	SAT0131_00251

SUQ:	HMPREF0772_10244

SUZ:

MS7_0248

SUD:	ST398NM01_0271

SUX:	SAEMRSA15_02170

SUW:	SATW20_02600

SUG:

SAPIG0271

SUF:	SARLGA251_02220

SAUA:

SAAG_00739

SAUE:

RSAU_000202

SAUN:

SAKOR_00237

SAUS:

SA40_0216

SAUU:

SA957_0231

SAUG:

SA268_0228

SAUZ:

SAZ172_0261

SAUT:

SAI1T1_2001990

SAUJ:

SAI2T2_1001990

SAUK:

SAI3T3_1001990

SAUQ:

SAI4T8_1001990

SAUV:

SAI7S6_1001990

SAUW:

SAI5S5_1001980

SAUX:

SAI6T6_1001990

SAUY:

SAI8T7_1001990

SAUF:

X998_0234

SAB:

SAB0197

SUY:	SA2981_0258

SAUB:

C248_0246

SAUM:

BN843_2570

SAUC:

CA347_265

SAUR:

SABB_01594

SAUI:

AZ30_01295

SAUD:

CH52_04435

SAMS:

NI36_01190

SUH:	SAMSHR1132_02260

SSP:

SSP0357

SXY:	BE24_10195

SXL:	SXYLSMQ121_0385 SXYLSMQ121_1643

SXO:	SXYL_00388

SEQO:

SE1039_21940

SKL:	C7J89_03600

SARL:

SAP2_04730

SSH:	NCTC13712_00204

SLLO:

ISP08_02345

SPSD:

JMB28_02435

SEDA:

MNY58_01960

SCAQ:

QMO72_02035

SROT:

ML435_01105(tarS)

STAP:

AOB58_2217

SGAI:

K3U27_08170

SSUC:

ACSSAF_01985

SSCU:

CEP64_08335

SHV:	AAT16_03725

LGZ:	NCTC10812_02570(hyaD_2)

LME:

LEUM_1424

LMK:

LMES_1202

LKI:

LKI_08580

LGE:	C269_03420

CGV:	CGLAU_09175(epsJ)

CSTR:

CBE89_04500

SGB:

WQO_10750

SFI:

SFUL_2168

SVL:	Strvi_8388

SRC:	M271_29755

SAUO:

BV401_19010

SSOI:

I1A49_19315

SFA:

Sfla_4283

SDV:	BN159_1018

STRP:

F750_2426

SXI:	SXIM_15270

STRC:

AA958_25165

SRW:	TUE45_00552(epsH_1)

STSI:

A4E84_38975

SLAU:

SLA_3568 SLA_5891

SALJ:

SMD11_0634

SGE:	DWG14_08205(epsJ_4)

SGD:	ELQ87_15565

SCYA:

EJ357_02990

SGZ:	C0216_08910 C0216_13325

SVN:	CP980_04260 CP980_07705

SSUB:

CP968_33610

STSU:

B7R87_09295

SDD:	D9753_03105

SCIR:

STRCI_007429

SKG:	KJK29_01640

SMOD:

POD33_36870

KAB:	B7C62_09645

KIT:	CFP65_2593

MIP:	AXH82_08125

MICR:

BMW26_01195

MFOL:

DXT68_01315

MPRT:

ET475_00800

MPAO:

IZR02_01420

LEU:	Leucomu_09005

ARL:	AFL94_17660

ASUF:

MNQ99_00375

AAI:	AARI_34170

GAR:	AOZ07_17870

GLM:	N6V40_12645

GEY:	QMQ05_07280

SERJ:

SGUI_1221

SRO:

Sros_0992

STP:	Strop_1692 Strop_2081

SAQ:

Sare_1690

MAU:	Micau_2094 Micau_2815

MIL:	ML5_2201 ML5_5581

MICB:

MicB006_5153 MicB006_5919

MTUA:

CSH63_10990 CSH63_14330

MTEM:

GCE86_03970

MCAB:

HXZ27_03165

MSAG:

GCM10017556_48200

MCRA:

ID554_03195

MCHL:

PVK74_01355 PVK74_04330 PVK74_17060

MFEU:

H1D33_16570

MHAW:

RMN56_01595

ASE:

ACPL_2131

ACTS:

ACWT_2009

ACTL:

L3i22_022230

PLAB:

C6361_18995 C6361_29015

PLAT:

C6W10_06425 C6W10_28685

MFC:

BRM9_0685

MSUB:

BK009_06240

» show all

Reference

1 [PMID:14085356]

Authors

NATHENSON SG, STROMINGER JL

Title

ENZYMATIC SYNTHESIS OF N-ACETYLGLUCOSAMINYLRIBITOL LINKAGES IN TEICHOIC ACID FROM STAPHYLOCOCCUS AUREUS, STRAIN COPENHAGEN.

Journal

J Biol Chem 238:3161-9 (1963)

Reference

2 [PMID:23027967]

Authors

Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S

Title

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.

Journal

Proc Natl Acad Sci U S A 109:18909-14 (2012)
DOI:10.1073/pnas.1209126109

Sequence

[sao:SAOUHSC_00228]

Reference

3 [PMID:27973583]

Authors

Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC

Title

Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid beta-glycosyltransferase Involved in Methicillin Resistance.

Journal

PLoS Pathog 12:e1006067 (2016)
DOI:10.1371/journal.ppat.1006067

Sequence

[sav:SAV0258]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.355

IUBMB Enzyme Nomenclature:

2.4.1.355

ExPASy - ENZYME nomenclature database:

2.4.1.355

BRENDA, the Enzyme Database:

2.4.1.355

All links

Gene (47)   
   MGENES (47)   
Protein sequence (517)   
   UniProt (18)   
   SWISS-PROT (2)   
   RefSeq(pep) (497)   
DNA sequence (19701)   
   RefSeq(nuc) (16916)   
   GenBank (1405)   
   EMBL (1380)   
All databases (20265)   

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