KEGG   ENZYME: 2.4.1.370
Entry
EC 2.4.1.370                Enzyme                                 
Name
inositol phosphorylceramide mannosyltransferase;
SUR1 (gene name);
CSH1 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine = a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + GDP [RN:R12472]
Reaction(KEGG)
R12472
Substrate
GDP-alpha-D-mannose [CPD:C00096];
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine
Product
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine;
GDP [CPD:C00035]
Comment
The simplest complex sphingolipid of yeast, inositol-phospho-alpha-hydroxyphytoceramide (IPC), is usually mannosylated to yield mannosyl-inositol-phospho-alpha hydroxyphytoceramide (MIPC). The enzyme is located in the Golgi apparatus, and utilizes GDP-mannose as the mannosyl group donor. It consists of a catalytic subunit (SUR1 or CSH1) and a regulatory subunit (CSG2).
History
EC 2.4.1.370 created 2019
Orthology
K22721  inositol phosphorylceramide mannosyltransferase catalytic subunit
Genes
EAF111706862 111712011 111715824
HROHELRODRAFT_193660 HELRODRAFT_85985
LGILOTGIDRAFT_165932 LOTGIDRAFT_234732
PCAN112554310 112554653
BGT106072066 106077463
GAE121380215
HRF124134110
HRJ124289679
CRG105322441
MYI110451184
PMAX117335231
MMER123526579 123526584 123528003 123532711 123534474 123534484 123536522 123537963 123542758 123548005 123548677 123553884 123553963 123555295 123555316 123558616 123558868 123559192 123559193 123559194 123559195 123559533 123566664
OBI106875328
OSN115231739
LAK106151176 106153359 106161453 106169507 106173083 106173093 106180932 106181098
QSU111991165 111992762 112001261 112011196 112011282 112021804
MNGMNEG_2602 MNEG_8864
CSLCOCSUDRAFT_38902 COCSUDRAFT_57606 COCSUDRAFT_62728 COCSUDRAFT_65781 COCSUDRAFT_66191
CVRCHLNCDRAFT_10358 CHLNCDRAFT_132903 CHLNCDRAFT_137953 CHLNCDRAFT_141367 CHLNCDRAFT_142222 CHLNCDRAFT_145050
APROF751_2198 F751_2890
MISMICPUN_101129
GSLGasu_00650 Gasu_19240
SCEYBR161W(CSH1) YPL057C(SUR1)
KLAKLLA0_B09768g
KMXKLMA_30359(SUR1)
LTHKLTH0E11946g
VPOKpol_457p1
ZROZYRO0F08800g
CGRCAGL0M05621g CAGL0M07315g
NCSNCAS_0B02330(NCAS0B02330) NCAS_0C02270(NCAS0C02270)
NDINDAI_0C05350(NDAI0C05350) NDAI_0E02960(NDAI0E02960)
TPFTPHA_0I02040(TPHA0I02040) TPHA_0L01480(TPHA0L01480)
TBLTBLA_0A00490(TBLA0A00490) TBLA_0H03450(TBLA0H03450)
TDLTDEL_0B01240(TDEL0B01240)
TGBHG536_0H01270
KAFKAFR_0A01170(KAFR0A01170) KAFR_0E03040(KAFR0E03040)
ZMKHG535_0A07810
PPAPAS_chr1-3_0218
DHADEHA2B11440g
PICPICST_83423
PGUPGUG_01730
SPAASPAPADRAFT_60194
LELLELG_02758
CALCAALFM_C209150WA(MIT1)
CTPCTRG_01978
COTCORT_0C04600
CDUCD36_23310
CTENCANTEDRAFT_100431
CLUCLUG_00533
CLUSA9F13_15g01056
CAURCJI97_003957
SLBAWJ20_3499(SUR1)
PKZC5L36_0B12270
BNNFOA43_002655
BBRXBRETT_001537
NCRNCU07761
NTENEUTE1DRAFT109478(NEUTE1DRAFT_109478) NEUTE1DRAFT59032(NEUTE1DRAFT_59032)
SMPSMAC_05159 SMAC_12617
PANPODANSg4680 PODANSg8472
TTTTHITE_2073944 THITE_2114740 THITE_2155406
MTMMYCTH_2301633
MGRMGG_13744 MGG_15239
TMNUCRPA7_400
SSCKSPSK_06290 SPSK_07656
FGRFGSG_03803
FPUFPSE_04573
FVRFVEG_12942 FVEG_12987
FOXFOXG_16891 FOXG_16893
NHENECHADRAFT_106413 NECHADRAFT_26612 NECHADRAFT_51853 NECHADRAFT_55741 NECHADRAFT_88959
TRETRIREDRAFT_120923 TRIREDRAFT_45252 TRIREDRAFT_64925
TRRM419DRAFT_108301 M419DRAFT_108458 M419DRAFT_85693
MAWMAC_06157 MAC_06266 MAC_09448
MAJMAA_04377 MAA_07951 MAA_09567 MAA_11118
CMTCCM_01739 CCM_08818 CCM_09270
PLJVFPFJ_00279 VFPFJ_01501 VFPFJ_04198 VFPFJ_08222 VFPFJ_09746 VFPFJ_10895 VFPFJ_10969 VFPFJ_11324 VFPFJ_11649 VFPFJ_11698
VALVDBG_05673
VDAVDAG_04881 VDAG_07615
CFJCFIO01_06606
SAPOSAPIO_CDS6649
ELAUCREL1_10331
PFYPFICI_11318
SSLSS1G_00432
BFUBCIN_03g04220 BCIN_04g06200
MBEMBM_03773
PSCOLY89DRAFT_600211 LY89DRAFT_641076 LY89DRAFT_696850
GLZGLAREA_07063
ANIAN6534.2
AFMAFUA_6G04680
ACTACLA_044880 ACLA_095870
NFINFIA_051220 NFIA_094100
AORAO090005001189 AO090010000612 AO090701000073
ANGANI_1_120134(An15g00630) ANI_1_924084(An09g00100)
AFVAFLA_004563
ALUCAKAW2_40009S AKAW2_60622S
ACHEACHE_50208S
APUUAPUU_10734S APUU_50134A
PCSPc12g06590 Pc20g11710
PDPPDIP_18130
TMFPMAA_012270 PMAA_015570 PMAA_049720
TRGTRUGW13939_07174 TRUGW13939_07551 TRUGW13939_10859
CIMCIMG_02806
CPWCPC735_036290
UREUREG_03030
PBLPAAG_03525
PBNPADG_06303
ABEARB_03983 ARB_04086
TVETRV_01806 TRV_03867
AJEHCAG_08692
BGHBDBG_07766
PNOSNOG_05811 SNOG_09174(SNOG_09175)
PTEPTT_16724
BZECOCCADRAFT_7971
BSCCOCSADRAFT_137254
BORCOCMIDRAFT_99036
AALTCC77DRAFT_145490 CC77DRAFT_960406
ZTRMYCGRDRAFT_49574 MYCGRDRAFT_74362
PFJMYCFIDRAFT_211649 MYCFIDRAFT_86687
BCOMBAUCODRAFT_47228
NPAUCRNP2_5554
TMLGSTUM_00006149001
SPOSPAC17G8.11c(imt3) SPAC2F3.01(imt1) SPCC4F11.04c(imt2)
CNECNH00360
CNBCNBL0340
CGICGB_H0400C
TMSTREMEDRAFT_40831
TASAA1Q1_02468
TVSTRAVEDRAFT_70229
DSQDICSQDRAFT_106213
PCOPHACADRAFT_249466
SHSSTEHIDRAFT_95404
HIRHETIRDRAFT_34312
PSQPUNSTDRAFT_145072
ADLAURDEDRAFT_52940
FMEFOMMEDRAFT_110885 FOMMEDRAFT_140591
GTRGLOTRDRAFT_109709 GLOTRDRAFT_113658
LBCLACBIDRAFT_231771
MPRMPER_15070
MRRMoror_7454
CCICC1G_00390
SCMSCHCODRAFT_109040 SCHCODRAFT_66391 SCHCODRAFT_71813
ABPAGABI1DRAFT91417(AGABI1DRAFT_91417)
ABVAGABI2DRAFT142533(AGABI2DRAFT_142533)
CPUTCONPUDRAFT_102860
WSEWALSEDRAFT_60299
WICJ056_000619
UMAUMAG_15072
PFPPFL1_05915
MGLMGL_0392
MRTMRET_2213
MSYMMSY001_3200(OCH1)
PGRPGTG_12162 PGTG_19402
MLRMELLADRAFT_117884 MELLADRAFT_49485
MBRMONBRDRAFT_2363 MONBRDRAFT_31860 MONBRDRAFT_8658
SREPTSG_04074 PTSG_05645 PTSG_06348
SMINv1.2.010590.t1(symbB.v1.2.010590.t1) v1.2.015706.t1(symbB.v1.2.015706.t1) v1.2.025490.t1(symbB.v1.2.025490.t1) v1.2.025490.t2(symbB.v1.2.025490.t2) v1.2.037975.t1(symbB.v1.2.037975.t1) v1.2.037975.t2(symbB.v1.2.037975.t2)
PSOJPHYSODRAFT_358700 PHYSODRAFT_486818
SPARSPRG_08368
EHXEMIHUDRAFT_197740 EMIHUDRAFT_433823 EMIHUDRAFT_467350 EMIHUDRAFT_471622
GTTGUITHDRAFT_110904
NGRNAEGRDRAFT_72157
FSMCCS41_13915
AJNBVL33_14670
ACUMC9E88_002480
WOCBA177_06640
CHROCXB49_08000
CRZD1345_03165
CHAECH06BL_06040
BOKDM82_1689
BOCBG90_3021
CBXCenrod_2388
MBACBN1209_1153
FPHOSHINM1_018310
PTCphytr_4680
AGRAGROH133_08736
ATFAch5_24700
AVIAvi_3933
ALFCFBP5473_02425
RIRBN877_I2670
ROYG3A56_12840
SHZshn_26300
STARG3545_03850
MTWCQW49_06995
HDIHDIA_3838
NOHG5V57_01045
PHRC6569_01000
PSTGE8M01_18500
PTPRCA23_c10380
ZMNZa10_1038
ZMPZymop_1037
APTAPA01_03500
APWAPA42C_03500
APFAPA03_03500
APUAPA07_03500
APGAPA12_03500
APQAPA22_03500
APXAPA26_03500
APZAPA32_03500
APKAPA386B_1831
APERA0U91_05110
AASCA4S02_10855
AOYEOV40_001775
ABGAsbog_00540
BOBGN304_03925
BOMBGT348_07535
EBLAJGUZn3_08170
LCKHN018_08545
SKTIGS68_31790
SMUCJL100_034635
TURAT726_11265
TSGHLK68_11455
DCOSAMEA4475696_2343
STRREKD16_25235
CGCCyagr_2110
ANBANA_C13067
CCURIAR63_16570
RBARB9614(sur1)
BVOPan97_07240
ABACLuPra_06262
PDIBDI_2922 BDI_3159
PARCCI960_20845 CI960_22050
ARKD6B99_16375
PHEPhep_0687
PSTYBFS30_25235 BFS30_25240
PGSCPT03_02290 CPT03_19540
SHTKO02_01450
HYZAXW84_14380
FBAFIC_00838
EENBBD30_11650
ELBVO54_03588
EGOBBD34_04390
ELZFCS00_15970
CHRYCEY12_06510
CPIPCJF12_02230
CILEG358_11970
CTAINCTC12078_00676
CBPEB354_07880
CCASEIB73_01185
EVAEIB75_05370
 » show all
Reference
1  [PMID:9323360]
  Authors
Beeler TJ, Fu D, Rivera J, Monaghan E, Gable K, Dunn TM
  Title
SUR1 (CSG1/BCL21), a gene necessary for growth of Saccharomyces cerevisiae in the presence of high Ca2+ concentrations at 37 degrees C, is required for mannosylation of inositolphosphorylceramide.
  Journal
Mol Gen Genet 255:570-9 (1997)
DOI:10.1007/s004380050530
  Sequence
Reference
2  [PMID:9395539]
  Authors
Dean N, Zhang YB, Poster JB
  Title
The VRG4 gene is required for GDP-mannose transport into the lumen of the Golgi in the yeast, Saccharomyces cerevisiae.
  Journal
J Biol Chem 272:31908-14 (1997)
DOI:10.1074/jbc.272.50.31908
Reference
3  [PMID:12954640]
  Authors
Uemura S, Kihara A, Inokuchi J, Igarashi Y
  Title
Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p.
  Journal
J Biol Chem 278:45049-55 (2003)
DOI:10.1074/jbc.M305498200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.370
IUBMB Enzyme Nomenclature: 2.4.1.370
ExPASy - ENZYME nomenclature database: 2.4.1.370
BRENDA, the Enzyme Database: 2.4.1.370

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