KEGG   ENZYME: 2.4.1.361
Entry
EC 2.4.1.361                Enzyme                                 

Name
GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase;
MDIP synthase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:bis(myo-inositol)-1,3'-phosphate 2-beta-D-mannosyltransferase
Reaction(IUBMB)
2 GDP-alpha-D-mannose + bis(myo-inositol) 1,3'-phosphate = 2 GDP + 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate (overall reaction) [RN:R12338];
(1a) GDP-alpha-D-mannose + bis(myo-inositol) 1,3'-phosphate = GDP + 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [RN:R12339];
(1b) GDP-alpha-D-mannose + 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate = GDP + 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [RN:R12340]
Reaction(KEGG)
Substrate
GDP-alpha-D-mannose [CPD:C00096];
bis(myo-inositol) 1,3'-phosphate [CPD:C22088];
2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [CPD:C22090]
Product
GDP [CPD:C00035];
2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [CPD:C22089];
2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [CPD:C22090]
Comment
The enzyme from the hyperthermophilic bacterium Thermotoga maritima is involved in the synthesis of the solutes 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate and 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate.
History
EC 2.4.1.361 created 2019
Orthology
K23395  GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase
Genes
TMA: TM0359
TMM: Tmari_0357
TMI: THEMA_02920
TMW: THMA_0367
TMQ: THMB_0367
TMX: THMC_0367
TPT: Tpet_0560
TRQ: TRQ2_0575
TNA: CTN_0288
TNP: Tnap_0995
 » show all
Reference
1  [PMID:19648237]
  Authors
Rodrigues MV, Borges N, Almeida CP, Lamosa P, Santos H
  Title
A unique beta-1,2-mannosyltransferase of Thermotoga maritima that uses di-myo-inositol phosphate as the mannosyl acceptor.
  Journal
J Bacteriol 191:6105-15 (2009)
DOI:10.1128/JB.00598-09
  Sequence
[tma:TM0359]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.361
IUBMB Enzyme Nomenclature: 2.4.1.361
ExPASy - ENZYME nomenclature database: 2.4.1.361
BRENDA, the Enzyme Database: 2.4.1.361

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