KEGG ENZYME: 2.4.1.357

ENZYME: 2.4.1.357

Entry

EC 2.4.1.357                Enzyme

Name

phlorizin synthase;
MdPGT1: P2'GT

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:phloretin 2'-O-D-glucosyltransferase

Reaction(IUBMB)

UDP-alpha-D-glucose + phloretin = UDP + phlorizin [RN:R12088]

Reaction(KEGG)

R12088

Substrate

UDP-alpha-D-glucose [CPD:C00029];
phloretin [CPD:C00774]

Product

UDP [CPD:C00015];
phlorizin [CPD:C01604]

Comment

Isolated from Malus X domestica (apple). Phlorizin inhibits sodium-linked glucose transporters. It gives the characteristic flavour of apples and cider.

History

EC 2.4.1.357 created 2018

Pathway

ec00941

Flavonoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K22845

phlorizin synthase

Genes

CIT:

102628772

CIC:	CICLE_v10025535mg

TCC:	18593023 18593025 18593028

GRA:	105761417 105768674 105768679

GHI:	107930943 107955595 107955596 107955597

GAB:	108466846 108470618

DZI:

111315054

EGR:	104449844 104449845

GMX:	100787088(IF7GT6)

GSJ:

114417443

PVU:	PHAVU_005G005500g PHAVU_005G005600g

VRA:

106759717

VAR:	108332538 108333069

VUN:	114186917 114186935 114186948

CCAJ:

109805617 109805618 109806020

APRC:

113874864

MTR:	25488512 25488513

CAM:	101490930(UGT88F9) 101511986

PSAT:

127086084 127086085

LJA:	Lj0g3v0272789.1(Lj0g3v0272789.1) Lj0g3v0272789.2(Lj0g3v0272789.2)

ADU:

107491529

AIP:

107645049

AHF:

112803117

LANG:

109346029

FVE:

101298317

RCN:	112177051 112180056 112202849 112202850

PPER:

18775123 18789262 18789439 18789761 18792481

PMUM:

103319270 103319271 103319329 103329047

PAVI:

110755978 110759101 110767050 110767051 110767054 110767066 110772231

PDUL:

117615538 117620112 117629570

MDM:	103402192 103409768 103420359 103425310

PXB:	103952554 103967781 103967800 103967813

ZJU:

107415790

MNT:	21391667 21391669

RCU:

8283251

JCU:	105636738 105636739 105643989

HBR:	110642627 110669034

MESC:

110605933

POP:	127903868 18107945

PEU:

105108601

PALZ:

118051946

JRE:

108982034

CILL:

122306606

QSU:	111988070 112001084 112001087 112038347

QLO:	115975110 115977881

VVI:	100243118 100247599 100247819 100249347 100249918 100254461 100259577 100264736 100264754 100265364 100265418 100853698 100853970 100854044 100854078 100854186 104882785

VRI:	117905356 117905933 117906001 117906024 117906141 117906173 117907780

CSIN:

114284897 114323023

NNU:	104588566 104589090 104590055 104590056 104590057 104608194

MING:

122068851 122070114 122076358 122078877 122083533 122086353

TSS:	122641361 122641362 122641372 122643931 122643932 122663262 122663434

» show all

Reference

1 [PMID:18573104]

Authors

Jugde H, Nguy D, Moller I, Cooney JM, Atkinson RG

Title

Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple.

Journal

FEBS J 275:3804-14 (2008)
DOI:10.1111/j.1742-4658.2008.06526.x

Sequence

[mdm:103402192]

Reference

2 [PMID:27316677]

Authors

Yahyaa M, Davidovich-Rikanati R, Eyal Y, Sheachter A, Marzouk S, Lewinsohn E, Ibdah M

Title

Identification and characterization of UDP-glucose:Phloretin 4'-O-glycosyltransferase from Malus x domestica Borkh.

Journal

Phytochemistry 130:47-55 (2016)
DOI:10.1016/j.phytochem.2016.06.004

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.357

IUBMB Enzyme Nomenclature:

2.4.1.357

ExPASy - ENZYME nomenclature database:

2.4.1.357

BRENDA, the Enzyme Database:

2.4.1.357

DBGET integrated database retrieval system