KEGG   ENZYME: 2.4.1.369
Entry
EC 2.4.1.369                Enzyme                                 
Name
enterobactin C-glucosyltransferase;
iroB (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:enterobactin 5'-C-beta-D-glucosyltransferase (configuration-inverting)
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + enterobactin = UDP + monoglucosyl-enterobactin [RN:R12469];
(2) UDP-alpha-D-glucose + monoglucosyl-enterobactin = UDP + diglucosyl-enterobactin [RN:R12470];
(3) UDP-alpha-D-glucose + diglucosyl-enterobactin = UDP + triglucosyl-enterobactin [RN:R12471]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
enterobactin [CPD:C05821];
monoglucosyl-enterobactin [CPD:C22180];
diglucosyl-enterobactin [CPD:C22181]
Product
UDP [CPD:C00015];
monoglucosyl-enterobactin [CPD:C22180];
diglucosyl-enterobactin [CPD:C22181];
triglucosyl-enterobactin [CPD:C22182]
Comment
The enzyme, found in pathogenic strains of the bacteria Escherichia coli and Salmonella enterica, catalyses the transfer of glucosyl groups to C-5 of one, two, or three of the 2,3-hydroxybenzoyl units of the siderophore enterobactin, forming C-glucosylated derivatives known as salmochelins.
History
EC 2.4.1.369 created 2019
Orthology
K23725  enterobactin C-glucosyltransferase
Genes
ECEZ1190
ECSECs_1370
ECFECH74115_1369
ELXCDCO157_1309
EOIECO111_1272
EOJECO26_1324
ECOOECRM13514_1270(iroB)
ECOHECRM13516_1230(iroB)
ESLO3K_15730
ESOO3O_09565
ESMO3M_15715
EUNUMNK88_1247
ECPECP_0306
ECVAPECO1_O1CoBM141(iroB)
ECIUTI89_C1122(iroB)
EIHECOK1_1111
ECZECS88_p0128(iroB)
ECCc1254(iroB)
ELOEC042_3202(mchA)
ELNNRG857_30008(iroB)
EABECABU_c12110(iroB)
ELUUM146_12295
ELCi14_1148(iroB)
ELDi02_1148(iroB)
ECOIECOPMV1_01082
STYSTY2890(iroB)
STTt2668(iroB)
SEXSTBHUCCB_28080
SENTTY21A_13510
STMSTM2773(iroB)
SEOSTM14_3344(iroB)
SEVSTMMW_27401
SEYSL1344_2758(iroB)
SEMSTMDT12_C28270
SEJSTMUK_2761(iroB)
SEBSTM474_2908(iroB)
SEFUMN798_3009(iroB)
SETUSTU288_14040
SETCCFSAN001921_03215
SENRSTMDT2_26791(iroB)
SENDDT104_27751(iroB)
SENICY43_14500
SEENSE451236_19960
SPTSPA2629(iroB)
SEKSSPA2451
SPQSPAB_03444
SEISPC_2813(iroB)
SECSCH_2704(iroB)
SEHSeHA_C2949
SHBSU5_03260
SENHCFSAN002069_18400
SEEHSEEH1578_22680
SEESNSL254_A2968
SENNSN31241_38610
SEWSeSA_A2915
SEASeAg_B2885
SENSQ786_13310
SEDSeD_A3071
SEGSG2678(iroB)
SELSPUL_2765(iroB)
SEGASPUCDC_2751(iroB)
SETSEN2619(iroB)
SENAAU38_13285
SENOAU37_13295
SENVAU39_13295
SENQAU40_14960
SENLIY59_13870
SENJCFSAN001992_19670
SEECCFSAN002050_20150
SEEBSEEB0189_006315
SEEPI137_13190
SENBBN855_28060
SENEIA1_13235
SENCSEET0819_20675
SESSARI_00205
SALZEOS98_05685
SDYSDY_1026(iroB)
SDZAsd1617_01308
ECLEECNIH2_07815
ECLYLI62_07670
ECLOENC_19070
EHMAB284_18090
ECANCWI88_15310
ENKLOC22_17650(iroB)
KPUKP1_3611(iroB) KP1_p028(iroB)
KPPA79E_1750
KPTVK055_5103(iroB)
KPOKPN2242_26226
KPNKBN49_pII0030(iroB)
EAEEAE_03270
EARCCG33326
PGELG71_24425
YREHEC60_09565(iroB)
IZHFEM41_21260
GQUAWC35_23165
RBADH2866_00495
SCADDN051_13795
SRIMCP984_01870
SPHVF9278_28315 F9278_28325 F9278_28335 F9278_28345
SCHACP983_03635 CP983_27930
MCRAID554_11935
 » show all
Reference
1  [PMID:15598734]
  Authors
Fischbach MA, Lin H, Liu DR, Walsh CT
  Title
In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.
  Journal
Proc Natl Acad Sci U S A 102:571-6 (2005)
DOI:10.1073/pnas.0408463102
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.369
IUBMB Enzyme Nomenclature: 2.4.1.369
ExPASy - ENZYME nomenclature database: 2.4.1.369
BRENDA, the Enzyme Database: 2.4.1.369

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